ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1135	423/7206	1.43477556645e-48
ko04724	Glutamatergic synapse	87/1135	152/7206	2.19884915211e-32
ko05033	Nicotine addiction	48/1135	56/7206	4.9382196659e-31
ko05032	Morphine addiction	70/1135	110/7206	2.84193970826e-30
ko04713	Circadian entrainment	76/1135	136/7206	1.88205284577e-27
ko04727	GABAergic synapse	67/1135	110/7206	2.30710556702e-27
ko04725	Cholinergic synapse	76/1135	160/7206	1.31476650059e-21
ko04728	Dopaminergic synapse	83/1135	185/7206	1.7904703532e-21
ko04723	Retrograde endocannabinoid signaling	79/1135	175/7206	1.08880959735e-20
ko04721	Synaptic vesicle cycle	47/1135	80/7206	1.29162033196e-18
ko04024	cAMP signaling pathway	101/1135	279/7206	1.30079629524e-17
ko04020	Calcium signaling pathway	94/1135	265/7206	9.73238147537e-16
ko04744	Phototransduction	27/1135	36/7206	3.60721821084e-15
ko04911	Insulin secretion	53/1135	117/7206	2.46452726672e-14
ko04742	Taste transduction	35/1135	61/7206	9.41413714452e-14
ko04261	Adrenergic signaling in cardiomyocytes	75/1135	205/7206	1.35581980289e-13
ko04921	Oxytocin signaling pathway	75/1135	209/7206	5.21337598732e-13
ko04726	Serotonergic synapse	55/1135	137/7206	3.52963664539e-12
ko03040	Spliceosome	1/1135	145/7206	5.2065900985e-10
ko05031	Amphetamine addiction	39/1135	91/7206	5.2527833827e-10
ko04970	Salivary secretion	40/1135	95/7206	6.00388150087e-10
ko04720	Long-term potentiation	40/1135	99/7206	2.60345272373e-09
ko04360	Axon guidance	72/1135	233/7206	3.99868911694e-09
ko04022	cGMP-PKG signaling pathway	65/1135	216/7206	6.68964870784e-08
ko04925	Aldosterone synthesis and secretion	39/1135	105/7206	7.82743173998e-08
ko05203	Viral carcinogenesis	15/1135	277/7206	1.22687285587e-07
ko04971	Gastric acid secretion	37/1135	98/7206	1.31176915398e-07
ko04070	Phosphatidylinositol signaling system	39/1135	112/7206	5.55024265174e-07
ko05030	Cocaine addiction	29/1135	73/7206	6.21394115094e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1135	74/7206	8.70429236711e-07
ko05322	Systemic lupus erythematosus	5/1135	151/7206	1.34071486722e-06
ko04740	Olfactory transduction	30/1135	80/7206	2.71798404064e-06
ko03013	RNA transport	7/1135	166/7206	4.13810072202e-06
ko04972	Pancreatic secretion	37/1135	111/7206	4.18667378426e-06
ko05164	Influenza A	7/1135	167/7206	4.25892256874e-06
ko04010	MAPK signaling pathway	82/1135	321/7206	4.44954344546e-06
ko05168	Herpes simplex infection	9/1135	182/7206	7.21019168375e-06
ko04060	Cytokine-cytokine receptor interaction	10/1135	191/7206	1.11566760873e-05
ko04621	NOD-like receptor signaling pathway	7/1135	157/7206	1.20191831534e-05
ko04610	Complement and coagulation cascades	1/1135	79/7206	3.25543505748e-05
ko04966	Collecting duct acid secretion	13/1135	26/7206	4.76383866344e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1135	79/7206	5.88846611559e-05
ko04072	Phospholipase D signaling pathway	53/1135	197/7206	5.93292593112e-05
ko04514	Cell adhesion molecules (CAMs)	38/1135	130/7206	8.13186280102e-05
ko04745	Phototransduction - fly	16/1135	38/7206	9.14419211811e-05
ko05414	Dilated cardiomyopathy	34/1135	112/7206	0.000107862532768
ko04730	Long-term depression	26/1135	78/7206	0.000111122495339
ko04120	Ubiquitin mediated proteolysis	7/1135	138/7206	0.000137067778714
ko04141	Protein processing in endoplasmic reticulum	12/1135	184/7206	0.000195838796561
ko04923	Regulation of lipolysis in adipocytes	25/1135	77/7206	0.000219655759364
ko05205	Proteoglycans in cancer	22/1135	271/7206	0.000233251836785
ko04915	Estrogen signaling pathway	37/1135	131/7206	0.000235150585711
ko04924	Renin secretion	27/1135	86/7206	0.000257452595974
ko03008	Ribosome biogenesis in eukaryotes	2/1135	79/7206	0.00026585648063
ko04014	Ras signaling pathway	67/1135	279/7206	0.000284098366186
ko04540	Gap junction	36/1135	128/7206	0.000321347032623
ko04640	Hematopoietic cell lineage	1/1135	64/7206	0.000397012227278
ko04976	Bile secretion	25/1135	80/7206	0.000507495421688
