ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	216/1288	423/7206	2.20332051097e-58
ko05033	Nicotine addiction	51/1288	56/7206	4.82179025383e-33
ko04724	Glutamatergic synapse	92/1288	152/7206	2.27585482135e-32
ko05032	Morphine addiction	72/1288	110/7206	1.22470474838e-28
ko04727	GABAergic synapse	71/1288	110/7206	1.09786797201e-27
ko04713	Circadian entrainment	79/1288	136/7206	3.17802063686e-26
ko04721	Synaptic vesicle cycle	57/1288	80/7206	8.08850305747e-26
ko04728	Dopaminergic synapse	90/1288	185/7206	2.70017468733e-22
ko04725	Cholinergic synapse	79/1288	160/7206	3.39879473644e-20
ko04020	Calcium signaling pathway	108/1288	265/7206	7.56079443015e-19
ko04024	cAMP signaling pathway	111/1288	279/7206	1.62725436592e-18
ko04723	Retrograde endocannabinoid signaling	81/1288	175/7206	1.76172091739e-18
ko04911	Insulin secretion	59/1288	117/7206	6.4213926438e-16
ko04742	Taste transduction	39/1288	61/7206	1.56637363903e-15
ko04921	Oxytocin signaling pathway	85/1288	209/7206	4.68213835209e-15
ko04744	Phototransduction	27/1288	36/7206	9.13784708297e-14
ko04726	Serotonergic synapse	61/1288	137/7206	2.89081057613e-13
ko04970	Salivary secretion	47/1288	95/7206	1.50385861215e-12
ko04720	Long-term potentiation	48/1288	99/7206	2.24855638081e-12
ko04261	Adrenergic signaling in cardiomyocytes	78/1288	205/7206	3.7497800302e-12
ko03040	Spliceosome	1/1288	145/7206	1.55877205662e-11
ko05031	Amphetamine addiction	44/1288	91/7206	2.11288751435e-11
ko04360	Axon guidance	84/1288	233/7206	2.20566955241e-11
ko04740	Olfactory transduction	39/1288	80/7206	2.16085871938e-10
ko05203	Viral carcinogenesis	17/1288	277/7206	8.79012848938e-09
ko05168	Herpes simplex infection	7/1288	182/7206	1.13224285939e-08
ko04925	Aldosterone synthesis and secretion	43/1288	105/7206	2.24405048551e-08
ko04022	cGMP-PKG signaling pathway	72/1288	216/7206	3.53944045037e-08
ko04971	Gastric acid secretion	40/1288	98/7206	7.8268510027e-08
ko04060	Cytokine-cytokine receptor interaction	9/1288	191/7206	7.87148352301e-08
ko03013	RNA transport	7/1288	166/7206	1.66188987607e-07
ko05030	Cocaine addiction	32/1288	73/7206	2.14604584452e-07
ko04966	Collecting duct acid secretion	16/1288	26/7206	8.68507306752e-07
ko04540	Gap junction	46/1288	128/7206	9.73349109923e-07
ko04924	Renin secretion	34/1288	86/7206	2.49086742269e-06
ko04141	Protein processing in endoplasmic reticulum	11/1288	184/7206	3.30142013754e-06
ko04610	Complement and coagulation cascades	1/1288	79/7206	4.77221227786e-06
ko05322	Systemic lupus erythematosus	8/1288	151/7206	7.59341919359e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1288	59/7206	9.51722533072e-06
ko04010	MAPK signaling pathway	88/1288	321/7206	1.39015686444e-05
ko05110	Vibrio cholerae infection	26/1288	63/7206	1.51336676075e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1288	74/7206	1.94358085626e-05
ko04260	Cardiac muscle contraction	35/1288	98/7206	2.42924779698e-05
ko04745	Phototransduction - fly	18/1288	38/7206	2.75792442409e-05
ko04972	Pancreatic secretion	38/1288	111/7206	2.80678857822e-05
ko04621	NOD-like receptor signaling pathway	10/1288	157/7206	3.32953411223e-05
ko04730	Long-term depression	29/1288	78/7206	4.20814565448e-05
ko04120	Ubiquitin mediated proteolysis	8/1288	138/7206	4.31002667766e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1288	79/7206	4.44838835643e-05
ko04371	Apelin signaling pathway	53/1288	177/7206	6.28564544649e-05
ko04064	NF-kappa B signaling pathway	4/1288	96/7206	8.0099401327e-05
ko05164	Influenza A	12/1288	167/7206	8.83934370501e-05
ko04070	Phosphatidylinositol signaling system	37/1288	112/7206	9.1249683701e-05
ko05140	Leishmaniasis	2/1288	75/7206	0.000101793906637
ko04514	Cell adhesion molecules (CAMs)	41/1288	130/7206	0.000119890176421
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1288	79/7206	0.000164948647925
ko04915	Estrogen signaling pathway	41/1288	131/7206	0.000186359120954
ko04014	Ras signaling pathway	74/1288	279/7206	0.000232511822976
ko05414	Dilated cardiomyopathy	36/1288	112/7206	0.000248566748335
ko05169	Epstein-Barr virus infection	18/1288	206/7206	0.000285783266589
ko04750	Inflammatory mediator regulation of TRP channels	38/1288	122/7206	0.000301888896097
ko05205	Proteoglycans in cancer	27/1288	271/7206	0.000346565263871
