ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 53/518 191/7206 1.26451583076e-18 ko05340 Primary immunodeficiency 16/518 30/7206 2.29866639272e-11 ko04380 Osteoclast differentiation 34/518 134/7206 3.82651289265e-11 ko05140 Leishmaniasis 24/518 75/7206 1.73288573539e-10 ko04621 NOD-like receptor signaling pathway 36/518 157/7206 2.26683587821e-10 ko05321 Inflammatory bowel disease (IBD) 20/518 56/7206 6.47587325966e-10 ko05145 Toxoplasmosis 31/518 126/7206 6.5818325378e-10 ko05330 Allograft rejection 13/518 24/7206 1.41464685334e-09 ko05164 Influenza A 35/518 167/7206 5.2622542872e-09 ko04217 Necroptosis 35/518 178/7206 2.98579469187e-08 ko04630 Jak-STAT signaling pathway 29/518 132/7206 3.73226659008e-08 ko04650 Natural killer cell mediated cytotoxicity 24/518 97/7206 5.18834610096e-08 ko04640 Hematopoietic cell lineage 19/518 64/7206 5.62577927286e-08 ko05162 Measles 27/518 120/7206 6.55810931314e-08 ko05150 Staphylococcus aureus infection 14/518 36/7206 7.17618894896e-08 ko04064 NF-kappa B signaling pathway 23/518 96/7206 1.8656182619e-07 ko05320 Autoimmune thyroid disease 12/518 29/7206 2.80945089387e-07 ko04612 Antigen processing and presentation 20/518 77/7206 2.90431889174e-07 ko04659 Th17 cell differentiation 24/518 106/7206 3.14521316348e-07 ko00120 Primary bile acid biosynthesis 10/518 20/7206 3.23787405625e-07 ko04660 T cell receptor signaling pathway 26/518 124/7206 5.06999203572e-07 ko04672 Intestinal immune network for IgA production 13/518 37/7206 8.43788381346e-07 ko05152 Tuberculosis 33/518 187/7206 1.03711743933e-06 ko05332 Graft-versus-host disease 9/518 18/7206 1.29392297558e-06 ko04620 Toll-like receptor signaling pathway 22/518 100/7206 1.64660513342e-06 ko05168 Herpes simplex infection 32/518 182/7206 2.70747604799e-06 ko05310 Asthma 8/518 17/7206 9.19351326671e-06 ko05144 Malaria 13/518 45/7206 1.0126185728e-05 ko04658 Th1 and Th2 cell differentiation 20/518 96/7206 1.17235565179e-05 ko05323 Rheumatoid arthritis 19/518 89/7206 1.3388232241e-05 ko04310 Wnt signaling pathway 1/518 181/7206 2.95570002467e-05 ko04610 Complement and coagulation cascades 17/518 79/7206 3.40652143219e-05 ko05133 Pertussis 18/518 87/7206 3.52726352409e-05 ko04137 Mitophagy - animal 17/518 82/7206 5.64168698366e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 29/518 191/7206 9.68014867202e-05 ko03013 RNA transport 1/518 166/7206 9.70199287674e-05 ko04146 Peroxisome 17/518 89/7206 0.000164685549692 ko04940 Type I diabetes mellitus 9/518 32/7206 0.000299995825992 ko04916 Melanogenesis 1/518 142/7206 0.000452627392279 ko04662 B cell receptor signaling pathway 16/518 88/7206 0.000457023644026 ko03040 Spliceosome 1/518 145/7206 0.000467242415301 ko04062 Chemokine signaling pathway 28/518 201/7206 0.000707443540818 ko04390 Hippo signaling pathway 3/518 188/7206 0.000840400825445 ko05142 Chagas disease (American trypanosomiasis) 20/518 130/7206 0.00096497695554 ko04728 Dopaminergic synapse 3/518 185/7206 0.00123674282359 ko03010 Ribosome 1/518 129/7206 0.00149934770903 ko04723 Retrograde endocannabinoid signaling 3/518 