ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1141	423/7206	3.37397508716e-48
ko04724	Glutamatergic synapse	79/1141	152/7206	1.59093518672e-25
ko05033	Nicotine addiction	44/1141	56/7206	2.3745006491e-25
ko04727	GABAergic synapse	59/1141	110/7206	3.21060299279e-20
ko05032	Morphine addiction	59/1141	110/7206	3.21060299279e-20
ko04713	Circadian entrainment	67/1141	136/7206	3.90268347758e-20
ko04728	Dopaminergic synapse	79/1141	185/7206	9.67648545727e-19
ko04020	Calcium signaling pathway	98/1141	265/7206	1.05694749245e-17
ko04921	Oxytocin signaling pathway	82/1141	209/7206	9.83888559731e-17
ko04261	Adrenergic signaling in cardiomyocytes	80/1141	205/7206	3.42541137906e-16
ko04721	Synaptic vesicle cycle	44/1141	80/7206	6.2436668066e-16
ko04725	Cholinergic synapse	67/1141	160/7206	1.53466953196e-15
ko04723	Retrograde endocannabinoid signaling	71/1141	175/7206	1.57086043396e-15
ko04024	cAMP signaling pathway	95/1141	279/7206	1.72359026647e-14
ko04744	Phototransduction	26/1141	36/7206	6.11558329255e-14
ko04742	Taste transduction	35/1141	61/7206	1.10757123598e-13
ko04911	Insulin secretion	50/1141	117/7206	2.59269165034e-12
ko04726	Serotonergic synapse	55/1141	137/7206	4.38833838648e-12
ko04260	Cardiac muscle contraction	44/1141	98/7206	7.11345648923e-12
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	38/1141	79/7206	1.487202674e-11
ko05203	Viral carcinogenesis	11/1141	277/7206	4.10365295694e-10
ko04740	Olfactory transduction	36/1141	80/7206	5.4592728047e-10
ko05410	Hypertrophic cardiomyopathy (HCM)	41/1141	100/7206	1.14264081874e-09
ko04970	Salivary secretion	39/1141	95/7206	2.78928905685e-09
ko03040	Spliceosome	2/1141	145/7206	6.54353336468e-09
ko05414	Dilated cardiomyopathy	42/1141	112/7206	2.06430423712e-08
ko04120	Ubiquitin mediated proteolysis	2/1141	138/7206	2.2840461547e-08
ko05168	Herpes simplex infection	6/1141	182/7206	8.29820462738e-08
ko04060	Cytokine-cytokine receptor interaction	7/1141	191/7206	1.04178585022e-07
ko04022	cGMP-PKG signaling pathway	65/1141	216/7206	1.11965032909e-07
ko05031	Amphetamine addiction	35/1141	91/7206	1.28871645325e-07
ko05164	Influenza A	5/1141	167/7206	1.35748574122e-07
ko05322	Systemic lupus erythematosus	4/1141	151/7206	2.08530246064e-07
ko04971	Gastric acid secretion	36/1141	98/7206	3.68700454968e-07
ko04925	Aldosterone synthesis and secretion	36/1141	105/7206	2.47969374659e-06
ko03013	RNA transport	7/1141	166/7206	4.19645838194e-06
ko04010	MAPK signaling pathway	82/1141	321/7206	4.73395619803e-06
ko04720	Long-term potentiation	34/1141	99/7206	4.74926948291e-06
ko04964	Proximal tubule bicarbonate reclamation	15/1141	29/7206	7.73552116096e-06
ko05030	Cocaine addiction	27/1141	73/7206	1.1537654497e-05
ko04621	NOD-like receptor signaling pathway	7/1141	157/7206	1.19450344161e-05
ko04514	Cell adhesion molecules (CAMs)	40/1141	130/7206	1.56396359253e-05
ko04360	Axon guidance	62/1141	233/7206	2.19452354856e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1141	79/7206	3.26007639522e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1141	74/7206	3.75087401453e-05
ko04730	Long-term depression	27/1141	78/7206	5.47888902959e-05
ko04141	Protein processing in endoplasmic reticulum	11/1141	184/7206	5.62982883376e-05
ko04976	Bile secretion	27/1141	80/7206	7.11855746592e-05
ko05161	Hepatitis B	10/1141	173/7206	7.83749803178e-05
ko04972	Pancreatic secretion	34/1141	111/7206	0.000103878211136
ko05162	Measles	5/1141	120/7206	0.000116633727516
ko04924	Renin secretion	28/1141	86/7206	0.00013430940355
ko04110	Cell cycle	8/1141	145/7206	0.000199200606454
ko05166	HTLV-I infection	25/1141	292/7206	0.000291722908685
ko05169	Epstein-Barr virus infection	15/1141	206/7206	0.000305127705484
ko04745	Phototransduction - fly	15/1141	38/7206	0.000376647088599
ko05205	Proteoglycans in cancer	23/1141	271/7206	0.00046493835263
ko05140	Leishmaniasis	2/1141	75/7206	0.000618318900989
ko04371	Apelin signaling pathway	45/1141	177/7206	0.00079663190373
ko04214	Apoptosis - fly	2/1141	72/7206	0.000891926313099
ko04512	ECM-receptor interaction	24/1141	79/7206	0.000975557585707
ko00520	Amino sugar and nucleotide sugar metabolism	1/1141	55/7206	0.0013340401742
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1141	182/7206	0.00134889021455
ko05215	Prostate cancer	6/1141	111/7206	0.00142685482814
