ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	184/1144	423/7206	1.33140335751e-44
ko04724	Glutamatergic synapse	88/1144	152/7206	5.29365757626e-33
ko05033	Nicotine addiction	48/1144	56/7206	7.18920324304e-31
ko05032	Morphine addiction	68/1144	110/7206	4.20751568263e-28
ko04727	GABAergic synapse	64/1144	110/7206	2.07845087582e-24
ko04713	Circadian entrainment	71/1144	136/7206	4.06542368843e-23
ko04728	Dopaminergic synapse	83/1144	185/7206	3.04327236681e-21
ko04721	Synaptic vesicle cycle	49/1144	80/7206	2.63282375792e-20
ko04725	Cholinergic synapse	72/1144	160/7206	1.1871827249e-18
ko04723	Retrograde endocannabinoid signaling	75/1144	175/7206	6.92852771022e-18
ko04024	cAMP signaling pathway	101/1144	279/7206	3.29748281869e-17
ko04911	Insulin secretion	54/1144	117/7206	7.36233752698e-15
ko04020	Calcium signaling pathway	92/1144	265/7206	1.41623230254e-14
ko04744	Phototransduction	26/1144	36/7206	6.52177821355e-14
ko04742	Taste transduction	34/1144	61/7206	8.55379832312e-13
ko04726	Serotonergic synapse	56/1144	137/7206	1.28982751685e-12
ko04921	Oxytocin signaling pathway	74/1144	209/7206	1.92727022901e-12
ko05031	Amphetamine addiction	42/1144	91/7206	7.65623030471e-12
ko04261	Adrenergic signaling in cardiomyocytes	70/1144	205/7206	7.74570869701e-11
ko04720	Long-term potentiation	42/1144	99/7206	2.15404164742e-10
ko03040	Spliceosome	2/1144	145/7206	6.47242514443e-09
ko03010	Ribosome	1/1144	129/7206	6.69333873061e-09
ko04970	Salivary secretion	37/1144	95/7206	4.10602870869e-08
ko05030	Cocaine addiction	31/1144	73/7206	4.94763867834e-08
ko04925	Aldosterone synthesis and secretion	39/1144	105/7206	9.22555281723e-08
ko04022	cGMP-PKG signaling pathway	64/1144	216/7206	2.20482896336e-07
ko05203	Viral carcinogenesis	16/1144	277/7206	2.35811470554e-07
ko04060	Cytokine-cytokine receptor interaction	8/1144	191/7206	5.48722339823e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1144	74/7206	1.03006451096e-06
ko05322	Systemic lupus erythematosus	5/1144	151/7206	1.35029583029e-06
ko04621	NOD-like receptor signaling pathway	6/1144	157/7206	2.39327902753e-06
ko04360	Axon guidance	65/1144	233/7206	2.4513967934e-06
ko04070	Phosphatidylinositol signaling system	38/1144	112/7206	2.5113788303e-06
ko04971	Gastric acid secretion	34/1144	98/7206	4.10182779377e-06
ko05168	Herpes simplex infection	9/1144	182/7206	7.24514770419e-06
ko04740	Olfactory transduction	29/1144	80/7206	7.42310561446e-06
ko04072	Phospholipase D signaling pathway	55/1144	197/7206	1.63021243568e-05
ko04010	MAPK signaling pathway	79/1144	321/7206	3.15859626311e-05
ko04514	Cell adhesion molecules (CAMs)	39/1144	130/7206	4.66045087555e-05
ko04110	Cell cycle	7/1144	145/7206	4.83339922619e-05
ko04612	Antigen processing and presentation	1/1144	77/7206	5.11344203531e-05
ko03013	RNA transport	9/1144	166/7206	5.545089327e-05
ko04745	Phototransduction - fly	16/1144	38/7206	0.000100787740421
ko04064	NF-kappa B signaling pathway	3/1144	96/7206	0.000110619410718
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1144	79/7206	0.00014574228819
ko04141	Protein processing in endoplasmic reticulum	12/1144	184/7206	0.000199523981364
ko04972	Pancreatic secretion	33/1144	111/7206	0.000199611271297
ko04966	Collecting duct acid secretion	12/1144	26/7206	0.000265949648926
ko04610	Complement and coagulation cascades	2/1144	79/7206	0.000267248145249
ko03008	Ribosome biogenesis in eukaryotes	2/1144	79/7206	0.000267248145249
ko04540	Gap junction	36/1144	128/7206	0.000351937611462
ko05164	Influenza A	11/1144	167/7206	0.000368899595475
ko05140	Leishmaniasis	2/1144	75/7206	0.000390084520599
ko04730	Long-term depression	25/1144	78/7206	0.000436173324743
ko05414	Dilated cardiomyopathy	32/1144	112/7206	0.000592281333347
ko04915	Estrogen signaling pathway	36/1144	131/7206	0.000631611454488
ko05169	Epstein-Barr virus infection	16/1144	206/7206	0.000660279209718
ko04260	Cardiac muscle contraction	29/1144	98/7206	0.000664994600685
ko00480	Glutathione metabolism	1/1144	55/7206	0.00133078006395
ko05162	Measles	7/1144	120/7206	0.00142729253992
