ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1186	423/7206	3.63691899935e-44
ko05033	Nicotine addiction	46/1186	56/7206	2.80657880207e-27
ko04724	Glutamatergic synapse	81/1186	152/7206	6.10331924606e-26
ko05032	Morphine addiction	61/1186	110/7206	5.62517659396e-21
ko04713	Circadian entrainment	68/1186	136/7206	6.4259253285e-20
ko04727	GABAergic synapse	58/1186	110/7206	1.39012216388e-18
ko04728	Dopaminergic synapse	78/1186	185/7206	4.16049852468e-17
ko04721	Synaptic vesicle cycle	46/1186	80/7206	5.93074860117e-17
ko04024	cAMP signaling pathway	102/1186	279/7206	1.16242870313e-16
ko04020	Calcium signaling pathway	97/1186	265/7206	7.84420387736e-16
ko04725	Cholinergic synapse	67/1186	160/7206	1.11841788155e-14
ko04723	Retrograde endocannabinoid signaling	70/1186	175/7206	5.90552957566e-14
ko04921	Oxytocin signaling pathway	78/1186	209/7206	1.52879287453e-13
ko04911	Insulin secretion	50/1186	117/7206	1.14969400423e-11
ko04726	Serotonergic synapse	53/1186	137/7206	2.71356430737e-10
ko04742	Taste transduction	31/1186	61/7206	5.30518671819e-10
ko04744	Phototransduction	22/1186	36/7206	1.76448565403e-09
ko05031	Amphetamine addiction	39/1186	91/7206	1.96460828568e-09
ko03040	Spliceosome	2/1186	145/7206	2.51921716487e-09
ko03010	Ribosome	1/1186	129/7206	2.57288947714e-09
ko04261	Adrenergic signaling in cardiomyocytes	67/1186	205/7206	7.82279630074e-09
ko04022	cGMP-PKG signaling pathway	69/1186	216/7206	1.16505657855e-08
ko05203	Viral carcinogenesis	16/1186	277/7206	8.19107000914e-08
ko04720	Long-term potentiation	38/1186	99/7206	1.30626341898e-07
ko04970	Salivary secretion	37/1186	95/7206	1.41659327344e-07
ko05322	Systemic lupus erythematosus	5/1186	151/7206	5.88033113225e-07
ko05168	Herpes simplex infection	8/1186	182/7206	7.36273333793e-07
ko03013	RNA transport	7/1186	166/7206	1.2762976014e-06
ko04514	Cell adhesion molecules (CAMs)	42/1186	130/7206	6.64352768964e-06
ko04966	Collecting duct acid secretion	14/1186	26/7206	1.34986394142e-05
ko04070	Phosphatidylinositol signaling system	37/1186	112/7206	1.42248841623e-05
ko05030	Cocaine addiction	27/1186	73/7206	1.91958162562e-05
ko04120	Ubiquitin mediated proteolysis	6/1186	138/7206	2.11046273136e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1186	74/7206	2.46375932715e-05
ko04925	Aldosterone synthesis and secretion	35/1186	105/7206	2.47080283142e-05
ko04740	Olfactory transduction	28/1186	80/7206	4.83564779177e-05
ko04360	Axon guidance	62/1186	233/7206	6.69309377212e-05
ko05164	Influenza A	10/1186	167/7206	7.53811331259e-05
ko04730	Long-term depression	27/1186	78/7206	7.98103301736e-05
ko04072	Phospholipase D signaling pathway	54/1186	197/7206	8.30091318909e-05
ko04971	Gastric acid secretion	32/1186	98/7206	8.32165265193e-05
ko04924	Renin secretion	29/1186	86/7206	9.19658933805e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1186	79/7206	9.71180242098e-05
ko04110	Cell cycle	8/1186	145/7206	9.74013492001e-05
ko04060	Cytokine-cytokine receptor interaction	13/1186	191/7206	9.76652056645e-05
ko05161	Hepatitis B	11/1186	173/7206	0.000102429321243
ko04010	MAPK signaling pathway	79/1186	321/7206	0.000146544871301
ko04745	Phototransduction - fly	16/1186	38/7206	0.000156595380762
ko03008	Ribosome biogenesis in eukaryotes	2/1186	79/7206	0.000173318221164
ko04621	NOD-like receptor signaling pathway	10/1186	157/7206	0.000193146524563
ko04710	Circadian rhythm	17/1186	43/7206	0.00024655837475
ko05140	Leishmaniasis	2/1186	75/7206	0.000251458505775
ko04612	Antigen processing and presentation	2/1186	77/7206	0.000264963577571
ko04014	Ras signaling pathway	69/1186	279/7206	0.000277418876432
ko04972	Pancreatic secretion	33/1186	111/7206	0.000416274461822
ko04141	Protein processing in endoplasmic reticulum	14/1186	184/7206	0.000556777788527
