ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1230	423/7206	4.81779739368e-49
ko04724	Glutamatergic synapse	90/1230	152/7206	2.99961637037e-32
ko05033	Nicotine addiction	48/1230	56/7206	2.2387418976e-29
ko05032	Morphine addiction	71/1230	110/7206	5.51284050338e-29
ko04713	Circadian entrainment	77/1230	136/7206	6.15964853127e-26
ko04727	GABAergic synapse	65/1230	110/7206	1.77088655991e-23
ko04728	Dopaminergic synapse	85/1230	185/7206	1.98673334716e-20
ko04725	Cholinergic synapse	76/1230	160/7206	1.95742703627e-19
ko04721	Synaptic vesicle cycle	49/1230	80/7206	6.41623430316e-19
ko04723	Retrograde endocannabinoid signaling	78/1230	175/7206	7.27426123123e-18
ko04024	cAMP signaling pathway	106/1230	279/7206	1.69333087405e-17
ko04020	Calcium signaling pathway	98/1230	265/7206	2.44218831214e-15
ko04744	Phototransduction	27/1230	36/7206	2.82691475829e-14
ko04911	Insulin secretion	55/1230	117/7206	3.77563368995e-14
ko04921	Oxytocin signaling pathway	80/1230	209/7206	1.01432781215e-13
ko04742	Taste transduction	35/1230	61/7206	1.10099733233e-12
ko04726	Serotonergic synapse	58/1230	137/7206	2.01363116652e-12
ko04261	Adrenergic signaling in cardiomyocytes	76/1230	205/7206	4.63753994049e-12
ko03040	Spliceosome	1/1230	145/7206	7.15473496692e-11
ko05031	Amphetamine addiction	42/1230	91/7206	8.60623565552e-11
ko04970	Salivary secretion	42/1230	95/7206	4.61434193648e-10
ko04720	Long-term potentiation	43/1230	99/7206	5.68848269531e-10
ko04360	Axon guidance	77/1230	233/7206	1.45781204847e-09
ko05203	Viral carcinogenesis	17/1230	277/7206	5.41797622995e-08
ko04925	Aldosterone synthesis and secretion	41/1230	105/7206	6.15507971414e-08
ko04971	Gastric acid secretion	38/1230	98/7206	2.32404967009e-07
ko04740	Olfactory transduction	33/1230	80/7206	2.5665018695e-07
ko04022	cGMP-PKG signaling pathway	67/1230	216/7206	2.97450611691e-07
ko03013	RNA transport	7/1230	166/7206	5.69179555274e-07
ko05322	Systemic lupus erythematosus	6/1230	151/7206	9.8115706079e-07
ko05030	Cocaine addiction	30/1230	73/7206	9.87586598238e-07
ko05168	Herpes simplex infection	9/1230	182/7206	1.09684622494e-06
ko04060	Cytokine-cytokine receptor interaction	10/1230	191/7206	1.2054302799e-06
ko04070	Phosphatidylinositol signaling system	40/1230	112/7206	1.54360161532e-06
ko04924	Renin secretion	33/1230	86/7206	1.92220962281e-06
ko05164	Influenza A	8/1230	167/7206	1.96264099378e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1230	74/7206	2.28749002537e-06
ko04010	MAPK signaling pathway	87/1230	321/7206	4.37296680362e-06
ko04514	Cell adhesion molecules (CAMs)	41/1230	130/7206	4.69403119182e-05
ko04745	Phototransduction - fly	17/1230	38/7206	6.20468095155e-05
ko04972	Pancreatic secretion	36/1230	111/7206	6.21646570993e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1230	79/7206	6.59735256798e-05
ko04072	Phospholipase D signaling pathway	56/1230	197/7206	6.86595085098e-05
ko04141	Protein processing in endoplasmic reticulum	13/1230	184/7206	9.2537044866e-05
ko04621	NOD-like receptor signaling pathway	10/1230	157/7206	9.6332857452e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1230	79/7206	0.000112395972436
ko04110	Cell cycle	9/1230	145/7206	0.000132768745313
ko05140	Leishmaniasis	2/1230	75/7206	0.000160533810358
ko04923	Regulation of lipolysis in adipocytes	27/1230	77/7206	0.000172736124595
ko05414	Dilated cardiomyopathy	35/1230	112/7206	0.000194990647333
ko05205	Proteoglycans in cancer	25/1230	271/7206	0.000268815125505
ko05161	Hepatitis B	13/1230	173/7206	0.000312130686691
ko04120	Ubiquitin mediated proteolysis	9/1230	138/7206	0.00035194274727
ko04730	Long-term depression	26/1230	78/7206	0.000399934898843
ko04612	Antigen processing and presentation	3/1230	77/7206	0.000675777582146
ko05169	Epstein-Barr virus infection	18/1230	206/7206	0.000681343534101
ko04064	NF-kappa B signaling pathway	5/1230	96/7206	0.000877640759572
ko04260	Cardiac muscle contraction	30/1230	98/7206	0.000975689532893
ko04640	Hematopoietic cell lineage	2/1230	64/7206	0.00119004981222
ko05162	Measles	8/1230	120/7206	0.00129781197813
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1230	59/7206	0.0014589654427
ko04014	Ras signaling pathway	68/1230	279/7206	0.00149402519617
