ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	172/1095	423/7206	1.49036739289e-39
ko05033	Nicotine addiction	47/1095	56/7206	2.79084062827e-30
ko04724	Glutamatergic synapse	81/1095	152/7206	2.14393751129e-28
ko05032	Morphine addiction	65/1095	110/7206	2.00215465321e-26
ko04727	GABAergic synapse	62/1095	110/7206	1.04270734096e-23
ko04728	Dopaminergic synapse	81/1095	185/7206	3.563902098e-21
ko04713	Circadian entrainment	67/1095	136/7206	3.80286145466e-21
ko04723	Retrograde endocannabinoid signaling	76/1095	175/7206	1.13958571676e-19
ko04721	Synaptic vesicle cycle	47/1095	80/7206	2.85113287896e-19
ko04725	Cholinergic synapse	70/1095	160/7206	2.05775855362e-18
ko04742	Taste transduction	38/1095	61/7206	4.90371815907e-17
ko04744	Phototransduction	27/1095	36/7206	1.43231225752e-15
ko04726	Serotonergic synapse	56/1095	137/7206	1.97774482839e-13
ko04024	cAMP signaling pathway	90/1095	279/7206	3.53595645971e-13
ko04911	Insulin secretion	50/1095	117/7206	5.18240114927e-13
ko04921	Oxytocin signaling pathway	69/1095	209/7206	5.81484804873e-11
ko03040	Spliceosome	1/1095	145/7206	1.36060424821e-09
ko04261	Adrenergic signaling in cardiomyocytes	65/1095	205/7206	2.1721744554e-09
ko05031	Amphetamine addiction	37/1095	91/7206	3.07412976256e-09
ko04740	Olfactory transduction	34/1095	80/7206	3.41912015299e-09
ko04020	Calcium signaling pathway	77/1095	265/7206	4.55410415303e-09
ko05203	Viral carcinogenesis	13/1095	277/7206	2.96884877322e-08
ko04720	Long-term potentiation	37/1095	99/7206	4.50600291442e-08
ko04060	Cytokine-cytokine receptor interaction	7/1095	191/7206	3.45760039408e-07
ko04360	Axon guidance	65/1095	233/7206	3.86279615628e-07
ko03013	RNA transport	5/1095	166/7206	4.74169459491e-07
ko05322	Systemic lupus erythematosus	4/1095	151/7206	4.96883268156e-07
ko05030	Cocaine addiction	28/1095	73/7206	1.06604235069e-06
ko05164	Influenza A	6/1095	167/7206	1.7957265646e-06
ko04970	Salivary secretion	33/1095	95/7206	1.81521148138e-06
ko04514	Cell adhesion molecules (CAMs)	41/1095	130/7206	2.75248641775e-06
ko04925	Aldosterone synthesis and secretion	35/1095	105/7206	2.97511257892e-06
ko05168	Herpes simplex infection	8/1095	182/7206	4.9612965172e-06
ko04971	Gastric acid secretion	33/1095	98/7206	5.28254514588e-06
ko04621	NOD-like receptor signaling pathway	6/1095	157/7206	7.92849699061e-06
ko04120	Ubiquitin mediated proteolysis	5/1095	138/7206	1.96037872548e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1095	79/7206	2.25060680875e-05
ko05205	Proteoglycans in cancer	19/1095	271/7206	4.40953541577e-05
ko04610	Complement and coagulation cascades	1/1095	79/7206	5.18821530215e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1095	79/7206	5.18821530215e-05
ko04745	Phototransduction - fly	16/1095	38/7206	5.85696735673e-05
ko04260	Cardiac muscle contraction	30/1095	98/7206	9.39100640277e-05
ko04022	cGMP-PKG signaling pathway	54/1095	216/7206	0.000149846085566
ko04141	Protein processing in endoplasmic reticulum	11/1095	184/7206	0.00015409665189
ko05161	Hepatitis B	10/1095	173/7206	0.00015453545532
ko05162	Measles	5/1095	120/7206	0.000169688094998
ko05014	Amyotrophic lateral sclerosis (ALS)	24/1095	74/7206	0.000217399907589
ko04972	Pancreatic secretion	32/1095	111/7206	0.000243451405394
ko05169	Epstein-Barr virus infection	14/1095	206/7206	0.000345530889796
ko04730	Long-term depression	24/1095	78/7206	0.000403034309443
ko05166	HTLV-I infection	24/1095	292/7206	0.000436147083494
ko04010	MAPK signaling pathway	71/1095	321/7206	0.000786545522195
ko04966	Collecting duct acid secretion	11/1095	26/7206	0.000809463030717
ko04064	NF-kappa B signaling pathway	4/1095	96/7206	0.000891022006535
ko05140	Leishmaniasis	2/1095	75/7206	0.000930885531186
ko04924	Renin secretion	25/1095	86/7206	0.00119861053587
ko04630	Jak-STAT signaling pathway	8/1095	132/7206	0.00198823198019
ko00480	Glutathione metabolism	1/1095	55/7206	0.00208649618609
ko04964	Proximal tubule bicarbonate reclamation	11/1095	29/7206	0.00234220642188
