ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 174/1098 423/7206 1.13431767194e-40 ko04724 Glutamatergic synapse 86/1098 152/7206 1.27836484342e-32 ko05033 Nicotine addiction 47/1098 56/7206 3.16894397103e-30 ko04727 GABAergic synapse 66/1098 110/7206 2.7196433874e-27 ko05032 Morphine addiction 65/1098 110/7206 2.3530923423e-26 ko04713 Circadian entrainment 72/1098 136/7206 4.96905488644e-25 ko04728 Dopaminergic synapse 83/1098 185/7206 1.90014833224e-22 ko04723 Retrograde endocannabinoid signaling 77/1098 175/7206 2.92610550628e-20 ko04725 Cholinergic synapse 71/1098 160/7206 5.16149987019e-19 ko04744 Phototransduction 27/1098 36/7206 1.53698529661e-15 ko04721 Synaptic vesicle cycle 42/1098 80/7206 6.46223221844e-15 ko04911 Insulin secretion 52/1098 117/7206 2.8366206535e-14 ko04742 Taste transduction 35/1098 61/7206 3.37590176585e-14 ko04024 cAMP signaling pathway 92/1098 279/7206 4.54179889541e-14 ko04726 Serotonergic synapse 57/1098 137/7206 5.41554211196e-14 ko04020 Calcium signaling pathway 88/1098 265/7206 8.91192886138e-14 ko04921 Oxytocin signaling pathway 71/1098 209/7206 7.11639759459e-12 ko05031 Amphetamine addiction 41/1098 91/7206 9.22334029232e-12 ko04740 Olfactory transduction 37/1098 80/7206 3.71693698041e-11 ko04720 Long-term potentiation 41/1098 99/7206 2.37179894653e-10 ko04261 Adrenergic signaling in cardiomyocytes 65/1098 205/7206 2.25530772127e-09 ko03040 Spliceosome 2/1098 145/7206 1.66647127121e-08 ko04925 Aldosterone synthesis and secretion 39/1098 105/7206 2.57035516734e-08 ko05030 Cocaine addiction 30/1098 73/7206 7.68731395262e-08 ko04970 Salivary secretion 35/1098 95/7206 1.68798725924e-07 ko05322 Systemic lupus erythematosus 4/1098 151/7206 4.9316961779e-07 ko03013 RNA transport 6/1098 166/7206 1.78476723243e-06 ko04745 Phototransduction - fly 18/1098 38/7206 2.74300538788e-06 ko04971 Gastric acid secretion 33/1098 98/7206 5.44193271926e-06 ko05203 Viral carcinogenesis 18/1098 277/7206 7.89677587958e-06 ko04070 Phosphatidylinositol signaling system 35/1098 112/7206 1.50384700425e-05 ko04730 Long-term depression 27/1098 78/7206 1.88510367958e-05 ko04072 Phospholipase D signaling pathway 53/1098 197/7206 1.88967863519e-05 ko04621 NOD-like receptor signaling pathway 7/1098 157/7206 2.55115819405e-05 ko04110 Cell cycle 6/1098 145/7206 3.27042864115e-05 ko04972 Pancreatic secretion 34/1098 111/7206 4.26330300814e-05 ko05168 Herpes simplex infection 10/1098 182/7206 5.90385302559e-05 ko04120 Ubiquitin mediated proteolysis 6/1098 138/7206 6.58714648833e-05 ko04022 cGMP-PKG signaling pathway 55/1098 216/7206 6.98176838665e-05 ko04010 MAPK signaling pathway 75/1098 321/7206 8.9190590887e-05 ko04514 Cell adhesion molecules (CAMs) 37/1098 130/7206 0.000102579823712 ko05164 Influenza A 9/1098 167/7206 0.000112336030095 ko05162 Measles 5/1098 120/7206 0.000168838420952 ko05014 Amyotrophic lateral sclerosis (ALS) 24/1098 74/7206 0.000221778281427 ko04750 Inflammatory mediator regulation of TRP channels 34/1098 122/7206 0.000303801920912 ko04710 Circadian rhythm 16/1098 43/7206 0.000340578135733 ko04141 Protein processing in endoplasmic reticulum 12/1098 184/7206 0.000371510297414 ko03008 Ribosome biogenesis in eukaryotes 2/1098 79/7206 0.000409315645834 ko04964 Proximal tubule bicarbonate reclamation 12/1098 29/7206 0.000615034716621 ko04612 Antigen processing and presentation 2/1098 77/7206 0.000615985717187 ko05169 Epstein-Barr virus infection 15/1098 206/7206 0.000749351496301 ko04976 Bile secretion 24/1098 80/7206 0.000777997313446 ko04966 Collecting duct acid secretion 11/1098 26/7206 0.000828887373797 ko04064 NF-kappa B signaling pathway 4/1098 96/7206 0.000887404730167 ko05140 Leishmaniasis 2/1098 75/7206 0.000938608914914 ko05205 Proteoglycans in cancer 23/1098 271/7206 0.00101037759405 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 23/1098 