ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	186/1157	423/7206	3.50945683725e-45
ko04724	Glutamatergic synapse	87/1157	152/7206	9.88051173292e-32
ko05033	Nicotine addiction	48/1157	56/7206	1.2299909364e-30
ko04727	GABAergic synapse	65/1157	110/7206	5.08419350294e-25
ko04713	Circadian entrainment	73/1157	136/7206	2.08644046161e-24
ko05032	Morphine addiction	64/1157	110/7206	3.96807102625e-24
ko04728	Dopaminergic synapse	83/1157	185/7206	6.48195687535e-21
ko04721	Synaptic vesicle cycle	48/1157	80/7206	3.63424709392e-19
ko04723	Retrograde endocannabinoid signaling	77/1157	175/7206	7.4122663472e-19
ko04725	Cholinergic synapse	71/1157	160/7206	1.02068661577e-17
ko04744	Phototransduction	29/1157	36/7206	1.79917125351e-17
ko04024	cAMP signaling pathway	98/1157	279/7206	2.47317779885e-15
ko04742	Taste transduction	37/1157	61/7206	2.82017568335e-15
ko04726	Serotonergic synapse	60/1157	137/7206	7.85072608549e-15
ko04911	Insulin secretion	54/1157	117/7206	1.20462173402e-14
ko04020	Calcium signaling pathway	92/1157	265/7206	3.57499087509e-14
ko04921	Oxytocin signaling pathway	77/1157	209/7206	1.70515072037e-13
ko04740	Olfactory transduction	39/1157	80/7206	7.34209909183e-12
ko05031	Amphetamine addiction	42/1157	91/7206	1.12093772391e-11
ko04720	Long-term potentiation	41/1157	99/7206	1.22258175723e-09
ko04261	Adrenergic signaling in cardiomyocytes	66/1157	205/7206	5.83917230892e-09
ko03040	Spliceosome	2/1157	145/7206	6.6159835788e-09
ko03010	Ribosome	1/1157	129/7206	6.8149875761e-09
ko04971	Gastric acid secretion	39/1157	98/7206	1.19847543689e-08
ko04970	Salivary secretion	38/1157	95/7206	1.56312113267e-08
ko05203	Viral carcinogenesis	15/1157	277/7206	5.97377940453e-08
ko04745	Phototransduction - fly	20/1157	38/7206	2.0201699248e-07
ko04925	Aldosterone synthesis and secretion	38/1157	105/7206	5.43568395994e-07
ko04972	Pancreatic secretion	39/1157	111/7206	6.6632880783e-07
ko05322	Systemic lupus erythematosus	5/1157	151/7206	8.83345355745e-07
ko05030	Cocaine addiction	29/1157	73/7206	9.37869644975e-07
ko04966	Collecting duct acid secretion	15/1157	26/7206	1.48481825974e-06
ko03013	RNA transport	7/1157	166/7206	2.81677234968e-06
ko04060	Cytokine-cytokine receptor interaction	10/1157	191/7206	5.29331209572e-06
ko04070	Phosphatidylinositol signaling system	37/1157	112/7206	6.82384488093e-06
ko05164	Influenza A	8/1157	167/7206	9.10815639207e-06
ko04110	Cell cycle	6/1157	145/7206	1.01628511431e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1157	74/7206	1.67495619169e-05
ko05168	Herpes simplex infection	10/1157	182/7206	2.10598069918e-05
ko05161	Hepatitis B	10/1157	173/7206	5.51753608509e-05
ko05110	Vibrio cholerae infection	23/1157	63/7206	7.67273370968e-05
ko05162	Measles	5/1157	120/7206	7.73911115445e-05
ko05166	HTLV-I infection	24/1157	292/7206	8.47285287085e-05
ko05169	Epstein-Barr virus infection	14/1157	206/7206	9.92815524033e-05
ko04621	NOD-like receptor signaling pathway	9/1157	157/7206	0.000103571381828
ko04612	Antigen processing and presentation	2/1157	77/7206	0.000259065170287
ko03008	Ribosome biogenesis in eukaryotes	2/1157	79/7206	0.000275306432288
ko04976	Bile secretion	26/1157	80/7206	0.000298516246064
ko04022	cGMP-PKG signaling pathway	55/1157	216/7206	0.000314474473654
ko04924	Renin secretion	27/1157	86/7206	0.000322397437268
ko04141	Protein processing in endoplasmic reticulum	13/1157	184/7206	0.000335512670438
ko04072	Phospholipase D signaling pathway	51/1157	197/7206	0.00035170999366
ko04514	Cell adhesion molecules (CAMs)	37/1157	130/7206	0.000388296785724
ko04730	Long-term depression	25/1157	78/7206	0.000468421842647
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1157	79/7206	0.000528809792587
ko05205	Proteoglycans in cancer	24/1157	271/7206	0.00068821298206
ko04120	Ubiquitin mediated proteolysis	9/1157	138/7206	0.00097641557016
ko05215	Prostate cancer	6/1157	111/7206	0.000977527724411
ko04750	Inflammatory mediator regulation of TRP channels	34/1157	122/7206	0.0010456447004
ko04260	Cardiac muscle contraction	28/1157	98/7206	0.00196457260903
ko05140	Leishmaniasis	3/1157	75/7206	0.00224088858741
ko05224	Breast cancer	14/1157	174/7206	0.00231673824721
ko04010	MAPK signaling pathway	72/1157	321/7206	0.00232893363807
ko04630	Jak-STAT signaling pathway	9/1157	132/7206	0.00250851065856
