ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	216/1260	423/7206	3.26422400439e-60
ko04724	Glutamatergic synapse	93/1260	152/7206	4.71248401553e-34
ko05033	Nicotine addiction	50/1260	56/7206	6.59220103749e-32
ko04713	Circadian entrainment	82/1260	136/7206	1.80753327378e-29
ko05032	Morphine addiction	71/1260	110/7206	2.64365066309e-28
ko04727	GABAergic synapse	69/1260	110/7206	1.99220654763e-26
ko04725	Cholinergic synapse	80/1260	160/7206	1.67383948378e-21
ko04721	Synaptic vesicle cycle	52/1260	80/7206	3.12803978145e-21
ko04020	Calcium signaling pathway	110/1260	265/7206	8.25390003434e-21
ko04728	Dopaminergic synapse	86/1260	185/7206	2.33560428389e-20
ko04024	cAMP signaling pathway	112/1260	279/7206	7.11133454903e-20
ko04723	Retrograde endocannabinoid signaling	80/1260	175/7206	1.85027405716e-18
ko04742	Taste transduction	40/1260	61/7206	8.15130200758e-17
ko04921	Oxytocin signaling pathway	87/1260	209/7206	8.39895586241e-17
ko04911	Insulin secretion	59/1260	117/7206	2.22711891827e-16
ko04744	Phototransduction	27/1260	36/7206	5.22488511944e-14
ko04726	Serotonergic synapse	61/1260	137/7206	1.04080410326e-13
ko04740	Olfactory transduction	42/1260	80/7206	8.61030445913e-13
ko04261	Adrenergic signaling in cardiomyocytes	78/1260	205/7206	1.80756440555e-12
ko04970	Salivary secretion	45/1260	95/7206	1.39341157069e-11
ko04720	Long-term potentiation	46/1260	99/7206	1.91708760576e-11
ko03040	Spliceosome	1/1260	145/7206	2.66511510887e-11
ko05031	Amphetamine addiction	43/1260	91/7206	4.40662050328e-11
ko04360	Axon guidance	81/1260	233/7206	1.06021149795e-10
ko04022	cGMP-PKG signaling pathway	75/1260	216/7206	7.79069782492e-10
ko04925	Aldosterone synthesis and secretion	43/1260	105/7206	1.24049121097e-08
ko04971	Gastric acid secretion	41/1260	98/7206	1.72156473837e-08
ko05030	Cocaine addiction	33/1260	73/7206	3.2149466448e-08
ko05203	Viral carcinogenesis	18/1260	277/7206	7.1881727646e-08
ko05168	Herpes simplex infection	8/1260	182/7206	9.95275814585e-08
ko04060	Cytokine-cytokine receptor interaction	9/1260	191/7206	1.16612559149e-07
ko03013	RNA transport	7/1260	166/7206	2.52948024467e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1260	74/7206	6.79271918777e-07
ko04924	Renin secretion	34/1260	86/7206	1.06809973238e-06
ko04010	MAPK signaling pathway	89/1260	321/7206	3.73457550268e-06
ko05164	Influenza A	9/1260	167/7206	4.20817479091e-06
ko05322	Systemic lupus erythematosus	8/1260	151/7206	1.11005736872e-05
ko04514	Cell adhesion molecules (CAMs)	43/1260	130/7206	1.22983603631e-05
ko04141	Protein processing in endoplasmic reticulum	12/1260	184/7206	1.85823585189e-05
ko04371	Apelin signaling pathway	54/1260	177/7206	1.97596779544e-05
ko04972	Pancreatic secretion	38/1260	111/7206	2.10100725206e-05
ko04966	Collecting duct acid secretion	14/1260	26/7206	2.76418156237e-05
ko04540	Gap junction	42/1260	128/7206	2.79792374892e-05
ko04730	Long-term depression	29/1260	78/7206	3.01866483219e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1260	79/7206	3.74160979788e-05
ko04120	Ubiquitin mediated proteolysis	8/1260	138/7206	6.32073915616e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1260	79/7206	7.03988973313e-05
ko05110	Vibrio cholerae infection	24/1260	63/7206	8.42190367492e-05
ko05205	Proteoglycans in cancer	25/1260	271/7206	0.000117966545063
ko04260	Cardiac muscle contraction	33/1260	98/7206	0.000128138729677
ko05414	Dilated cardiomyopathy	36/1260	112/7206	0.00013505910539
ko04976	Bile secretion	28/1260	80/7206	0.000150986480696
ko04621	NOD-like receptor signaling pathway	11/1260	157/7206	0.000175483407813
ko05169	Epstein-Barr virus infection	17/1260	206/7206	0.000177023046639
ko05162	Measles	7/1260	120/7206	0.00023595712087
ko04072	Phospholipase D signaling pathway	55/1260	197/7206	0.000264829271515
ko04745	Phototransduction - fly	16/1260	38/7206	0.000323620870221
ko04146	Peroxisome	4/1260	89/7206	0.000367799074492
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1260	59/7206	0.000377587175736
ko04750	Inflammatory mediator regulation of TRP channels	37/1260	122/7206	0.000424821813729
