ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1158	423/7206	1.57592362554e-53
ko05033	Nicotine addiction	49/1158	56/7206	3.82757684452e-32
ko04724	Glutamatergic synapse	87/1158	152/7206	1.0570089337e-31
ko04727	GABAergic synapse	68/1158	110/7206	8.96623954536e-28
ko05032	Morphine addiction	68/1158	110/7206	8.96623954536e-28
ko04713	Circadian entrainment	75/1158	136/7206	5.0368330403e-26
ko04728	Dopaminergic synapse	85/1158	185/7206	3.19448645437e-22
ko04721	Synaptic vesicle cycle	51/1158	80/7206	5.51118691474e-22
ko04725	Cholinergic synapse	76/1158	160/7206	4.64386380971e-21
ko04723	Retrograde endocannabinoid signaling	78/1158	175/7206	1.77114209555e-19
ko04911	Insulin secretion	59/1158	117/7206	3.55708255061e-18
ko04024	cAMP signaling pathway	102/1158	279/7206	2.22408397435e-17
ko04020	Calcium signaling pathway	98/1158	265/7206	3.31094393328e-17
ko04742	Taste transduction	38/1158	61/7206	3.38051892195e-16
ko04744	Phototransduction	26/1158	36/7206	8.78297869969e-14
ko04726	Serotonergic synapse	58/1158	137/7206	1.411408371e-13
ko04921	Oxytocin signaling pathway	74/1158	209/7206	4.27711139792e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1158	205/7206	1.2214248623e-11
ko04740	Olfactory transduction	38/1158	80/7206	3.80446584605e-11
ko05031	Amphetamine addiction	40/1158	91/7206	2.30179146487e-10
ko04970	Salivary secretion	41/1158	95/7206	2.73980018475e-10
ko03040	Spliceosome	1/1158	145/7206	3.16843828684e-10
ko04720	Long-term potentiation	41/1158	99/7206	1.25575038905e-09
ko04360	Axon guidance	71/1158	233/7206	2.91837221659e-08
ko05203	Viral carcinogenesis	15/1158	277/7206	6.00332758617e-08
ko04971	Gastric acid secretion	38/1158	98/7206	7.41985648037e-08
ko04925	Aldosterone synthesis and secretion	39/1158	105/7206	1.22030029694e-07
ko05030	Cocaine addiction	30/1158	73/7206	2.5827956543e-07
ko04972	Pancreatic secretion	39/1158	111/7206	6.78854643816e-07
ko05168	Herpes simplex infection	8/1158	182/7206	1.08238940679e-06
ko04060	Cytokine-cytokine receptor interaction	9/1158	191/7206	1.80166333166e-06
ko03013	RNA transport	7/1158	166/7206	2.82453111902e-06
ko05322	Systemic lupus erythematosus	6/1158	151/7206	4.97019711543e-06
ko04745	Phototransduction - fly	18/1158	38/7206	5.99405162601e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1158	74/7206	6.74493981964e-06
ko05164	Influenza A	8/1158	167/7206	9.11097265804e-06
ko04022	cGMP-PKG signaling pathway	60/1158	216/7206	1.16916799816e-05
ko04010	MAPK signaling pathway	81/1158	321/7206	1.64087058845e-05
ko04141	Protein processing in endoplasmic reticulum	11/1158	184/7206	3.996745843e-05
ko04514	Cell adhesion molecules (CAMs)	39/1158	130/7206	5.47336342095e-05
ko04966	Collecting duct acid secretion	13/1158	26/7206	5.9215619073e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1158	79/7206	7.13593914267e-05
ko04621	NOD-like receptor signaling pathway	9/1158	157/7206	0.000103387267996
ko04070	Phosphatidylinositol signaling system	34/1158	112/7206	0.000131680656597
ko05205	Proteoglycans in cancer	22/1158	271/7206	0.000133046931153
ko04730	Long-term depression	26/1158	78/7206	0.000141614695134
ko05110	Vibrio cholerae infection	22/1158	63/7206	0.000205311084436
ko04612	Antigen processing and presentation	2/1158	77/7206	0.00025873085621
ko04260	Cardiac muscle contraction	30/1158	98/7206	0.000261981705072
ko03008	Ribosome biogenesis in eukaryotes	2/1158	79/7206	0.000276229871539
ko04072	Phospholipase D signaling pathway	51/1158	197/7206	0.000354495313165
ko04120	Ubiquitin mediated proteolysis	8/1158	138/7206	0.000380267080291
ko05140	Leishmaniasis	2/1158	75/7206	0.000385436429347
ko04750	Inflammatory mediator regulation of TRP channels	35/1158	122/7206	0.000410352892134
ko04014	Ras signaling pathway	67/1158	279/7206	0.000449250615408
ko04110	Cell cycle	9/1158	145/7206	0.000527602303716
ko04540	Gap junction	36/1158	128/7206	0.000563389871323
ko05414	Dilated cardiomyopathy	32/1158	112/7206	0.00067480256914
ko04924	Renin secretion	26/1158	86/7206	0.000937597219705
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1158	59/7206	0.00095750539165