ko00520	Amino sugar and nucleotide sugar metabolism	1/1186	55/7206	0.000854754021566
ko04610	Complement and coagulation cascades	3/1186	79/7206	0.00107547652642
ko05414	Dilated cardiomyopathy	32/1186	112/7206	0.00115852631798
ko04964	Proximal tubule bicarbonate reclamation	12/1186	29/7206	0.00125078569098
ko04064	NF-kappa B signaling pathway	5/1186	96/7206	0.00127320526942
ko04260	Cardiac muscle contraction	29/1186	98/7206	0.00134691586753
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1186	100/7206	0.00155050162544
ko05169	Epstein-Barr virus infection	18/1186	206/7206	0.00157179526723
ko04371	Apelin signaling pathway	45/1186	177/7206	0.00196178038398
ko00562	Inositol phosphate metabolism	26/1186	89/7206	0.0022628227329
ko05166	HTLV-I infection	30/1186	292/7206	0.00279014860388
ko05219	Bladder cancer	1/1186	48/7206	0.00291697223987
ko04923	Regulation of lipolysis in adipocytes	23/1186	77/7206	0.00294769452225
ko05110	Vibrio cholerae infection	20/1186	63/7206	0.00299688761174
ko04922	Glucagon signaling pathway	34/1186	128/7206	0.00357320301647
ko04540	Gap junction	34/1186	128/7206	0.00357320301647
ko04270	Vascular smooth muscle contraction	39/1186	154/7206	0.00414203396701
ko04630	Jak-STAT signaling pathway	10/1186	132/7206	0.00414446279192
ko05144	Malaria	1/1186	45/7206	0.00440886093619
ko03420	Nucleotide excision repair	1/1186	46/7206	0.00440935163356
ko05205	Proteoglycans in cancer	28/1186	271/7206	0.00442504206364
ko04626	Plant-pathogen interaction	8/1186	18/7206	0.00487591342415
ko04657	IL-17 signaling pathway	5/1186	87/7206	0.00509292382515
ko04930	Type II diabetes mellitus	17/1186	54/7206	0.00526682281596
ko04217	Necroptosis	16/1186	178/7206	0.00544698466071
ko05321	Inflammatory bowel disease (IBD)	2/1186	56/7206	0.0057387908898
ko05162	Measles	9/1186	120/7206	0.00591112626073
ko00240	Pyrimidine metabolism	8/1186	110/7206	0.00624221065598
ko03022	Basal transcription factors	1/1186	44/7206	0.00671997025124
ko04915	Estrogen signaling pathway	33/1186	131/7206	0.0088019930983
ko04330	Notch signaling pathway	3/1186	62/7206	0.00919128638856
ko04622	RIG-I-like receptor signaling pathway	3/1186	62/7206	0.00919128638856
ko04750	Inflammatory mediator regulation of TRP channels	31/1186	122/7206	0.00961980347759
ko04214	Apoptosis - fly	4/1186	72/7206	0.00968434928694
ko05200	Pathways in cancer	61/1186	492/7206	0.0116284803424
ko05133	Pertussis	6/1186	87/7206	0.0127752769913
ko04976	Bile secretion	22/1186	80/7206	0.014037782443
ko00630	Glyoxylate and dicarboxylate metabolism	1/1186	38/7206	0.0147989272586
ko03410	Base excision repair	1/1186	38/7206	0.0147989272586
ko05145	Toxoplasmosis	11/1186	126/7206	0.0151915604452
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1186	14/7206	0.0178773477486
ko00010	Glycolysis / Gluconeogenesis	20/1186	74/7206	0.0179633639155
ko04210	Apoptosis	18/1186	180/7206	0.0186660958599
ko05131	Shigellosis	6/1186	82/7206	0.0236549246068
ko05231	Choline metabolism in cancer	32/1186	134/7206	0.0248754259208
ko04115	p53 signaling pathway	5/1186	74/7206	0.0257267788154
ko00280	Valine, leucine and isoleucine degradation	3/1186	54/7206	0.0263382657838
ko00480	Glutathione metabolism	3/1186	55/7206	0.0266825231624
ko04658	Th1 and Th2 cell differentiation	8/1186	96/7206	0.0267377469034
ko04146	Peroxisome	7/1186	89/7206	0.0296548475963
ko05222	Small cell lung cancer	7/1186	89/7206	0.0296548475963
ko03320	PPAR signaling pathway	5/1186	69/7206	0.0341402531767
ko04113	Meiosis - yeast	5/1186	70/7206	0.0341930317448
ko01524	Platinum drug resistance	6/1186	76/7206	0.0426380357575
ko04015	Rap1 signaling pathway	58/1186	278/7206	0.0476039803754
ko04659	Th17 cell differentiation	10/1186	106/7206	0.0479615322629
ko04711	Circadian rhythm - fly	5/1186	13/7206	0.0486293817771
ko05340	Primary immunodeficiency	1/1186	30/7206	0.0490534230314