ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1263	423/7206	1.15543336964e-52
ko04724	Glutamatergic synapse	94/1263	152/7206	7.15496219418e-35
ko05033	Nicotine addiction	48/1263	56/7206	7.83125495755e-29
ko04713	Circadian entrainment	81/1263	136/7206	1.6064613354e-28
ko05032	Morphine addiction	68/1263	110/7206	1.88500484223e-25
ko04727	GABAergic synapse	67/1263	110/7206	1.47898430254e-24
ko04728	Dopaminergic synapse	88/1263	185/7206	1.39216583068e-21
ko04721	Synaptic vesicle cycle	52/1263	80/7206	3.50024289981e-21
ko04020	Calcium signaling pathway	111/1263	265/7206	3.6234588687e-21
ko04725	Cholinergic synapse	77/1263	160/7206	2.16169563363e-19
ko04024	cAMP signaling pathway	110/1263	279/7206	9.77379812821e-19
ko04723	Retrograde endocannabinoid signaling	77/1263	175/7206	1.42607734911e-16
ko04911	Insulin secretion	59/1263	117/7206	2.49842161529e-16
ko04921	Oxytocin signaling pathway	84/1263	209/7206	5.79214905414e-15
ko04742	Taste transduction	38/1263	61/7206	6.52350904493e-15
ko04726	Serotonergic synapse	62/1263	137/7206	2.89207503593e-14
ko04970	Salivary secretion	47/1263	95/7206	7.1648129871e-13
ko04744	Phototransduction	26/1263	36/7206	7.26832799813e-13
ko05031	Amphetamine addiction	45/1263	91/7206	2.2729003617e-12
ko04720	Long-term potentiation	47/1263	99/7206	4.80715319362e-12
ko04261	Adrenergic signaling in cardiomyocytes	76/1263	205/7206	1.69044766085e-11
ko04740	Olfactory transduction	39/1263	80/7206	1.17513214208e-10
ko03040	Spliceosome	2/1263	145/7206	6.07800691333e-10
ko04022	cGMP-PKG signaling pathway	75/1263	216/7206	8.0989410884e-10
ko04925	Aldosterone synthesis and secretion	43/1263	105/7206	1.31659261714e-08
ko05203	Viral carcinogenesis	17/1263	277/7206	2.67851727027e-08
ko05168	Herpes simplex infection	7/1263	182/7206	2.72165669201e-08
ko05322	Systemic lupus erythematosus	5/1263	151/7206	1.04680109751e-07
ko05030	Cocaine addiction	32/1263	73/7206	1.34154051837e-07
ko04971	Gastric acid secretion	39/1263	98/7206	1.46869585059e-07
ko04360	Axon guidance	73/1263	233/7206	1.62318518112e-07
ko03013	RNA transport	7/1263	166/7206	2.51150215242e-07
ko04924	Renin secretion	35/1263	86/7206	3.81277833768e-07
ko04060	Cytokine-cytokine receptor interaction	10/1263	191/7206	5.61961881135e-07
ko04540	Gap junction	45/1263	128/7206	1.491473484e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1263	74/7206	3.06080448067e-06
ko04120	Ubiquitin mediated proteolysis	6/1263	138/7206	4.13852024857e-06
ko04621	NOD-like receptor signaling pathway	8/1263	157/7206	5.68492551014e-06
ko04110	Cell cycle	7/1263	145/7206	7.03056162175e-06
ko05164	Influenza A	10/1263	167/7206	1.82562688086e-05
ko04514	Cell adhesion molecules (CAMs)	43/1263	130/7206	1.92195090978e-05
ko04371	Apelin signaling pathway	54/1263	177/7206	2.023434568e-05
ko04745	Phototransduction - fly	18/1263	38/7206	2.09011871523e-05
ko04972	Pancreatic secretion	38/1263	111/7206	2.15110072402e-05
ko04966	Collecting duct acid secretion	14/1263	26/7206	2.84255251109e-05
ko04730	Long-term depression	29/1263	78/7206	3.11991212314e-05
ko04141	Protein processing in endoplasmic reticulum	13/1263	184/7206	4.74775906507e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1263	79/7206	7.06919550055e-05
ko04976	Bile secretion	29/1263	80/7206	7.58513582057e-05
ko04010	MAPK signaling pathway	84/1263	321/7206	8.49402168737e-05
ko05110	Vibrio cholerae infection	24/1263	63/7206	8.72118707387e-05
ko04064	NF-kappa B signaling pathway	4/1263	96/7206	0.000120011581648
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1263	79/7206	0.000133006042691
ko04070	Phosphatidylinositol signaling system	36/1263	112/7206	0.000139277723084
ko05140	Leishmaniasis	2/1263	75/7206	0.000165741818901
ko05169	Epstein-Barr virus infection	17/1263	206/7206	0.000177246527536
ko04014	Ras signaling pathway	73/1263	279/7206	0.000209735075563
ko04260	Cardiac muscle contraction	32/1263	98/7206	0.000242429656766
ko04072	Phospholipase D signaling pathway	55/1263	197/7206	0.000269133229401
ko05414	Dilated cardiomyopathy	35/1263	112/7206	0.00036956262942