ko04976	Bile secretion	25/1230	80/7206	0.00152899710364
ko04371	Apelin signaling pathway	47/1230	177/7206	0.00157287777898
ko04540	Gap junction	36/1230	128/7206	0.00183389436612
ko05110	Vibrio cholerae infection	21/1230	63/7206	0.00193063436468
ko04966	Collecting duct acid secretion	11/1230	26/7206	0.0021755346471
ko04146	Peroxisome	5/1230	89/7206	0.00251954760745
ko03420	Nucleotide excision repair	1/1230	46/7206	0.00282819436616
ko04750	Inflammatory mediator regulation of TRP channels	34/1230	122/7206	0.00324960194658
ko05321	Inflammatory bowel disease (IBD)	2/1230	56/7206	0.00375114679543
ko00480	Glutathione metabolism	2/1230	55/7206	0.00375514063198
ko03022	Basal transcription factors	1/1230	44/7206	0.00425537024989
ko05144	Malaria	1/1230	45/7206	0.00436121074771
ko00071	Fatty acid degradation	1/1230	45/7206	0.00436121074771
ko00240	Pyrimidine metabolism	8/1230	110/7206	0.00454883922726
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1230	14/7206	0.00467803063922
ko00310	Lysine degradation	4/1230	73/7206	0.00468194808416
ko04115	p53 signaling pathway	4/1230	74/7206	0.00468799810152
ko04915	Estrogen signaling pathway	35/1230	131/7206	0.00471999923845
ko05131	Shigellosis	5/1230	82/7206	0.00480828151679
ko04964	Proximal tubule bicarbonate reclamation	11/1230	29/7206	0.00594570682139
ko04626	Plant-pathogen interaction	8/1230	18/7206	0.00613727563313
ko04622	RIG-I-like receptor signaling pathway	3/1230	62/7206	0.00623655712633
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1230	100/7206	0.00679321435363
ko00590	Arachidonic acid metabolism	2/1230	52/7206	0.00829673544531
ko04658	Th1 and Th2 cell differentiation	7/1230	96/7206	0.00880715049937
ko04657	IL-17 signaling pathway	6/1230	87/7206	0.00917314116537
ko05133	Pertussis	6/1230	87/7206	0.00917314116537
ko00330	Arginine and proline metabolism	3/1230	61/7206	0.00919931459797
ko03320	PPAR signaling pathway	4/1230	69/7206	0.00935692250893
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1230	40/7206	0.00980693684213
ko05215	Prostate cancer	9/1230	111/7206	0.0103662614678
ko00260	Glycine, serine and threonine metabolism	2/1230	48/7206	0.0117449091014
ko05219	Bladder cancer	2/1230	48/7206	0.0117449091014
ko03018	RNA degradation	6/1230	84/7206	0.0124827808921
ko04710	Circadian rhythm	14/1230	43/7206	0.0127471195925
ko05231	Choline metabolism in cancer	34/1230	134/7206	0.0143599220597
ko00982	Drug metabolism - cytochrome P450	1/1230	37/7206	0.0144975750798
ko03410	Base excision repair	1/1230	38/7206	0.0149985987905
ko04620	Toll-like receptor signaling pathway	8/1230	100/7206	0.0150895702059
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1230	182/7206	0.0161558102766
ko05166	HTLV-I infection	35/1230	292/7206	0.0171099239402
ko04214	Apoptosis - fly	5/1230	72/7206	0.0178267240269
ko00280	Valine, leucine and isoleucine degradation	3/1230	54/7206	0.0182528255757
ko04217	Necroptosis	19/1230	178/7206	0.0201023976117
ko04918	Thyroid hormone synthesis	23/1230	86/7206	0.0208278080513
ko00500	Starch and sucrose metabolism	1/1230	35/7206	0.021936032804
ko04510	Focal adhesion	28/1230	240/7206	0.0230496651752
ko04922	Glucagon signaling pathway	32/1230	128/7206	0.0234502015204
ko04630	Jak-STAT signaling pathway	13/1230	132/7206	0.02592524857
ko04930	Type II diabetes mellitus	16/1230	54/7206	0.0270326310167
ko04270	Vascular smooth muscle contraction	37/1230	154/7206	0.0295761158322
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1230	15/7206	0.0303777563974
ko04916	Melanogenesis	34/1230	142/7206	0.0321787503468
ko00562	Inositol phosphate metabolism	23/1230	89/7206	0.0329300049277
ko04210	Apoptosis	20/1230	180/7206	0.0344804869414
ko04140	Autophagy - animal	18/1230	164/7206	0.03549236275
ko00140	Steroid hormone biosynthesis	2/1230	41/7206	0.0359639428819
ko00380	Tryptophan metabolism	3/1230	50/7206	0.0365789292643
ko04912	GnRH signaling pathway	30/1230	122/7206	0.0379929395498
ko05132	Salmonella infection	9/1230	98/7206	0.0413157301223
ko05145	Toxoplasmosis	13/1230	126/7206	0.0420080244852
ko04218	Cellular senescence	20/1230	177/7206	0.0424290813475
ko05320	Autoimmune thyroid disease	1/1230	29/7206	0.0482284370747
ko05340	Primary immunodeficiency	1/1230	30/7206	0.0487075662668