ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1250	423/7206	6.24802498541e-50
ko04724	Glutamatergic synapse	89/1250	152/7206	8.02236349047e-31
ko05033	Nicotine addiction	47/1250	56/7206	1.27270692343e-27
ko05032	Morphine addiction	69/1250	110/7206	1.21139739636e-26
ko04713	Circadian entrainment	76/1250	136/7206	1.18326949047e-24
ko04727	GABAergic synapse	65/1250	110/7206	4.48015961634e-23
ko04721	Synaptic vesicle cycle	52/1250	80/7206	2.14551200274e-21
ko04728	Dopaminergic synapse	85/1250	185/7206	5.89531432509e-20
ko04725	Cholinergic synapse	77/1250	160/7206	1.13676862133e-19
ko04024	cAMP signaling pathway	107/1250	279/7206	1.55023727709e-17
ko04020	Calcium signaling pathway	103/1250	265/7206	2.08846439388e-17
ko04723	Retrograde endocannabinoid signaling	77/1250	175/7206	7.7464223999e-17
ko04742	Taste transduction	38/1250	61/7206	4.59495140146e-15
ko04744	Phototransduction	27/1250	36/7206	4.26516565704e-14
ko04726	Serotonergic synapse	61/1250	137/7206	7.16906234586e-14
ko04911	Insulin secretion	55/1250	117/7206	7.63179669712e-14
ko04921	Oxytocin signaling pathway	80/1250	209/7206	2.80860700364e-13
ko04261	Adrenergic signaling in cardiomyocytes	76/1250	205/7206	7.34128947121e-12
ko03040	Spliceosome	1/1250	145/7206	4.31263496941e-11
ko04970	Salivary secretion	43/1250	95/7206	1.92489502564e-10
ko05031	Amphetamine addiction	41/1250	91/7206	6.08120989935e-10
ko04720	Long-term potentiation	43/1250	99/7206	9.60381894004e-10
ko05203	Viral carcinogenesis	16/1250	277/7206	9.16936869431e-09
ko04022	cGMP-PKG signaling pathway	70/1250	216/7206	4.34595814908e-08
ko04740	Olfactory transduction	34/1250	80/7206	1.05740736356e-07
ko04360	Axon guidance	73/1250	233/7206	1.33624298431e-07
ko03013	RNA transport	7/1250	166/7206	3.7935128479e-07
ko05322	Systemic lupus erythematosus	6/1250	151/7206	6.49137909e-07
ko04070	Phosphatidylinositol signaling system	41/1250	112/7206	8.67411387935e-07
ko04971	Gastric acid secretion	37/1250	98/7206	1.20553371387e-06
ko04925	Aldosterone synthesis and secretion	39/1250	105/7206	1.35981708063e-06
ko05168	Herpes simplex infection	10/1250	182/7206	2.29661538282e-06
ko04060	Cytokine-cytokine receptor interaction	11/1250	191/7206	2.44431127895e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1250	74/7206	2.67267206845e-06
ko04966	Collecting duct acid secretion	15/1250	26/7206	4.07681544594e-06
ko05030	Cocaine addiction	29/1250	73/7206	5.58749352837e-06
ko04924	Renin secretion	32/1250	86/7206	9.35392123047e-06
ko04514	Cell adhesion molecules (CAMs)	43/1250	130/7206	1.06730657834e-05
ko04621	NOD-like receptor signaling pathway	9/1250	157/7206	2.45926243396e-05
ko04010	MAPK signaling pathway	85/1250	321/7206	2.96013341072e-05
ko04972	Pancreatic secretion	37/1250	111/7206	3.77069035215e-05
ko05164	Influenza A	11/1250	167/7206	6.93780487057e-05
ko04610	Complement and coagulation cascades	2/1250	79/7206	7.0196177239e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1250	79/7206	7.0196177239e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1250	79/7206	0.000122196061815
ko04540	Gap junction	40/1250	128/7206	0.000127802293542
ko05205	Proteoglycans in cancer	25/1250	271/7206	0.000155334822849
ko04141	Protein processing in endoplasmic reticulum	14/1250	184/7206	0.000159474948645
ko05140	Leishmaniasis	2/1250	75/7206	0.000160597410606
ko04072	Phospholipase D signaling pathway	55/1250	197/7206	0.000177067239618
ko04064	NF-kappa B signaling pathway	4/1250	96/7206	0.000184598954457
ko04120	Ubiquitin mediated proteolysis	9/1250	138/7206	0.000249439413935
ko05110	Vibrio cholerae infection	23/1250	63/7206	0.000289827047088
ko04745	Phototransduction - fly	16/1250	38/7206	0.000294427374935
ko04976	Bile secretion	27/1250	80/7206	0.00030796604097
ko05414	Dilated cardiomyopathy	35/1250	112/7206	0.000343436857691
ko04923	Regulation of lipolysis in adipocytes	26/1250	77/7206	0.000407249235759
ko04014	Ras signaling pathway	71/1250	279/7206	0.000495723149738
