ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	216/1372	423/7206	3.22796249288e-53
ko04724	Glutamatergic synapse	95/1372	152/7206	1.06232286142e-32
ko05033	Nicotine addiction	50/1372	56/7206	4.52060425285e-30
ko04713	Circadian entrainment	83/1372	136/7206	1.27769913558e-27
ko05032	Morphine addiction	72/1372	110/7206	7.6923109042e-27
ko04727	GABAergic synapse	71/1372	110/7206	6.36124705823e-26
ko04721	Synaptic vesicle cycle	54/1372	80/7206	2.28756251204e-21
ko04728	Dopaminergic synapse	90/1372	185/7206	2.52924352651e-20
ko04725	Cholinergic synapse	81/1372	160/7206	9.22880537362e-20
ko04024	cAMP signaling pathway	117/1372	279/7206	2.83930620794e-19
ko04020	Calcium signaling pathway	113/1372	265/7206	2.92574978819e-19
ko04726	Serotonergic synapse	68/1372	137/7206	3.36327858911e-16
ko04723	Retrograde endocannabinoid signaling	80/1372	175/7206	4.0283964293e-16
ko04911	Insulin secretion	61/1372	117/7206	5.89848982411e-16
ko04742	Taste transduction	40/1372	61/7206	1.75770745429e-15
ko04744	Phototransduction	29/1372	36/7206	2.09135512273e-15
ko04921	Oxytocin signaling pathway	87/1372	209/7206	2.71564222529e-14
ko04740	Olfactory transduction	45/1372	80/7206	1.11939321877e-13
ko04970	Salivary secretion	48/1372	95/7206	3.58537962443e-12
ko04720	Long-term potentiation	49/1372	99/7206	5.70959098117e-12
ko05031	Amphetamine addiction	46/1372	91/7206	9.95216735333e-12
ko04261	Adrenergic signaling in cardiomyocytes	80/1372	205/7206	1.34193481629e-11
ko03040	Spliceosome	2/1372	145/7206	5.16704543944e-11
ko04022	cGMP-PKG signaling pathway	77/1372	216/7206	5.54384104179e-09
ko05203	Viral carcinogenesis	19/1372	277/7206	7.64010886253e-09
ko04925	Aldosterone synthesis and secretion	45/1372	105/7206	1.92431442718e-08
ko03013	RNA transport	7/1372	166/7206	2.01053814207e-08
ko05168	Herpes simplex infection	9/1372	182/7206	4.55559906605e-08
ko05322	Systemic lupus erythematosus	6/1372	151/7206	5.02324983719e-08
ko04971	Gastric acid secretion	42/1372	98/7206	6.43527527225e-08
ko04060	Cytokine-cytokine receptor interaction	11/1372	191/7206	1.70952882144e-07
ko05030	Cocaine addiction	33/1372	73/7206	4.51729876969e-07
ko04360	Axon guidance	76/1372	233/7206	6.17103851775e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	32/1372	74/7206	1.51951426643e-06
ko04540	Gap junction	47/1372	128/7206	2.0743042465e-06
ko04966	Collecting duct acid secretion	16/1372	26/7206	2.10406590931e-06
ko04730	Long-term depression	32/1372	78/7206	6.65826586089e-06
ko04972	Pancreatic secretion	41/1372	111/7206	7.86103326481e-06
ko04924	Renin secretion	34/1372	86/7206	9.99182467119e-06
ko04976	Bile secretion	32/1372	80/7206	1.10347732143e-05
ko04110	Cell cycle	9/1372	145/7206	1.43914646786e-05
ko04745	Phototransduction - fly	19/1372	38/7206	1.58371532364e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1372	79/7206	1.7439770496e-05
ko05164	Influenza A	12/1372	167/7206	2.20616830542e-05
ko04070	Phosphatidylinositol signaling system	40/1372	112/7206	2.71933305012e-05
ko04621	NOD-like receptor signaling pathway	11/1372	157/7206	3.08021517601e-05
ko04010	MAPK signaling pathway	91/1372	321/7206	3.15013860914e-05
ko05140	Leishmaniasis	2/1372	75/7206	4.0411375817e-05
ko04120	Ubiquitin mediated proteolysis	9/1372	138/7206	4.04889601121e-05
ko04750	Inflammatory mediator regulation of TRP channels	42/1372	122/7206	5.74388358513e-05
ko05110	Vibrio cholerae infection	26/1372	63/7206	6.08997014763e-05
ko04514	Cell adhesion molecules (CAMs)	44/1372	130/7206	6.09717947364e-05
ko04371	Apelin signaling pathway	55/1372	177/7206	9.37933440191e-05
ko04923	Regulation of lipolysis in adipocytes	29/1372	77/7206	0.000111488176174
ko04064	NF-kappa B signaling pathway	5/1372	96/7206	0.000123625210204
ko04141	Protein processing in endoplasmic reticulum	16/1372	184/7206	0.000124550239237
ko00520	Amino sugar and nucleotide sugar metabolism	1/1372	55/7206	0.000199331656288
ko04072	Phospholipase D signaling pathway	59/1372	197/7206	0.000204958174907
ko05414	Dilated cardiomyopathy	38/1372	112/7206	0.000217941777828
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1372	79/7206	0.000229044224379
ko04014	Ras signaling pathway	78/1372	279/7206	0.000236509039396
ko05169	Epstein-Barr virus infection	20/1372	206/7206	0.000288008531397
ko04915	Estrogen signaling pathway	42/1372	131/7206	0.000294934509087
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1372	59/7206	0.000332862038209
ko04964	Proximal tubule bicarbonate reclamation	14/1372	29/7206	0.000336999454962
