ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1143	423/7206	8.81387730441e-60
ko04724	Glutamatergic synapse	89/1143	152/7206	6.21876216122e-34
ko05033	Nicotine addiction	49/1143	56/7206	2.02706055479e-32
ko04713	Circadian entrainment	79/1143	136/7206	7.21763081113e-30
ko05032	Morphine addiction	69/1143	110/7206	4.30933379966e-29
ko04727	GABAergic synapse	66/1143	110/7206	3.0307803737e-26
ko04728	Dopaminergic synapse	85/1143	185/7206	1.29188353441e-22
ko04725	Cholinergic synapse	76/1143	160/7206	2.04710495342e-21
ko04723	Retrograde endocannabinoid signaling	78/1143	175/7206	7.83971365948e-20
ko04721	Synaptic vesicle cycle	48/1143	80/7206	2.15098312894e-19
ko04020	Calcium signaling pathway	101/1143	265/7206	2.94184604533e-19
ko04024	cAMP signaling pathway	104/1143	279/7206	5.74855719482e-19
ko04911	Insulin secretion	55/1143	117/7206	1.46010606059e-15
ko04742	Taste transduction	36/1143	61/7206	1.53420802808e-14
ko04726	Serotonergic synapse	59/1143	137/7206	1.89318426018e-14
ko04921	Oxytocin signaling pathway	75/1143	209/7206	6.64079123548e-13
ko04261	Adrenergic signaling in cardiomyocytes	73/1143	205/7206	1.99968569386e-12
ko05031	Amphetamine addiction	42/1143	91/7206	7.43318633159e-12
ko04720	Long-term potentiation	43/1143	99/7206	5.02368077617e-11
ko04744	Phototransduction	23/1143	36/7206	9.50008285526e-11
ko03040	Spliceosome	1/1143	145/7206	5.13595164899e-10
ko04970	Salivary secretion	40/1143	95/7206	7.44940389677e-10
ko04740	Olfactory transduction	35/1143	80/7206	2.5299951022e-09
ko05030	Cocaine addiction	31/1143	73/7206	4.84556196089e-08
ko04360	Axon guidance	69/1143	233/7206	7.62431055138e-08
ko05203	Viral carcinogenesis	15/1143	277/7206	8.49518569199e-08
ko04925	Aldosterone synthesis and secretion	39/1143	105/7206	9.05210896588e-08
ko04971	Gastric acid secretion	37/1143	98/7206	1.43428188101e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1143	74/7206	1.01106752253e-06
ko05322	Systemic lupus erythematosus	5/1143	151/7206	1.34643932891e-06
ko04022	cGMP-PKG signaling pathway	62/1143	216/7206	1.56356765523e-06
ko04010	MAPK signaling pathway	83/1143	321/7206	2.31349474859e-06
ko04060	Cytokine-cytokine receptor interaction	9/1143	191/7206	2.64479416599e-06
ko03013	RNA transport	7/1143	166/7206	4.23379170383e-06
ko04141	Protein processing in endoplasmic reticulum	9/1143	184/7206	5.05692262291e-06
ko05164	Influenza A	8/1143	167/7206	1.33274002209e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1143	79/7206	1.61555229402e-05
ko04070	Phosphatidylinositol signaling system	36/1143	112/7206	1.86570635896e-05
ko05168	Herpes simplex infection	10/1143	182/7206	2.07542088582e-05
ko04745	Phototransduction - fly	17/1143	38/7206	2.33795264441e-05
ko04972	Pancreatic secretion	35/1143	111/7206	3.31915852262e-05
ko04514	Cell adhesion molecules (CAMs)	39/1143	130/7206	4.61512243104e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1143	122/7206	4.83944454163e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1143	59/7206	5.03294396268e-05
ko05414	Dilated cardiomyopathy	34/1143	112/7206	0.000114271369224
ko04730	Long-term depression	26/1143	78/7206	0.000120317714435
ko04072	Phospholipase D signaling pathway	52/1143	197/7206	0.000145348786561
ko04621	NOD-like receptor signaling pathway	9/1143	157/7206	0.000146183596607
ko04014	Ras signaling pathway	68/1143	279/7206	0.000158048581813
ko04540	Gap junction	37/1143	128/7206	0.000195966611736
ko04110	Cell cycle	8/1143	145/7206	0.000199395516139
ko03008	Ribosome biogenesis in eukaryotes	2/1143	79/7206	0.000266926616061
ko04924	Renin secretion	27/1143	86/7206	0.00027810572552
ko05140	Leishmaniasis	2/1143	75/7206	0.000390811592396
ko04612	Antigen processing and presentation	2/1143	77/7206	0.000405736685134
ko04120	Ubiquitin mediated proteolysis	8/1143	138/7206	0.000547152216547
ko05169	Epstein-Barr virus infection	16/1143	206/7206	0.000660639932197
ko04260	Cardiac muscle contraction	29/1143	98/7206	0.000661591818518
ko05110	Vibrio cholerae infection	21/1143	63/7206	0.000686796868648
ko05205	Proteoglycans in cancer	24/1143	271/7206	0.000886409472736