ko04612	Antigen processing and presentation	3/1141	77/7206	0.00154806693819
ko04610	Complement and coagulation cascades	3/1141	79/7206	0.00158861922088
ko04146	Peroxisome	4/1141	89/7206	0.00180697406984
ko04540	Gap junction	34/1141	128/7206	0.00199965797347
ko00590	Arachidonic acid metabolism	1/1141	52/7206	0.00201482688344
ko00280	Valine, leucine and isoleucine degradation	1/1141	54/7206	0.00209688107001
ko04630	Jak-STAT signaling pathway	9/1141	132/7206	0.0024786054947
ko04064	NF-kappa B signaling pathway	5/1141	96/7206	0.00270866440098
ko04330	Notch signaling pathway	2/1141	62/7206	0.00272463847811
ko00240	Pyrimidine metabolism	7/1141	110/7206	0.00362932248736
ko00330	Arginine and proline metabolism	2/1141	61/7206	0.00406782661381
ko00260	Glycine, serine and threonine metabolism	1/1141	48/7206	0.0045713707317
ko05219	Bladder cancer	1/1141	48/7206	0.0045713707317
ko04142	Lysosome	12/1141	151/7206	0.00644245904336
ko00071	Fatty acid degradation	1/1141	45/7206	0.00679810920481
ko03420	Nucleotide excision repair	1/1141	46/7206	0.00699884143787
ko01524	Platinum drug resistance	4/1141	76/7206	0.00700059138459
ko04657	IL-17 signaling pathway	5/1141	87/7206	0.00716484159477
ko04978	Mineral absorption	13/1141	40/7206	0.00772774950131
ko05321	Inflammatory bowel disease (IBD)	2/1141	56/7206	0.00875596753525
ko04140	Autophagy - animal	14/1141	164/7206	0.00896321179727
ko05212	Pancreatic cancer	5/1141	83/7206	0.00982347981582
ko05220	Chronic myeloid leukemia	5/1141	85/7206	0.0101032637691
ko03022	Basal transcription factors	1/1141	44/7206	0.0108110176195
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1141	59/7206	0.0109122898247
ko04668	TNF signaling pathway	9/1141	120/7206	0.0109759592883
ko04933	AGE-RAGE signaling pathway in diabetic complications	11/1141	135/7206	0.0119463488442
ko00564	Glycerophospholipid metabolism	7/1141	99/7206	0.0123797467399
ko04620	Toll-like receptor signaling pathway	7/1141	100/7206	0.0124152104406
ko04622	RIG-I-like receptor signaling pathway	3/1141	62/7206	0.0134664013566
ko00561	Glycerolipid metabolism	3/1141	63/7206	0.013776793452
ko00600	Sphingolipid metabolism	3/1141	63/7206	0.013776793452
ko05131	Shigellosis	5/1141	82/7206	0.0138293917245
ko04137	Mitophagy - animal	5/1141	82/7206	0.0138293917245
ko04966	Collecting duct acid secretion	9/1141	26/7206	0.0147844935316
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1141	14/7206	0.0148680799764
ko04626	Plant-pathogen interaction	7/1141	18/7206	0.0156572648494
ko04658	Th1 and Th2 cell differentiation	7/1141	96/7206	0.0166822739639
ko04210	Apoptosis	17/1141	180/7206	0.0169249344397
ko04550	Signaling pathways regulating pluripotency of stem cells	15/1141	165/7206	0.0170069010964
ko00380	Tryptophan metabolism	2/1141	50/7206	0.0180612021766
ko05217	Basal cell carcinoma	4/1141	68/7206	0.0191478068735
ko04217	Necroptosis	17/1141	178/7206	0.0215481810236
ko04672	Intestinal immune network for IgA production	1/1141	37/7206	0.0226049761329
ko05110	Vibrio cholerae infection	17/1141	63/7206	0.0226211062685
ko04974	Protein digestion and absorption	24/1141	96/7206	0.0230386326047
ko00630	Glyoxylate and dicarboxylate metabolism	1/1141	38/7206	0.0231153468796
ko04930	Type II diabetes mellitus	15/1141	54/7206	0.0232204131348
ko04750	Inflammatory mediator regulation of TRP channels	29/1141	122/7206	0.0233571285708
ko04150	mTOR signaling pathway	18/1141	184/7206	0.0238176492608
ko03018	RNA degradation	6/1141	84/7206	0.0240278213326
ko04664	Fc epsilon RI signaling pathway	5/1141	77/7206	0.0263180207757
ko00640	Propanoate metabolism	1/1141	34/7206	0.0335914592764
ko00860	Porphyrin and chlorophyll metabolism	1/1141	34/7206	0.0335914592764
ko00310	Lysine degradation	5/1141	73/7206	0.0349166394015
ko04115	p53 signaling pathway	5/1141	74/7206	0.0355710352339
ko04014	Ras signaling pathway	57/1141	279/7206	0.0363124312278
ko05016	Huntington's disease	23/1141	215/7206	0.0366074608452
ko04218	Cellular senescence	18/1141	177/7206	0.0367129946085
ko04640	Hematopoietic cell lineage	4/1141	64/7206	0.0371736976099
ko04922	Glucagon signaling pathway	29/1141	128/7206	0.037678691234
ko00480	Glutathione metabolism	3/1141	55/7206	0.038823123706
ko05200	Pathways in cancer	62/1141	492/7206	0.0407479827974
ko04270	Vascular smooth muscle contraction	34/1141	154/7206	0.0436070361258
ko04113	Meiosis - yeast	5/1141	70/7206	0.0472147309221