ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/1132	423/7206	4.65622768716e-48
ko04724	Glutamatergic synapse	89/1132	152/7206	2.84300419506e-34
ko05033	Nicotine addiction	48/1132	56/7206	4.35407490374e-31
ko05032	Morphine addiction	69/1132	110/7206	2.33011141191e-29
ko04713	Circadian entrainment	76/1132	136/7206	1.57383167228e-27
ko04727	GABAergic synapse	67/1132	110/7206	1.96245774593e-27
ko04721	Synaptic vesicle cycle	55/1132	80/7206	1.31717033023e-26
ko04728	Dopaminergic synapse	89/1132	185/7206	9.68766116126e-26
ko04725	Cholinergic synapse	76/1132	160/7206	1.11242957434e-21
ko04723	Retrograde endocannabinoid signaling	79/1132	175/7206	9.18852619135e-21
ko04911	Insulin secretion	56/1132	117/7206	1.85879086115e-16
ko04024	cAMP signaling pathway	98/1132	279/7206	3.44227514672e-16
ko04726	Serotonergic synapse	60/1132	137/7206	2.79161585174e-15
ko04744	Phototransduction	27/1132	36/7206	3.36994801637e-15
ko04020	Calcium signaling pathway	92/1132	265/7206	9.05318607267e-15
ko04921	Oxytocin signaling pathway	78/1132	209/7206	9.66688012981e-15
ko05031	Amphetamine addiction	44/1132	91/7206	2.13056700903e-13
ko04720	Long-term potentiation	46/1132	99/7206	3.78350865944e-13
ko04742	Taste transduction	34/1132	61/7206	6.25884221766e-13
ko04261	Adrenergic signaling in cardiomyocytes	73/1132	205/7206	1.3854620019e-12
ko04925	Aldosterone synthesis and secretion	43/1132	105/7206	3.614827626e-10
ko04970	Salivary secretion	40/1132	95/7206	5.53425999305e-10
ko03040	Spliceosome	1/1132	145/7206	8.79073811018e-10
ko04971	Gastric acid secretion	39/1132	98/7206	6.37347969945e-09
ko05030	Cocaine addiction	32/1132	73/7206	9.06350243245e-09
ko04740	Olfactory transduction	33/1132	80/7206	3.31886695523e-08
ko04060	Cytokine-cytokine receptor interaction	7/1132	191/7206	1.56203071111e-07
ko04360	Axon guidance	67/1132	233/7206	3.12390041317e-07
ko05168	Herpes simplex infection	7/1132	182/7206	4.66779540753e-07
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1132	59/7206	8.41682548768e-07
ko04010	MAPK signaling pathway	84/1132	321/7206	8.82640848861e-07
ko04022	cGMP-PKG signaling pathway	62/1132	216/7206	8.83437102406e-07
ko04966	Collecting duct acid secretion	15/1132	26/7206	1.11328608663e-06
ko04070	Phosphatidylinositol signaling system	38/1132	112/7206	1.3769540524e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1132	74/7206	2.89245844601e-06
ko05203	Viral carcinogenesis	18/1132	277/7206	3.0183188514e-06
ko05110	Vibrio cholerae infection	25/1132	63/7206	3.59229456917e-06
ko04972	Pancreatic secretion	37/1132	111/7206	4.05347714235e-06
ko03013	RNA transport	7/1132	166/7206	4.13846702304e-06
ko05322	Systemic lupus erythematosus	6/1132	151/7206	7.34008839298e-06
ko04730	Long-term depression	28/1132	78/7206	1.0966361795e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1132	79/7206	1.37629246258e-05
ko04745	Phototransduction - fly	17/1132	38/7206	2.05202093958e-05
ko04072	Phospholipase D signaling pathway	54/1132	197/7206	2.38086637602e-05
ko04915	Estrogen signaling pathway	39/1132	131/7206	4.57443843348e-05
ko04260	Cardiac muscle contraction	31/1132	98/7206	6.61902969767e-05
ko04141	Protein processing in endoplasmic reticulum	11/1132	184/7206	7.94371740418e-05
ko04540	Gap junction	37/1132	128/7206	0.000121429957101
ko05164	Influenza A	10/1132	167/7206	0.00014895969985
ko05414	Dilated cardiomyopathy	33/1132	112/7206	0.000198328371552
ko04120	Ubiquitin mediated proteolysis	7/1132	138/7206	0.000201104621727
ko04014	Ras signaling pathway	67/1132	279/7206	0.000209956508823
ko04924	Renin secretion	27/1132	86/7206	0.000250522124232
ko04610	Complement and coagulation cascades	2/1132	79/7206	0.000266137544369
ko03008	Ribosome biogenesis in eukaryotes	2/1132	79/7206	0.000266137544369
ko04612	Antigen processing and presentation	2/1132	77/7206	0.000398524995083
ko04976	Bile secretion	25/1132	80/7206	0.000496822453809
ko04621	NOD-like receptor signaling pathway	10/1132	157/7206	0.000523441611664
ko04514	Cell adhesion molecules (CAMs)	36/1132	130/7206	0.000551734219049
ko04750	Inflammatory mediator regulation of TRP channels	34/1132	122/7206	0.000587829042884
ko04110	Cell cycle	9/1132	145/7206	0.000733263778815
ko00480	Glutathione metabolism	1/1132	55/7206	0.00134974383707
