ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 58/686 191/7206 1.78251097623e-16 ko04380 Osteoclast differentiation 37/686 134/7206 1.25797136766e-09 ko04621 NOD-like receptor signaling pathway 39/686 157/7206 1.21000263588e-08 ko00120 Primary bile acid biosynthesis 12/686 20/7206 3.10484061295e-08 ko05340 Primary immunodeficiency 14/686 30/7206 1.5083022043e-07 ko05164 Influenza A 38/686 167/7206 2.71122541127e-07 ko05321 Inflammatory bowel disease (IBD) 19/686 56/7206 4.40383250056e-07 ko05145 Toxoplasmosis 31/686 126/7206 4.88796231002e-07 ko04672 Intestinal immune network for IgA production 15/686 37/7206 5.22734939013e-07 ko04064 NF-kappa B signaling pathway 25/686 96/7206 2.06159692284e-06 ko04650 Natural killer cell mediated cytotoxicity 25/686 97/7206 2.53259597431e-06 ko05162 Measles 28/686 120/7206 5.33779954568e-06 ko04658 Th1 and Th2 cell differentiation 24/686 96/7206 7.12021211295e-06 ko04610 Complement and coagulation cascades 21/686 79/7206 9.53059080184e-06 ko04217 Necroptosis 36/686 178/7206 1.17834530277e-05 ko04659 Th17 cell differentiation 25/686 106/7206 1.39007840528e-05 ko05140 Leishmaniasis 20/686 75/7206 1.47256584541e-05 ko05330 Allograft rejection 10/686 24/7206 3.2562820507e-05 ko04630 Jak-STAT signaling pathway 28/686 132/7206 3.71915345728e-05 ko05320 Autoimmune thyroid disease 11/686 29/7206 3.74074620941e-05 ko05144 Malaria 14/686 45/7206 4.45576652563e-05 ko04620 Toll-like receptor signaling pathway 23/686 100/7206 4.6735485727e-05 ko03010 Ribosome 1/686 129/7206 5.54604910676e-05 ko05150 Staphylococcus aureus infection 12/686 36/7206 7.34134148012e-05 ko05034 Alcoholism 7/686 238/7206 0.000110084592925 ko03040 Spliceosome 2/686 145/7206 0.00013973809171 ko04640 Hematopoietic cell lineage 16/686 64/7206 0.000238007190245 ko04612 Antigen processing and presentation 18/686 77/7206 0.000247075645793 ko04660 T cell receptor signaling pathway 25/686 124/7206 0.000268825621955 ko03013 RNA transport 4/686 166/7206 0.000437296610319 ko00360 Phenylalanine metabolism 7/686 17/7206 0.000569562270003 ko00350 Tyrosine metabolism 10/686 33/7206 0.0006960274219 ko05332 Graft-versus-host disease 7/686 18/7206 0.000856179409502 ko05152 Tuberculosis 32/686 187/7206 0.000908221698706 ko04068 FoxO signaling pathway 29/686 167/7206 0.00121594026306 ko05168 Herpes simplex infection 31/686 182/7206 0.00121745940765 ko04662 B cell receptor signaling pathway 18/686 88/7206 0.00148985016209 ko04146 Peroxisome 18/686 89/7206 0.00167176270705 ko03015 mRNA surveillance pathway 1/686 93/7206 0.00195136507528 ko05161 Hepatitis B 29/686 173/7206 0.00229931999359 ko04110 Cell cycle 4/686 145/7206 0.00241312468589 ko04668 TNF signaling pathway 22/686 120/7206 0.00242942912076 ko05167 Kaposi's sarcoma-associated herpesvirus infection 31/686 191/7206 0.00258504834507 ko04210 Apoptosis 30/686 180/7206 0.00273480256067 ko04390 Hippo signaling pathway 7/686 188/7206 0.00354426578606 ko05142 Chagas disease (American trypanosomiasis) 23/686 130/7206 0.00355570150562 ko05310 Asthma 6/686 17/7206 0.00359969552858 ko04623 Cytosolic DNA-sensing pathway 10/686 41/7206 0.00419381221273 ko05133 Pertussis 17/686 87/7206 0.00464145014897 ko05323 Rheumatoid arthritis 17/686 89/7206 0.00522021697192 ko04721 Synaptic vesicle cycle 1/686 80/7206 0.00614718404018 ko04137 Mitophagy - animal 16/686 82/7206 0.00656066843235 ko00592 alpha-Linolenic acid metabolism 6/686 19/7206 0.00669112768303 ko04062 Chemokine signaling pathway 31/686 201/7206 0.00683286203603 ko04933 AGE-RAGE signaling pathway in diabetic complications 23/686 135/7206 0.0068456648111 ko00281 Geraniol degradation 3/686 5/7206 0.00741750242323 ko05032 Morphine addiction 3/686 110/7206 0.00855901214729 ko04723 Retrograde endocannabinoid signaling 7/686 175/7206 0.00864536872331 ko00950 Isoquinoline alkaloid biosynthesis 4/686 10/7206 0.0107107155924 ko04530 Tight junction 11/686 228/7206 0.0112976590593 ko00140 Steroid hormone biosynthesis 9/686 41/7206 0.0132179411156 ko00362 Benzoate degradation 3/686 6/7206 0.0137906273551 ko00590 Arachidonic acid metabolism 11/686 52/7206 0.0140126823397 ko04710 Circadian rhythm 9/686 43/7206 0.0179393211877 ko00982 Drug metabolism - cytochrome P450 8/686 37/7206 0.0207725840322 ko05160 Hepatitis C 23/686 153/7206 0.0250888128719 ko05134 Legionellosis 13/686 74/7206 0.0264188369775 ko04940 Type I diabetes mellitus 7/686 32/7206 0.0280380054045 ko04666 Fc gamma R-mediated phagocytosis 19/686 122/7206 0.028447734523 ko04611 Platelet activation 24/686 163/7206 0.0296835452613 ko04728 Dopaminergic synapse 9/686 185/7206 0.0298488301213 ko04727 GABAergic synapse 4/686 110/7206 0.0320005389079 ko04972 Pancreatic secretion 4/686 111/7206 0.0323075737492 ko00071 Fatty acid degradation 9/686 45/7206 0.0347108075824 ko04724 Glutamatergic synapse 7/686 152/7206 0.0353500005319 ko05146 Amoebiasis 16/686 99/7206 0.0359154930877 ko03320 PPAR signaling pathway 12/686 69/7206 0.0362986415337 ko04310 Wnt signaling pathway 9/686 181/7206 0.0387656903407 ko05033 Nicotine addiction 1/686 56/7206 0.0400382253229 ko04360 Axon guidance 13/686 233/7206 0.0401321728166 ko04340 Hedgehog signaling pathway 1/686 58/7206 0.0403811640778 ko04622 RIG-I-like receptor signaling pathway 11/686 62/7206 0.0454094541446 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/686 4/7206 0.0476744082427 ko00643 Styrene degradation 2/686 4/7206 0.0476744082427