ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 93/471 423/7206 2.33602189276e-27 ko04724 Glutamatergic synapse 47/471 152/7206 1.92923596558e-20 ko05033 Nicotine addiction 29/471 56/7206 2.72180949723e-20 ko04727 GABAergic synapse 36/471 110/7206 8.7669210403e-17 ko05032 Morphine addiction 34/471 110/7206 4.57369605404e-15 ko04728 Dopaminergic synapse 42/471 185/7206 3.88235327085e-13 ko04721 Synaptic vesicle cycle 25/471 80/7206 1.61440086814e-11 ko04713 Circadian entrainment 33/471 136/7206 2.11198809651e-11 ko04723 Retrograde endocannabinoid signaling 38/471 175/7206 2.28824976261e-11 ko04024 cAMP signaling pathway 48/471 279/7206 3.15803761675e-10 ko04911 Insulin secretion 27/471 117/7206 4.86413771292e-09 ko04726 Serotonergic synapse 29/471 137/7206 1.0743706117e-08 ko05031 Amphetamine addiction 23/471 91/7206 1.08160444968e-08 ko04725 Cholinergic synapse 31/471 160/7206 3.03087062142e-08 ko04921 Oxytocin signaling pathway 35/471 209/7206 1.79866860021e-07 ko04720 Long-term potentiation 21/471 99/7206 1.1458777463e-06 ko05030 Cocaine addiction 17/471 73/7206 3.14405367461e-06 ko04261 Adrenergic signaling in cardiomyocytes 32/471 205/7206 3.78913750741e-06 ko04260 Cardiac muscle contraction 19/471 98/7206 1.48078923861e-05 ko04971 Gastric acid secretion 19/471 98/7206 1.48078923861e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 16/471 74/7206 1.68673186574e-05 ko04742 Taste transduction 14/471 61/7206 2.78842501815e-05 ko04020 Calcium signaling pathway 35/471 265/7206 6.11505817542e-05 ko04964 Proximal tubule bicarbonate reclamation 9/471 29/7206 6.21091434565e-05 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/471 59/7206 8.46546203687e-05 ko04970 Salivary secretion 17/471 95/7206 0.000119199962052 ko04744 Phototransduction 9/471 36/7206 0.000387082675148 ko04925 Aldosterone synthesis and secretion 17/471 105/7206 0.000414763261503 ko04745 Phototransduction - fly 9/471 38/7206 0.000596202635357 ko05322 Systemic lupus erythematosus 1/471 151/7206 0.000687987433196 ko03040 Spliceosome 1/471 145/7206 0.0010098721002 ko04960 Aldosterone-regulated sodium reabsorption 9/471 41/7206 0.00107534701578 ko04972 Pancreatic secretion 17/471 111/7206 0.00132067295944 ko04070 Phosphatidylinositol signaling system 17/471 112/7206 0.00137402230792 ko04360 Axon guidance 28/471 233/7206 0.00166257556252 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 13/471 79/7206 0.00166338735889 ko05110 Vibrio cholerae infection 11/471 63/7206 0.00229076537946 ko04750 Inflammatory mediator regulation of TRP channels 17/471 122/7206 0.00256259027485 ko04730 Long-term depression 12/471 78/7206 0.00439731081244 ko04022 cGMP-PKG signaling pathway 25/471 216/7206 0.00473025269338 ko04973 Carbohydrate digestion and absorption 8/471 42/7206 0.00514833159198 ko04966 Collecting duct acid secretion 6/471 26/7206 0.00565240498569 ko05164 Influenza A 3/471 167/7206 0.00672920181763 ko04060 Cytokine-cytokine receptor interaction 4/471 191/7206 0.00715435128066 ko04120 Ubiquitin mediated proteolysis 2/471 138/7206 0.00842017957316 ko05203 Viral carcinogenesis 8/471 277/7206 0.00885983006286 ko03013 RNA transport 3/471 166/7206 0.0098034701538 ko04141 Protein processing in endoplasmic reticulum 4/471 184/7206 0.00984312450171 ko04010 MAPK signaling pathway 33/471 321/7206 0.0104006367604 ko04540 Gap junction 16/471 128/7206 0.0105710315031 ko04514 Cell adhesion molecules (CAMs) 16/471 130/7206 0.0117649220177 ko04924 Renin secretion 12/471 86/7206 0.0125346002384 ko04918 Thyroid hormone synthesis 12/471 86/7206 0.0125346002384 ko04621 NOD-like receptor signaling pathway 3/471 157/7206 0.0132103987621 ko04978 Mineral absorption 7/471 40/7206 0.0138219681815 ko04510 Focal adhesion 7/471 240/7206 0.0164592881305 ko04976 Bile secretion 11/471 80/7206 0.0187083861576 ko05010 Alzheimer's disease 22/471 202/7206 0.0194108491418 ko04071 Sphingolipid signaling pathway 18/471 162/7206 0.0235439398469 ko05162 Measles 2/471 120/7206 0.0239329636084 ko04668 TNF signaling pathway 2/471 120/7206 0.0239329636084 ko04626 Plant-pathogen interaction 4/471 18/7206 0.026478134185 ko04072 Phospholipase D signaling pathway 21/471 197/7206 0.0267326372242 ko05166 HTLV-I infection 10/471 292/7206 0.0285618681103 ko04146 Peroxisome 1/471 89/7206 0.0297108832444 ko04920 Adipocytokine signaling pathway 1/471 89/7206 0.0297108832444 ko04657 IL-17 signaling pathway 1/471 87/7206 0.0448189679508 ko05133 Pertussis 1/471 87/7206 0.0448189679508 ko00562 Inositol phosphate metabolism 11/471 89/7206 0.0468031290041 ko05414 Dilated cardiomyopathy 13/471 112/7206 0.0498658101223