ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 51/502 191/7206 9.22587382564e-18 ko05340 Primary immunodeficiency 16/502 30/7206 1.42483848762e-11 ko04621 NOD-like receptor signaling pathway 37/502 157/7206 2.13342178879e-11 ko04380 Osteoclast differentiation 32/502 134/7206 3.52492042609e-10 ko05164 Influenza A 35/502 167/7206 2.29331491907e-09 ko00120 Primary bile acid biosynthesis 11/502 20/7206 1.59069004583e-08 ko04064 NF-kappa B signaling pathway 24/502 96/7206 2.27897906803e-08 ko05162 Measles 26/502 120/7206 1.37749504455e-07 ko04620 Toll-like receptor signaling pathway 23/502 100/7206 2.34324014846e-07 ko05145 Toxoplasmosis 26/502 126/7206 3.82921641939e-07 ko05150 Staphylococcus aureus infection 13/502 36/7206 4.07341543725e-07 ko04217 Necroptosis 32/502 178/7206 4.92971530309e-07 ko05140 Leishmaniasis 19/502 75/7206 5.41544040392e-07 ko04650 Natural killer cell mediated cytotoxicity 22/502 97/7206 5.5639488013e-07 ko05321 Inflammatory bowel disease (IBD) 16/502 56/7206 7.43338356582e-07 ko04612 Antigen processing and presentation 18/502 77/7206 3.7873454443e-06 ko04640 Hematopoietic cell lineage 16/502 64/7206 5.17138943716e-06 ko05168 Herpes simplex infection 30/502 182/7206 8.81682399106e-06 ko04630 Jak-STAT signaling pathway 24/502 132/7206 1.10509742416e-05 ko05320 Autoimmune thyroid disease 10/502 29/7206 1.47247110191e-05 ko05330 Allograft rejection 9/502 24/7206 1.82620383806e-05 ko04672 Intestinal immune network for IgA production 11/502 37/7206 2.72017531555e-05 ko04659 Th17 cell differentiation 20/502 106/7206 3.42302740674e-05 ko00590 Arachidonic acid metabolism 13/502 52/7206 3.97794827313e-05 ko04310 Wnt signaling pathway 1/502 181/7206 4.43559234291e-05 ko04062 Chemokine signaling pathway 30/502 201/7206 5.83510070371e-05 ko00140 Steroid hormone biosynthesis 11/502 41/7206 7.78597987846e-05 ko05133 Pertussis 17/502 87/7206 8.35102251119e-05 ko04610 Complement and coagulation cascades 16/502 79/7206 8.59440283176e-05 ko05152 Tuberculosis 28/502 187/7206 0.000104146655482 ko04660 T cell receptor signaling pathway 21/502 124/7206 0.00011438210222 ko05332 Graft-versus-host disease 7/502 18/7206 0.000123546775332 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/502 191/7206 0.000139421820703 ko05034 Alcoholism 4/502 238/7206 0.000248086799894 ko04622 RIG-I-like receptor signaling pathway 13/502 62/7206 0.000273441661952 ko04658 Th1 and Th2 cell differentiation 17/502 96/7206 0.000292838932585 ko04662 B cell receptor signaling pathway 16/502 88/7206 0.000321610026675 ko04146 Peroxisome 16/502 89/7206 0.000367483122589 ko05323 Rheumatoid arthritis 16/502 89/7206 0.000367483122589 ko04623 Cytosolic DNA-sensing pathway 10/502 41/7206 0.000385282574668 ko04916 Melanogenesis 1/502 142/7206 0.000675994538754 ko05224 Breast cancer 2/502 174/7206 0.000701300052813 ko00360 Phenylalanine metabolism 6/502 17/7206 0.000707314366284 ko03040 Spliceosome 1/502 145/7206 0.000712602440053 ko05144 Malaria 10/502 45/7206 0.000851971165029 ko04390 Hippo signaling pathway 3/502 188/7206 0.00120250409188 ko00592 alpha-Linolenic acid metabolism 6/502 19/7206 0.00137545725243 ko00980 Metabolism of xenobiotics by cytochrome P450 9/502 40/7206 0.00140018990335 ko05204 Chemical carcinogenesis 10/502 48/7206 0.00144638502191 ko03010 Ribosome 1/502 129/7206 0.00144882353435 ko00350 Tyrosine metabolism 8/502 33/7206 0.00153801116978 ko04210 Apoptosis 24/502 180/7206 0.00253657313755 ko03320 PPAR signaling pathway 12/502 69/7206 0.00260842807916 ko05160 Hepatitis C 21/502 153/7206 0.00316273155452 ko00982 Drug metabolism - cytochrome P450 8/502 37/7206 0.00334349157485 ko00950 Isoquinoline alkaloid biosynthesis 4/502 10/7206 0.00348363714933 ko04110 Cell cycle 2/502 145/7206 0.00427555027612 ko04911 Insulin secretion 1/502 117/7206 0.00485807601593 ko05310 Asthma 5/502 17/7206 0.0049293518023 ko04940 Type I diabetes mellitus 7/502 32/7206 0.00556831293775 ko04080 Neuroactive ligand-receptor interaction 16/502 423/7206 0.00572363915384 ko00362 Benzoate degradation 3/502 6/7206 0.00573293510705 ko05161 Hepatitis B 22/502 173/7206 0.00575242879248 ko05032 Morphine addiction 1/502 110/7206 0.00686779086726 ko00380 Tryptophan metabolism 9/502 50/7206 0.0068972950278 ko00051 Fructose and mannose metabolism 8/502 42/7206 0.00752474843612 ko01212 Fatty acid metabolism 10/502 60/7206 0.00787041461975 ko04723 Retrograde endocannabinoid signaling 4/502 175/7206 0.00981216507807 ko05206 MicroRNAs in cancer 4/502 177/7206 0.0100170632238 ko00071 Fatty acid degradation 8/502 45/7206 0.0114442623498 ko04145 Phagosome 20/502 162/7206 0.0114694668942 ko04611 Platelet activation 20/502 163/7206 0.011894432847 ko04360 Axon guidance 7/502 233/7206 0.0123542854602 ko05142 Chagas disease (American trypanosomiasis) 17/502 130/7206 0.0130677418863 ko04137 Mitophagy - animal 12/502 82/7206 0.013369055291 ko04142 Lysosome 19/502 151/7206 0.0137895661558 ko04728 Dopaminergic synapse 5/502 185/7206 0.0181421008945 ko04550 Signaling pathways regulating pluripotency of stem cells 4/502 165/7206 0.0187852181151 ko00983 Drug metabolism - other enzymes 7/502 42/7206 0.024491770404 ko04713 Circadian entrainment 3/502 136/7206 0.0252423975513 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/502 4/7206 0.0264448080407 ko04668 TNF signaling pathway 15/502 120/7206 0.0272990555987 ko05131 Shigellosis 11/502 82/7206 0.0286509664895 ko04666 Fc gamma R-mediated phagocytosis 15/502 122/7206 0.0291753040781 ko04012 ErbB signaling pathway 2/502 109/7206 0.0341241903684 ko04540 Gap junction 3/502 128/7206 0.0343336413682 ko05134 Legionellosis 10/502 74/7206 0.0361806664726 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/502 5/7206 0.0420597582578 ko00281 Geraniol degradation 2/502 5/7206 0.0420597582578 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1/502 79/7206 0.0427943874569 ko04740 Olfactory transduction 1/502 80/7206 0.0432511553066 ko05132 Salmonella infection 12/502 98/7206 0.045608858104 ko01522 Endocrine resistance 3/502 124/7206 0.0477564711605