ko00562	Inositol phosphate metabolism	27/1135	89/7206	0.0005794362084
ko04064	NF-kappa B signaling pathway	4/1135	96/7206	0.000599933009937
ko05140	Leishmaniasis	2/1135	75/7206	0.000607630663606
ko04260	Cardiac muscle contraction	29/1135	98/7206	0.000638634945181
ko00480	Glutathione metabolism	1/1135	55/7206	0.00134352311482
ko00240	Pyrimidine metabolism	6/1135	110/7206	0.00138508597894
ko04750	Inflammatory mediator regulation of TRP channels	33/1135	122/7206	0.00149822527733
ko04371	Apelin signaling pathway	44/1135	177/7206	0.00157750764087
ko05169	Epstein-Barr virus infection	17/1135	206/7206	0.00179856242773
ko04612	Antigen processing and presentation	3/1135	77/7206	0.00232813217105
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1135	14/7206	0.00291900544011
ko04964	Proximal tubule bicarbonate reclamation	11/1135	29/7206	0.00313785210964
ko00590	Arachidonic acid metabolism	1/1135	52/7206	0.0032255641364
ko05162	Measles	8/1135	120/7206	0.00352622544413
ko04626	Plant-pathogen interaction	8/1135	18/7206	0.00368149613336
ko00330	Arginine and proline metabolism	2/1135	61/7206	0.00404602899472
ko05161	Hepatitis B	14/1135	173/7206	0.00408178294457
ko05110	Vibrio cholerae infection	19/1135	63/7206	0.00449274688564
ko00260	Glycine, serine and threonine metabolism	1/1135	48/7206	0.00456539874694
ko04146	Peroxisome	5/1135	89/7206	0.00511971250439
ko04110	Cell cycle	11/1135	145/7206	0.00533021661881
ko00071	Fatty acid degradation	1/1135	45/7206	0.00681067375685
ko03420	Nucleotide excision repair	1/1135	46/7206	0.00695581693728
ko04930	Type II diabetes mellitus	16/1135	54/7206	0.00828657443859
ko03018	RNA degradation	5/1135	84/7206	0.00986793311586
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1135	59/7206	0.0106211119864
ko03022	Basal transcription factors	1/1135	44/7206	0.0107022011
ko04510	Focal adhesion	24/1135	240/7206	0.0114238681431
ko04622	RIG-I-like receptor signaling pathway	3/1135	62/7206	0.0134705360992
ko05131	Shigellosis	5/1135	82/7206	0.013743516636
ko04214	Apoptosis - fly	4/1135	72/7206	0.0138366982803
ko04015	Rap1 signaling pathway	59/1135	278/7206	0.0145679196356
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1135	40/7206	0.0152398155741
ko04210	Apoptosis	17/1135	180/7206	0.0168843316608
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1135	100/7206	0.0176574632034
ko04657	IL-17 signaling pathway	6/1135	87/7206	0.0178353521669
ko00380	Tryptophan metabolism	2/1135	50/7206	0.0180300835277
ko04062	Chemokine signaling pathway	44/1135	201/7206	0.018336924062
ko03320	PPAR signaling pathway	4/1135	69/7206	0.0192282942242
ko04722	Neurotrophin signaling pathway	36/1135	160/7206	0.0211224702326
ko00982	Drug metabolism - cytochrome P450	1/1135	37/7206	0.0226493281142
ko04658	Th1 and Th2 cell differentiation	7/1135	96/7206	0.0228212036618
ko00630	Glyoxylate and dicarboxylate metabolism	1/1135	38/7206	0.0230244582467
ko03410	Base excision repair	1/1135	38/7206	0.0230244582467
ko05219	Bladder cancer	2/1135	48/7206	0.0264416844462
ko05321	Inflammatory bowel disease (IBD)	3/1135	56/7206	0.026960292946
ko04912	GnRH signaling pathway	28/1135	122/7206	0.0327971997287
ko00640	Propanoate metabolism	1/1135	34/7206	0.0337095143452
ko00310	Lysine degradation	5/1135	73/7206	0.0348762081121
ko04115	p53 signaling pathway	5/1135	74/7206	0.0353459270166
ko04710	Circadian rhythm	12/1135	43/7206	0.0354660477601
ko05016	Huntington's disease	23/1135	215/7206	0.0366874735504
ko04217	Necroptosis	18/1135	178/7206	0.0368002494552
ko00280	Valine, leucine and isoleucine degradation	3/1135	54/7206	0.0379522380961
ko00620	Pyruvate metabolism	2/1135	46/7206	0.0389696936638
ko05231	Choline metabolism in cancer	30/1135	134/7206	0.0410491528
ko04711	Circadian rhythm - fly	5/1135	13/7206	0.0411200552541
ko04114	Oocyte meiosis	31/1135	139/7206	0.0445164949716
ko04916	Melanogenesis	31/1135	142/7206	0.0481632070799
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1135	182/7206	0.0496326621773