ko04966	Collecting duct acid secretion	11/1143	26/7206	0.00117122434315
ko04610	Complement and coagulation cascades	3/1143	79/7206	0.00159486614265
ko04371	Apelin signaling pathway	44/1143	177/7206	0.00166461795364
ko04146	Peroxisome	4/1143	89/7206	0.00181603927533
ko04915	Estrogen signaling pathway	34/1143	131/7206	0.00244230859728
ko04064	NF-kappa B signaling pathway	5/1143	96/7206	0.00272237731039
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1143	182/7206	0.00280864544622
ko05161	Hepatitis B	14/1143	173/7206	0.00307079629386
ko04976	Bile secretion	23/1143	80/7206	0.00308758562015
ko05162	Measles	8/1143	120/7206	0.00350594936903
ko00240	Pyrimidine metabolism	7/1143	110/7206	0.00362143229921
ko04923	Regulation of lipolysis in adipocytes	22/1143	77/7206	0.00424712406135
ko00260	Glycine, serine and threonine metabolism	1/1143	48/7206	0.00457553160179
ko05144	Malaria	1/1143	45/7206	0.00679667648678
ko00071	Fatty acid degradation	1/1143	45/7206	0.00679667648678
ko04658	Th1 and Th2 cell differentiation	6/1143	96/7206	0.00701224012641
ko03420	Nucleotide excision repair	1/1143	46/7206	0.00701613576181
ko04657	IL-17 signaling pathway	5/1143	87/7206	0.00717844056893
ko00562	Inositol phosphate metabolism	24/1143	89/7206	0.00775671277112
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1143	100/7206	0.00830539549849
ko00480	Glutathione metabolism	2/1143	55/7206	0.00852255575421
ko05321	Inflammatory bowel disease (IBD)	2/1143	56/7206	0.00878072465346
ko04217	Necroptosis	16/1143	178/7206	0.00916302287022
ko04640	Hematopoietic cell lineage	3/1143	64/7206	0.00941739771118
ko00310	Lysine degradation	4/1143	73/7206	0.00983225024107
ko04711	Circadian rhythm - fly	6/1143	13/7206	0.00987170503812
ko03018	RNA degradation	5/1143	84/7206	0.00989005940537
ko03022	Basal transcription factors	1/1143	44/7206	0.0108512610114
ko00590	Arachidonic acid metabolism	2/1143	52/7206	0.012342185322
ko00330	Arginine and proline metabolism	3/1143	61/7206	0.0134162187444
ko04622	RIG-I-like receptor signaling pathway	3/1143	62/7206	0.0134715873538
ko05131	Shigellosis	5/1143	82/7206	0.0138670172881
ko04214	Apoptosis - fly	4/1143	72/7206	0.0138957868371
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1143	14/7206	0.0149933525032
ko04626	Plant-pathogen interaction	7/1143	18/7206	0.0158034051805
ko00140	Steroid hormone biosynthesis	1/1143	41/7206	0.015818062558
ko04918	Thyroid hormone synthesis	22/1143	86/7206	0.0172506173401
ko05166	HTLV-I infection	32/1143	292/7206	0.0176221885091
ko05133	Pertussis	6/1143	87/7206	0.0177293546727
ko05016	Huntington's disease	22/1143	215/7206	0.0224524786855
ko04912	GnRH signaling pathway	29/1143	122/7206	0.0234794259241
ko04015	Rap1 signaling pathway	58/1143	278/7206	0.0235715284359
ko05215	Prostate cancer	9/1143	111/7206	0.0250208801944
ko05219	Bladder cancer	2/1143	48/7206	0.026643883934
ko04620	Toll-like receptor signaling pathway	8/1143	100/7206	0.0272039782249
ko04071	Sphingolipid signaling pathway	36/1143	162/7206	0.0293708012827
ko04210	Apoptosis	18/1143	180/7206	0.0295357902776
ko04630	Jak-STAT signaling pathway	12/1143	132/7206	0.0300946814712
ko04140	Autophagy - animal	16/1143	164/7206	0.0301295405727
ko04510	Focal adhesion	26/1143	240/7206	0.0306603518178
ko04115	p53 signaling pathway	5/1143	74/7206	0.0356618245798
ko04710	Circadian rhythm	12/1143	43/7206	0.0367029481039
ko04218	Cellular senescence	18/1143	177/7206	0.0367265633253
ko04964	Proximal tubule bicarbonate reclamation	9/1143	29/7206	0.0374242706293
ko04922	Glucagon signaling pathway	29/1143	128/7206	0.0379900180174
ko00280	Valine, leucine and isoleucine degradation	3/1143	54/7206	0.0379988213448
ko04270	Vascular smooth muscle contraction	34/1143	154/7206	0.043769286943
ko05418	Fluid shear stress and atherosclerosis	18/1143	173/7206	0.0454421625679
ko05034	Alcoholism	49/1143	238/7206	0.0469616083006
ko04722	Neurotrophin signaling pathway	35/1143	160/7206	0.0478832155409
ko05145	Toxoplasmosis	12/1143	126/7206	0.0489744132165
ko01200	Carbon metabolism	12/1143	128/7206	0.0496165702669