ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 34/283 191/7206 5.06701204344e-14 ko05340 Primary immunodeficiency 13/283 30/7206 2.64795806275e-11 ko05164 Influenza A 27/283 167/7206 2.37902990203e-10 ko04621 NOD-like receptor signaling pathway 25/283 157/7206 1.58796468423e-09 ko05140 Leishmaniasis 17/283 75/7206 2.95793197539e-09 ko05152 Tuberculosis 27/283 187/7206 3.19047196167e-09 ko04659 Th17 cell differentiation 20/283 106/7206 3.59886310482e-09 ko04650 Natural killer cell mediated cytotoxicity 19/283 97/7206 4.6665450124e-09 ko04217 Necroptosis 26/283 178/7206 4.94011478189e-09 ko05162 Measles 21/283 120/7206 6.00239243798e-09 ko04380 Osteoclast differentiation 22/283 134/7206 8.86193352212e-09 ko05145 Toxoplasmosis 21/283 126/7206 1.48374322269e-08 ko04612 Antigen processing and presentation 16/283 77/7206 3.30049243862e-08 ko05168 Herpes simplex infection 25/283 182/7206 3.51553834553e-08 ko05320 Autoimmune thyroid disease 10/283 29/7206 7.69732262953e-08 ko04658 Th1 and Th2 cell differentiation 17/283 96/7206 1.47165746413e-07 ko04064 NF-kappa B signaling pathway 17/283 96/7206 1.47165746413e-07 ko05330 Allograft rejection 9/283 24/7206 1.52370657772e-07 ko05321 Inflammatory bowel disease (IBD) 13/283 56/7206 1.66450824818e-07 ko04620 Toll-like receptor signaling pathway 16/283 100/7206 1.43494023002e-06 ko05332 Graft-versus-host disease 7/283 18/7206 2.93457416462e-06 ko04062 Chemokine signaling pathway 23/283 201/7206 3.38662763197e-06 ko04630 Jak-STAT signaling pathway 18/283 132/7206 3.45287893312e-06 ko04622 RIG-I-like receptor signaling pathway 11/283 62/7206 2.40274795141e-05 ko04660 T cell receptor signaling pathway 16/283 124/7206 2.47188423126e-05 ko05133 Pertussis 13/283 87/7206 3.01706055028e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/283 191/7206 5.494754522e-05 ko05150 Staphylococcus aureus infection 8/283 36/7206 5.93973530258e-05 ko04145 Phagosome 18/283 162/7206 5.98819679939e-05 ko04672 Intestinal immune network for IgA production 8/283 37/7206 7.32347399945e-05 ko04662 B cell receptor signaling pathway 12/283 88/7206 0.000151333637516 ko00590 Arachidonic acid metabolism 9/283 52/7206 0.000162742114031 ko04640 Hematopoietic cell lineage 10/283 64/7206 0.000171989104497 ko04940 Type I diabetes mellitus 7/283 32/7206 0.000193251015888 ko03050 Proteasome 9/283 54/7206 0.000219582767269 ko05310 Asthma 5/283 17/7206 0.000378077790271 ko05161 Hepatitis B 17/283 173/7206 0.000426052547482 ko04623 Cytosolic DNA-sensing pathway 7/283 41/7206 0.000953643533334 ko04360 Axon guidance 1/283 233/7206 0.00161467122928 ko05144 Malaria 7/283 45/7206 0.00168343728288 ko05142 Chagas disease (American trypanosomiasis) 13/283 130/7206 0.0017043054151 ko05160 Hepatitis C 14/283 153/7206 0.0026652391561 ko04664 Fc epsilon RI signaling pathway 9/283 77/7206 0.00302845314352 ko05416 Viral myocarditis 7/283 55/7206 0.00539208440367 ko05034 Alcoholism 2/283 238/7206 0.00626142625438 ko00120 Primary bile acid biosynthesis 4/283 20/7206 0.00685688995394 ko04390 Hippo signaling pathway 1/283 188/7206 0.00716163953815 ko04146 Peroxisome 9/283 89/7206 0.00793240493205 ko05323 Rheumatoid arthritis 9/283 89/7206 0.00793240493205 ko04080 Neuroactive ligand-receptor interaction 7/283 423/7206 0.00944965202043 ko04310 Wnt signaling pathway 1/283 181/7206 0.0104581722888 ko04728 Dopaminergic synapse 1/283 185/7206 0.0108034974906 ko04610 Complement and coagulation cascades 8/283 79/7206 0.0119339584035 ko04611 Platelet activation 13/283 163/7206 0.0129768426195 ko05132 Salmonella infection 9/283 98/7206 0.0144800050137 ko05131 Shigellosis 8/283 82/7206 0.0147462782872 ko04137 Mitophagy - animal 8/283 82/7206 0.0147462782872 ko05224 Breast cancer 1/283 174/7206 0.0154900318991 ko04723 Retrograde endocannabinoid signaling 1/283 175/7206 0.0156533581199 ko00511 Other glycan degradation 4/283 26/7206 0.017597615639 ko04670 Leukocyte transendothelial migration 12/283 151/7206 0.0176428422784 ko00980 Metabolism of xenobiotics by cytochrome P450 5/283 40/7206 0.0192587008491 ko04510 Focal adhesion 3/283 240/7206 0.0263542020705 ko04666 Fc gamma R-mediated phagocytosis 10/283 122/7206 0.0285740781638 ko04210 Apoptosis 13/283 180/7206 0.0303337360081 ko04724 Glutamatergic synapse 1/283 152/7206 0.0317816429286 ko04020 Calcium signaling pathway 4/283 265/7206 0.0352080505962 ko04530 Tight junction 3/283 228/7206 0.0360475932294 ko00592 alpha-Linolenic acid metabolism 3/283 19/7206 0.0364443113563 ko04514 Cell adhesion molecules (CAMs) 10/283 130/7206 0.0366802098091 ko05204 Chemical carcinogenesis 5/283 48/7206 0.0389646628645 ko00966 Glucosinolate biosynthesis 1/283 1/7206 0.0392728281988 ko05169 Epstein-Barr virus infection 14/283 206/7206 0.0426298007405 ko04713 Circadian entrainment 1/283 136/7206 0.0449397218595 ko04114 Oocyte meiosis 1/283 139/7206 0.0450580976998 ko03040 Spliceosome 1/283 145/7206 0.0469952840017 ko05206 MicroRNAs in cancer 2/283 177/7206 0.0489220871423