ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1148	423/7206	1.00221767371e-52
ko05033	Nicotine addiction	46/1148	56/7206	6.47684409322e-28
ko04724	Glutamatergic synapse	81/1148	152/7206	6.17535871263e-27
ko05032	Morphine addiction	66/1148	110/7206	3.93414986106e-26
ko04713	Circadian entrainment	69/1148	136/7206	1.76735375149e-21
ko04727	GABAergic synapse	58/1148	110/7206	2.76295743297e-19
ko04728	Dopaminergic synapse	79/1148	185/7206	1.41401550259e-18
ko04725	Cholinergic synapse	72/1148	160/7206	1.45310843542e-18
ko04024	cAMP signaling pathway	103/1148	279/7206	3.09469228163e-18
ko04020	Calcium signaling pathway	98/1148	265/7206	2.17603643491e-17
ko04723	Retrograde endocannabinoid signaling	73/1148	175/7206	1.43078272257e-16
ko04726	Serotonergic synapse	58/1148	137/7206	9.57546569344e-14
ko04911	Insulin secretion	52/1148	117/7206	1.8000008825e-13
ko04721	Synaptic vesicle cycle	41/1148	80/7206	1.89698117759e-13
ko04742	Taste transduction	33/1148	61/7206	6.29940925429e-12
ko04921	Oxytocin signaling pathway	70/1148	209/7206	2.64284114626e-10
ko03040	Spliceosome	1/1148	145/7206	5.22000109765e-10
ko04261	Adrenergic signaling in cardiomyocytes	68/1148	205/7206	6.69179757536e-10
ko04744	Phototransduction	22/1148	36/7206	9.30609647576e-10
ko04360	Axon guidance	73/1148	233/7206	2.64346092347e-09
ko05031	Amphetamine addiction	38/1148	91/7206	2.99243624528e-09
ko03010	Ribosome	1/1148	129/7206	6.65906746971e-09
ko03013	RNA transport	4/1148	166/7206	1.91740297924e-08
ko05322	Systemic lupus erythematosus	4/1148	151/7206	2.10877156851e-07
ko05030	Cocaine addiction	30/1148	73/7206	2.1235977512e-07
ko04720	Long-term potentiation	36/1148	99/7206	5.41699285544e-07
ko04970	Salivary secretion	35/1148	95/7206	5.73348114529e-07
ko04022	cGMP-PKG signaling pathway	62/1148	216/7206	1.64164214825e-06
ko04070	Phosphatidylinositol signaling system	38/1148	112/7206	2.61165494522e-06
ko04925	Aldosterone synthesis and secretion	36/1148	105/7206	2.80558100438e-06
ko05203	Viral carcinogenesis	19/1148	277/7206	5.24083374723e-06
ko04072	Phospholipase D signaling pathway	56/1148	197/7206	6.72281360551e-06
ko04514	Cell adhesion molecules (CAMs)	41/1148	130/7206	8.37434432435e-06
ko04060	Cytokine-cytokine receptor interaction	11/1148	191/7206	2.11290385145e-05
ko05164	Influenza A	9/1148	167/7206	3.86971612276e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1148	74/7206	4.12798766309e-05
ko04730	Long-term depression	27/1148	78/7206	5.70401705268e-05
ko05168	Herpes simplex infection	11/1148	182/7206	7.91405293623e-05
ko04971	Gastric acid secretion	31/1148	98/7206	0.000121617178288
ko04621	NOD-like receptor signaling pathway	9/1148	157/7206	0.000146967232578
ko04710	Circadian rhythm	17/1148	43/7206	0.000164065672369
ko04972	Pancreatic secretion	33/1148	111/7206	0.000208665552868
ko04740	Olfactory transduction	26/1148	80/7206	0.00028580896802
ko04612	Antigen processing and presentation	2/1148	77/7206	0.000411398739418
ko04010	MAPK signaling pathway	75/1148	321/7206	0.000415510284638
ko04141	Protein processing in endoplasmic reticulum	13/1148	184/7206	0.000461695895381
ko04923	Regulation of lipolysis in adipocytes	24/1148	77/7206	0.000783491287313
ko04924	Renin secretion	26/1148	86/7206	0.000876985675637
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1148	79/7206	0.00104228633773
ko04146	Peroxisome	4/1148	89/7206	0.00121514751795
ko04930	Type II diabetes mellitus	18/1148	54/7206	0.00128104049172
ko04120	Ubiquitin mediated proteolysis	9/1148	138/7206	0.00135665387876
ko04745	Phototransduction - fly	14/1148	38/7206	0.00139447083195
ko04750	Inflammatory mediator regulation of TRP channels	33/1148	122/7206	0.00160657658158