ko04550	Signaling pathways regulating pluripotency of stem cells	13/1157	165/7206	0.00251923547606
ko04964	Proximal tubule bicarbonate reclamation	11/1157	29/7206	0.00366287147432
ko04626	Plant-pathogen interaction	8/1157	18/7206	0.00416406312431
ko05200	Pathways in cancer	57/1157	492/7206	0.00418504922661
ko05217	Basal cell carcinoma	3/1157	68/7206	0.00457678729583
ko05219	Bladder cancer	1/1157	48/7206	0.00463524102817
ko04657	IL-17 signaling pathway	5/1157	87/7206	0.00505420809354
ko05321	Inflammatory bowel disease (IBD)	2/1157	56/7206	0.00577065287396
ko04710	Circadian rhythm	14/1157	43/7206	0.00611119068723
ko05414	Dilated cardiomyopathy	29/1157	112/7206	0.00631300240492
ko03022	Basal transcription factors	1/1157	44/7206	0.00671482329161
ko04140	Autophagy - animal	14/1157	164/7206	0.00680566959233
ko05144	Malaria	1/1157	45/7206	0.00682533460453
ko04064	NF-kappa B signaling pathway	6/1157	96/7206	0.00713200936539
ko03420	Nucleotide excision repair	1/1157	46/7206	0.00717885903092
ko00562	Inositol phosphate metabolism	24/1157	89/7206	0.0082285342052
ko04978	Mineral absorption	13/1157	40/7206	0.00847753784494
ko00520	Amino sugar and nucleotide sugar metabolism	2/1157	55/7206	0.00859596466316
ko00480	Glutathione metabolism	2/1157	55/7206	0.00859596466316
ko05131	Shigellosis	5/1157	82/7206	0.00973157325773
ko05145	Toxoplasmosis	10/1157	126/7206	0.00981451457641
ko04115	p53 signaling pathway	4/1157	74/7206	0.0098993459319
ko04540	Gap junction	32/1157	128/7206	0.0101047384778
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1157	182/7206	0.0103819517584
ko04974	Protein digestion and absorption	25/1157	96/7206	0.0111481143519
ko04915	Estrogen signaling pathway	32/1157	131/7206	0.011419848093
ko05202	Transcriptional misregulation in cancer	18/1157	188/7206	0.0117548453245
ko00590	Arachidonic acid metabolism	2/1157	52/7206	0.0123673052825
ko04210	Apoptosis	17/1157	180/7206	0.0132332023359
ko04610	Complement and coagulation cascades	5/1157	79/7206	0.0134506240174
ko04330	Notch signaling pathway	3/1157	62/7206	0.0135999329763
ko04622	RIG-I-like receptor signaling pathway	3/1157	62/7206	0.0135999329763
ko04214	Apoptosis - fly	4/1157	72/7206	0.0141510504592
ko00290	Valine, leucine and isoleucine biosynthesis	3/1157	4/7206	0.0145356942439
ko04510	Focal adhesion	25/1157	240/7206	0.0154050833301
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1157	14/7206	0.0158919684813
ko04658	Th1 and Th2 cell differentiation	7/1157	96/7206	0.0165979678374
ko05206	MicroRNAs in cancer	17/1157	177/7206	0.0167387131354
ko05016	Huntington's disease	22/1157	215/7206	0.017989133058
ko04350	TGF-beta signaling pathway	8/1157	103/7206	0.0206224022545
ko05418	Fluid shear stress and atherosclerosis	17/1157	173/7206	0.0210914031908
ko04371	Apelin signaling pathway	40/1157	177/7206	0.0220010910432
ko05150	Staphylococcus aureus infection	1/1157	36/7206	0.0224370498133
ko04341	Hedgehog signaling pathway - fly	1/1157	38/7206	0.0234880132965
ko03410	Base excision repair	1/1157	38/7206	0.0234880132965
ko03018	RNA degradation	6/1157	84/7206	0.0239566650382
ko05220	Chronic myeloid leukemia	6/1157	85/7206	0.0243954541226
ko05416	Viral myocarditis	3/1157	55/7206	0.0266908495488
ko04922	Glucagon signaling pathway	30/1157	128/7206	0.0280608437547
ko04217	Necroptosis	18/1157	178/7206	0.0294039157208
ko04014	Ras signaling pathway	58/1157	279/7206	0.0306525283155
ko04810	Regulation of actin cytoskeleton	30/1157	264/7206	0.032766874873
ko00830	Retinol metabolism	12/1157	42/7206	0.0343673678414
ko04973	Carbohydrate digestion and absorption	12/1157	42/7206	0.0343673678414
ko00310	Lysine degradation	5/1157	73/7206	0.0353615742622
ko00280	Valine, leucine and isoleucine degradation	3/1157	54/7206	0.038309253035
ko00071	Fatty acid degradation	2/1157	45/7206	0.03842507991
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1157	100/7206	0.0384489304884
ko00512	Mucin type O-glycan biosynthesis	9/1157	29/7206	0.0392606279904
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1157	92/7206	0.0450399669099
ko03320	PPAR signaling pathway	5/1157	69/7206	0.0469256292513
ko04113	Meiosis - yeast	5/1157	70/7206	0.0476167932561
ko02010	ABC transporters	11/1157	39/7206	0.0477242720745
ko00240	Pyrimidine metabolism	10/1157	110/7206	0.0486605318838
ko04218	Cellular senescence	19/1157	177/7206	0.0491871997277