ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	36/504	56/7206	1.64919261491e-28
ko04724	Glutamatergic synapse	55/504	152/7206	3.59750826159e-26
ko04080	Neuroactive ligand-receptor interaction	92/504	423/7206	2.13283602294e-24
ko04727	GABAergic synapse	39/504	110/7206	1.879792302e-18
ko05032	Morphine addiction	39/504	110/7206	1.879792302e-18
ko04723	Retrograde endocannabinoid signaling	48/504	175/7206	3.24273836203e-17
ko04713	Circadian entrainment	38/504	136/7206	3.92969286938e-14
ko04728	Dopaminergic synapse	42/504	185/7206	3.80970753199e-12
ko04024	cAMP signaling pathway	52/504	279/7206	3.11904279939e-11
ko04020	Calcium signaling pathway	49/504	265/7206	1.61748213137e-10
ko04911	Insulin secretion	29/504	117/7206	1.03990015592e-09
ko05031	Amphetamine addiction	25/504	91/7206	1.50273209897e-09
ko04721	Synaptic vesicle cycle	23/504	80/7206	2.60297761006e-09
ko04742	Taste transduction	19/504	61/7206	1.5022518328e-08
ko04725	Cholinergic synapse	32/504	160/7206	4.10206546181e-08
ko04720	Long-term potentiation	24/504	99/7206	4.6871658213e-08
ko04010	MAPK signaling pathway	50/504	321/7206	5.94690203851e-08
ko05030	Cocaine addiction	20/504	73/7206	7.06846459262e-08
ko04261	Adrenergic signaling in cardiomyocytes	36/504	205/7206	1.90319017611e-07
ko04921	Oxytocin signaling pathway	36/504	209/7206	5.20791008573e-07
ko04514	Cell adhesion molecules (CAMs)	26/504	130/7206	7.84033624666e-07
ko05203	Viral carcinogenesis	3/504	277/7206	5.41275654979e-06
ko04060	Cytokine-cytokine receptor interaction	1/504	191/7206	2.01750010951e-05
ko04072	Phospholipase D signaling pathway	31/504	197/7206	2.2734068252e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	17/504	79/7206	2.39355707468e-05
ko05414	Dilated cardiomyopathy	21/504	112/7206	2.56256467505e-05
ko04925	Aldosterone synthesis and secretion	19/504	105/7206	0.000102209308684
ko05014	Amyotrophic lateral sclerosis (ALS)	15/504	74/7206	0.000147336111701
ko04970	Salivary secretion	17/504	95/7206	0.000269600565966
ko04915	Estrogen signaling pathway	21/504	131/7206	0.000336256359304
ko04022	cGMP-PKG signaling pathway	29/504	216/7206	0.000591934505356
ko04110	Cell cycle	1/504	145/7206	0.000723493144157
ko03013	RNA transport	2/504	166/7206	0.000981618092771
ko04120	Ubiquitin mediated proteolysis	1/504	138/7206	0.00102552149579
ko04930	Type II diabetes mellitus	11/504	54/7206	0.0010666385651
ko04740	Olfactory transduction	14/504	80/7206	0.00115545269167
ko04726	Serotonergic synapse	20/504	137/7206	0.0017690585759
ko04730	Long-term depression	13/504	78/7206	0.00269858769428
ko04260	Cardiac muscle contraction	15/504	98/7206	0.00389812912807
ko05410	Hypertrophic cardiomyopathy (HCM)	15/504	100/7206	0.00447372429588
ko05205	Proteoglycans in cancer	8/504	271/7206	0.00497589009652
ko04141	Protein processing in endoplasmic reticulum	4/504	184/7206	0.00511422579817
ko05169	Epstein-Barr virus infection	5/504	206/7206	0.00527710150162
ko04360	Axon guidance	28/504	233/7206	0.00552037449161
ko00240	Pyrimidine metabolism	1/504	110/7206	0.00692657608692
ko04972	Pancreatic secretion	16/504	111/7206	0.00710515135795
ko05168	Herpes simplex infection	4/504	182/7206	0.00724626519191
ko04630	Jak-STAT signaling pathway	2/504	132/7206	0.00854644323271
ko04142	Lysosome	3/504	151/7206	0.00928489283015
ko04670	Leukocyte transendothelial migration	3/504	151/7206	0.00928489283015
ko04350	TGF-beta signaling pathway	1/504	103/7206	0.00983713840057
ko04923	Regulation of lipolysis in adipocytes	12/504	77/7206	0.010406468244
ko04744	Phototransduction	7/504	36/7206	0.0110797074895
ko05164	Influenza A	4/504	167/7206	0.0133683955268
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/504	14/7206	0.0134640483855
ko00512	Mucin type O-glycan biosynthesis	6/504	29/7206	0.0135412997121
ko05231	Choline metabolism in cancer	17/504	134/7206	0.0152891574923
ko05162	Measles	2/504	120/7206	0.0170965871399
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/504	182/7206	0.0179520034218
ko04146	Peroxisome	1/504	89/7206	0.0202914429594
ko04971	Gastric acid secretion	13/504	98/7206	0.0250223640466
ko04621	NOD-like receptor signaling pathway	4/504	157/7206	0.0252061710245
ko00515	Mannose type O-glycan biosynthesis	5/504	25/7206	0.0271200939666
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/504	26/7206	0.031710287846
ko05322	Systemic lupus erythematosus	4/504	151/7206	0.0342052616693
ko00190	Oxidative phosphorylation	3/504	127/7206	0.0342663989596
ko01200	Carbon metabolism	3/504	128/7206	0.0343891164297
ko04070	Phosphatidylinositol signaling system	14/504	112/7206	0.0365009902777
ko04150	mTOR signaling pathway	6/504	184/7206	0.0402355420319
ko04151	PI3K-Akt signaling pathway	17/504	390/7206	0.0403067827047
ko00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/504	28/7206	0.0422717993041
ko03008	Ribosome biogenesis in eukaryotes	1/504	79/7206	0.042890854962
ko04140	Autophagy - animal	5/504	164/7206	0.0432047259827
ko05131	Shigellosis	1/504	82/7206	0.045042814427
ko05146	Amoebiasis	2/504	99/7206	0.0465318298758