ko04110	Cell cycle	10/1148	145/7206	0.00177450832267
ko04711	Circadian rhythm - fly	7/1148	13/7206	0.0018079626149
ko04014	Ras signaling pathway	64/1148	279/7206	0.00192232938415
ko00280	Valine, leucine and isoleucine degradation	1/1148	54/7206	0.00212764532418
ko04260	Cardiac muscle contraction	27/1148	98/7206	0.00315051326573
ko00562	Inositol phosphate metabolism	25/1148	89/7206	0.00320483575379
ko04540	Gap junction	33/1148	128/7206	0.00464509308212
ko04966	Collecting duct acid secretion	10/1148	26/7206	0.00464974411119
ko05414	Dilated cardiomyopathy	29/1148	112/7206	0.00595077715484
ko05169	Epstein-Barr virus infection	19/1148	206/7206	0.0065792361884
ko03022	Basal transcription factors	1/1148	44/7206	0.00676899450754
ko00071	Fatty acid degradation	1/1148	45/7206	0.00679913090904
ko03420	Nucleotide excision repair	1/1148	46/7206	0.00706585914166
ko05133	Pertussis	5/1148	87/7206	0.00722513134107
ko05162	Measles	9/1148	120/7206	0.00803878123654
ko05231	Choline metabolism in cancer	33/1148	134/7206	0.00836203732662
ko05205	Proteoglycans in cancer	28/1148	271/7206	0.00862417840559
ko04960	Aldosterone-regulated sodium reabsorption	13/1148	41/7206	0.0097078926647
ko03018	RNA degradation	5/1148	84/7206	0.00993286607451
ko05140	Leishmaniasis	4/1148	75/7206	0.0100780683638
ko05016	Huntington's disease	21/1148	215/7206	0.0104518443184
ko04915	Estrogen signaling pathway	32/1148	131/7206	0.0109055767362
ko04071	Sphingolipid signaling pathway	38/1148	162/7206	0.0120253983636
ko00590	Arachidonic acid metabolism	2/1148	52/7206	0.0123368371355
ko04142	Lysosome	13/1148	151/7206	0.0128346045809
ko00330	Arginine and proline metabolism	3/1148	61/7206	0.0133672772969
ko04622	RIG-I-like receptor signaling pathway	3/1148	62/7206	0.0134989211755
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1148	14/7206	0.0153099082059
ko04658	Th1 and Th2 cell differentiation	7/1148	96/7206	0.0165984578707
ko04064	NF-kappa B signaling pathway	7/1148	96/7206	0.0165984578707
ko04973	Carbohydrate digestion and absorption	13/1148	42/7206	0.017093343722
ko04964	Proximal tubule bicarbonate reclamation	10/1148	29/7206	0.0176088505057
ko04657	IL-17 signaling pathway	6/1148	87/7206	0.0177091699916
ko05130	Pathogenic Escherichia coli infection	5/1148	77/7206	0.018571942612
ko04610	Complement and coagulation cascades	5/1148	79/7206	0.0190413655708
ko04976	Bile secretion	21/1148	80/7206	0.0197159580009
ko01200	Carbon metabolism	11/1148	128/7206	0.0201531579547
ko03410	Base excision repair	1/1148	38/7206	0.0232550520093
ko00620	Pyruvate metabolism	2/1148	46/7206	0.0257795133492
ko05219	Bladder cancer	2/1148	48/7206	0.0268040363562
ko04371	Apelin signaling pathway	39/1148	177/7206	0.0287915939788
ko04217	Necroptosis	18/1148	178/7206	0.0294177981167
ko05131	Shigellosis	6/1148	82/7206	0.0324425098964
ko00640	Propanoate metabolism	1/1148	34/7206	0.0334920002845
ko00860	Porphyrin and chlorophyll metabolism	1/1148	34/7206	0.0334920002845
ko00500	Starch and sucrose metabolism	1/1148	35/7206	0.0340757579843
ko04214	Apoptosis - fly	5/1148	72/7206	0.0346588012256
ko00310	Lysine degradation	5/1148	73/7206	0.035051008237
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1148	100/7206	0.0375708971913
ko05144	Malaria	2/1148	45/7206	0.0380724640999
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1148	182/7206	0.0399916821862
ko04666	Fc gamma R-mediated phagocytosis	28/1148	122/7206	0.0446439905429
ko05161	Hepatitis B	18/1148	173/7206	0.0453780603884
ko04113	Meiosis - yeast	5/1148	70/7206	0.0473204816065
ko04722	Neurotrophin signaling pathway	35/1148	160/7206	0.0483246258001
ko04152	AMPK signaling pathway	35/1148	161/7206	0.0493039505805