ko04750	Inflammatory mediator regulation of TRP channels	37/1263	122/7206	0.000436338148517
ko04612	Antigen processing and presentation	3/1263	77/7206	0.000448734778376
ko04610	Complement and coagulation cascades	3/1263	79/7206	0.000468763792797
ko05161	Hepatitis B	14/1263	173/7206	0.000519181060178
ko05205	Proteoglycans in cancer	27/1263	271/7206	0.000581603328022
ko04922	Glucagon signaling pathway	38/1263	128/7206	0.00059821217561
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1263	59/7206	0.0008102455558
ko05162	Measles	8/1263	120/7206	0.000931472442133
ko04330	Notch signaling pathway	2/1263	62/7206	0.00114109629526
ko04923	Regulation of lipolysis in adipocytes	25/1263	77/7206	0.00130748232462
ko04214	Apoptosis - fly	3/1263	72/7206	0.00147242251919
ko04626	Plant-pathogen interaction	9/1263	18/7206	0.00161707488241
ko04146	Peroxisome	5/1263	89/7206	0.0017304453837
ko05166	HTLV-I infection	32/1263	292/7206	0.00209256167645
ko04964	Proximal tubule bicarbonate reclamation	12/1263	29/7206	0.0021985612691
ko04915	Estrogen signaling pathway	37/1263	131/7206	0.00232935489539
ko00071	Fatty acid degradation	1/1263	45/7206	0.00275226188584
ko03420	Nucleotide excision repair	1/1263	46/7206	0.00279515251281
ko00240	Pyrimidine metabolism	8/1263	110/7206	0.00329803015357
ko04630	Jak-STAT signaling pathway	11/1263	132/7206	0.00363086601731
ko03022	Basal transcription factors	1/1263	44/7206	0.00429229961775
ko00310	Lysine degradation	4/1263	73/7206	0.00469123221483
ko05131	Shigellosis	5/1263	82/7206	0.00488222312295
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1263	100/7206	0.00489563706083
ko04270	Vascular smooth muscle contraction	41/1263	154/7206	0.00501560082878
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1263	14/7206	0.00545367811304
ko04930	Type II diabetes mellitus	18/1263	54/7206	0.00587696586765
ko04622	RIG-I-like receptor signaling pathway	3/1263	62/7206	0.00632139400471
ko04657	IL-17 signaling pathway	6/1263	87/7206	0.00650673437603
ko05215	Prostate cancer	9/1263	111/7206	0.00767390390091
ko03018	RNA degradation	6/1263	84/7206	0.00891409708286
ko01524	Platinum drug resistance	5/1263	76/7206	0.0092051477336
ko00630	Glyoxylate and dicarboxylate metabolism	1/1263	38/7206	0.00944216247785
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1263	182/7206	0.00992599142214
ko00562	Inositol phosphate metabolism	25/1263	89/7206	0.011398073458
ko05219	Bladder cancer	2/1263	48/7206	0.0117651478515
ko04217	Necroptosis	19/1263	178/7206	0.0125130450602
ko05321	Inflammatory bowel disease (IBD)	3/1263	56/7206	0.0125822877969
ko04115	p53 signaling pathway	5/1263	74/7206	0.0129021125575
ko04658	Th1 and Th2 cell differentiation	8/1263	96/7206	0.0145303838803
ko04710	Circadian rhythm	14/1263	43/7206	0.0146610823954
ko04912	GnRH signaling pathway	32/1263	122/7206	0.0156520056871
ko05133	Pertussis	7/1263	87/7206	0.0156597877681
ko05145	Toxoplasmosis	12/1263	126/7206	0.0173620911551
ko00280	Valine, leucine and isoleucine degradation	3/1263	54/7206	0.0180868463935
ko04210	Apoptosis	20/1263	180/7206	0.0219553503177
ko04620	Toll-like receptor signaling pathway	9/1263	100/7206	0.0235421439878
ko05217	Basal cell carcinoma	5/1263	68/7206	0.0241337033906
ko05212	Pancreatic cancer	7/1263	83/7206	0.0284072863652
ko04668	TNF signaling pathway	12/1263	120/7206	0.0286884510979
ko05132	Salmonella infection	9/1263	98/7206	0.0311929148933
ko04916	Melanogenesis	35/1263	142/7206	0.0333029867658
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1263	40/7206	0.0354963857797
ko04015	Rap1 signaling pathway	62/1263	278/7206	0.0363558532886
ko04142	Lysosome	17/1263	151/7206	0.0397624019813
ko00230	Purine metabolism	45/1263	194/7206	0.0437707722658
ko00010	Glycolysis / Gluconeogenesis	20/1263	74/7206	0.0438616502547
ko05220	Chronic myeloid leukemia	8/1263	85/7206	0.0450464752482
ko05206	MicroRNAs in cancer	21/1263	177/7206	0.0451390047273
ko04640	Hematopoietic cell lineage	5/1263	64/7206	0.0456343704432
ko00480	Glutathione metabolism	4/1263	55/7206	0.0485459712315
ko05200	Pathways in cancer	70/1263	492/7206	0.0491434936963