ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 63/707 191/7206 3.4594768238e-19 ko04380 Osteoclast differentiation 45/707 134/7206 2.46766041106e-14 ko04621 NOD-like receptor signaling pathway 47/707 157/7206 8.14822574772e-13 ko05164 Influenza A 47/707 167/7206 9.54068035819e-12 ko05162 Measles 37/707 120/7206 9.1416852597e-11 ko05340 Primary immunodeficiency 17/707 30/7206 2.11738261413e-10 ko04650 Natural killer cell mediated cytotoxicity 32/707 97/7206 2.50649102913e-10 ko05330 Allograft rejection 15/707 24/7206 3.66915168262e-10 ko04640 Hematopoietic cell lineage 25/707 64/7206 4.04552861952e-10 ko05140 Leishmaniasis 27/707 75/7206 7.02945605357e-10 ko04064 NF-kappa B signaling pathway 30/707 96/7206 3.9661982966e-09 ko05321 Inflammatory bowel disease (IBD) 22/707 56/7206 4.0658901194e-09 ko04217 Necroptosis 44/707 178/7206 4.16922074737e-09 ko04630 Jak-STAT signaling pathway 36/707 132/7206 6.89252267631e-09 ko05150 Staphylococcus aureus infection 17/707 36/7206 8.61122498909e-09 ko04659 Th17 cell differentiation 31/707 106/7206 1.29304175669e-08 ko05320 Autoimmune thyroid disease 15/707 29/7206 1.3586548698e-08 ko05145 Toxoplasmosis 34/707 126/7206 2.43761907108e-08 ko00120 Primary bile acid biosynthesis 12/707 20/7206 4.36733360396e-08 ko04620 Toll-like receptor signaling pathway 29/707 100/7206 4.70356543252e-08 ko04672 Intestinal immune network for IgA production 16/707 37/7206 1.11649453218e-07 ko05332 Graft-versus-host disease 11/707 18/7206 1.25695336562e-07 ko04660 T cell receptor signaling pathway 32/707 124/7206 1.95938220075e-07 ko05168 Herpes simplex infection 41/707 182/7206 3.44674375741e-07 ko04612 Antigen processing and presentation 23/707 77/7206 6.51792455806e-07 ko05310 Asthma 10/707 17/7206 7.97022651339e-07 ko04658 Th1 and Th2 cell differentiation 26/707 96/7206 1.01467109013e-06 ko04610 Complement and coagulation cascades 23/707 79/7206 1.07789546756e-06 ko05152 Tuberculosis 40/707 187/7206 2.10483490277e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 40/707 191/7206 2.89135920066e-06 ko03040 Spliceosome 1/707 145/7206 7.35845996214e-06 ko03013 RNA transport 2/707 166/7206 8.80078655508e-06 ko05144 Malaria 15/707 45/7206 1.34498174007e-05 ko04622 RIG-I-like receptor signaling pathway 18/707 62/7206 1.66352286399e-05 ko04662 B cell receptor signaling pathway 22/707 88/7206 2.74203224579e-05 ko04062 Chemokine signaling pathway 39/707 201/7206 3.01665585242e-05 ko03010 Ribosome 1/707 129/7206 3.64111617648e-05 ko04390 Hippo signaling pathway 4/707 188/7206 5.21408427821e-05 ko05133 Pertussis 21/707 87/7206 7.25186965073e-05 ko05323 Rheumatoid arthritis 21/707 89/7206 0.000103183792132 ko04940 Type I diabetes mellitus 11/707 32/7206 0.00014048297011 ko04137 Mitophagy - animal 19/707 82/7206 0.000280562341215 ko00590 Arachidonic acid metabolism 14/707 52/7206 0.000344634896821 ko05142 Chagas disease (American trypanosomiasis) 26/707 130/7206 0.000456323107883 ko04668 TNF signaling pathway 24/707 120/7206 0.000562778591287 ko04611 Platelet activation 