ko05110	Vibrio cholerae infection	20/1144	63/7206	0.00147880193117
ko04750	Inflammatory mediator regulation of TRP channels	33/1144	122/7206	0.00156772788678
ko05205	Proteoglycans in cancer	25/1144	271/7206	0.00163650187367
ko04924	Renin secretion	25/1144	86/7206	0.00165373801181
ko04710	Circadian rhythm	15/1144	43/7206	0.00231785572034
ko04014	Ras signaling pathway	63/1144	279/7206	0.00257519146969
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1144	14/7206	0.00305861019726
ko05161	Hepatitis B	14/1144	173/7206	0.00306832966209
ko04964	Proximal tubule bicarbonate reclamation	11/1144	29/7206	0.00334457682682
ko00240	Pyrimidine metabolism	7/1144	110/7206	0.00361827676553
ko04626	Plant-pathogen interaction	8/1144	18/7206	0.0038731807719
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1144	59/7206	0.00393937239155
ko04923	Regulation of lipolysis in adipocytes	22/1144	77/7206	0.00427384087135
ko00071	Fatty acid degradation	1/1144	45/7206	0.00679647724815
ko03022	Basal transcription factors	1/1144	44/7206	0.00680154233647
ko04922	Glucagon signaling pathway	32/1144	128/7206	0.00689016026647
ko03420	Nucleotide excision repair	1/1144	46/7206	0.00702533821315
ko04657	IL-17 signaling pathway	5/1144	87/7206	0.00718632668221
ko04630	Jak-STAT signaling pathway	10/1144	132/7206	0.00765291647786
ko00562	Inositol phosphate metabolism	24/1144	89/7206	0.00778517876053
ko05230	Central carbon metabolism in cancer	22/1144	81/7206	0.00866429145023
ko05321	Inflammatory bowel disease (IBD)	2/1144	56/7206	0.00879391414868
ko04120	Ubiquitin mediated proteolysis	11/1144	138/7206	0.00916198220493
ko04350	TGF-beta signaling pathway	7/1144	103/7206	0.00923236487422
ko04640	Hematopoietic cell lineage	3/1144	64/7206	0.00941219053285
ko04371	Apelin signaling pathway	41/1144	177/7206	0.0119498984302
ko04930	Type II diabetes mellitus	16/1144	54/7206	0.0131958827366
ko05145	Toxoplasmosis	10/1144	126/7206	0.0132195506685
ko04622	RIG-I-like receptor signaling pathway	3/1144	62/7206	0.0134754116142
ko04214	Apoptosis - fly	4/1144	72/7206	0.0139076012923
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1144	40/7206	0.0152511490881
ko04658	Th1 and Th2 cell differentiation	7/1144	96/7206	0.0166374051253
ko04973	Carbohydrate digestion and absorption	13/1144	42/7206	0.016926993001
ko05133	Pertussis	6/1144	87/7206	0.0177224851117
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1144	100/7206	0.018154041008
ko04146	Peroxisome	6/1144	89/7206	0.0182885376003
ko04510	Focal adhesion	25/1144	240/7206	0.0190982026446
ko03320	PPAR signaling pathway	4/1144	69/7206	0.0192709959092
ko04976	Bile secretion	21/1144	80/7206	0.0195363924127
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1144	15/7206	0.021789117229
ko00630	Glyoxylate and dicarboxylate metabolism	1/1144	38/7206	0.0231707790372
ko05202	Transcriptional misregulation in cancer	19/1144	188/7206	0.0260463316281
ko05219	Bladder cancer	2/1144	48/7206	0.0266738349117
ko05166	HTLV-I infection	33/1144	292/7206	0.0272985449617
ko04210	Apoptosis	18/1144	180/7206	0.0295509186854
ko05131	Shigellosis	6/1144	82/7206	0.0323996117845
ko04975	Fat digestion and absorption	1/1144	35/7206	0.0340098742629
ko00500	Starch and sucrose metabolism	1/1144	35/7206	0.0340098742629
ko04115	p53 signaling pathway	5/1144	74/7206	0.0357101728251
ko05016	Huntington's disease	23/1144	215/7206	0.0366483109294
ko04330	Notch signaling pathway	4/1144	62/7206	0.0367350534636
ko05206	MicroRNAs in cancer	18/1144	177/7206	0.0367407030715
ko04217	Necroptosis	18/1144	178/7206	0.0370378231787
ko00512	Mucin type O-glycan biosynthesis	9/1144	29/7206	0.0375506573273
ko05231	Choline metabolism in cancer	30/1144	134/7206	0.0423315719758
ko04711	Circadian rhythm - fly	5/1144	13/7206	0.0423862196955
ko04114	Oocyte meiosis	31/1144	139/7206	0.045407653857
ko05418	Fluid shear stress and atherosclerosis	18/1144	173/7206	0.0454183869006
ko00230	Purine metabolism	41/1144	194/7206	0.0463293524142
ko05034	Alcoholism	49/1144	238/7206	0.0471275195574
ko04113	Meiosis - yeast	5/1144	70/7206	0.0472466688093