ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	180/1139	423/7206	3.05492239817e-42
ko05033	Nicotine addiction	46/1139	56/7206	4.5418662153e-28
ko04724	Glutamatergic synapse	79/1139	152/7206	1.41134721617e-25
ko05032	Morphine addiction	63/1139	110/7206	1.23894212675e-23
ko04727	GABAergic synapse	59/1139	110/7206	2.93503777894e-20
ko04713	Circadian entrainment	67/1139	136/7206	3.53593562326e-20
ko04725	Cholinergic synapse	69/1139	160/7206	8.08399914852e-17
ko04721	Synaptic vesicle cycle	45/1139	80/7206	8.40847964382e-17
ko04723	Retrograde endocannabinoid signaling	73/1139	175/7206	9.17848041517e-17
ko04728	Dopaminergic synapse	75/1139	185/7206	2.30278812716e-16
ko04921	Oxytocin signaling pathway	76/1139	209/7206	1.51883381964e-13
ko04020	Calcium signaling pathway	89/1139	265/7206	4.22368605685e-13
ko04024	cAMP signaling pathway	92/1139	279/7206	4.76155160472e-13
ko04911	Insulin secretion	51/1139	117/7206	5.71329907387e-13
ko04742	Taste transduction	34/1139	61/7206	7.51349975759e-13
ko04261	Adrenergic signaling in cardiomyocytes	70/1139	205/7206	4.44271408413e-11
ko03040	Spliceosome	1/1139	145/7206	5.14053111112e-10
ko04726	Serotonergic synapse	51/1139	137/7206	6.78009773336e-10
ko04360	Axon guidance	73/1139	233/7206	2.27019954396e-09
ko05203	Viral carcinogenesis	15/1139	277/7206	8.53670018552e-08
ko03013	RNA transport	5/1139	166/7206	1.34171531437e-07
ko05322	Systemic lupus erythematosus	4/1139	151/7206	2.08960118752e-07
ko04720	Long-term potentiation	36/1139	99/7206	4.54730396847e-07
ko04022	cGMP-PKG signaling pathway	63/1139	216/7206	5.46706651389e-07
ko05031	Amphetamine addiction	34/1139	91/7206	5.61795017751e-07
ko04010	MAPK signaling pathway	84/1139	321/7206	9.98214936094e-07
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	30/1139	79/7206	1.34302245835e-06
ko05168	Herpes simplex infection	8/1139	182/7206	1.6038419997e-06
ko04744	Phototransduction	18/1139	36/7206	1.74650613956e-06
ko04925	Aldosterone synthesis and secretion	36/1139	105/7206	2.39578926729e-06
ko04970	Salivary secretion	33/1139	95/7206	5.43392855642e-06
ko04621	NOD-like receptor signaling pathway	7/1139	157/7206	1.19484955521e-05
ko05164	Influenza A	8/1139	167/7206	1.32532638955e-05
ko04514	Cell adhesion molecules (CAMs)	40/1139	130/7206	1.51946536723e-05
ko04060	Cytokine-cytokine receptor interaction	11/1139	191/7206	2.99917417462e-05
ko04610	Complement and coagulation cascades	1/1139	79/7206	3.25598693247e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1139	79/7206	3.25598693247e-05
ko04141	Protein processing in endoplasmic reticulum	11/1139	184/7206	5.64884623034e-05
ko04260	Cardiac muscle contraction	31/1139	98/7206	7.26614660039e-05
ko04072	Phospholipase D signaling pathway	52/1139	197/7206	0.000100793002073
ko05414	Dilated cardiomyopathy	34/1139	112/7206	0.000110829285654
ko05030	Cocaine addiction	25/1139	73/7206	0.000126021520914
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1139	74/7206	0.000140986755737
ko04070	Phosphatidylinositol signaling system	33/1139	112/7206	0.000214441722603
ko05410	Hypertrophic cardiomyopathy (HCM)	30/1139	100/7206	0.000282901697935
ko04612	Antigen processing and presentation	2/1139	77/7206	0.000402287654714
ko04730	Long-term depression	25/1139	78/7206	0.000426800233287
ko04371	Apelin signaling pathway	46/1139	177/7206	0.000504160915617
ko04972	Pancreatic secretion	32/1139	111/7206	0.000525331414446
ko04120	Ubiquitin mediated proteolysis	8/1139	138/7206	0.000541283644455
ko04014	Ras signaling pathway	66/1139	279/7206	0.000553693441081
ko04064	NF-kappa B signaling pathway	4/1139	96/7206	0.000599828965688
ko04971	Gastric acid secretion	29/1139	98/7206	0.00064917258962
ko05205	Proteoglycans in cancer	24/1139	271/7206	0.000881889795145
