ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 34/362 191/7206 6.02216897991e-11 ko04380 Osteoclast differentiation 26/362 134/7206 1.77204791749e-09 ko04621 NOD-like receptor signaling pathway 28/362 157/7206 3.07015195652e-09 ko05164 Influenza A 28/362 167/7206 1.28060029071e-08 ko04064 NF-kappa B signaling pathway 18/362 96/7206 1.01459428459e-06 ko05340 Primary immunodeficiency 10/362 30/7206 1.10185685499e-06 ko05145 Toxoplasmosis 20/362 126/7206 3.92060159481e-06 ko04658 Th1 and Th2 cell differentiation 17/362 96/7206 4.61739243954e-06 ko05162 Measles 19/362 120/7206 7.11920193152e-06 ko04672 Intestinal immune network for IgA production 10/362 37/7206 9.31130735259e-06 ko05321 Inflammatory bowel disease (IBD) 12/362 56/7206 1.6160676808e-05 ko05140 Leishmaniasis 14/362 75/7206 1.72828260308e-05 ko04611 Platelet activation 21/362 163/7206 6.01067967377e-05 ko04659 Th17 cell differentiation 16/362 106/7206 6.88216570574e-05 ko04650 Natural killer cell mediated cytotoxicity 15/362 97/7206 8.7251839778e-05 ko05168 Herpes simplex infection 22/362 182/7206 0.000106154158559 ko04620 Toll-like receptor signaling pathway 15/362 100/7206 0.000124476936569 ko04610 Complement and coagulation cascades 13/362 79/7206 0.000134836531931 ko04512 ECM-receptor interaction 13/362 79/7206 0.000134836531931 ko04668 TNF signaling pathway 16/362 120/7206 0.000304468795325 ko00120 Primary bile acid biosynthesis 6/362 20/7206 0.000327675834097 ko05150 Staphylococcus aureus infection 8/362 36/7206 0.00032881230079 ko04662 B cell receptor signaling pathway 13/362 88/7206 0.000407172257415 ko04660 T cell receptor signaling pathway 16/362 124/7206 0.000443601390933 ko04217 Necroptosis 20/362 178/7206 0.0006667114356 ko00140 Steroid hormone biosynthesis 8/362 41/7206 0.000833246669316 ko04622 RIG-I-like receptor signaling pathway 10/362 62/7206 0.000935294249797 ko00590 Arachidonic acid metabolism 9/362 52/7206 0.000994263350385 ko04933 AGE-RAGE signaling pathway in diabetic complications 16/362 135/7206 0.0011373920186 ko05161 Hepatitis B 19/362 173/7206 0.00115629868987 ko05133 Pertussis 12/362 87/7206 0.00125818394859 ko04612 Antigen processing and presentation 11/362 77/7206 0.00148736377881 ko05323 Rheumatoid arthritis 12/362 89/7206 0.00153856922261 ko05144 Malaria 8/362 45/7206 0.00157726351863 ko05152 Tuberculosis 20/362 187/7206 0.00171422603677 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/362 191/7206 0.00192410616002 ko05160 Hepatitis C 17/362 153/7206 0.0020005311354 ko04062 Chemokine signaling pathway 20/362 201/7206 0.00290346697162 ko03013 RNA transport 1/362 166/7206 0.00335102329104 ko04630 Jak-STAT signaling pathway 15/362 132/7206 0.00349149443569 ko05166 HTLV-I infection 26/362 292/7206 0.00381932855729 ko04623 Cytosolic DNA-sensing pathway 7/362 41/7206 0.00389788346766 ko04640 Hematopoietic cell lineage 9/362 64/7206 0.00438057748251 ko05330 Allograft rejection 5/362 24/7206 0.00599352645326 ko05131 Shigellosis 10/362 82/7206 0.00764841004132 ko05310 Asthma 4/362 17/7206 0.00885146911212 ko03040 Spliceosome 1/362 145/7206 0.0106367443901 ko05332 Graft-versus-host disease 4/362 18/7206 0.0109379539618 ko05134 Legionellosis 9/362 74/7206 0.0113354796987 ko04657 IL-17 signaling pathway 10/362 87/7206 0.0114692279819 ko04723 Retrograde endocannabinoid signaling 2/362 175/7206 0.0126599229832 ko04210 Apoptosis 17/362 180/7206 0.013629257112 ko05320 Autoimmune thyroid disease 5/362 29/7206 0.0136365931276 ko05034 Alcoholism 4/362 238/7206 0.0144047879765 ko05142 Chagas disease (American trypanosomiasis) 13/362 130/7206 0.0144551699481 ko04664 Fc epsilon RI signaling pathway 9/362 77/7206 0.014512643055 ko04510 Focal adhesion 21/362 240/7206 0.0147536225784 ko05132 Salmonella infection 11/362 98/7206 0.0159409416687 ko04666 Fc gamma R-mediated phagocytosis 12/362 122/7206 0.0209275092073 ko01200 Carbon metabolism 1/362 128/7206 0.0219154470055 ko03010 Ribosome 1/362 129/7206 0.0222085205253 ko00350 Tyrosine metabolism 5/362 33/7206 0.0231486552309 ko05215 Prostate cancer 11/362 111/7206 0.0263021740282 ko04974 Protein digestion and absorption 10/362 96/7206 0.0286270239225 ko04145 Phagosome 14/362 162/7206 0.04311376206 ko02010 ABC transporters 5/362 39/7206 0.0440431903589 ko04727 GABAergic synapse 1/362 110/7206 0.0446237202119 ko04360 Axon guidance 5/362 233/7206 0.0453033532765 ko04120 Ubiquitin mediated proteolysis 2/362 138/7206 0.0482318537899 ko04916 Melanogenesis 2/362 142/7206 0.0491068413263