ko04915	Estrogen signaling pathway	39/1260	131/7206	0.000443544144673
ko04923	Regulation of lipolysis in adipocytes	26/1260	77/7206	0.000449086059354
ko04610	Complement and coagulation cascades	3/1260	79/7206	0.000465513588094
ko04064	NF-kappa B signaling pathway	5/1260	96/7206	0.000596876949629
ko05140	Leishmaniasis	3/1260	75/7206	0.000656828169589
ko04110	Cell cycle	11/1260	145/7206	0.000829923559873
ko00240	Pyrimidine metabolism	7/1260	110/7206	0.000906634561881
ko04014	Ras signaling pathway	70/1260	279/7206	0.00123053059159
ko04070	Phosphatidylinositol signaling system	33/1260	112/7206	0.00156039981477
ko04626	Plant-pathogen interaction	9/1260	18/7206	0.00158895269652
ko04612	Antigen processing and presentation	4/1260	77/7206	0.00226057713063
ko05144	Malaria	1/1260	45/7206	0.00276141663024
ko00071	Fatty acid degradation	1/1260	45/7206	0.00276141663024
ko03420	Nucleotide excision repair	1/1260	46/7206	0.00279095035985
ko03018	RNA degradation	5/1260	84/7206	0.00341020404435
ko00480	Glutathione metabolism	2/1260	55/7206	0.00369478363753
ko05321	Inflammatory bowel disease (IBD)	2/1260	56/7206	0.00386534917053
ko03022	Basal transcription factors	1/1260	44/7206	0.00427910547452
ko04214	Apoptosis - fly	4/1260	72/7206	0.00457859419614
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1260	100/7206	0.00484960004998
ko05131	Shigellosis	5/1260	82/7206	0.00485468667729
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1260	14/7206	0.00537926153008
ko00590	Arachidonic acid metabolism	2/1260	52/7206	0.00538096577186
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1260	182/7206	0.00539603789621
ko05161	Hepatitis B	17/1260	173/7206	0.00599318629781
ko04622	RIG-I-like receptor signaling pathway	3/1260	62/7206	0.0062945169501
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1260	40/7206	0.00631686626958
ko04657	IL-17 signaling pathway	6/1260	87/7206	0.00650191592457
ko04630	Jak-STAT signaling pathway	12/1260	132/7206	0.00772702816213
ko00630	Glyoxylate and dicarboxylate metabolism	1/1260	38/7206	0.00946217586107
ko04916	Melanogenesis	37/1260	142/7206	0.00984893214087
ko04015	Rap1 signaling pathway	65/1260	278/7206	0.00994504205592
ko04964	Proximal tubule bicarbonate reclamation	11/1260	29/7206	0.0109198708797
ko00260	Glycine, serine and threonine metabolism	2/1260	48/7206	0.0117395420961
ko00310	Lysine degradation	5/1260	73/7206	0.0127087545105
ko04115	p53 signaling pathway	5/1260	74/7206	0.0128686272377
ko04640	Hematopoietic cell lineage	4/1260	64/7206	0.0128882590027
ko04270	Vascular smooth muscle contraction	39/1260	154/7206	0.0132426737733
ko04658	Th1 and Th2 cell differentiation	8/1260	96/7206	0.0145455209953
ko00982	Drug metabolism - cytochrome P450	1/1260	37/7206	0.0146756580209
ko04912	GnRH signaling pathway	32/1260	122/7206	0.0155038272605
ko05133	Pertussis	7/1260	87/7206	0.0157020518691
ko00280	Valine, leucine and isoleucine degradation	3/1260	54/7206	0.018064993442
ko04922	Glucagon signaling pathway	33/1260	128/7206	0.0181690818623
ko04210	Apoptosis	20/1260	180/7206	0.0219307129079
ko01524	Platinum drug resistance	6/1260	76/7206	0.0227567642655
ko04620	Toll-like receptor signaling pathway	9/1260	100/7206	0.0235191654111
ko05034	Alcoholism	55/1260	238/7206	0.0238455374094
ko00983	Drug metabolism - other enzymes	2/1260	42/7206	0.0244754272398
ko01200	Carbon metabolism	13/1260	128/7206	0.0255054316166
ko00330	Arginine and proline metabolism	4/1260	61/7206	0.0259066714264
ko04918	Thyroid hormone synthesis	23/1260	86/7206	0.0310306043565
ko05132	Salmonella infection	9/1260	98/7206	0.0311159034632
ko05145	Toxoplasmosis	13/1260	126/7206	0.0326656478252
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1260	26/7206	0.033909865794
ko05204	Chemical carcinogenesis	3/1260	48/7206	0.0360228797395
ko00380	Tryptophan metabolism	3/1260	50/7206	0.0372413239137
ko04142	Lysosome	17/1260	151/7206	0.0398311965286
ko00600	Sphingolipid metabolism	5/1260	63/7206	0.0450457228248
ko05320	Autoimmune thyroid disease	1/1260	29/7206	0.0478534982061