ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1204	423/7206	4.88888509941e-52
ko04724	Glutamatergic synapse	86/1204	152/7206	1.53479077896e-29
ko05033	Nicotine addiction	46/1204	56/7206	5.52382620206e-27
ko04713	Circadian entrainment	75/1204	136/7206	6.50043346018e-25
ko05032	Morphine addiction	66/1204	110/7206	6.67881596688e-25
ko04727	GABAergic synapse	63/1204	110/7206	2.73650081921e-22
ko04728	Dopaminergic synapse	84/1204	185/7206	2.07642504703e-20
ko04020	Calcium signaling pathway	106/1204	265/7206	4.71842397513e-20
ko04725	Cholinergic synapse	76/1204	160/7206	5.25069723706e-20
ko04024	cAMP signaling pathway	106/1204	279/7206	3.40808194693e-18
ko04721	Synaptic vesicle cycle	46/1204	80/7206	1.08841304078e-16
ko04911	Insulin secretion	58/1204	117/7206	1.27164962045e-16
ko04723	Retrograde endocannabinoid signaling	75/1204	175/7206	1.36085777108e-16
ko04921	Oxytocin signaling pathway	82/1204	209/7206	3.15456030677e-15
ko04726	Serotonergic synapse	61/1204	137/7206	1.21952855254e-14
ko04742	Taste transduction	36/1204	61/7206	8.0374840332e-14
ko04970	Salivary secretion	46/1204	95/7206	5.72671744488e-13
ko04261	Adrenergic signaling in cardiomyocytes	75/1204	205/7206	3.13183879161e-12
ko03040	Spliceosome	1/1204	145/7206	1.17106605715e-10
ko05031	Amphetamine addiction	41/1204	91/7206	1.84875890317e-10
ko04720	Long-term potentiation	42/1204	99/7206	1.10622192909e-09
ko04744	Phototransduction	22/1204	36/7206	2.36937237942e-09
ko04925	Aldosterone synthesis and secretion	43/1204	105/7206	2.62815615463e-09
ko04022	cGMP-PKG signaling pathway	71/1204	216/7206	4.25624872552e-09
ko05203	Viral carcinogenesis	16/1204	277/7206	3.96573129133e-08
ko04740	Olfactory transduction	34/1204	80/7206	4.07747439892e-08
ko04971	Gastric acid secretion	39/1204	98/7206	5.17547193068e-08
ko04360	Axon guidance	71/1204	233/7206	1.40657013845e-07
ko05322	Systemic lupus erythematosus	5/1204	151/7206	3.8228874816e-07
ko05168	Herpes simplex infection	8/1204	182/7206	4.98363528545e-07
ko03013	RNA transport	7/1204	166/7206	8.56997826632e-07
ko04972	Pancreatic secretion	39/1204	111/7206	2.0436050453e-06
ko04070	Phosphatidylinositol signaling system	39/1204	112/7206	2.47882793364e-06
ko04010	MAPK signaling pathway	86/1204	321/7206	3.57896450147e-06
ko04730	Long-term depression	30/1204	78/7206	3.81806537406e-06
ko04540	Gap junction	42/1204	128/7206	6.36367008599e-06
ko04060	Cytokine-cytokine receptor interaction	11/1204	191/7206	7.31184372343e-06
ko05030	Cocaine addiction	28/1204	73/7206	8.75953716365e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1204	74/7206	1.10994303342e-05
ko04514	Cell adhesion molecules (CAMs)	41/1204	130/7206	2.4418757899e-05
ko04924	Renin secretion	30/1204	86/7206	3.31846805978e-05
ko04745	Phototransduction - fly	17/1204	38/7206	4.6813083103e-05
ko04621	NOD-like receptor signaling pathway	9/1204	157/7206	5.05327326772e-05
ko04072	Phospholipase D signaling pathway	55/1204	197/7206	6.10622650679e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1204	122/7206	6.87397797443e-05
ko04014	Ras signaling pathway	72/1204	279/7206	7.83186238755e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1204	29/7206	7.88538758042e-05
ko04966	Collecting duct acid secretion	13/1204	26/7206	9.00637717495e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1204	79/7206	0.0001109513142
ko05164	Influenza A	11/1204	167/7206	0.000136217192321
ko04612	Antigen processing and presentation	2/1204	77/7206	0.000165669047914
ko04141	Protein processing in endoplasmic reticulum	13/1204	184/7206	0.000181134627349
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1204	79/7206	0.000183572091725
ko04120	Ubiquitin mediated proteolysis	8/1204	138/7206	0.000187567358964
ko04976	Bile secretion	27/1204	80/7206	0.000203956049828
ko04110	Cell cycle	9/1204	145/7206	0.000267882813336
ko04923	Regulation of lipolysis in adipocytes	26/1204	77/7206	0.000285609967233