79/7206 0.00140925119752 ko04260 Cardiac muscle contraction 27/1098 98/7206 0.00158219581072 ko05131 Shigellosis 3/1098 82/7206 0.00164230672291 ko04540 Gap junction 33/1098 128/7206 0.00172755443255 ko04630 Jak-STAT signaling pathway 8/1098 132/7206 0.00200058794673 ko00520 Amino sugar and nucleotide sugar metabolism 1/1098 55/7206 0.00208644318342 ko05416 Viral myocarditis 1/1098 55/7206 0.00208644318342 ko04610 Complement and coagulation cascades 3/1098 79/7206 0.00234690625738 ko05166 HTLV-I infection 27/1098 292/7206 0.00268684950041 ko04014 Ras signaling pathway 61/1098 279/7206 0.0028115751756 ko04060 Cytokine-cytokine receptor interaction 15/1098 191/7206 0.00290695546578 ko04915 Estrogen signaling pathway 33/1098 131/7206 0.00291911140685 ko04932 Non-alcoholic fatty liver disease (NAFLD) 14/1098 182/7206 0.00321476840528 ko04510 Focal adhesion 21/1098 240/7206 0.00333781452402 ko04930 Type II diabetes mellitus 17/1098 54/7206 0.0033760584851 ko00562 Inositol phosphate metabolism 24/1098 89/7206 0.00421937971271 ko04924 Renin secretion 23/1098 86/7206 0.00584033858323 ko05200 Pathways in cancer 54/1098 492/7206 0.00622660353694 ko05016 Huntington's disease 19/1098 215/7206 0.00674816151256 ko03420 Nucleotide excision repair 1/1098 46/7206 0.00698111892748 ko00240 Pyrimidine metabolism 7/1098 110/7206 0.00698118924684 ko05161 Hepatitis B 14/1098 173/7206 0.00706203489102 ko04146 Peroxisome 5/1098 89/7206 0.00728057531903 ko05414 Dilated cardiomyopathy 28/1098 112/7206 0.00737830182063 ko04711 Circadian rhythm - fly 6/1098 13/7206 0.00808792265751 ko05130 Pathogenic Escherichia coli infection 4/1098 77/7206 0.0100794303821 ko04657 IL-17 signaling pathway 5/1098 87/7206 0.0100917279333 ko05133 Pertussis 5/1098 87/7206 0.0100917279333 ko03022 Basal transcription factors 1/1098 44/7206 0.0104213516986 ko05144 Malaria 1/1098 45/7206 0.0106938216496 ko04810 Regulation of actin cytoskeleton 26/1098 264/7206 0.011279921011 ko04626 Plant-pathogen interaction 7/1098 18/7206 0.0127520325082 ko05321 Inflammatory bowel disease (IBD) 2/1098 56/7206 0.0133558095189 ko00910 Nitrogen metabolism 7/1098 19/7206 0.0175913240278 ko04217 Necroptosis 16/1098 178/7206 0.0195435042466 ko04622 RIG-I-like receptor signaling pathway 3/1098 62/7206 0.0196124881466 ko04214 Apoptosis - fly 4/1098 72/7206 0.0197449671119 ko00310 Lysine degradation 4/1098 73/7206 0.0202569976573 ko04918 Thyroid hormone synthesis 21/1098 86/7206 0.0228647639959 ko00630 Glyoxylate and dicarboxylate metabolism 1/1098 38/7206 0.0230526672388 ko03410 Base excision repair 1/1098 38/7206 0.0230526672388 ko04960 Aldosterone-regulated sodium reabsorption 12/1098 41/7206 0.0256088387277 ko04360 Axon guidance 48/1098 233/7206 0.0257265357574 ko05219 Bladder cancer 2/1098 48/7206 0.0263718274548 ko05217 Basal cell carcinoma 4/1098 68/7206 0.0270696822866 ko04210 Apoptosis 17/1098 180/7206 0.0271320464122 ko05231 Choline metabolism in cancer 30/1098 134/7206 0.0280012716855 ko04658 Th1 and Th2 cell differentiation 7/1098 96/7206 0.0307071430142 ko05110 Vibrio cholerae infection 16/1098 63/7206 0.0330233722367 ko05410 Hypertrophic cardiomyopathy (HCM) 23/1098 100/7206 0.0352422399229 ko04520 Adherens junction 8/1098 103/7206 0.0369877936288 ko00071 Fatty acid degradation 2/1098 45/7206 0.0379383311936 ko04142 Lysosome 14/1098 151/7206 0.039038878707 ko05224 Breast cancer 17/1098 174/7206 0.0422065306683 ko05145 Toxoplasmosis 11/1098 126/7206 0.0443452060473 ko03018 RNA degradation 6/1098 84/7206 0.045183461855 ko04922 Glucagon signaling pathway 28/1098 128/7206 0.0458904567456 ko04062 Chemokine signaling pathway 41/1098 201/7206 0.0459511602641 ko05132 Salmonella infection 8/1098 98/7206 0.0477858565977 ko04140 Autophagy - animal 16/1098 164/7206 0.0478069929545 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/1098 14/7206 0.049408035157