ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 41/337 157/7206 2.19794326732e-20 ko04380 Osteoclast differentiation 35/337 134/7206 1.57786854704e-17 ko04060 Cytokine-cytokine receptor interaction 41/337 191/7206 4.9715377285e-17 ko04064 NF-kappa B signaling pathway 29/337 96/7206 1.46410548955e-16 ko04217 Necroptosis 38/337 178/7206 9.20289323665e-16 ko04620 Toll-like receptor signaling pathway 25/337 100/7206 2.29906788514e-12 ko05164 Influenza A 32/337 167/7206 4.4796075668e-12 ko05161 Hepatitis B 31/337 173/7206 6.04253680969e-11 ko05140 Leishmaniasis 20/337 75/7206 1.09478951509e-10 ko04622 RIG-I-like receptor signaling pathway 18/337 62/7206 2.05837727952e-10 ko05321 Inflammatory bowel disease (IBD) 17/337 56/7206 3.03991480926e-10 ko04660 T cell receptor signaling pathway 25/337 124/7206 3.52298600038e-10 ko05145 Toxoplasmosis 25/337 126/7206 5.04183596923e-10 ko05152 Tuberculosis 30/337 187/7206 2.03329560406e-09 ko05168 Herpes simplex infection 29/337 182/7206 4.50081992487e-09 ko04662 B cell receptor signaling pathway 19/337 88/7206 1.50364985897e-08 ko05162 Measles 22/337 120/7206 2.63916126272e-08 ko05340 Primary immunodeficiency 11/337 30/7206 4.88599323457e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/337 191/7206 5.46344673212e-08 ko04650 Natural killer cell mediated cytotoxicity 19/337 97/7206 8.00565594146e-08 ko04668 TNF signaling pathway 21/337 120/7206 1.27471559656e-07 ko04623 Cytosolic DNA-sensing pathway 12/337 41/7206 2.08620784736e-07 ko04210 Apoptosis 26/337 180/7206 2.24942996425e-07 ko04659 Th17 cell differentiation 19/337 106/7206 3.48245975206e-07 ko04658 Th1 and Th2 cell differentiation 18/337 96/7206 3.53742761848e-07 ko05150 Staphylococcus aureus infection 11/337 36/7206 4.17074474562e-07 ko05323 Rheumatoid arthritis 17/337 89/7206 5.70929874812e-07 ko04630 Jak-STAT signaling pathway 21/337 132/7206 6.7349838811e-07 ko05133 Pertussis 16/337 87/7206 2.09371880297e-06 ko05144 Malaria 11/337 45/7206 4.82130654042e-06 ko04672 Intestinal immune network for IgA production 10/337 37/7206 4.9258139454e-06 ko05142 Chagas disease (American trypanosomiasis) 19/337 130/7206 8.38547256925e-06 ko04664 Fc epsilon RI signaling pathway 14/337 77/7206 1.05120374171e-05 ko04062 Chemokine signaling pathway 24/337 201/7206 1.97227643991e-05 ko05160 Hepatitis C 20/337 153/7206 2.65026629383e-05 ko05134 Legionellosis 13/337 74/7206 3.19282989746e-05 ko04657 IL-17 signaling pathway 14/337 87/7206 4.42487045952e-05 ko04612 Antigen processing and presentation 13/337 77/7206 4.9368680746e-05 ko05330 Allograft rejection 7/337 24/7206 7.97902038021e-05 ko04666 Fc gamma R-mediated phagocytosis 16/337 122/7206 0.000163337462896 ko04610 Complement and coagulation cascades 12/337 79/7206 0.000271698680792 ko05320 Autoimmune thyroid disease 7/337 29/7206 0.000293905773998 ko05131 Shigellosis 12/337 82/7206 0.000387488536812 ko04611 Platelet activation 18/337 163/7206 0.000571444129866 ko05310 Asthma 5/337 17/7206 0.000843175637343 ko05120 Epithelial cell signaling in Helicobacter pylori infection 12/337 92/7206 0.00111550423511 ko05332 Graft-versus-host disease 5/337 18/7206 0.00112319927703 ko05034 Alcoholism 2/337 238/7206 0.00150108385965 ko04624 Toll and Imd signaling pathway 8/337 49/7206 0.00176750058797 ko04145 Phagosome 17/337 162/7206 0.00182170244036 ko05132 Salmonella infection 12/337 98/7206 0.00194285917663 ko05169 Epstein-Barr virus infection 20/337 206/7206 0.00199360219163 ko04728 Dopaminergic synapse 1/337 185/7206 0.00229542064287 ko00590 Arachidonic acid metabolism 8/337 52/7206 0.0026111773815 ko04640 Hematopoietic cell lineage 9/337 64/7206 0.00271920027945 ko04940 Type I diabetes mellitus 6/337 32/7206 0.00322803496842 ko04142 Lysosome 15/337 151/7206 0.00520710936192 ko05146 Amoebiasis 11/337 99/7206 0.0062735632224 ko04550 Signaling pathways regulating pluripotency of stem cells 1/337 165/7206 0.00747898325434 ko05418 Fluid shear stress and atherosclerosis 16/337 173/7206 0.00906584752492 ko00565 Ether lipid metabolism 6/337 42/7206 0.0126335341586 ko04390 Hippo signaling pathway 2/337 188/7206 0.0127421761776 ko05416 Viral myocarditis 7/337 55/7206 0.0135013408439 ko04916 Melanogenesis 1/337 142/7206 0.0148492345816 ko05166 HTLV-I infection 23/337 292/7206 0.014920654385 ko04670 Leukocyte transendothelial migration 14/337 151/7206 0.0165841036858 ko05202 Transcriptional misregulation in cancer 16/337 188/7206 0.0206126490566 ko04114 Oocyte meiosis 1/337 139/7206 0.0224950882977 ko05130 Pathogenic Escherichia coli infection 8/337 77/7206 0.026713479306 ko00511 Other glycan degradation 4/337 26/7206 0.031113967147 ko04933 AGE-RAGE signaling pathway in diabetic complications 12/337 135/7206 0.0351208987748 ko04152 AMPK signaling pathway 2/337 161/7206 0.0352431400412 ko03050 Proteasome 6/337 54/7206 0.0390998234491 ko00140 Steroid hormone biosynthesis 5/337 41/7206 0.0409231281385 ko04911 Insulin secretion 1/337 117/7206 0.0446119921285 ko05016 Huntington's disease 4/337 215/7206 0.0474157203162 ko04310 Wnt signaling pathway 3/337 181/7206 0.0488357250029 ko01523 Antifolate resistance 4/337 30/7206 0.0493458008041