ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 71/577 423/7206 8.41481453591e-10 ko04974 Protein digestion and absorption 24/577 96/7206 3.20951836189e-07 ko04020 Calcium signaling pathway 45/577 265/7206 1.2420862657e-06 ko04744 Phototransduction 13/577 36/7206 2.00489346292e-06 ko04976 Bile secretion 20/577 80/7206 3.09985453364e-06 ko04724 Glutamatergic synapse 29/577 152/7206 1.06301026877e-05 ko04710 Circadian rhythm 13/577 43/7206 1.87826242257e-05 ko05033 Nicotine addiction 15/577 56/7206 2.19321598912e-05 ko03013 RNA transport 1/577 166/7206 2.98557796245e-05 ko04512 ECM-receptor interaction 18/577 79/7206 3.76735065814e-05 ko00643 Styrene degradation 4/577 4/7206 4.07157718187e-05 ko04740 Olfactory transduction 18/577 80/7206 4.50629609161e-05 ko03040 Spliceosome 1/577 145/7206 0.00013867523625 ko04110 Cell cycle 1/577 145/7206 0.00013867523625 ko04727 GABAergic synapse 21/577 110/7206 0.00013952010197 ko05203 Viral carcinogenesis 7/577 277/7206 0.000164323650554 ko04713 Circadian entrainment 24/577 136/7206 0.000182870600243 ko04120 Ubiquitin mediated proteolysis 1/577 138/7206 0.000199374030685 ko04971 Gastric acid secretion 19/577 98/7206 0.000233022281651 ko05032 Morphine addiction 20/577 110/7206 0.0004895167821 ko02010 ABC transporters 10/577 39/7206 0.000756220378912 ko04911 Insulin secretion 20/577 117/7206 0.00149564126781 ko04970 Salivary secretion 17/577 95/7206 0.00160818801687 ko05205 Proteoglycans in cancer 9/577 271/7206 0.00195183574911 ko04711 Circadian rhythm - fly 5/577 13/7206 0.00241985664068 ko04745 Phototransduction - fly 9/577 38/7206 0.00251468088443 ko04742 Taste transduction 12/577 61/7206 0.00283237705577 ko05164 Influenza A 4/577 167/7206 0.0035731129328 ko04726 Serotonergic synapse 21/577 137/7206 0.0036033071915 ko00350 Tyrosine metabolism 8/577 33/7206 0.00370594462484 ko04620 Toll-like receptor signaling pathway 1/577 100/7206 0.00445562839377 ko04145 Phagosome 4/577 162/7206 0.00496431206205 ko04925 Aldosterone synthesis and secretion 17/577 105/7206 0.00533200487865 ko03015 mRNA surveillance pathway 1/577 93/7206 0.00637399858888 ko04024 cAMP signaling pathway 35/577 279/7206 0.006715726011 ko04217 Necroptosis 5/577 178/7206 0.00716647129678 ko04972 Pancreatic secretion 17/577 111/7206 0.00775131938362 ko05161 Hepatitis B 5/577 173/7206 0.00979842560239 ko04022 cGMP-PKG signaling pathway 28/577 216/7206 0.0103187086159 ko04916 Melanogenesis 20/577 142/7206 0.0116385355535 ko00190 Oxidative phosphorylation 3/577 127/7206 0.0125806473563 ko05168 Herpes simplex infection 6/577 182/7206 0.0125910910716 ko05152 Tuberculosis 6/577 187/7206 0.012992604956 ko04921 Oxytocin signaling pathway 27/577 209/7206 0.0131456829889 ko05212 Pancreatic cancer 1/577 83/7206 0.0135655590365 ko05220 Chronic myeloid leukemia 1/577 85/7206 0.0138654621526 ko04270 Vascular smooth muscle contraction 21/577 154/7206 0.0151882820544 ko04218 Cellular senescence 6/577 177/7206 0.0168507179422 ko04210 Apoptosis 6/577 180/7206 0.0170565795648 ko05031 Amphetamine addiction 14/577 91/7206 0.0171798436479 ko04660 T cell receptor signaling pathway 3/577 124/7206 0.0178583093865 ko04261 Adrenergic signaling in cardiomyocytes 26/577 205/7206 0.0179555019835 ko00120 Primary bile acid biosynthesis 5/577 20/7206 0.018253379079 ko03008 Ribosome biogenesis in eukaryotes 1/577 79/7206 0.0198925011585 ko05166 HTLV-I infection 13/577 292/7206 0.0203109681802 ko04514 Cell adhesion molecules (CAMs) 18/577 130/7206 0.0208502547227 ko05167 Kaposi's sarcoma-associated herpesvirus infection 7/577 191/7206 0.0211087182457 ko04650 Natural killer cell mediated cytotoxicity 2/577 97/7206 0.0229638947098 ko05100 Bacterial invasion of epithelial cells 2/577 99/7206 0.0232833231035 ko04380 Osteoclast differentiation 4/577 134/7206 0.0243025814192 ko04964 Proximal tubule bicarbonate reclamation 6/577 29/7206 0.0249155086831 ko05162 Measles 3/577 120/7206 0.0252359843236 ko04725 Cholinergic synapse 21/577 160/7206 0.0254607090106 ko05140 Leishmaniasis 1/577 75/7206 0.0293200231283 ko04142 Lysosome 5/577 151/7206 0.0321957748488 ko04723 Retrograde endocannabinoid signaling 22/577 175/7206 0.0330516230035 ko05211 Renal cell carcinoma 2/577 96/7206 0.0340543310398 ko04141 Protein processing in endoplasmic reticulum 7/577 184/7206 0.0373613750129 ko00140 Steroid hormone biosynthesis 7/577 41/7206 0.0420719128106 ko04060 Cytokine-cytokine receptor interaction 23/577 191/7206 0.0425057761001 ko04113 Meiosis - yeast 1/577 70/7206 0.0425152005107 ko01522 Endocrine resistance 4/577 124/7206 0.0446985836579 ko00340 Histidine metabolism 5/577 25/7206 0.0449947983507 ko05133 Pertussis 2/577 87/7206 0.0455993907733 ko05323 Rheumatoid arthritis 2/577 89/7206 0.0463540152975