ko05169	Epstein-Barr virus infection	18/1250	206/7206	0.000509556825876
ko04964	Proximal tubule bicarbonate reclamation	13/1250	29/7206	0.000524173497282
ko04371	Apelin signaling pathway	49/1250	177/7206	0.000564711425779
ko04260	Cardiac muscle contraction	31/1250	98/7206	0.000634222863921
ko04612	Antigen processing and presentation	3/1250	77/7206	0.000680964487713
ko04730	Long-term depression	26/1250	78/7206	0.000722778084783
ko04110	Cell cycle	11/1250	145/7206	0.000835514742205
ko04750	Inflammatory mediator regulation of TRP channels	36/1250	122/7206	0.000973909759157
ko00240	Pyrimidine metabolism	7/1250	110/7206	0.00130937572677
ko04626	Plant-pathogen interaction	9/1250	18/7206	0.00149812306885
ko05161	Hepatitis B	15/1250	173/7206	0.00151248945127
ko04915	Estrogen signaling pathway	37/1250	131/7206	0.00158435226028
ko04146	Peroxisome	5/1250	89/7206	0.00170956254439
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1250	59/7206	0.00267029301978
ko03420	Nucleotide excision repair	1/1250	46/7206	0.00278739649386
ko05162	Measles	9/1250	120/7206	0.00319613202261
ko00480	Glutathione metabolism	2/1250	55/7206	0.00369059732156
ko03022	Basal transcription factors	1/1250	44/7206	0.00424941097817
ko05144	Malaria	1/1250	45/7206	0.0044879641909
ko00071	Fatty acid degradation	1/1250	45/7206	0.0044879641909
ko04214	Apoptosis - fly	4/1250	72/7206	0.00461103730903
ko00310	Lysine degradation	4/1250	73/7206	0.0046360398781
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1250	14/7206	0.00513693871602
ko00590	Arachidonic acid metabolism	2/1250	52/7206	0.00541963028144
ko00330	Arginine and proline metabolism	3/1250	61/7206	0.00615546590135
ko04622	RIG-I-like receptor signaling pathway	3/1250	62/7206	0.00623274616449
ko00140	Steroid hormone biosynthesis	1/1250	41/7206	0.00632704208545
ko04657	IL-17 signaling pathway	6/1250	87/7206	0.00652589442868
ko05133	Pertussis	6/1250	87/7206	0.00652589442868
ko04210	Apoptosis	18/1250	180/7206	0.00690480428045
ko04710	Circadian rhythm	15/1250	43/7206	0.00696832823915
ko05145	Toxoplasmosis	11/1250	126/7206	0.00857415106785
ko04510	Focal adhesion	27/1250	240/7206	0.00925927875675
ko00630	Glyoxylate and dicarboxylate metabolism	1/1250	38/7206	0.00955109262025
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1250	40/7206	0.0100032491725
ko00562	Inositol phosphate metabolism	25/1250	89/7206	0.0106701211232
ko05131	Shigellosis	6/1250	82/7206	0.0123087062357
ko05321	Inflammatory bowel disease (IBD)	3/1250	56/7206	0.0126418184356
ko03018	RNA degradation	6/1250	84/7206	0.0127201017207
ko04115	p53 signaling pathway	5/1250	74/7206	0.012814550236
ko00982	Drug metabolism - cytochrome P450	1/1250	37/7206	0.014568518661
ko04711	Circadian rhythm - fly	6/1250	13/7206	0.015278886988
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1250	100/7206	0.0158019508835
ko04640	Hematopoietic cell lineage	4/1250	64/7206	0.0186935295542
ko04630	Jak-STAT signaling pathway	13/1250	132/7206	0.0199591548381
ko04658	Th1 and Th2 cell differentiation	8/1250	96/7206	0.0199957606752
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1250	182/7206	0.0221048060767
ko03320	PPAR signaling pathway	5/1250	69/7206	0.0243386458936
ko00983	Drug metabolism - other enzymes	2/1250	42/7206	0.0246522308889
ko04922	Glucagon signaling pathway	32/1250	128/7206	0.025071423666
ko04930	Type II diabetes mellitus	16/1250	54/7206	0.0280627753865
ko05231	Choline metabolism in cancer	33/1250	134/7206	0.028592566214
ko04918	Thyroid hormone synthesis	23/1250	86/7206	0.030231889139
ko05132	Salmonella infection	9/1250	98/7206	0.0310033755645
ko00380	Tryptophan metabolism	3/1250	50/7206	0.0368946585268
ko04973	Carbohydrate digestion and absorption	13/1250	42/7206	0.0376050706229
ko05320	Autoimmune thyroid disease	1/1250	29/7206	0.0478934576141
ko05166	HTLV-I infection	38/1250	292/7206	0.0482936926085
ko05340	Primary immunodeficiency	1/1250	30/7206	0.0491305356863