ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 151/947 423/7206 1.29153120386e-34 ko05033 Nicotine addiction 43/947 56/7206 1.85888339937e-27 ko04724 Glutamatergic synapse 74/947 152/7206 6.85209862958e-27 ko05032 Morphine addiction 57/947 110/7206 1.15762080543e-22 ko04728 Dopaminergic synapse 77/947 185/7206 1.60369963099e-22 ko04727 GABAergic synapse 53/947 110/7206 2.77009769318e-19 ko04721 Synaptic vesicle cycle 44/947 80/7206 4.34073292541e-19 ko04713 Circadian entrainment 58/947 136/7206 8.16494079058e-18 ko04725 Cholinergic synapse 63/947 160/7206 3.71686098147e-17 ko04723 Retrograde endocannabinoid signaling 66/947 175/7206 8.67996966462e-17 ko04024 cAMP signaling pathway 85/947 279/7206 1.26899566701e-14 ko04911 Insulin secretion 44/947 117/7206 1.51807433981e-11 ko04921 Oxytocin signaling pathway 64/947 209/7206 2.0357845156e-11 ko04020 Calcium signaling pathway 75/947 265/7206 2.55498853482e-11 ko04726 Serotonergic synapse 48/947 137/7206 3.4333213603e-11 ko04744 Phototransduction 21/947 36/7206 1.99098129458e-10 ko05031 Amphetamine addiction 36/947 91/7206 2.09084138286e-10 ko04742 Taste transduction 28/947 61/7206 3.65933276205e-10 ko04720 Long-term potentiation 36/947 99/7206 3.21511047368e-09 ko04261 Adrenergic signaling in cardiomyocytes 58/947 205/7206 5.58304874258e-09 ko04360 Axon guidance 62/947 233/7206 2.89213923857e-08 ko03040 Spliceosome 1/947 145/7206 3.69062696632e-08 ko05203 Viral carcinogenesis 12/947 277/7206 1.09111114183e-06 ko05030 Cocaine addiction 25/947 73/7206 2.9681596082e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 25/947 74/7206 3.93281803816e-06 ko04925 Aldosterone synthesis and secretion 31/947 105/7206 7.47889536426e-06 ko05164 Influenza A 5/947 167/7206 7.93274884517e-06 ko04514 Cell adhesion molecules (CAMs) 36/947 130/7206 8.86878207951e-06 ko04745 Phototransduction - fly 16/947 38/7206 9.15019858404e-06 ko04060 Cytokine-cytokine receptor interaction 7/947 191/7206 1.09067957674e-05 ko04070 Phosphatidylinositol signaling system 32/947 112/7206 1.31212595409e-05 ko04971 Gastric acid secretion 29/947 98/7206 1.42744034315e-05 ko04970 Salivary secretion 28/947 95/7206 2.17725740308e-05 ko05168 Herpes simplex infection 7/947 182/7206 3.08132086518e-05 ko03013 RNA transport 6/947 166/7206 3.90884035508e-05 ko04966 Collecting duct acid secretion 12/947 26/7206 4.06709845692e-05 ko04010 MAPK signaling pathway 68/947 321/7206 4.32762933843e-05 ko04120 Ubiquitin mediated proteolysis 4/947 138/7206 5.83244226704e-05 ko04740 Olfactory transduction 24/947 80/7206 6.92078251487e-05 ko05322 Systemic lupus erythematosus 5/947 151/7206 7.24142866693e-05 ko04621 NOD-like receptor signaling pathway 6/947 157/7206 0.00011019215286 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 23/947 79/7206 0.000148959043285 ko05169 Epstein-Barr virus infection 11/947 206/7206 0.000328639504526 ko04141 Protein processing in endoplasmic reticulum 9/947 184/7206 0.000344297195223 ko04730 Long-term depression 22/947 78/7206 0.000515080882124 ko04972 Pancreatic secretion 28/947 111/7206 0.000534463228478 ko04260 Cardiac muscle contraction 25/947 98/7206 0.000784225882122 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/947 14/7206 0.00098011743864 ko04014 Ras signaling pathway 56/947 279/7206 0.00105391079955 ko04626 