ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 53/663 152/7206 9.48541998662e-19 ko05033 Nicotine addiction 31/663 56/7206 2.36813578499e-18 ko05032 Morphine addiction 42/663 110/7206 9.88535610162e-17 ko04721 Synaptic vesicle cycle 35/663 80/7206 2.47844137735e-16 ko04727 GABAergic synapse 41/663 110/7206 6.30895197871e-16 ko04723 Retrograde endocannabinoid signaling 52/663 175/7206 4.5916576309e-15 ko04728 Dopaminergic synapse 52/663 185/7206 5.66638591151e-14 ko04713 Circadian entrainment 40/663 136/7206 1.06020140421e-11 ko04360 Axon guidance 54/663 233/7206 7.83571960277e-11 ko04024 cAMP signaling pathway 61/663 279/7206 9.39379359072e-11 ko04725 Cholinergic synapse 40/663 160/7206 2.37701750297e-09 ko04080 Neuroactive ligand-receptor interaction 76/663 423/7206 5.69062873084e-09 ko04911 Insulin secretion 32/663 117/7206 9.44075081358e-09 ko04744 Phototransduction 16/663 36/7206 2.7916200052e-08 ko04726 Serotonergic synapse 34/663 137/7206 4.69679328045e-08 ko05203 Viral carcinogenesis 6/663 277/7206 3.42009140584e-06 ko05322 Systemic lupus erythematosus 1/663 151/7206 1.16146764469e-05 ko04514 Cell adhesion molecules (CAMs) 28/663 130/7206 1.72333949074e-05 ko05030 Cocaine addiction 19/663 73/7206 2.15494327828e-05 ko04261 Adrenergic signaling in cardiomyocytes 38/663 205/7206 2.20651461179e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 19/663 74/7206 2.65479295967e-05 ko03013 RNA transport 2/663 166/7206 2.99128983411e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/663 14/7206 0.000104270455267 ko04060 Cytokine-cytokine receptor interaction 4/663 191/7206 0.000110175776719 ko04010 MAPK signaling pathway 50/663 321/7206 0.000157674860768 ko03040 Spliceosome 2/663 145/7206 0.00020382041426 ko04720 Long-term potentiation 20/663 99/7206 0.0006355193666 ko01200 Carbon metabolism 2/663 128/7206 0.000921182608382 ko05031 Amphetamine addiction 18/663 91/7206 0.0015099704213 ko04966 Collecting duct acid secretion 8/663 26/7206 0.00171579629317 ko04921 Oxytocin signaling pathway 33/663 209/7206 0.00212372135492 ko04146 Peroxisome 1/663 89/7206 0.00282703196151 ko04742 Taste transduction 13/663 61/7206 0.00311025536046 ko04970 Salivary secretion 18/663 95/7206 0.0033193989611 ko04964 Proximal tubule bicarbonate reclamation 8/663 29/7206 0.00368092530424 ko04972 Pancreatic secretion 20/663 111/7206 0.00406056353343 ko04391 Hippo signaling pathway - fly 17/663 90/7206 0.00470417533914 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/663 79/7206 0.005468645786 ko03018 RNA degradation 1/663 84/7206 0.00644223910446 ko04141 Protein processing in endoplasmic reticulum 7/663 184/7206 0.00650580352848 ko04120 Ubiquitin mediated proteolysis 4/663 138/7206 0.00669909330902 ko05168 Herpes simplex infection 7/663 182/7206 0.00879104633202 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/663 15/7206 0.00892265917773 ko05205 Proteoglycans in cancer 13/663 271/7206 0.00964763443665 ko05120 Epithelial cell signaling in Helicobacter pylori infection 16/663 92/7206 0.0104928755603 ko04064 NF-kappa B signaling pathway 2/663 96/7206 0.0113210093592 ko04022 cGMP-PKG signaling pathway 31/663 216/7206 0.0116016556064 ko04110 Cell cycle 5/663 145/7206 0.0126714089883 ko05110 Vibrio cholerae infection 12/663 63/7206 0.0133867337939 ko05169 Epstein-Barr virus infection 9/663 206/7206 0.0136880349353 ko04014 Ras signaling pathway 38/663 279/7206 0.0145037284713 ko04020 Calcium signaling pathway 36/663 265/7206 0.0166536367343 ko04071 Sphingolipid signaling pathway 24/663 162/7206 0.0184608320494 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/663 182/7206 0.0190576659419 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/663 59/7206 0.0205435235294 ko04260 Cardiac muscle contraction 16/663 98/7206 0.0208490701909 ko04915 Estrogen signaling pathway 20/663 131/7206 0.0212970356339 ko00515 Mannose type O-glycan biosynthesis 6/663 25/7206 0.0229934010143 ko05162 Measles 4/663 120/7206 0.0240750192475 ko04140 Autophagy - animal 7/663 164/7206 0.0274824781781 ko04730 Long-term depression 13/663 78/7206 0.0292908871513 ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series 3/663 8/7206 0.0305368230491 ko04630 Jak-STAT signaling pathway 5/663 132/7206 0.0315555855285 ko04138 Autophagy - yeast 2/663 81/7206 0.0316251945803 ko04621 NOD-like receptor signaling pathway 7/663 157/7206 0.0355748928596 ko04924 Renin secretion 14/663 86/7206 0.0357494860657 ko04550 Signaling pathways regulating pluripotency of stem cells 23/663 165/7206 0.0401687509965 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/663 191/7206 0.0412312073751 ko05164 Influenza A 8/663 167/7206 0.042315523619 ko05231 Choline metabolism in cancer 19/663 134/7206 0.049691874898