ko04260	Cardiac muscle contraction	31/1204	98/7206	0.00029784290012
ko04371	Apelin signaling pathway	47/1204	177/7206	0.000721485536846
ko05414	Dilated cardiomyopathy	33/1204	112/7206	0.00075737628583
ko05110	Vibrio cholerae infection	21/1204	63/7206	0.00105237684461
ko05169	Epstein-Barr virus infection	18/1204	206/7206	0.0011932414053
ko05140	Leishmaniasis	3/1204	75/7206	0.00151197610463
ko00330	Arginine and proline metabolism	2/1204	61/7206	0.00273014940022
ko04610	Complement and coagulation cascades	4/1204	79/7206	0.00343681323381
ko04064	NF-kappa B signaling pathway	6/1204	96/7206	0.00352744828811
ko05205	Proteoglycans in cancer	28/1204	271/7206	0.00353158415948
ko04915	Estrogen signaling pathway	35/1204	131/7206	0.00419019034379
ko05162	Measles	9/1204	120/7206	0.00431817421796
ko00071	Fatty acid degradation	1/1204	45/7206	0.00433567893093
ko03420	Nucleotide excision repair	1/1204	46/7206	0.00445142422206
ko04626	Plant-pathogen interaction	8/1204	18/7206	0.00536426414731
ko04214	Apoptosis - fly	4/1204	72/7206	0.00673349413946
ko03022	Basal transcription factors	1/1204	44/7206	0.00686229796463
ko04115	p53 signaling pathway	4/1204	74/7206	0.00690660615002
ko05161	Hepatitis B	16/1204	173/7206	0.00697619218715
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1204	59/7206	0.00774823316953
ko04217	Necroptosis	17/1204	178/7206	0.00793440384144
ko04015	Rap1 signaling pathway	63/1204	278/7206	0.0085682129824
ko04930	Type II diabetes mellitus	17/1204	54/7206	0.00885755828595
ko04622	RIG-I-like receptor signaling pathway	3/1204	62/7206	0.00924887193287
ko04146	Peroxisome	6/1204	89/7206	0.00933920658983
ko05166	HTLV-I infection	33/1204	292/7206	0.010253250053
ko04973	Carbohydrate digestion and absorption	14/1204	42/7206	0.0106300227779
ko04270	Vascular smooth muscle contraction	38/1204	154/7206	0.011506882447
ko04710	Circadian rhythm	14/1204	43/7206	0.0116367458085
ko00380	Tryptophan metabolism	2/1204	50/7206	0.0120494356277
ko04658	Th1 and Th2 cell differentiation	7/1204	96/7206	0.012279996289
ko04657	IL-17 signaling pathway	6/1204	87/7206	0.0129667562432
ko05133	Pertussis	6/1204	87/7206	0.0129667562432
ko00240	Pyrimidine metabolism	9/1204	110/7206	0.0138364327141
ko00562	Inositol phosphate metabolism	24/1204	89/7206	0.0141683450868
ko03410	Base excision repair	1/1204	38/7206	0.0147617656543
ko04922	Glucagon signaling pathway	32/1204	128/7206	0.0161455609497
ko03018	RNA degradation	6/1204	84/7206	0.0174802412239
ko05219	Bladder cancer	2/1204	48/7206	0.0178147257264
ko04960	Aldosterone-regulated sodium reabsorption	13/1204	41/7206	0.0182382136979
ko05231	Choline metabolism in cancer	33/1204	134/7206	0.0187011708352
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1204	14/7206	0.0191965899876
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1204	182/7206	0.0203451456417
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1204	100/7206	0.020629197139
ko05131	Shigellosis	6/1204	82/7206	0.0240860064612
ko05144	Malaria	2/1204	45/7206	0.0254310960358
ko04330	Notch signaling pathway	4/1204	62/7206	0.0258244661291
ko00280	Valine, leucine and isoleucine degradation	3/1204	54/7206	0.0263615606092
ko04912	GnRH signaling pathway	30/1204	122/7206	0.026613822826
ko04142	Lysosome	15/1204	151/7206	0.0266785920168
ko00480	Glutathione metabolism	3/1204	55/7206	0.0271682318573
ko05215	Prostate cancer	10/1204	111/7206	0.0285030993555
ko05145	Toxoplasmosis	12/1204	126/7206	0.0294424450284
ko04630	Jak-STAT signaling pathway	13/1204	132/7206	0.0334407690143
ko05217	Basal cell carcinoma	5/1204	68/7206	0.0338818884332
ko03320	PPAR signaling pathway	5/1204	69/7206	0.0339530300719
ko04113	Meiosis - yeast	5/1204	70/7206	0.0345485867959
ko00590	Arachidonic acid metabolism	3/1204	52/7206	0.0377027856444
ko04918	Thyroid hormone synthesis	22/1204	86/7206	0.0400740400825
ko01200	Carbon metabolism	13/1204	128/7206	0.0424567071643
ko05340	Primary immunodeficiency	1/1204	30/7206	0.0486983802074