ko04610	Complement and coagulation cascades	4/1372	79/7206	0.000476142354772
ko05162	Measles	9/1372	120/7206	0.000585955314413
ko04626	Plant-pathogen interaction	10/1372	18/7206	0.000594813946756
ko04260	Cardiac muscle contraction	33/1372	98/7206	0.000621202679647
ko03420	Nucleotide excision repair	1/1372	46/7206	0.00108729625936
ko04710	Circadian rhythm	17/1372	43/7206	0.00152514599738
ko05205	Proteoglycans in cancer	32/1372	271/7206	0.00153915379616
ko00480	Glutathione metabolism	2/1372	55/7206	0.00153922625592
ko04146	Peroxisome	6/1372	89/7206	0.00158731420983
ko05321	Inflammatory bowel disease (IBD)	2/1372	56/7206	0.00162433698621
ko03022	Basal transcription factors	1/1372	44/7206	0.0016583483436
ko00071	Fatty acid degradation	1/1372	45/7206	0.00171948693282
ko04622	RIG-I-like receptor signaling pathway	3/1372	62/7206	0.00185477794812
ko04922	Glucagon signaling pathway	39/1372	128/7206	0.00195264894761
ko04657	IL-17 signaling pathway	6/1372	87/7206	0.00223563931355
ko05166	HTLV-I infection	36/1372	292/7206	0.00226893471721
ko05161	Hepatitis B	18/1372	173/7206	0.00230068594112
ko03018	RNA degradation	6/1372	84/7206	0.00311010604433
ko00562	Inositol phosphate metabolism	28/1372	89/7206	0.00419359332757
ko05131	Shigellosis	6/1372	82/7206	0.00433728255177
ko04658	Th1 and Th2 cell differentiation	8/1372	96/7206	0.00556440714535
ko05133	Pertussis	7/1372	87/7206	0.00581945521431
ko00630	Glyoxylate and dicarboxylate metabolism	1/1372	38/7206	0.00590310884492
ko04640	Hematopoietic cell lineage	4/1372	64/7206	0.0060249369701
ko04214	Apoptosis - fly	5/1372	72/7206	0.00612134440386
ko00310	Lysine degradation	5/1372	73/7206	0.00627460259562
ko00240	Pyrimidine metabolism	10/1372	110/7206	0.00661274235195
ko05144	Malaria	2/1372	45/7206	0.00737329645686
ko04612	Antigen processing and presentation	6/1372	77/7206	0.00833329425958
ko04330	Notch signaling pathway	4/1372	62/7206	0.0085860696133
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1372	14/7206	0.00875191178534
ko05145	Toxoplasmosis	13/1372	126/7206	0.0112782134469
ko04217	Necroptosis	21/1372	178/7206	0.0116839517905
ko05217	Basal cell carcinoma	5/1372	68/7206	0.0120748562172
ko04213	Longevity regulating pathway - multiple species	26/1372	86/7206	0.0121342421365
ko04270	Vascular smooth muscle contraction	42/1372	154/7206	0.0123334830112
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1372	100/7206	0.0143869429487
ko04115	p53 signaling pathway	6/1372	74/7206	0.0161263244415
ko04912	GnRH signaling pathway	34/1372	122/7206	0.0192595723372
ko04620	Toll-like receptor signaling pathway	10/1372	100/7206	0.0202100671327
ko04015	Rap1 signaling pathway	68/1372	278/7206	0.0235602638979
ko04711	Circadian rhythm - fly	6/1372	13/7206	0.0237937826038
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1372	40/7206	0.0238919941057
ko00280	Valine, leucine and isoleucine degradation	4/1372	54/7206	0.0239471340995
ko05231	Choline metabolism in cancer	36/1372	134/7206	0.0257260428539
ko04918	Thyroid hormone synthesis	25/1372	86/7206	0.0258391908309
ko04142	Lysosome	18/1372	151/7206	0.0271438075463
ko04932	Non-alcoholic fatty liver disease (NAFLD)	23/1372	182/7206	0.027363299389
ko05214	Glioma	23/1372	79/7206	0.0295692763093
ko05320	Autoimmune thyroid disease	1/1372	29/7206	0.0305808356468
ko04350	TGF-beta signaling pathway	11/1372	103/7206	0.0308278391087
ko01212	Fatty acid metabolism	5/1372	60/7206	0.0314916401144
ko00330	Arginine and proline metabolism	5/1372	61/7206	0.0317980508596
ko00590	Arachidonic acid metabolism	4/1372	52/7206	0.033331383643
ko05016	Huntington's disease	29/1372	215/7206	0.0342903654187
ko04930	Type II diabetes mellitus	17/1372	54/7206	0.0345972276067
ko03410	Base excision repair	2/1372	38/7206	0.0351752930022
ko04722	Neurotrophin signaling pathway	41/1372	160/7206	0.0409748190215
ko04978	Mineral absorption	13/1372	40/7206	0.0410896703739
ko04630	Jak-STAT signaling pathway	16/1372	132/7206	0.0434462425557
ko04668	TNF signaling pathway	14/1372	120/7206	0.0452071617349
ko00040	Pentose and glucuronate interconversions	1/1372	26/7206	0.0456551228748
ko04960	Aldosterone-regulated sodium reabsorption	13/1372	41/7206	0.0458161049837
ko04114	Oocyte meiosis	36/1372	139/7206	0.0486840578336
ko00860	Porphyrin and chlorophyll metabolism	2/1372	34/7206	0.0490107528898
ko04974	Protein digestion and absorption	26/1372	96/7206	0.0493540318211
ko00500	Starch and sucrose metabolism	2/1372	35/7206	0.0495355020688