Plant-pathogen interaction 8/947 18/7206 0.00111680236267 ko04072 Phospholipase D signaling pathway 42/947 197/7206 0.00122364741343 ko04064 NF-kappa B signaling pathway 3/947 96/7206 0.00125417386858 ko04022 cGMP-PKG signaling pathway 45/947 216/7206 0.00140585803095 ko04110 Cell cycle 7/947 145/7206 0.00167399961978 ko05205 Proteoglycans in cancer 19/947 271/7206 0.00171370420262 ko05161 Hepatitis B 10/947 173/7206 0.00201944017582 ko03008 Ribosome biogenesis in eukaryotes 2/947 79/7206 0.00216483788109 ko04640 Hematopoietic cell lineage 1/947 64/7206 0.00235853386023 ko00562 Inositol phosphate metabolism 22/947 89/7206 0.00247905521204 ko05166 HTLV-I infection 22/947 292/7206 0.00257517676414 ko05140 Leishmaniasis 2/947 75/7206 0.0031257540203 ko04915 Estrogen signaling pathway 29/947 131/7206 0.0038169979733 ko00240 Pyrimidine metabolism 5/947 110/7206 0.00416309878296 ko05110 Vibrio cholerae infection 16/947 63/7206 0.00763105063087 ko00480 Glutathione metabolism 1/947 55/7206 0.00779697877567 ko04964 Proximal tubule bicarbonate reclamation 9/947 29/7206 0.0096765636141 ko04750 Inflammatory mediator regulation of TRP channels 26/947 122/7206 0.0100537756844 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/947 59/7206 0.0102129803461 ko04612 Antigen processing and presentation 3/947 77/7206 0.0105105718754 ko04146 Peroxisome 4/947 89/7206 0.0109331232579 ko00590 Arachidonic acid metabolism 1/947 52/7206 0.0115860012266 ko05162 Measles 7/947 120/7206 0.0136731987512 ko05410 Hypertrophic cardiomyopathy (HCM) 22/947 100/7206 0.0157797854211 ko05219 Bladder cancer 1/947 48/7206 0.0167893251815 ko05120 Epithelial cell signaling in Helicobacter pylori infection 20/947 92/7206 0.0192396631941 ko00330 Arginine and proline metabolism 2/947 61/7206 0.0202235784818 ko04214 Apoptosis - fly 3/947 72/7206 0.0211022666561 ko04924 Renin secretion 19/947 86/7206 0.0227865697716 ko05414 Dilated cardiomyopathy 23/947 112/7206 0.0240480331413 ko03022 Basal transcription factors 1/947 44/7206 0.0246735642294 ko00071 Fatty acid degradation 1/947 45/7206 0.0248255564697 ko03420 Nucleotide excision repair 1/947 46/7206 0.0254639428319 ko04630 Jak-STAT signaling pathway 9/947 132/7206 0.0268305002728 ko05321 Inflammatory bowel disease (IBD) 2/947 56/7206 0.0281321020252 ko04371 Apelin signaling pathway 33/947 177/7206 0.0322898896181 ko04210 Apoptosis 14/947 180/7206 0.0329526482992 ko00140 Steroid hormone biosynthesis 1/947 41/7206 0.0363221581414 ko00983 Drug metabolism - other enzymes 1/947 42/7206 0.0366449620957 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/947 15/7206 0.0375133022288 ko04668 TNF signaling pathway 8/947 120/7206 0.0394610353026 ko01524 Platinum drug resistance 4/947 76/7206 0.0395900709631 ko05034 Alcoholism 42/947 238/7206 0.0403999376511 ko00280 Valine, leucine and isoleucine degradation 2/947 54/7206 0.0406614614349 ko05206 MicroRNAs in cancer 14/947 177/7206 0.0416175483942 ko04722 Neurotrophin signaling pathway 30/947 160/7206 0.0432163712881 ko04976 Bile secretion 17/947 80/7206 0.0435638894922 ko05145 Toxoplasmosis 9/947 126/7206 0.0452678315113 ko04071 Sphingolipid signaling pathway 30/947 162/7206 0.0453948247574 ko00512 Mucin type O-glycan biosynthesis 8/947 29/7206 0.0460193945311 ko04140 Autophagy - animal 13/947 164/7206 0.0463710967114