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1095	14/7206	0.00235854181899
ko04146	Peroxisome	4/1095	89/7206	0.00258778468087
ko00590	Arachidonic acid metabolism	1/1095	52/7206	0.0031201765101
ko05414	Dilated cardiomyopathy	29/1095	112/7206	0.00314116444392
ko04110	Cell cycle	10/1095	145/7206	0.00326789701737
ko04612	Antigen processing and presentation	3/1095	77/7206	0.00344593551118
ko04540	Gap junction	32/1095	128/7206	0.00387361423528
ko04976	Bile secretion	22/1095	80/7206	0.00424402155772
ko04640	Hematopoietic cell lineage	2/1095	64/7206	0.00427811037405
ko04072	Phospholipase D signaling pathway	45/1095	197/7206	0.00456226211676
ko00330	Arginine and proline metabolism	2/1095	61/7206	0.00617033792852
ko00240	Pyrimidine metabolism	7/1095	110/7206	0.00696732036981
ko03420	Nucleotide excision repair	1/1095	46/7206	0.00700496917437
ko05215	Prostate cancer	7/1095	111/7206	0.00708870939554
ko05219	Bladder cancer	1/1095	48/7206	0.00723416628849
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1095	59/7206	0.00927903823748
ko04658	Th1 and Th2 cell differentiation	6/1095	96/7206	0.00983846599261
ko04657	IL-17 signaling pathway	5/1095	87/7206	0.0100906972766
ko03022	Basal transcription factors	1/1095	44/7206	0.0104277586195
ko05144	Malaria	1/1095	45/7206	0.0106618677997
ko00071	Fatty acid degradation	1/1095	45/7206	0.0106618677997
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1095	100/7206	0.0106802618018
ko04217	Necroptosis	15/1095	178/7206	0.0106864188661
ko04750	Inflammatory mediator regulation of TRP channels	29/1095	122/7206	0.0107433586878
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1095	182/7206	0.0120014497022
ko00280	Valine, leucine and isoleucine degradation	2/1095	54/7206	0.0126560431961
ko05321	Inflammatory bowel disease (IBD)	2/1095	56/7206	0.0132804491977
ko05418	Fluid shear stress and atherosclerosis	15/1095	173/7206	0.0134071216536
ko04371	Apelin signaling pathway	39/1095	177/7206	0.0143068492298
ko04668	TNF signaling pathway	9/1095	120/7206	0.0145824650069
ko01524	Platinum drug resistance	4/1095	76/7206	0.0145901481154
ko04620	Toll-like receptor signaling pathway	7/1095	100/7206	0.0170633888542
ko04915	Estrogen signaling pathway	30/1095	131/7206	0.018847988354
ko05131	Shigellosis	5/1095	82/7206	0.0192081286384
ko04622	RIG-I-like receptor signaling pathway	3/1095	62/7206	0.0195842940682
ko04214	Apoptosis - fly	4/1095	72/7206	0.0197095484273
ko04930	Type II diabetes mellitus	15/1095	54/7206	0.0199538247111
ko00561	Glycerolipid metabolism	3/1095	63/7206	0.0200680772916
ko04933	AGE-RAGE signaling pathway in diabetic complications	11/1095	135/7206	0.0207631983274
ko05145	Toxoplasmosis	10/1095	126/7206	0.0232573336925
ko04070	Phosphatidylinositol signaling system	26/1095	112/7206	0.0233075333048
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1095	40/7206	0.0240186803047
ko00260	Glycine, serine and threonine metabolism	2/1095	48/7206	0.0264287118101
ko04014	Ras signaling pathway	56/1095	279/7206	0.0265662868084
ko04210	Apoptosis	17/1095	180/7206	0.0271629823745
ko04140	Autophagy - animal	15/1095	164/7206	0.0274690563743
ko04710	Circadian rhythm	12/1095	43/7206	0.0302867619094
ko05220	Chronic myeloid leukemia	6/1095	85/7206	0.0329554330828
ko05133	Pertussis	6/1095	87/7206	0.0337507805143
ko00982	Drug metabolism - cytochrome P450	1/1095	37/7206	0.0352048846221
ko04711	Circadian rhythm - fly	5/1095	13/7206	0.035792309666
ko00620	Pyruvate metabolism	2/1095	46/7206	0.0379835381787
ko00270	Cysteine and methionine metabolism	2/1095	47/7206	0.0386875117973
ko04142	Lysosome	14/1095	151/7206	0.039064846607
ko04626	Plant-pathogen interaction	6/1095	18/7206	0.0440854261116
ko04137	Mitophagy - animal	6/1095	82/7206	0.0440924211248
ko05212	Pancreatic cancer	6/1095	83/7206	0.0443187001531
ko03018	RNA degradation	6/1095	84/7206	0.045008525988
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1095	26/7206	0.0477641435905
ko00310	Lysine degradation	5/1095	73/7206	0.0480325458542
ko04115	p53 signaling pathway	5/1095	74/7206	0.0487324288731