175/7206 0.00168117780565 ko04623 Cytosolic DNA-sensing pathway 9/518 41/7206 0.0020961388353 ko04360 Axon guidance 6/518 233/7206 0.00284679004924 ko04110 Cell cycle 2/518 145/7206 0.00290206441131 ko05034 Alcoholism 6/518 238/7206 0.00295972124179 ko04210 Apoptosis 24/518 180/7206 0.00302060294059 ko03320 PPAR signaling pathway 12/518 69/7206 0.00337980184941 ko04668 TNF signaling pathway 18/518 120/7206 0.0034138192308 ko00590 Arachidonic acid metabolism 10/518 52/7206 0.00342034651252 ko04622 RIG-I-like receptor signaling pathway 11/518 62/7206 0.00420633834613 ko03050 Proteasome 10/518 54/7206 0.0045466100557 ko05132 Salmonella infection 15/518 98/7206 0.00467535868215 ko04724 Glutamatergic synapse 3/518 152/7206 0.00659949320015 ko05224 Breast cancer 4/518 174/7206 0.00703089101372 ko04540 Gap junction 2/518 128/7206 0.00843669616145 ko00983 Drug metabolism - other enzymes 8/518 42/7206 0.00903992425142 ko00592 alpha-Linolenic acid metabolism 5/518 19/7206 0.00940166616892 ko04910 Insulin signaling pathway 4/518 172/7206 0.0100250414767 ko05160 Hepatitis C 20/518 153/7206 0.0100640516219 ko05161 Hepatitis B 22/518 173/7206 0.0101971001704 ko04912 GnRH signaling pathway 2/518 122/7206 0.0119318708281 ko00071 Fatty acid degradation 8/518 45/7206 0.0136687213283 ko00982 Drug metabolism - cytochrome P450 7/518 37/7206 0.0148060388476 ko04911 Insulin secretion 2/518 117/7206 0.0170679113756 ko05206 MicroRNAs in cancer 5/518 177/7206 0.0178712681348 ko04713 Circadian entrainment 3/518 136/7206 0.0179204947765 ko04114 Oocyte meiosis 3/518 139/7206 0.0184797224704 ko04145 Phagosome 20/518 162/7206 0.019328972129 ko04611 Platelet activation 20/518 163/7206 0.0197273087135 ko05204 Chemical carcinogenesis 8/518 48/7206 0.0198251319525 ko00980 Metabolism of xenobiotics by cytochrome P450 7/518 40/7206 0.022275193549 ko04012 ErbB signaling pathway 2/518 109/7206 0.0235388122886 ko04664 Fc epsilon RI signaling pathway 11/518 77/7206 0.0240566704519 ko04080 Neuroactive ligand-receptor interaction 19/518 423/7206 0.0253166662551 ko04530 Tight junction 8/518 228/7206 0.0260906565733 ko04020 Calcium signaling pathway 10/518 265/7206 0.0282278056314 ko00051 Fructose and mannose metabolism 7/518 42/7206 0.0284998163274 ko04721 Synaptic vesicle cycle 1/518 80/7206 0.0292476455958 ko04740 Olfactory transduction 1/518 80/7206 0.0292476455958 ko01040 Biosynthesis of unsaturated fatty acids 5/518 25/7206 0.0301061773466 ko00950 Isoquinoline alkaloid biosynthesis 3/518 10/7206 0.0302784209537 ko04550 Signaling pathways regulating pluripotency of stem cells 5/518 165/7206 0.0322344425041 ko04925 Aldosterone synthesis and secretion 2/518 105/7206 0.0336661935374 ko04514 Cell adhesion molecules (CAMs) 16/518 130/7206 0.036909516396 ko05134 Legionellosis 10/518 74/7206 0.0418355805004 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/518 5/7206 0.0445807569267 ko04068 FoxO signaling pathway 19/518 167/7206 0.0466094235324 ko04971 Gastric acid secretion 2/518 98/7206 0.0466683378504 ko04720 Long-term potentiation 2/518 99/7206 0.0470932970828