30/707 163/7206 0.000706961942437 ko05034 Alcoholism 9/707 238/7206 0.000774943729344 ko04210 Apoptosis 32/707 180/7206 0.000825577311509 ko04068 FoxO signaling pathway 30/707 167/7206 0.000898639774031 ko04146 Peroxisome 19/707 89/7206 0.000931801839401 ko05161 Hepatitis B 31/707 173/7206 0.0010212520379 ko03015 mRNA surveillance pathway 1/707 93/7206 0.0012693837946 ko04310 Wnt signaling pathway 6/707 181/7206 0.00138266643877 ko04623 Cytosolic DNA-sensing pathway 11/707 41/7206 0.00151378986153 ko04110 Cell cycle 4/707 145/7206 0.00170071533864 ko04391 Hippo signaling pathway - fly 1/707 90/7206 0.00191014113884 ko05160 Hepatitis C 27/707 153/7206 0.00225202844311 ko04664 Fc epsilon RI signaling pathway 16/707 77/7206 0.00314598865722 ko04933 AGE-RAGE signaling pathway in diabetic complications 24/707 135/7206 0.00331298052486 ko00350 Tyrosine metabolism 9/707 33/7206 0.00355364254122 ko04740 Olfactory transduction 1/707 80/7206 0.00404242356309 ko00140 Steroid hormone biosynthesis 10/707 41/7206 0.00520560460575 ko00051 Fructose and mannose metabolism 10/707 42/7206 0.00624706734848 ko05224 Breast cancer 7/707 174/7206 0.00637754135582 ko04723 Retrograde endocannabinoid signaling 7/707 175/7206 0.00642208625727 ko04916 Melanogenesis 5/707 142/7206 0.00658770469292 ko00592 alpha-Linolenic acid metabolism 6/707 19/7206 0.00775130260351 ko04728 Dopaminergic synapse 8/707 185/7206 0.00814168322913 ko04666 Fc gamma R-mediated phagocytosis 21/707 122/7206 0.00881984141676 ko05418 Fluid shear stress and atherosclerosis 28/707 173/7206 0.00892919591604 ko04114 Oocyte meiosis 5/707 139/7206 0.00901796724132 ko05143 African trypanosomiasis 8/707 32/7206 0.010300318704 ko00950 Isoquinoline alkaloid biosynthesis 4/707 10/7206 0.0119084167278 ko05217 Basal cell carcinoma 1/707 68/7206 0.0127933884448 ko05132 Salmonella infection 17/707 98/7206 0.0164347201988 ko04530 Tight junction 12/707 228/7206 0.0169967559555 ko00360 Phenylalanine metabolism 5/707 17/7206 0.0203962103524 ko04721 Synaptic vesicle cycle 2/707 80/7206 0.0219126461614 ko04145 Phagosome 25/707 162/7206 0.0220628222025 ko04080 Neuroactive ligand-receptor interaction 28/707 423/7206 0.0225979806586 ko05032 Morphine addiction 4/707 110/7206 0.0231682737392 ko05146 Amoebiasis 17/707 99/7206 0.0247109994167 ko04360 Axon guidance 13/707 233/7206 0.0248124903261 ko04724 Glutamatergic synapse 7/707 152/7206 0.0267001805669 ko04917 Prolactin signaling pathway 15/707 87/7206 0.0277014388803 ko04657 IL-17 signaling pathway 15/707 87/7206 0.0277014388803 ko04713 Circadian entrainment 6/707 136/7206 0.0286158758548 ko04670 Leukocyte transendothelial migration 23/707 151/7206 0.0364163632222 ko05131 Shigellosis 14/707 82/7206 0.0373855696041 ko04930 Type II diabetes mellitus 10/707 54/7206 0.0387026022634 ko03050 Proteasome 10/707 54/7206 0.0387026022634 ko04931 Insulin resistance 21/707 137/7206 0.0404870246956 ko03320 PPAR signaling pathway 12/707 69/7206 0.0412591825332 ko04340 Hedgehog signaling pathway 1/707 58/7206 0.0415983020731