ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 29/390 134/7206 7.34798988991e-11 ko04060 Cytokine-cytokine receptor interaction 33/390 191/7206 1.85401241176e-09 ko04621 NOD-like receptor signaling pathway 28/390 157/7206 1.60774359608e-08 ko04512 ECM-receptor interaction 19/390 79/7206 2.43992017029e-08 ko04668 TNF signaling pathway 22/390 120/7206 3.51521991101e-07 ko04510 Focal adhesion 33/390 240/7206 5.56995628985e-07 ko04660 T cell receptor signaling pathway 22/390 124/7206 6.34614172578e-07 ko00643 Styrene degradation 4/390 4/7206 8.4555436747e-06 ko05164 Influenza A 24/390 167/7206 9.55044416069e-06 ko04064 NF-kappa B signaling pathway 17/390 96/7206 1.24568112591e-05 ko04662 B cell receptor signaling pathway 16/390 88/7206 1.58889910162e-05 ko04611 Platelet activation 23/390 163/7206 1.98884753427e-05 ko05131 Shigellosis 15/390 82/7206 2.71332999434e-05 ko04933 AGE-RAGE signaling pathway in diabetic complications 20/390 135/7206 3.40048402025e-05 ko04623 Cytosolic DNA-sensing pathway 10/390 41/7206 4.74804034913e-05 ko04974 Protein digestion and absorption 16/390 96/7206 4.87857689575e-05 ko05133 Pertussis 15/390 87/7206 5.58889175457e-05 ko05132 Salmonella infection 16/390 98/7206 6.32035473267e-05 ko04610 Complement and coagulation cascades 14/390 79/7206 7.22810191425e-05 ko05323 Rheumatoid arthritis 15/390 89/7206 7.33672859881e-05 ko04672 Intestinal immune network for IgA production 9/390 37/7206 0.000116612934507 ko04810 Regulation of actin cytoskeleton 30/390 264/7206 0.000126080232088 ko04657 IL-17 signaling pathway 14/390 87/7206 0.00021150652737 ko04630 Jak-STAT signaling pathway 18/390 132/7206 0.00024619244882 ko04666 Fc gamma R-mediated phagocytosis 17/390 122/7206 0.000280557519861 ko04620 Toll-like receptor signaling pathway 15/390 100/7206 0.000282222567604 ko00350 Tyrosine metabolism 8/390 33/7206 0.000287471806167 ko04622 RIG-I-like receptor signaling pathway 11/390 62/7206 0.000422859009149 ko04640 Hematopoietic cell lineage 11/390 64/7206 0.000561221728484 ko04658 Th1 and Th2 cell differentiation 14/390 96/7206 0.000600050496958 ko05140 Leishmaniasis 12/390 75/7206 0.000625986656999 ko04670 Leukocyte transendothelial migration 19/390 151/7206 0.000679932647865 ko05162 Measles 16/390 120/7206 0.000693836921415 ko05146 Amoebiasis 14/390 99/7206 0.000821902350884 ko04723 Retrograde endocannabinoid signaling 1/390 175/7206 0.00105417821836 ko00140 Steroid hormone biosynthesis 8/390 41/7206 0.00135275318534 ko05161 Hepatitis B 20/390 173/7206 0.0016693208128 ko05034 Alcoholism 3/390 238/7206 0.00184963055349 ko04650 Natural killer cell mediated cytotoxicity 13/390 97/7206 0.00205907566612 ko05150 Staphylococcus aureus infection 7/390 36/7206 0.0027460642244 ko05321 Inflammatory bowel disease (IBD) 9/390 56/7206 0.00285497348538 ko04724 Glutamatergic synapse 1/390 152/7206 0.00327592341768 ko05012 Parkinson's disease 1/390 155/7206 0.0033460730738 ko05145 Toxoplasmosis 15/390 126/7206 0.00402059505291 ko04141 Protein processing in endoplasmic reticulum 2/390 184/7206 0.00434477416786 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/390 191/7206 0.00492241985234 ko05016 Huntington's disease 3/390 215/7206 0.0051205098615 ko05160 Hepatitis C 17/390 153/7206 0.00543645991768 ko05168 Herpes simplex infection 19/390 182/7206 0.00673951861163 ko04713 Circadian entrainment 1/390 136/7206 0.00694039146216 ko05152 Tuberculosis 19/390 187/7206 0.0077202810678 ko05130 Pathogenic Escherichia coli infection 10/390 77/7206 0.00817806678851 ko04664 Fc epsilon RI signaling pathway 10/390 77/7206 0.00817806678851 ko05144 Malaria 7/390 45/7206 0.00983011987309 ko04217 Necroptosis 18/390 178/7206 0.0104225319957 ko04659 Th17 cell differentiation 12/390 106/7206 0.0143080052404 ko00190 Oxidative phosphorylation 1/390 127/7206 0.0152044263347 ko05120 Epithelial cell signaling in Helicobacter pylori infection 11/390 92/7206 0.0162544647346 ko05134 Legionellosis 9/390 74/7206 0.0177456954869 ko04115 p53 signaling pathway 9/390 74/7206 0.0177456954869 ko04728 Dopaminergic synapse 3/390 185/7206 0.0193102880462 ko00120 Primary bile acid biosynthesis 4/390 20/7206 0.0205218248927 ko00590 Arachidonic acid metabolism 7/390 52/7206 0.0209943378577 ko05340 Primary immunodeficiency 5/390 30/7206 0.0210509964427 ko05100 Bacterial invasion of epithelial cells 11/390 99/7206 0.0214495777365 ko05010 Alzheimer's disease 4/390 202/7206 0.0258307832974 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/390 5/7206 0.0261978477966 ko04270 Vascular smooth muscle contraction 15/390 154/7206 0.0279016146927 ko05205 Proteoglycans in cancer 23/390 271/7206 0.0281086040672 ko04727 GABAergic synapse 1/390 110/7206 0.0308835874903 ko05202 Transcriptional misregulation in cancer 17/390 188/7206 0.032839396256 ko04062 Chemokine signaling pathway 18/390 201/7206 0.0374207925698 ko05418 Fluid shear stress and atherosclerosis 16/390 173/7206 0.0383314681927 ko05219 Bladder cancer 6/390 48/7206 0.0434390687415 ko04720 Long-term potentiation 1/390 99/7206 0.0438507075837 ko01200 Carbon metabolism 2/390 128/7206 0.0479296706041 ko04540 Gap junction 2/390 128/7206 0.0479296706041 ko04151 PI3K-Akt signaling pathway 30/390 390/7206 0.0494449398516