ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	182/1130	423/7206	4.36961960803e-44
ko04724	Glutamatergic synapse	85/1130	152/7206	8.78501881517e-31
ko05033	Nicotine addiction	46/1130	56/7206	3.17539317303e-28
ko05032	Morphine addiction	65/1130	110/7206	1.27601698484e-25
ko04713	Circadian entrainment	71/1130	136/7206	1.91175789876e-23
ko04727	GABAergic synapse	61/1130	110/7206	4.24426451292e-22
ko04728	Dopaminergic synapse	83/1130	185/7206	1.33011336236e-21
ko04725	Cholinergic synapse	74/1130	160/7206	2.53116052088e-20
ko04721	Synaptic vesicle cycle	48/1130	80/7206	1.31264925641e-19
ko04723	Retrograde endocannabinoid signaling	76/1130	175/7206	7.72299134691e-19
ko04024	cAMP signaling pathway	100/1130	279/7206	2.9681868127e-17
ko04921	Oxytocin signaling pathway	79/1130	209/7206	2.68424876563e-15
ko04911	Insulin secretion	52/1130	117/7206	9.3748407341e-14
ko04020	Calcium signaling pathway	89/1130	265/7206	1.80668806783e-13
ko04726	Serotonergic synapse	55/1130	137/7206	2.94010371132e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1130	205/7206	3.43249469237e-12
ko04742	Taste transduction	33/1130	61/7206	4.02043980677e-12
ko04360	Axon guidance	77/1130	233/7206	2.23102200022e-11
ko05031	Amphetamine addiction	40/1130	91/7206	1.06765647971e-10
ko04720	Long-term potentiation	42/1130	99/7206	1.44494662198e-10
ko03040	Spliceosome	1/1130	145/7206	8.64731858021e-10
ko04744	Phototransduction	21/1130	36/7206	5.5446952834e-09
ko04022	cGMP-PKG signaling pathway	65/1130	216/7206	5.97063847054e-08
ko04925	Aldosterone synthesis and secretion	39/1130	105/7206	7.19714067752e-08
ko04970	Salivary secretion	36/1130	95/7206	1.03144777962e-07
ko05030	Cocaine addiction	30/1130	73/7206	1.48377139167e-07
ko04060	Cytokine-cytokine receptor interaction	8/1130	191/7206	8.17088114127e-07
ko04971	Gastric acid secretion	35/1130	98/7206	8.68901547855e-07
ko03013	RNA transport	6/1130	166/7206	1.21907441126e-06
ko04740	Olfactory transduction	30/1130	80/7206	2.6343448291e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1130	74/7206	2.79090172109e-06
ko04010	MAPK signaling pathway	82/1130	321/7206	2.98431135869e-06
ko04514	Cell adhesion molecules (CAMs)	41/1130	130/7206	4.50878040372e-06
ko05322	Systemic lupus erythematosus	6/1130	151/7206	7.34727939059e-06
ko05203	Viral carcinogenesis	19/1130	277/7206	9.80082398674e-06
ko04070	Phosphatidylinositol signaling system	36/1130	112/7206	1.05786913226e-05
ko05168	Herpes simplex infection	10/1130	182/7206	2.93888768672e-05
ko04730	Long-term depression	27/1130	78/7206	2.96577760655e-05
ko04924	Renin secretion	29/1130	86/7206	3.19636767645e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1130	79/7206	3.26889443625e-05
ko05164	Influenza A	9/1130	167/7206	5.52777933187e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1130	79/7206	5.70531449799e-05
ko04972	Pancreatic secretion	34/1130	111/7206	6.03521539777e-05
ko04745	Phototransduction - fly	16/1130	38/7206	8.6590226326e-05
ko04072	Phospholipase D signaling pathway	52/1130	197/7206	9.04285223765e-05
ko04014	Ras signaling pathway	67/1130	279/7206	0.000204888957467
ko04915	Estrogen signaling pathway	37/1130	131/7206	0.000223935001733
ko04371	Apelin signaling pathway	46/1130	177/7206	0.000333275277117
ko04260	Cardiac muscle contraction	29/1130	98/7206	0.000405456744501
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1130	59/7206	0.000453863295266
ko04621	NOD-like receptor signaling pathway	10/1130	157/7206	0.000523621755248
ko05414	Dilated cardiomyopathy	32/1130	112/7206	0.00053467426954
ko04120	Ubiquitin mediated proteolysis	8/1130	138/7206	0.000536251513902
ko04064	NF-kappa B signaling pathway	4/1130	96/7206	0.000602369489833
