ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	35/449	56/7206	7.1840881733e-29
ko04724	Glutamatergic synapse	53/449	152/7206	8.072885145e-27
ko04080	Neuroactive ligand-receptor interaction	83/449	423/7206	2.57736991446e-22
ko04727	GABAergic synapse	36/449	110/7206	1.8487577644e-17
ko05032	Morphine addiction	36/449	110/7206	1.8487577644e-17
ko04728	Dopaminergic synapse	46/449	185/7206	1.04735075964e-16
ko04723	Retrograde endocannabinoid signaling	44/449	175/7206	3.2440511229e-16
ko04713	Circadian entrainment	34/449	136/7206	1.06850057465e-12
ko04024	cAMP signaling pathway	49/449	279/7206	1.68832813009e-11
ko05030	Cocaine addiction	23/449	73/7206	3.34615478666e-11
ko04020	Calcium signaling pathway	46/449	265/7206	1.11789698551e-10
ko05031	Amphetamine addiction	25/449	91/7206	1.29850458221e-10
ko04720	Long-term potentiation	26/449	99/7206	1.64836494404e-10
ko04721	Synaptic vesicle cycle	22/449	80/7206	1.67910614562e-09
ko04911	Insulin secretion	27/449	117/7206	1.70562152058e-09
ko04261	Adrenergic signaling in cardiomyocytes	36/449	205/7206	9.67646980528e-09
ko04514	Cell adhesion molecules (CAMs)	26/449	130/7206	8.06640603366e-08
ko04742	Taste transduction	17/449	61/7206	9.94364305718e-08
ko04725	Cholinergic synapse	29/449	160/7206	1.37779865516e-07
ko04921	Oxytocin signaling pathway	34/449	209/7206	1.76567056681e-07
ko04010	MAPK signaling pathway	45/449	321/7206	1.85290625471e-07
ko04726	Serotonergic synapse	25/449	137/7206	8.97299494343e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	17/449	74/7206	1.99556846586e-06
ko04072	Phospholipase D signaling pathway	28/449	197/7206	3.34320133895e-05
ko04915	Estrogen signaling pathway	21/449	131/7206	5.21642008163e-05
ko04730	Long-term depression	15/449	78/7206	7.51335876153e-05
ko05203	Viral carcinogenesis	4/449	277/7206	0.000184516061374
ko04970	Salivary secretion	16/449	95/7206	0.000224968172342
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	14/449	79/7206	0.000319738242234
ko04925	Aldosterone synthesis and secretion	16/449	105/7206	0.000717463472003
ko04022	cGMP-PKG signaling pathway	26/449	216/7206	0.00135454949894
ko04110	Cell cycle	1/449	145/7206	0.0014933728399
ko04972	Pancreatic secretion	16/449	111/7206	0.00207197316407
ko05414	Dilated cardiomyopathy	16/449	112/7206	0.00215909824788
ko04360	Axon guidance	26/449	233/7206	0.00342909125486
ko04260	Cardiac muscle contraction	14/449	98/7206	0.00458124332285
ko04930	Type II diabetes mellitus	9/449	54/7206	0.0056434872988
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/449	14/7206	0.00901938155848
ko05205	Proteoglycans in cancer	7/449	271/7206	0.0096571202877
ko05410	Hypertrophic cardiomyopathy (HCM)	13/449	100/7206	0.0103578544156
ko05231	Choline metabolism in cancer	16/449	134/7206	0.010523002194
ko03013	RNA transport	3/449	166/7206	0.013472405561
ko05164	Influenza A	3/449	167/7206	0.0136407525164
ko04070	Phosphatidylinositol signaling system	14/449	112/7206	0.0154277852216
ko04740	Olfactory transduction	11/449	80/7206	0.0159302109964
ko04630	Jak-STAT signaling pathway	2/449	132/7206	0.0170568808295
ko05169	Epstein-Barr virus infection	5/449	206/7206	0.0183314385607
ko05168	Herpes simplex infection	4/449	182/7206	0.0186937140184
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/449	182/7206	0.0186937140184
ko04071	Sphingolipid signaling pathway	18/449	162/7206	0.019389435884
ko04924	Renin secretion	11/449	86/7206	0.0210213645078
ko04014	Ras signaling pathway	27/449	279/7206	0.0219853052037
ko00190	Oxidative phosphorylation	2/449	127/7206	0.0242920546377
ko05034	Alcoholism	23/449	238/7206	0.0390399068577
ko04150	mTOR signaling pathway	5/449	184/7206	0.0437518197656
ko04141	Protein processing in endoplasmic reticulum	5/449	184/7206	0.0437518197656
ko04940	Type I diabetes mellitus	5/449	32/7206	0.0459407006313
ko04140	Autophagy - animal	4/449	164/7206	0.0473284422349
ko04550	Signaling pathways regulating pluripotency of stem cells	4/449	165/7206	0.0478266131936
ko04120	Ubiquitin mediated proteolysis	3/449	138/7206	0.0481711660939