ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1185	423/7206	8.42055467482e-52
ko04724	Glutamatergic synapse	87/1185	152/7206	6.36129745685e-31
ko05033	Nicotine addiction	46/1185	56/7206	2.70209394786e-27
ko05032	Morphine addiction	67/1185	110/7206	3.18156748345e-26
ko04713	Circadian entrainment	75/1185	136/7206	2.29454056941e-25
ko04721	Synaptic vesicle cycle	53/1185	80/7206	1.68019280269e-23
ko04727	GABAergic synapse	63/1185	110/7206	1.13149992018e-22
ko04728	Dopaminergic synapse	84/1185	185/7206	7.13157893573e-21
ko04725	Cholinergic synapse	75/1185	160/7206	9.4271320457e-20
ko04020	Calcium signaling pathway	102/1185	265/7206	1.28180977177e-18
ko04723	Retrograde endocannabinoid signaling	76/1185	175/7206	1.32810702219e-17
ko04024	cAMP signaling pathway	102/1185	279/7206	1.12111419377e-16
ko04742	Taste transduction	38/1185	61/7206	7.45125533311e-16
ko04921	Oxytocin signaling pathway	81/1185	209/7206	4.55574972049e-15
ko04911	Insulin secretion	55/1185	117/7206	7.30804410676e-15
ko04726	Serotonergic synapse	60/1185	137/7206	2.41007391754e-14
ko04970	Salivary secretion	44/1185	95/7206	7.18299312287e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1185	205/7206	4.00091694694e-11
ko05031	Amphetamine addiction	41/1185	91/7206	1.10977003322e-10
ko04720	Long-term potentiation	43/1185	99/7206	1.67267194254e-10
ko03040	Spliceosome	1/1185	145/7206	1.92409247761e-10
ko04744	Phototransduction	22/1185	36/7206	1.73556045381e-09
ko04022	cGMP-PKG signaling pathway	68/1185	216/7206	3.46882137516e-08
ko04360	Axon guidance	71/1185	233/7206	6.88013663196e-08
ko05203	Viral carcinogenesis	16/1185	277/7206	8.15933841599e-08
ko04971	Gastric acid secretion	38/1185	98/7206	1.01394907518e-07
ko05168	Herpes simplex infection	7/1185	182/7206	1.38895437987e-07
ko04924	Renin secretion	34/1185	86/7206	2.27051297286e-07
ko04966	Collecting duct acid secretion	16/1185	26/7206	2.6623935429e-07
ko04925	Aldosterone synthesis and secretion	39/1185	105/7206	3.33883070031e-07
ko04740	Olfactory transduction	32/1185	80/7206	3.75272317944e-07
ko05322	Systemic lupus erythematosus	5/1185	151/7206	5.86009256935e-07
ko04060	Cytokine-cytokine receptor interaction	9/1185	191/7206	8.23617913086e-07
ko03013	RNA transport	7/1185	166/7206	1.27945333992e-06
ko05164	Influenza A	7/1185	167/7206	1.28857404674e-06
ko04540	Gap junction	43/1185	128/7206	1.5391883104e-06
ko05030	Cocaine addiction	29/1185	73/7206	1.55830896939e-06
ko04120	Ubiquitin mediated proteolysis	5/1185	138/7206	3.88601621045e-06
ko04514	Cell adhesion molecules (CAMs)	42/1185	130/7206	6.547654301e-06
ko04010	MAPK signaling pathway	83/1185	321/7206	1.01227043302e-05
ko04972	Pancreatic secretion	37/1185	111/7206	1.23634049113e-05
ko04976	Bile secretion	29/1185	80/7206	2.20919177916e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1185	74/7206	2.4298055751e-05
ko04260	Cardiac muscle contraction	33/1185	98/7206	2.47203336908e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1185	59/7206	2.68015050948e-05
ko04745	Phototransduction - fly	17/1185	38/7206	3.79033308365e-05
ko05110	Vibrio cholerae infection	24/1185	63/7206	3.97610896411e-05
ko05169	Epstein-Barr virus infection	14/1185	206/7206	5.15726507315e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1185	29/7206	6.58079075659e-05
ko04621	NOD-like receptor signaling pathway	9/1185	157/7206	7.23551924822e-05
ko04141	Protein processing in endoplasmic reticulum	12/1185	184/7206	7.28819474357e-05
ko04730	Long-term depression	27/1185	78/7206	7.89533196006e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1185	79/7206	9.59651508292e-05
ko04110	Cell cycle	8/1185	145/7206	9.73537956751e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1185	122/7206	0.000109094112602
ko03008	Ribosome biogenesis in eukaryotes	2/1185	79/7206	0.000173022299288
ko04070	Phosphatidylinositol signaling system	34/1185	112/7206	0.000249841471453
ko05140	Leishmaniasis	2/1185	75/7206	0.000251914828818
ko04612	Antigen processing and presentation	2/1185	77/7206	0.000264210665998
ko05205	Proteoglycans in cancer	24/1185	271/7206	0.000307760081235