ko04626	Plant-pathogen interaction	10/1288	18/7206	0.000348870657667
ko04072	Phospholipase D signaling pathway	55/1288	197/7206	0.000437675795151
ko04612	Antigen processing and presentation	3/1288	77/7206	0.00044567059677
ko00480	Glutathione metabolism	1/1288	55/7206	0.000536044302559
ko04916	Melanogenesis	42/1288	142/7206	0.000539909375593
ko04976	Bile secretion	27/1288	80/7206	0.000586596624483
ko00240	Pyrimidine metabolism	7/1288	110/7206	0.000632885212327
ko04640	Hematopoietic cell lineage	2/1288	64/7206	0.000780541564952
ko00590	Arachidonic acid metabolism	1/1288	52/7206	0.00078358135088
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1288	14/7206	0.00110167122039
ko04146	Peroxisome	5/1288	89/7206	0.00117202891277
ko05162	Measles	9/1288	120/7206	0.00162983894104
ko05161	Hepatitis B	16/1288	173/7206	0.00175566848649
ko04923	Regulation of lipolysis in adipocytes	25/1288	77/7206	0.00234016429234
ko03018	RNA degradation	5/1288	84/7206	0.00234039663357
ko05321	Inflammatory bowel disease (IBD)	2/1288	56/7206	0.0024401905976
ko03022	Basal transcription factors	1/1288	44/7206	0.00270385998811
ko05144	Malaria	1/1288	45/7206	0.00272857531945
ko00071	Fatty acid degradation	1/1288	45/7206	0.00272857531945
ko04912	GnRH signaling pathway	35/1288	122/7206	0.00275592377317
ko03420	Nucleotide excision repair	1/1288	46/7206	0.00288727061988
ko04110	Cell cycle	13/1288	145/7206	0.00302859542406
ko04622	RIG-I-like receptor signaling pathway	3/1288	62/7206	0.00416656912639
ko04214	Apoptosis - fly	4/1288	72/7206	0.0046915780583
ko05145	Toxoplasmosis	11/1288	126/7206	0.00474200618187
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1288	40/7206	0.00618276380891
ko00330	Arginine and proline metabolism	3/1288	61/7206	0.00627510571237
ko04015	Rap1 signaling pathway	67/1288	278/7206	0.00821092685408
ko05131	Shigellosis	6/1288	82/7206	0.00877703996377
ko04115	p53 signaling pathway	5/1288	74/7206	0.00901171394726
ko00982	Drug metabolism - cytochrome P450	1/1288	37/7206	0.00932007943981
ko00630	Glyoxylate and dicarboxylate metabolism	1/1288	38/7206	0.00939483015452
ko03410	Base excision repair	1/1288	38/7206	0.00939483015452
ko04270	Vascular smooth muscle contraction	40/1288	154/7206	0.0105288331229
ko04658	Th1 and Th2 cell differentiation	8/1288	96/7206	0.0106824238313
ko04964	Proximal tubule bicarbonate reclamation	11/1288	29/7206	0.0117557952683
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1288	100/7206	0.0118653284771
ko00500	Starch and sucrose metabolism	1/1288	35/7206	0.0140002458094
ko04630	Jak-STAT signaling pathway	13/1288	132/7206	0.0154059512358
ko05133	Pertussis	7/1288	87/7206	0.0157243694474
ko04620	Toll-like receptor signaling pathway	9/1288	100/7206	0.0175210921361
ko04062	Chemokine signaling pathway	49/1288	201/7206	0.0191765763144
ko00290	Valine, leucine and isoleucine biosynthesis	3/1288	4/7206	0.0197475124214
ko04668	TNF signaling pathway	12/1288	120/7206	0.0219639253795
ko04918	Thyroid hormone synthesis	24/1288	86/7206	0.0222835948934
ko01524	Platinum drug resistance	6/1288	76/7206	0.0227382047633
ko00380	Tryptophan metabolism	3/1288	50/7206	0.025165605497
ko05222	Small cell lung cancer	8/1288	89/7206	0.0255120024242
ko04922	Glucagon signaling pathway	33/1288	128/7206	0.0261433677256
ko05418	Fluid shear stress and atherosclerosis	20/1288	173/7206	0.0269466940256
ko04350	TGF-beta signaling pathway	10/1288	103/7206	0.0273701377317
ko00310	Lysine degradation	6/1288	73/7206	0.0305238617034
ko04142	Lysosome	17/1288	151/7206	0.0314897082915
ko04657	IL-17 signaling pathway	8/1288	87/7206	0.0338864794204
ko05206	MicroRNAs in cancer	21/1288	177/7206	0.0364785090114
ko04217	Necroptosis	21/1288	178/7206	0.036821188274
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1288	26/7206	0.0369380071996
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1288	15/7206	0.0373535999394
ko05034	Alcoholism	55/1288	238/7206	0.0385113188071
ko04114	Oocyte meiosis	34/1288	139/7206	0.0443568531224
ko00600	Sphingolipid metabolism	5/1288	63/7206	0.0454583995813
ko05132	Salmonella infection	10/1288	98/7206	0.0461964696384
ko00280	Valine, leucine and isoleucine degradation	4/1288	54/7206	0.0481409207708
ko05320	Autoimmune thyroid disease	1/1288	29/7206	0.0481901965107
ko04210	Apoptosis	22/1288	180/7206	0.0482978982166