ko00240	Pyrimidine metabolism	6/1132	110/7206	0.00138682378667
ko05162	Measles	7/1132	120/7206	0.00140677458729
ko04912	GnRH signaling pathway	33/1132	122/7206	0.0014804449353
ko04146	Peroxisome	4/1132	89/7206	0.00177835706715
ko05169	Epstein-Barr virus infection	17/1132	206/7206	0.00180015923354
ko05205	Proteoglycans in cancer	25/1132	271/7206	0.00209171513762
ko05140	Leishmaniasis	3/1132	75/7206	0.0022486737255
ko04064	NF-kappa B signaling pathway	5/1132	96/7206	0.00266531599223
ko04640	Hematopoietic cell lineage	2/1132	64/7206	0.00278341482895
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1132	14/7206	0.00287361369945
ko04964	Proximal tubule bicarbonate reclamation	11/1132	29/7206	0.00307133287252
ko00590	Arachidonic acid metabolism	1/1132	52/7206	0.0032051859974
ko00310	Lysine degradation	3/1132	73/7206	0.00323298001975
ko04626	Plant-pathogen interaction	8/1132	18/7206	0.00361931702665
ko03018	RNA degradation	4/1132	84/7206	0.00362293876541
ko04350	TGF-beta signaling pathway	6/1132	103/7206	0.00376308573497
ko00260	Glycine, serine and threonine metabolism	1/1132	48/7206	0.00456606565892
ko04371	Apelin signaling pathway	42/1132	177/7206	0.00457079520913
ko00071	Fatty acid degradation	1/1132	45/7206	0.00682160210132
ko03320	PPAR signaling pathway	3/1132	69/7206	0.00685182842334
ko03420	Nucleotide excision repair	1/1132	46/7206	0.00693927100699
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1132	182/7206	0.00718890568895
ko05321	Inflammatory bowel disease (IBD)	2/1132	56/7206	0.00867122440584
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1132	92/7206	0.00902616271751
ko04916	Melanogenesis	34/1132	142/7206	0.00990888201308
ko04062	Chemokine signaling pathway	45/1132	201/7206	0.010507525237
ko03022	Basal transcription factors	1/1132	44/7206	0.01065447063
ko05034	Alcoholism	52/1132	238/7206	0.0109444102526
ko05231	Choline metabolism in cancer	32/1132	134/7206	0.0116420799703
ko05214	Glioma	21/1132	79/7206	0.0120243890442
ko00562	Inositol phosphate metabolism	23/1132	89/7206	0.0121482903621
ko05145	Toxoplasmosis	10/1132	126/7206	0.0131157150548
ko04270	Vascular smooth muscle contraction	36/1132	154/7206	0.0131798819941
ko04622	RIG-I-like receptor signaling pathway	3/1132	62/7206	0.0134836788649
ko04214	Apoptosis - fly	4/1132	72/7206	0.0138307592483
ko04015	Rap1 signaling pathway	59/1132	278/7206	0.0144464454518
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1132	40/7206	0.0152463151152
ko04918	Thyroid hormone synthesis	22/1132	86/7206	0.016328951033
ko04210	Apoptosis	17/1132	180/7206	0.0169034236454
ko00512	Mucin type O-glycan biosynthesis	10/1132	29/7206	0.0170852359185
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1132	100/7206	0.0175218362232
ko04923	Regulation of lipolysis in adipocytes	20/1132	77/7206	0.0176536480262
ko05161	Hepatitis B	16/1132	173/7206	0.0193458995376
ko00330	Arginine and proline metabolism	3/1132	61/7206	0.0197473027953
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1132	15/7206	0.0207465342747
ko04930	Type II diabetes mellitus	15/1132	54/7206	0.022411345622
ko04668	TNF signaling pathway	10/1132	120/7206	0.0224849189639
ko00982	Drug metabolism - cytochrome P450	1/1132	37/7206	0.0226809469697
ko04658	Th1 and Th2 cell differentiation	7/1132	96/7206	0.022738243324
ko00630	Glyoxylate and dicarboxylate metabolism	1/1132	38/7206	0.0229889984871
ko04960	Aldosterone-regulated sodium reabsorption	12/1132	41/7206	0.0280442985706
ko04071	Sphingolipid signaling pathway	36/1132	162/7206	0.0282303453961
ko00513	Various types of N-glycan biosynthesis	12/1132	42/7206	0.0311584626422
ko04973	Carbohydrate digestion and absorption	12/1132	42/7206	0.0311584626422
ko05131	Shigellosis	6/1132	82/7206	0.0324675844794
ko04975	Fat digestion and absorption	1/1132	35/7206	0.0338972117474
ko04115	p53 signaling pathway	5/1132	74/7206	0.0352599626199
ko04722	Neurotrophin signaling pathway	35/1132	160/7206	0.0363218981882
ko04620	Toll-like receptor signaling pathway	8/1132	100/7206	0.0365595626827
ko04217	Necroptosis	18/1132	178/7206	0.0368103721918
ko04140	Autophagy - animal	16/1132	164/7206	0.0383140156011
ko04114	Oocyte meiosis	31/1132	139/7206	0.0442976895907
ko04012	ErbB signaling pathway	25/1132	109/7206	0.0456058771734
ko01200	Carbon metabolism	12/1132	128/7206	0.04924490203