ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	186/1051	423/7206	7.20193414834e-52
ko05033	Nicotine addiction	47/1051	56/7206	4.14452525437e-31
ko04724	Glutamatergic synapse	82/1051	152/7206	1.54439396565e-30
ko05032	Morphine addiction	64/1051	110/7206	1.54763953663e-26
ko04713	Circadian entrainment	71/1051	136/7206	2.14404199745e-25
ko04727	GABAergic synapse	62/1051	110/7206	1.06703744226e-24
ko04728	Dopaminergic synapse	84/1051	185/7206	1.82250353809e-24
ko04721	Synaptic vesicle cycle	50/1051	80/7206	6.01364514536e-23
ko04725	Cholinergic synapse	74/1051	160/7206	2.94404957139e-22
ko04723	Retrograde endocannabinoid signaling	76/1051	175/7206	9.08733659359e-21
ko04024	cAMP signaling pathway	97/1051	279/7206	7.47678441118e-18
ko04911	Insulin secretion	52/1051	117/7206	4.48917141456e-15
ko04726	Serotonergic synapse	57/1051	137/7206	7.63026403454e-15
ko04742	Taste transduction	35/1051	61/7206	8.63420790552e-15
ko04020	Calcium signaling pathway	86/1051	265/7206	5.71350672361e-14
ko04921	Oxytocin signaling pathway	72/1051	209/7206	3.4587531055e-13
ko04744	Phototransduction	24/1051	36/7206	1.45916011105e-12
ko04261	Adrenergic signaling in cardiomyocytes	68/1051	205/7206	1.21752653901e-11
ko04720	Long-term potentiation	42/1051	99/7206	1.32591548796e-11
ko05031	Amphetamine addiction	39/1051	91/7206	4.95422121402e-11
ko03040	Spliceosome	1/1051	145/7206	3.56836183378e-09
ko04970	Salivary secretion	37/1051	95/7206	3.95981530896e-09
ko04925	Aldosterone synthesis and secretion	38/1051	105/7206	2.62068158229e-08
ko05203	Viral carcinogenesis	12/1051	277/7206	2.97208863968e-08
ko04740	Olfactory transduction	31/1051	80/7206	8.34953523974e-08
ko04971	Gastric acid secretion	35/1051	98/7206	1.36163277592e-07
ko05168	Herpes simplex infection	5/1051	182/7206	1.69330649578e-07
ko04360	Axon guidance	64/1051	233/7206	2.16121923641e-07
ko05030	Cocaine addiction	27/1051	73/7206	1.67830295766e-06
ko04966	Collecting duct acid secretion	14/1051	26/7206	3.1388750376e-06
ko04972	Pancreatic secretion	35/1051	111/7206	4.36164279688e-06
ko04022	cGMP-PKG signaling pathway	57/1051	216/7206	4.83398843306e-06
ko04010	MAPK signaling pathway	77/1051	321/7206	4.85051647398e-06
ko04060	Cytokine-cytokine receptor interaction	8/1051	191/7206	5.51058595407e-06
ko05322	Systemic lupus erythematosus	5/1051	151/7206	6.84075109976e-06
ko04745	Phototransduction - fly	17/1051	38/7206	7.44017276498e-06
ko04730	Long-term depression	27/1051	78/7206	1.14860370524e-05
ko04514	Cell adhesion molecules (CAMs)	38/1051	130/7206	1.36094245638e-05
ko04621	NOD-like receptor signaling pathway	6/1051	157/7206	1.70013937698e-05
ko03013	RNA transport	7/1051	166/7206	2.83734725883e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1051	79/7206	3.31351018757e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1051	74/7206	3.33577373811e-05
ko04070	Phosphatidylinositol signaling system	33/1051	112/7206	3.93804823063e-05
ko04120	Ubiquitin mediated proteolysis	5/1051	138/7206	4.30359867541e-05
ko04540	Gap junction	36/1051	128/7206	6.48602882907e-05
ko05164	Influenza A	8/1051	167/7206	8.24673541288e-05
ko04072	Phospholipase D signaling pathway	49/1051	197/7206	0.000126924857843
ko05110	Vibrio cholerae infection	21/1051	63/7206	0.000184495500681
ko04915	Estrogen signaling pathway	35/1051	131/7206	0.000240724951495
ko04014	Ras signaling pathway	63/1051	279/7206	0.000257545756382
ko04110	Cell cycle	7/1051	145/7206	0.000299628880169
ko04976	Bile secretion	24/1051	80/7206	0.000344271524189
ko05414	Dilated cardiomyopathy	31/1051	112/7206	0.000347514719286
ko04064	NF-kappa B signaling pathway	3/1051	96/7206	0.000380562404393
ko04626	Plant-pathogen interaction	9/1051	18/7206	0.000404572470753
ko04260	Cardiac muscle contraction	28/1051	98/7206	0.000408681789132
ko04141	Protein processing in endoplasmic reticulum	11/1051	184/7206	0.000416019934549
ko04924	Renin secretion	25/1051	86/7206	0.000533791120483
ko05169	Epstein-Barr virus infection	14/1051	206/7206	0.000623806261228