ko04214	Apoptosis - fly	2/1139	72/7206	0.000887906027468
ko04740	Olfactory transduction	24/1139	80/7206	0.00166107272858
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1139	59/7206	0.00173869795698
ko05169	Epstein-Barr virus infection	17/1139	206/7206	0.00180455151438
ko05140	Leishmaniasis	3/1139	75/7206	0.00223147861467
ko04217	Necroptosis	14/1139	178/7206	0.00237276915837
ko04640	Hematopoietic cell lineage	2/1139	64/7206	0.00280905040402
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1139	14/7206	0.00298041250546
ko04540	Gap junction	33/1139	128/7206	0.00314525054796
ko05162	Measles	8/1139	120/7206	0.0035115650942
ko00240	Pyrimidine metabolism	7/1139	110/7206	0.0036393181915
ko04930	Type II diabetes mellitus	17/1139	54/7206	0.00397560226657
ko04923	Regulation of lipolysis in adipocytes	22/1139	77/7206	0.0041445659633
ko04924	Renin secretion	24/1139	86/7206	0.00415998072537
ko04966	Collecting duct acid secretion	10/1139	26/7206	0.00438609764238
ko04915	Estrogen signaling pathway	33/1139	131/7206	0.00508318454124
ko04146	Peroxisome	5/1139	89/7206	0.00510783810345
ko04745	Phototransduction - fly	13/1139	38/7206	0.00547351798498
ko05144	Malaria	1/1139	45/7206	0.00680092015115
ko00071	Fatty acid degradation	1/1139	45/7206	0.00680092015115
ko03420	Nucleotide excision repair	1/1139	46/7206	0.0069830254004
ko04657	IL-17 signaling pathway	5/1139	87/7206	0.00715413626438
ko05133	Pertussis	5/1139	87/7206	0.00715413626438
ko04976	Bile secretion	22/1139	80/7206	0.00786209841162
ko05161	Hepatitis B	15/1139	173/7206	0.00800951650386
ko00480	Glutathione metabolism	2/1139	55/7206	0.00851999764687
ko04115	p53 signaling pathway	4/1139	74/7206	0.00983134704332
ko03022	Basal transcription factors	1/1139	44/7206	0.0107727624731
ko04110	Cell cycle	12/1139	145/7206	0.0109020731737
ko00590	Arachidonic acid metabolism	2/1139	52/7206	0.0123579123908
ko00280	Valine, leucine and isoleucine degradation	2/1139	54/7206	0.0130636730055
ko04622	RIG-I-like receptor signaling pathway	3/1139	62/7206	0.013464497884
ko00330	Arginine and proline metabolism	3/1139	61/7206	0.013469623008
ko04270	Vascular smooth muscle contraction	36/1139	154/7206	0.0134943874445
ko05131	Shigellosis	5/1139	82/7206	0.013796269867
ko00310	Lysine degradation	4/1139	73/7206	0.014219675971
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1139	40/7206	0.0152391426188
ko00140	Steroid hormone biosynthesis	1/1139	41/7206	0.0157398709922
ko04964	Proximal tubule bicarbonate reclamation	10/1139	29/7206	0.0172998542937
ko00380	Tryptophan metabolism	2/1139	50/7206	0.0180475528398
ko04710	Circadian rhythm	13/1139	43/7206	0.018237821251
ko03320	PPAR signaling pathway	4/1139	69/7206	0.0192353296872
ko00982	Drug metabolism - cytochrome P450	1/1139	37/7206	0.0226169641223
ko04658	Th1 and Th2 cell differentiation	7/1139	96/7206	0.022958518717
ko04750	Inflammatory mediator regulation of TRP channels	29/1139	122/7206	0.0232446845151
ko03018	RNA degradation	6/1139	84/7206	0.0240672023204
ko05215	Prostate cancer	9/1139	111/7206	0.0249333884705
ko00260	Glycine, serine and threonine metabolism	2/1139	48/7206	0.0265344727954
ko05219	Bladder cancer	2/1139	48/7206	0.0265344727954
ko04973	Carbohydrate digestion and absorption	12/1139	42/7206	0.0319947051416
ko04137	Mitophagy - animal	6/1139	82/7206	0.0323920496102
ko00640	Propanoate metabolism	1/1139	34/7206	0.033627441561
ko04975	Fat digestion and absorption	1/1139	35/7206	0.0339474284082
ko00500	Starch and sucrose metabolism	1/1139	35/7206	0.0339474284082
ko04711	Circadian rhythm - fly	5/1139	13/7206	0.0416797046851
ko04113	Meiosis - yeast	5/1139	70/7206	0.0472046061712
ko05145	Toxoplasmosis	12/1139	126/7206	0.0490845165815