ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	38/747	56/7206	5.68662206967e-25
ko04724	Glutamatergic synapse	63/747	152/7206	4.90382597664e-24
ko04727	GABAergic synapse	46/747	110/7206	5.20484496672e-18
ko05032	Morphine addiction	45/747	110/7206	3.37842846575e-17
ko04728	Dopaminergic synapse	59/747	185/7206	4.19442661582e-16
ko04721	Synaptic vesicle cycle	36/747	80/7206	1.40260595234e-15
ko04080	Neuroactive ligand-receptor interaction	96/747	423/7206	2.47692354361e-14
ko04723	Retrograde endocannabinoid signaling	54/747	175/7206	3.73147312396e-14
ko04713	Circadian entrainment	45/747	136/7206	3.39724448774e-13
ko04725	Cholinergic synapse	49/747	160/7206	8.19915136785e-13
ko04024	cAMP signaling pathway	66/747	279/7206	6.47680522746e-11
ko04911	Insulin secretion	37/747	117/7206	1.9941863822e-10
ko04744	Phototransduction	19/747	36/7206	2.48464964859e-10
ko05030	Cocaine addiction	26/747	73/7206	6.20228125798e-09
ko04360	Axon guidance	54/747	233/7206	8.77808711407e-09
ko05031	Amphetamine addiction	26/747	91/7206	9.48242464017e-07
ko04742	Taste transduction	20/747	61/7206	1.61787512344e-06
ko04726	Serotonergic synapse	33/747	137/7206	2.72645329718e-06
ko03040	Spliceosome	1/747	145/7206	3.12415895637e-06
ko04514	Cell adhesion molecules (CAMs)	31/747	130/7206	6.77807198268e-06
ko04261	Adrenergic signaling in cardiomyocytes	42/747	205/7206	1.20599242309e-05
ko04060	Cytokine-cytokine receptor interaction	4/747	191/7206	1.72992581773e-05
ko05203	Viral carcinogenesis	10/747	277/7206	4.65180551801e-05
ko04120	Ubiquitin mediated proteolysis	2/747	138/7206	5.7703409106e-05
ko04010	MAPK signaling pathway	56/747	321/7206	7.25714435036e-05
ko03013	RNA transport	4/747	166/7206	0.000146233047363
ko04720	Long-term potentiation	23/747	99/7206	0.000165696183722
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/747	14/7206	0.000223243311906
ko04621	NOD-like receptor signaling pathway	4/747	157/7206	0.000293755825035
ko05014	Amyotrophic lateral sclerosis (ALS)	18/747	74/7206	0.000418526306007
ko05168	Herpes simplex infection	6/747	182/7206	0.000506147777268
ko04730	Long-term depression	18/747	78/7206	0.00100974556058
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	18/747	79/7206	0.00113229886831
ko04141	Protein processing in endoplasmic reticulum	7/747	184/7206	0.00136383060052
ko05322	Systemic lupus erythematosus	5/747	151/7206	0.00177811931547
ko05169	Epstein-Barr virus infection	9/747	206/7206	0.00239762389042
ko04972	Pancreatic secretion	22/747	111/7206	0.002473314586
ko05205	Proteoglycans in cancer	14/747	271/7206	0.00301943857023
ko04064	NF-kappa B signaling pathway	2/747	96/7206	0.00359452655398
ko00240	Pyrimidine metabolism	3/747	110/7206	0.0041683131226
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/747	182/7206	0.00447742045029
ko04140	Autophagy - animal	7/747	164/7206	0.00624104821036
ko05164	Influenza A	7/747	167/7206	0.00641616257345
ko04260	Cardiac muscle contraction	19/747	98/7206	0.00665572369967
ko04921	Oxytocin signaling pathway	34/747	209/7206	0.00762136752575
ko04350	TGF-beta signaling pathway	3/747	103/7206	0.00835629523597
ko04110	Cell cycle	6/747	145/7206	0.00868862491636
ko04970	Salivary secretion	18/747	95/7206	0.01010705615
ko03018	RNA degradation	2/747	84/7206	0.0106244852867
ko04930	Type II diabetes mellitus	12/747	54/7206	0.0106966051615
ko00515	Mannose type O-glycan biosynthesis	7/747	25/7206	0.0113245885966
ko00564	Glycerophospholipid metabolism	3/747	99/7206	0.0117367369468
ko04014	Ras signaling pathway	42/747	279/7206	0.011981738443
ko04640	Hematopoietic cell lineage	1/747	64/7206	0.0125256418352
ko04391	Hippo signaling pathway - fly	17/747	90/7206	0.0134140024094
ko04966	Collecting duct acid secretion	7/747	26/7206	0.0141456297355
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/747	26/7206	0.0141456297355
ko03008	Ribosome biogenesis in eukaryotes	2/747	79/7206	0.0150702068181
ko04138	Autophagy - yeast	2/747	81/7206	0.0154252552733
ko04137	Mitophagy - animal	2/747	82/7206	0.0158262807441
ko05145	Toxoplasmosis	5/747	126/7206	0.0169878510289
ko04072	Phospholipase D signaling pathway	31/747	197/7206	0.0171544504563
ko05140	Leishmaniasis	2/747	75/7206	0.0214646284466
ko05418	Fluid shear stress and atherosclerosis	9/747	173/7206	0.0223254210925
ko05162	Measles	5/747	120/7206	0.0223539146011
ko04022	cGMP-PKG signaling pathway	33/747	216/7206	0.0226404941065
ko04146	Peroxisome	3/747	89/7206	0.0227276835758
ko05414	Dilated cardiomyopathy	19/747	112/7206	0.0277826685025
ko04630	Jak-STAT signaling pathway	6/747	132/7206	0.0290417601993
ko05034	Alcoholism	35/747	238/7206	0.030259516752
ko04214	Apoptosis - fly	2/747	72/7206	0.0306854100773
ko05133	Pertussis	3/747	87/7206	0.031882206767
ko05206	MicroRNAs in cancer	10/747	177/7206	0.0337333087323
ko04218	Cellular senescence	10/747	177/7206	0.0337333087323
ko00590	Arachidonic acid metabolism	1/747	52/7206	0.0391391284963
ko00280	Valine, leucine and isoleucine degradation	1/747	54/7206	0.0400557043007
ko04915	Estrogen signaling pathway	21/747	131/7206	0.0414006515959
ko00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/747	8/7206	0.0417299365197
ko05161	Hepatitis B	10/747	173/7206	0.0432085981854
ko05146	Amoebiasis	4/747	99/7206	0.0438152636834
ko03320	PPAR signaling pathway	2/747	69/7206	0.0440831418942
ko04062	Chemokine signaling pathway	30/747	201/7206	0.0448008756085
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/747	59/7206	0.0498191517348