ko04141	Protein processing in endoplasmic reticulum	13/1130	184/7206	0.000627446175839
ko04626	Plant-pathogen interaction	9/1130	18/7206	0.000703642056268
ko04110	Cell cycle	9/1130	145/7206	0.000732508273562
ko04540	Gap junction	35/1130	128/7206	0.00078582805075
ko04966	Collecting duct acid secretion	11/1130	26/7206	0.00106189759055
ko05110	Vibrio cholerae infection	20/1130	63/7206	0.00133006637808
ko04610	Complement and coagulation cascades	3/1130	79/7206	0.00156816047501
ko04612	Antigen processing and presentation	3/1130	77/7206	0.00230598184411
ko04976	Bile secretion	23/1130	80/7206	0.00283489057567
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1130	14/7206	0.00284366570935
ko04964	Proximal tubule bicarbonate reclamation	11/1130	29/7206	0.00302763661229
ko05140	Leishmaniasis	3/1130	75/7206	0.00341720834773
ko05205	Proteoglycans in cancer	26/1130	271/7206	0.00371690762796
ko04930	Type II diabetes mellitus	17/1130	54/7206	0.00380455554027
ko04923	Regulation of lipolysis in adipocytes	22/1130	77/7206	0.00393856524345
ko00330	Arginine and proline metabolism	2/1130	61/7206	0.0040366403857
ko05169	Epstein-Barr virus infection	18/1130	206/7206	0.00457881512984
ko05162	Measles	8/1130	120/7206	0.00489965874863
ko04146	Peroxisome	5/1130	89/7206	0.00514717247167
ko00071	Fatty acid degradation	1/1130	45/7206	0.00683060759438
ko03420	Nucleotide excision repair	1/1130	46/7206	0.00693007419984
ko00480	Glutathione metabolism	2/1130	55/7206	0.00854407164291
ko05321	Inflammatory bowel disease (IBD)	2/1130	56/7206	0.00865829716395
ko04711	Circadian rhythm - fly	6/1130	13/7206	0.00932884200353
ko03022	Basal transcription factors	1/1130	44/7206	0.0106251153873
ko04750	Inflammatory mediator regulation of TRP channels	30/1130	122/7206	0.0112888959594
ko00240	Pyrimidine metabolism	8/1130	110/7206	0.0116554589594
ko00590	Arachidonic acid metabolism	2/1130	52/7206	0.0124305192336
ko04622	RIG-I-like receptor signaling pathway	3/1130	62/7206	0.0134965434115
ko00310	Lysine degradation	4/1130	73/7206	0.0140480336
ko04640	Hematopoietic cell lineage	3/1130	64/7206	0.0140565107585
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1130	40/7206	0.0152535030469
ko04912	GnRH signaling pathway	29/1130	122/7206	0.0168406879009
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1130	182/7206	0.0170514857457
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1130	100/7206	0.0174396826374
ko04710	Circadian rhythm	13/1130	43/7206	0.0177523322047
ko04270	Vascular smooth muscle contraction	35/1130	154/7206	0.0185011018496
ko04916	Melanogenesis	33/1130	142/7206	0.0189551662271
ko03320	PPAR signaling pathway	4/1130	69/7206	0.0192463779004
ko05161	Hepatitis B	16/1130	173/7206	0.0192773246085
ko04922	Glucagon signaling pathway	30/1130	128/7206	0.019356919685
ko04722	Neurotrophin signaling pathway	36/1130	160/7206	0.0206163298862
ko04217	Necroptosis	17/1130	178/7206	0.0213391770079
ko00982	Drug metabolism - cytochrome P450	1/1130	37/7206	0.0227055276191
ko03410	Base excision repair	1/1130	38/7206	0.0229690560493
ko04114	Oocyte meiosis	32/1130	139/7206	0.0243240256678
ko00260	Glycine, serine and threonine metabolism	2/1130	48/7206	0.0263490677428
ko04071	Sphingolipid signaling pathway	36/1130	162/7206	0.0280721376799
ko04015	Rap1 signaling pathway	57/1130	278/7206	0.0284719891403
ko05131	Shigellosis	6/1130	82/7206	0.032507654846
ko03018	RNA degradation	6/1130	84/7206	0.0330519918519
ko04975	Fat digestion and absorption	1/1130	35/7206	0.0338908468101
ko04115	p53 signaling pathway	5/1130	74/7206	0.0352125050431
ko04510	Focal adhesion	26/1130	240/7206	0.037413400614
ko00280	Valine, leucine and isoleucine degradation	3/1130	54/7206	0.0379715696021
ko04658	Th1 and Th2 cell differentiation	8/1130	96/7206	0.0472726205861