ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	185/1084	423/7206	5.62656284534e-49
ko04724	Glutamatergic synapse	87/1084	152/7206	5.85923227637e-34
ko05033	Nicotine addiction	47/1084	56/7206	1.74593184524e-30
ko05032	Morphine addiction	65/1084	110/7206	1.10240000928e-26
ko04713	Circadian entrainment	73/1084	136/7206	3.21778706344e-26
ko04727	GABAergic synapse	64/1084	110/7206	9.32740319137e-26
ko04721	Synaptic vesicle cycle	52/1084	80/7206	2.33256514209e-24
ko04728	Dopaminergic synapse	84/1084	185/7206	1.58871986278e-23
ko04725	Cholinergic synapse	76/1084	160/7206	7.06625067774e-23
ko04723	Retrograde endocannabinoid signaling	76/1084	175/7206	6.13651307602e-20
ko04024	cAMP signaling pathway	102/1084	279/7206	1.24461218643e-19
ko04911	Insulin secretion	54/1084	117/7206	6.85869857448e-16
ko04921	Oxytocin signaling pathway	78/1084	209/7206	7.93474362561e-16
ko04020	Calcium signaling pathway	90/1084	265/7206	5.36529284335e-15
ko04742	Taste transduction	35/1084	61/7206	2.26560878886e-14
ko04726	Serotonergic synapse	56/1084	137/7206	1.27698476897e-13
ko04744	Phototransduction	25/1084	36/7206	2.39358781298e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1084	205/7206	4.51950642106e-13
ko04720	Long-term potentiation	44/1084	99/7206	1.79957776277e-12
ko05031	Amphetamine addiction	41/1084	91/7206	6.02971180093e-12
ko04970	Salivary secretion	39/1084	95/7206	6.05562080676e-10
ko03040	Spliceosome	1/1084	145/7206	2.20835940781e-09
ko04925	Aldosterone synthesis and secretion	40/1084	105/7206	5.01019709494e-09
ko04740	Olfactory transduction	33/1084	80/7206	1.10921280573e-08
ko04971	Gastric acid secretion	37/1084	98/7206	2.50466491178e-08
ko04022	cGMP-PKG signaling pathway	62/1084	216/7206	1.81890795068e-07
ko05030	Cocaine addiction	29/1084	73/7206	2.28643936476e-07
ko05168	Herpes simplex infection	6/1084	182/7206	2.8524243745e-07
ko04360	Axon guidance	65/1084	233/7206	3.12181056183e-07
ko05203	Viral carcinogenesis	15/1084	277/7206	4.93567903562e-07
ko04060	Cytokine-cytokine receptor interaction	7/1084	191/7206	5.17184746765e-07
ko04966	Collecting duct acid secretion	14/1084	26/7206	4.57383869037e-06
ko04010	MAPK signaling pathway	78/1084	321/7206	9.29250483198e-06
ko04514	Cell adhesion molecules (CAMs)	39/1084	130/7206	1.05744279487e-05
ko04745	Phototransduction - fly	17/1084	38/7206	1.13825490825e-05
ko04924	Renin secretion	29/1084	86/7206	1.19633119089e-05
ko04070	Phosphatidylinositol signaling system	35/1084	112/7206	1.21880493194e-05
ko03013	RNA transport	7/1084	166/7206	1.31869060109e-05
ko04730	Long-term depression	27/1084	78/7206	1.5781270038e-05
ko05322	Systemic lupus erythematosus	6/1084	151/7206	1.6193966214e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1084	74/7206	1.92128820078e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1084	79/7206	1.93236771399e-05
ko04120	Ubiquitin mediated proteolysis	5/1084	138/7206	1.97126395441e-05
ko04072	Phospholipase D signaling pathway	52/1084	197/7206	2.74161851454e-05
ko04915	Estrogen signaling pathway	38/1084	131/7206	3.46989668923e-05
ko05414	Dilated cardiomyopathy	34/1084	112/7206	4.19680117015e-05
ko04610	Complement and coagulation cascades	1/1084	79/7206	5.28138242003e-05
ko04141	Protein processing in endoplasmic reticulum	10/1084	184/7206	5.98099388772e-05
ko04972	Pancreatic secretion	33/1084	111/7206	7.28728926653e-05
ko04626	Plant-pathogen interaction	10/1084	18/7206	7.84874836872e-05
ko04260	Cardiac muscle contraction	30/1084	98/7206	8.27414487976e-05
ko05110	Vibrio cholerae infection	22/1084	63/7206	0.000102804578388
ko04014	Ras signaling pathway	66/1084	279/7206	0.000108522386739
ko04540	Gap junction	36/1084	128/7206	0.000138245082813
ko04110	Cell cycle	7/1084	145/7206	0.000144861240822
ko05164	Influenza A	9/1084	167/7206	0.00016115293161
ko04976	Bile secretion	25/1084	80/7206	0.000211457946282
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1084	59/7206	0.000298263707671
ko04621	NOD-like receptor signaling pathway	9/1084	157/7206	0.000407617892131
ko03008	Ribosome biogenesis in eukaryotes	2/1084	79/7206	0.000414324928481
