ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	36/825	56/7206	5.34585676496e-21
ko04724	Glutamatergic synapse	60/825	152/7206	2.05547551522e-19
ko04080	Neuroactive ligand-receptor interaction	113/825	423/7206	2.54636140503e-19
ko04721	Synaptic vesicle cycle	38/825	80/7206	6.63747912187e-16
ko04727	GABAergic synapse	43/825	110/7206	4.62176314595e-14
ko04728	Dopaminergic synapse	57/825	185/7206	5.81998025506e-13
ko05032	Morphine addiction	41/825	110/7206	1.17702332995e-12
ko04713	Circadian entrainment	46/825	136/7206	2.78773752413e-12
ko04723	Retrograde endocannabinoid signaling	50/825	175/7206	3.32102201114e-10
ko04744	Phototransduction	19/825	36/7206	1.38038789828e-09
ko04725	Cholinergic synapse	46/825	160/7206	1.38099837394e-09
ko04742	Taste transduction	24/825	61/7206	1.72733459335e-08
ko05030	Cocaine addiction	26/825	73/7206	4.96596309536e-08
ko04024	cAMP signaling pathway	63/825	279/7206	7.39615737162e-08
ko04360	Axon guidance	55/825	233/7206	9.25139877914e-08
ko04911	Insulin secretion	34/825	117/7206	1.50394162861e-07
ko03040	Spliceosome	1/825	145/7206	5.49341307609e-07
ko04514	Cell adhesion molecules (CAMs)	35/825	130/7206	8.73897099808e-07
ko05203	Viral carcinogenesis	9/825	277/7206	1.02275363072e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	23/825	74/7206	4.46332907085e-06
ko04261	Adrenergic signaling in cardiomyocytes	45/825	205/7206	1.66729916613e-05
ko04120	Ubiquitin mediated proteolysis	2/825	138/7206	1.73060538064e-05
ko05031	Amphetamine addiction	25/825	91/7206	1.96747942228e-05
ko04726	Serotonergic synapse	33/825	137/7206	2.97481325625e-05
ko03013	RNA transport	4/825	166/7206	3.2898996738e-05
ko04740	Olfactory transduction	22/825	80/7206	6.03804891007e-05
ko05164	Influenza A	5/825	167/7206	0.000111136050983
ko05168	Herpes simplex infection	6/825	182/7206	0.000127501848952
ko00564	Glycerophospholipid metabolism	1/825	99/7206	0.000166880196728
ko04964	Proximal tubule bicarbonate reclamation	11/825	29/7206	0.000203957907329
ko01200	Carbon metabolism	3/825	128/7206	0.000225557723827
ko04621	NOD-like receptor signaling pathway	5/825	157/7206	0.00031688433949
ko05162	Measles	3/825	120/7206	0.000698102999616
ko03018	RNA degradation	1/825	84/7206	0.000791223896062
ko04950	Maturity onset diabetes of the young	10/825	29/7206	0.000953929434313
ko05205	Proteoglycans in cancer	15/825	271/7206	0.00121956771793
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/825	182/7206	0.00130004690352
ko00240	Pyrimidine metabolism	3/825	110/7206	0.00137769357706
ko04060	Cytokine-cytokine receptor interaction	9/825	191/7206	0.00170986644609
ko05322	Systemic lupus erythematosus	6/825	151/7206	0.00175217242743
ko04140	Autophagy - animal	7/825	164/7206	0.00176733958599
ko04260	Cardiac muscle contraction	22/825	98/7206	0.0019184765769
ko04976	Bile secretion	19/825	80/7206	0.00202411476472
ko04146	Peroxisome	2/825	89/7206	0.00234877695214
ko04214	Apoptosis - fly	1/825	72/7206	0.00253805765255
ko04010	MAPK signaling pathway	54/825	321/7206	0.00300873681329
ko04141	Protein processing in endoplasmic reticulum	9/825	184/7206	0.00309570167597
ko04974	Protein digestion and absorption	21/825	96/7206	0.00310629552162
ko05169	Epstein-Barr virus infection	11/825	206/7206	0.00364294102517
ko04978	Mineral absorption	11/825	40/7206	0.00418913836731
ko04137	Mitophagy - animal	2/825	82/7206	0.00490030405082
ko04970	Salivary secretion	20/825	95/7206	0.00556107865478
ko04064	NF-kappa B signaling pathway	3/825	96/7206	0.00563107212496
ko04966	Collecting duct acid secretion	8/825	26/7206	0.00676042767582
ko03008	Ribosome biogenesis in eukaryotes	2/825	79/7206	0.00705944730672
ko04640	Hematopoietic cell lineage	1/825	64/7206	0.00862814426217
ko05140	Leishmaniasis	2/825	75/7206	0.0101363119668
ko04611	Platelet activation	9/825	163/7206	0.0125824381904
ko00010	Glycolysis / Gluconeogenesis	2/825	74/7206	0.0151270500385
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/825	14/7206	0.0160637295562
ko00430	Taurine and hypotaurine metabolism	5/825	14/7206	0.0160637295562
ko05133	Pertussis	3/825	87/7206	0.0161365249046
ko00520	Amino sugar and nucleotide sugar metabolism	1/825	55/7206	0.0177822398743
ko04730	Long-term depression	16/825	78/7206	0.0184789048628
ko04512	ECM-receptor interaction	16/825	79/7206	0.0198020054684
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/825	59/7206	0.0207535550518
ko04138	Autophagy - yeast	3/825	81/7206	0.02198789004
ko04217	Necroptosis	11/825	178/7206	0.0230748208759
ko04720	Long-term potentiation	19/825	99/7206	0.024252931377
ko04540	Gap junction	23/825	128/7206	0.0246175726358
ko04142	Lysosome	9/825	151/7206	0.0281209413049
ko05418	Fluid shear stress and atherosclerosis	11/825	173/7206	0.0296041606571
ko05145	Toxoplasmosis	7/825	126/7206	0.0336934139143
ko04962	Vasopressin-regulated water reabsorption	12/825	58/7206	0.0362183424214
ko00380	Tryptophan metabolism	1/825	50/7206	0.0403092187257
ko04924	Renin secretion	16/825	86/7206	0.0413032525996
ko04657	IL-17 signaling pathway	4/825	87/7206	0.0413220644834
ko01212	Fatty acid metabolism	2/825	60/7206	0.0419843614272
ko05134	Legionellosis	3/825	74/7206	0.0425609343915
ko04391	Hippo signaling pathway - fly	17/825	90/7206	0.0430351848386
ko00600	Sphingolipid metabolism	2/825	63/7206	0.0434432605971
ko04110	Cell cycle	9/825	145/7206	0.0471622109396
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	15/825	79/7206	0.0479046447322
ko04151	PI3K-Akt signaling pathway	57/825	390/7206	0.0493547865143