ko03008	Ribosome biogenesis in eukaryotes	2/1051	79/7206	0.00062839716879
ko05140	Leishmaniasis	2/1051	75/7206	0.00140310867598
ko05205	Proteoglycans in cancer	22/1051	271/7206	0.0014968056557
ko04750	Inflammatory mediator regulation of TRP channels	31/1051	122/7206	0.00164751515335
ko04964	Proximal tubule bicarbonate reclamation	11/1051	29/7206	0.00166814044005
ko00480	Glutathione metabolism	1/1051	55/7206	0.00326568133413
ko04146	Peroxisome	4/1051	89/7206	0.00373904215221
ko05162	Measles	7/1051	120/7206	0.00385613370592
ko05166	HTLV-I infection	26/1051	292/7206	0.00389249468571
ko00240	Pyrimidine metabolism	6/1051	110/7206	0.00392593701299
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1051	59/7206	0.00449879949184
ko00590	Arachidonic acid metabolism	1/1051	52/7206	0.00485306093472
ko04612	Antigen processing and presentation	3/1051	77/7206	0.0050261785926
ko00562	Inositol phosphate metabolism	23/1051	89/7206	0.00573542764968
ko04330	Notch signaling pathway	2/1051	62/7206	0.00616562362535
ko04912	GnRH signaling pathway	29/1051	122/7206	0.00620328264572
ko04640	Hematopoietic cell lineage	2/1051	64/7206	0.00646859026116
ko04371	Apelin signaling pathway	39/1051	177/7206	0.00675363155706
ko04214	Apoptosis - fly	3/1051	72/7206	0.00699475591239
ko00260	Glycine, serine and threonine metabolism	1/1051	48/7206	0.00718689116948
ko04923	Regulation of lipolysis in adipocytes	20/1051	77/7206	0.00840414357688
ko00330	Arginine and proline metabolism	2/1051	61/7206	0.00932347173457
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1051	14/7206	0.00998405760851
ko03420	Nucleotide excision repair	1/1051	46/7206	0.0107084181195
ko05161	Hepatitis B	14/1051	173/7206	0.0119164966434
ko05321	Inflammatory bowel disease (IBD)	2/1051	56/7206	0.0129612898699
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1051	182/7206	0.0138838063676
ko03022	Basal transcription factors	1/1051	44/7206	0.0162183933626
ko05144	Malaria	1/1051	45/7206	0.0169691351356
ko00071	Fatty acid degradation	1/1051	45/7206	0.0169691351356
ko04658	Th1 and Th2 cell differentiation	6/1051	96/7206	0.0187691694419
ko00280	Valine, leucine and isoleucine degradation	2/1051	54/7206	0.0187998517214
ko03018	RNA degradation	5/1051	84/7206	0.0194568873572
ko01524	Platinum drug resistance	4/1051	76/7206	0.0205542275905
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1051	100/7206	0.0218000471611
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1051	40/7206	0.0235517980578
ko05214	Glioma	19/1051	79/7206	0.0236080719757
ko00140	Steroid hormone biosynthesis	1/1051	41/7206	0.0239287464469
ko04062	Chemokine signaling pathway	41/1051	201/7206	0.0250980302715
ko05131	Shigellosis	5/1051	82/7206	0.026603271355
ko04622	RIG-I-like receptor signaling pathway	3/1051	62/7206	0.0282945616185
ko00310	Lysine degradation	4/1051	73/7206	0.0283507254164
ko05145	Toxoplasmosis	10/1051	126/7206	0.0302350203192
ko04930	Type II diabetes mellitus	14/1051	54/7206	0.0303045088952
ko04217	Necroptosis	16/1051	178/7206	0.0311832139541
ko04210	Apoptosis	16/1051	180/7206	0.031638544232
ko00982	Drug metabolism - cytochrome P450	1/1051	37/7206	0.0348532257932
ko03410	Base excision repair	1/1051	38/7206	0.0352686617935
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1051	92/7206	0.0356807353256
ko04015	Rap1 signaling pathway	53/1051	278/7206	0.0371059091446
ko00270	Cysteine and methionine metabolism	2/1051	47/7206	0.0386436558338
ko05034	Alcoholism	46/1051	238/7206	0.0396875118183
ko04071	Sphingolipid signaling pathway	33/1051	162/7206	0.0420400391116
ko04630	Jak-STAT signaling pathway	11/1051	132/7206	0.0452622650578
ko04657	IL-17 signaling pathway	6/1051	87/7206	0.0453257683623
ko05133	Pertussis	6/1051	87/7206	0.0453257683623
ko05231	Choline metabolism in cancer	28/1051	134/7206	0.0469331816175
ko04350	TGF-beta signaling pathway	8/1051	103/7206	0.0485669795738
ko05418	Fluid shear stress and atherosclerosis	16/1051	173/7206	0.0488587483614