ko04371	Apelin signaling pathway	44/1084	177/7206	0.000577649801881
ko04612	Antigen processing and presentation	2/1084	77/7206	0.000610288280562
ko05162	Measles	6/1084	120/7206	0.000742182524588
ko05140	Leishmaniasis	2/1084	75/7206	0.000911985100331
ko05169	Epstein-Barr virus infection	15/1084	206/7206	0.00100534148062
ko04750	Inflammatory mediator regulation of TRP channels	32/1084	122/7206	0.00122124995683
ko05205	Proteoglycans in cancer	23/1084	271/7206	0.00130649004002
ko04064	NF-kappa B signaling pathway	4/1084	96/7206	0.00131000892195
ko04923	Regulation of lipolysis in adipocytes	22/1084	77/7206	0.00200591652532
ko00480	Glutathione metabolism	1/1084	55/7206	0.00209960755018
ko04964	Proximal tubule bicarbonate reclamation	11/1084	29/7206	0.00215553350392
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1084	14/7206	0.00222056942929
ko04146	Peroxisome	4/1084	89/7206	0.00258301703212
ko04912	GnRH signaling pathway	31/1084	122/7206	0.00294275860296
ko05161	Hepatitis B	13/1084	173/7206	0.00348533021973
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1084	100/7206	0.00430673682848
ko00310	Lysine degradation	3/1084	73/7206	0.00479000313386
ko04922	Glucagon signaling pathway	31/1084	128/7206	0.00568906359988
ko00330	Arginine and proline metabolism	2/1084	61/7206	0.00610126882973
ko00240	Pyrimidine metabolism	7/1084	110/7206	0.00698788825082
ko04214	Apoptosis - fly	3/1084	72/7206	0.00705224587159
ko03022	Basal transcription factors	1/1084	44/7206	0.0104885360177
ko05144	Malaria	1/1084	45/7206	0.010584294774
ko00071	Fatty acid degradation	1/1084	45/7206	0.010584294774
ko03420	Nucleotide excision repair	1/1084	46/7206	0.0109903387208
ko04114	Oocyte meiosis	32/1084	139/7206	0.0114220367732
ko05034	Alcoholism	50/1084	238/7206	0.0124395374028
ko05321	Inflammatory bowel disease (IBD)	2/1084	56/7206	0.0130630403917
ko04658	Th1 and Th2 cell differentiation	6/1084	96/7206	0.0136370753241
ko00140	Steroid hormone biosynthesis	1/1084	41/7206	0.0156481142784
ko04062	Chemokine signaling pathway	43/1084	201/7206	0.0158009063742
ko00562	Inositol phosphate metabolism	22/1084	89/7206	0.0159260045419
ko04350	TGF-beta signaling pathway	7/1084	103/7206	0.0173319822713
ko04722	Neurotrophin signaling pathway	35/1084	160/7206	0.0185122943585
ko05166	HTLV-I infection	30/1084	292/7206	0.0190681463023
ko04330	Notch signaling pathway	3/1084	62/7206	0.0195671664287
ko04622	RIG-I-like receptor signaling pathway	3/1084	62/7206	0.0195671664287
ko04210	Apoptosis	16/1084	180/7206	0.019595276645
ko03018	RNA degradation	5/1084	84/7206	0.0198304319051
ko05231	Choline metabolism in cancer	30/1084	134/7206	0.0202777414626
ko04015	Rap1 signaling pathway	56/1084	278/7206	0.0204769933363
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1084	40/7206	0.0237515552291
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1084	92/7206	0.026184251466
ko04973	Carbohydrate digestion and absorption	12/1084	42/7206	0.0267002988121
ko04630	Jak-STAT signaling pathway	11/1084	132/7206	0.0268033995474
ko00380	Tryptophan metabolism	2/1084	50/7206	0.0268779503281
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1084	182/7206	0.0272770571755
ko04916	Melanogenesis	31/1084	142/7206	0.0318162457227
ko04657	IL-17 signaling pathway	6/1084	87/7206	0.0333685210743
ko04930	Type II diabetes mellitus	14/1084	54/7206	0.0338195253093
ko00982	Drug metabolism - cytochrome P450	1/1084	37/7206	0.0349357545007
ko01524	Platinum drug resistance	5/1084	76/7206	0.0355363792505
ko00630	Glyoxylate and dicarboxylate metabolism	1/1084	38/7206	0.0363554437782
ko05214	Glioma	19/1084	79/7206	0.0376098622492
ko00260	Glycine, serine and threonine metabolism	2/1084	48/7206	0.0395175538743
ko04217	Necroptosis	17/1084	178/7206	0.0428412739549
ko05145	Toxoplasmosis	11/1084	126/7206	0.0442158385639
ko04213	Longevity regulating pathway - multiple species	20/1084	86/7206	0.0465367508832
ko04918	Thyroid hormone synthesis	20/1084	86/7206	0.0465367508832
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1084	26/7206	0.046623878827
ko04115	p53 signaling pathway	5/1084	74/7206	0.0483494306924