ko04064	NF-kappa B signaling pathway	4/1185	96/7206	0.00041278004363
ko05414	Dilated cardiomyopathy	33/1185	112/7206	0.000462643028148
ko04072	Phospholipase D signaling pathway	51/1185	197/7206	0.000597033756711
ko04371	Apelin signaling pathway	47/1185	177/7206	0.000624187669293
ko05162	Measles	7/1185	120/7206	0.000699263140879
ko05161	Hepatitis B	13/1185	173/7206	0.000802065249858
ko05166	HTLV-I infection	28/1185	292/7206	0.000896386115006
ko04014	Ras signaling pathway	67/1185	279/7206	0.000928151131503
ko04626	Plant-pathogen interaction	9/1185	18/7206	0.00100667141902
ko04922	Glucagon signaling pathway	35/1185	128/7206	0.00160111261249
ko04214	Apoptosis - fly	3/1185	72/7206	0.00215303144047
ko04330	Notch signaling pathway	2/1185	62/7206	0.00277614659849
ko04146	Peroxisome	5/1185	89/7206	0.00357952642215
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1185	100/7206	0.00384894956788
ko04630	Jak-STAT signaling pathway	10/1185	132/7206	0.00413977985029
ko03420	Nucleotide excision repair	1/1185	46/7206	0.00440933260142
ko01524	Platinum drug resistance	4/1185	76/7206	0.00481851149758
ko00480	Glutathione metabolism	2/1185	55/7206	0.00565579383819
ko05321	Inflammatory bowel disease (IBD)	2/1185	56/7206	0.00573468914061
ko04915	Estrogen signaling pathway	34/1185	131/7206	0.00577161123199
ko03022	Basal transcription factors	1/1185	44/7206	0.00671520799598
ko05144	Malaria	1/1185	45/7206	0.00708789681315
ko00071	Fatty acid degradation	1/1185	45/7206	0.00708789681315
ko05145	Toxoplasmosis	10/1185	126/7206	0.00729956858475
ko00590	Arachidonic acid metabolism	2/1185	52/7206	0.00829195518155
ko04622	RIG-I-like receptor signaling pathway	3/1185	62/7206	0.00919372383209
ko00310	Lysine degradation	4/1185	73/7206	0.00998849443862
ko04217	Necroptosis	17/1185	178/7206	0.0102340698986
ko04710	Circadian rhythm	14/1185	43/7206	0.0110371552411
ko04657	IL-17 signaling pathway	6/1185	87/7206	0.0127749626972
ko05133	Pertussis	6/1185	87/7206	0.0127749626972
ko00562	Inositol phosphate metabolism	24/1185	89/7206	0.0133717772553
ko04610	Complement and coagulation cascades	5/1185	79/7206	0.0135194513756
ko05215	Prostate cancer	9/1185	111/7206	0.0139289602179
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1185	182/7206	0.0146911290836
ko03410	Base excision repair	1/1185	38/7206	0.0148058115889
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1185	92/7206	0.0158746367819
ko03018	RNA degradation	6/1185	84/7206	0.0173659820677
ko00260	Glycine, serine and threonine metabolism	2/1185	48/7206	0.0176079763026
ko05219	Bladder cancer	2/1185	48/7206	0.0176079763026
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1185	14/7206	0.0178060381289
ko04210	Apoptosis	18/1185	180/7206	0.0186398373204
ko00240	Pyrimidine metabolism	9/1185	110/7206	0.0187308447346
ko04912	GnRH signaling pathway	30/1185	122/7206	0.0188064035406
ko04923	Regulation of lipolysis in adipocytes	21/1185	77/7206	0.018977442924
ko04620	Toll-like receptor signaling pathway	8/1185	100/7206	0.0202086983942
ko05131	Shigellosis	6/1185	82/7206	0.0236462056397
ko05212	Pancreatic cancer	6/1185	83/7206	0.0240888494987
ko04115	p53 signaling pathway	5/1185	74/7206	0.0256912512153
ko04640	Hematopoietic cell lineage	4/1185	64/7206	0.0262599355198
ko00280	Valine, leucine and isoleucine degradation	3/1185	54/7206	0.0263475743659
ko05222	Small cell lung cancer	7/1185	89/7206	0.0296265135315
ko04978	Mineral absorption	12/1185	40/7206	0.0300240672801
ko04140	Autophagy - animal	17/1185	164/7206	0.032806808049
ko04668	TNF signaling pathway	11/1185	120/7206	0.0336817146372
ko04658	Th1 and Th2 cell differentiation	8/1185	96/7206	0.0361496798351
ko00330	Arginine and proline metabolism	4/1185	61/7206	0.0361661693549
ko04916	Melanogenesis	33/1185	142/7206	0.0385865514854
ko05220	Chronic myeloid leukemia	7/1185	85/7206	0.0388971776959
ko04930	Type II diabetes mellitus	15/1185	54/7206	0.0398015680487
ko05217	Basal cell carcinoma	5/1185	68/7206	0.046814321788
ko05418	Fluid shear stress and atherosclerosis	19/1185	173/7206	0.0487103228155