ko05162	Measles	7/1158	120/7206	0.00099444120166
ko05169	Epstein-Barr virus infection	17/1158	206/7206	0.00137803989633
ko04976	Bile secretion	24/1158	80/7206	0.00180558830282
ko04640	Hematopoietic cell lineage	2/1158	64/7206	0.00182586665956
ko04064	NF-kappa B signaling pathway	5/1158	96/7206	0.0018429626868
ko00330	Arginine and proline metabolism	2/1158	61/7206	0.00269407721353
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1158	182/7206	0.00282598560849
ko05161	Hepatitis B	14/1158	173/7206	0.00311178648657
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1158	14/7206	0.00328626291987
ko00240	Pyrimidine metabolism	7/1158	110/7206	0.00362949564296
ko04964	Proximal tubule bicarbonate reclamation	11/1158	29/7206	0.00368835228935
ko00260	Glycine, serine and threonine metabolism	1/1158	48/7206	0.00464156650025
ko05219	Bladder cancer	1/1158	48/7206	0.00464156650025
ko04371	Apelin signaling pathway	43/1158	177/7206	0.00484247052371
ko04657	IL-17 signaling pathway	5/1158	87/7206	0.00504810008227
ko04146	Peroxisome	5/1158	89/7206	0.00517441372994
ko05166	HTLV-I infection	30/1158	292/7206	0.00549520042218
ko05321	Inflammatory bowel disease (IBD)	2/1158	56/7206	0.00576436961149
ko03022	Basal transcription factors	1/1158	44/7206	0.00671043251049
ko05144	Malaria	1/1158	45/7206	0.00682998024166
ko00071	Fatty acid degradation	1/1158	45/7206	0.00682998024166
ko04658	Th1 and Th2 cell differentiation	6/1158	96/7206	0.00714649176254
ko03420	Nucleotide excision repair	1/1158	46/7206	0.00719329106706
ko04915	Estrogen signaling pathway	33/1158	131/7206	0.00771404017071
ko00480	Glutathione metabolism	2/1158	55/7206	0.00860505851497
ko05131	Shigellosis	5/1158	82/7206	0.00972607735773
ko00310	Lysine degradation	4/1158	73/7206	0.00973597045148
ko00140	Steroid hormone biosynthesis	1/1158	41/7206	0.0100770089211
ko03018	RNA degradation	5/1158	84/7206	0.0100856835164
ko04630	Jak-STAT signaling pathway	11/1158	132/7206	0.0117843926137
ko00590	Arachidonic acid metabolism	2/1158	52/7206	0.0123738762186
ko04622	RIG-I-like receptor signaling pathway	3/1158	62/7206	0.0136152769813
ko04214	Apoptosis - fly	4/1158	72/7206	0.0141767118574
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1158	40/7206	0.0153607904722
ko04626	Plant-pathogen interaction	7/1158	18/7206	0.0169319665487
ko05133	Pertussis	6/1158	87/7206	0.0177749984249
ko05215	Prostate cancer	9/1158	111/7206	0.0186684393878
ko00562	Inositol phosphate metabolism	23/1158	89/7206	0.0188910482853
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1158	100/7206	0.0191969075967
ko03320	PPAR signaling pathway	4/1158	69/7206	0.0195298520172
ko00982	Drug metabolism - cytochrome P450	1/1158	37/7206	0.0226157857348
ko04210	Apoptosis	18/1158	180/7206	0.023450247399
ko00630	Glyoxylate and dicarboxylate metabolism	1/1158	38/7206	0.0235176067313
ko03410	Base excision repair	1/1158	38/7206	0.0235176067313
ko04140	Autophagy - animal	16/1158	164/7206	0.0237509851936
ko04115	p53 signaling pathway	5/1158	74/7206	0.0253109969377
ko04620	Toll-like receptor signaling pathway	8/1158	100/7206	0.027238035771
ko04217	Necroptosis	18/1158	178/7206	0.0294234290979
ko04015	Rap1 signaling pathway	58/1158	278/7206	0.0301935974985
ko04330	Notch signaling pathway	4/1158	62/7206	0.0364612616826
ko01200	Carbon metabolism	12/1158	128/7206	0.0383396746877
ko00280	Valine, leucine and isoleucine degradation	3/1158	54/7206	0.038342554308
ko04918	Thyroid hormone synthesis	21/1158	86/7206	0.0387916438654
ko04510	Focal adhesion	27/1158	240/7206	0.0394901842805
ko04670	Leukocyte transendothelial migration	15/1158	151/7206	0.0429114269339
ko04923	Regulation of lipolysis in adipocytes	19/1158	77/7206	0.0431272478685
ko04711	Circadian rhythm - fly	5/1158	13/7206	0.0444057768623
ko05418	Fluid shear stress and atherosclerosis	18/1158	173/7206	0.0456598594
ko04912	GnRH signaling pathway	28/1158	122/7206	0.0457144187585
ko05016	Huntington's disease	24/1158	215/7206	0.047522370649
ko04113	Meiosis - yeast	5/1158	70/7206	0.0476608305186
ko05145	Toxoplasmosis	12/1158	126/7206	0.0491524023976
ko04218	Cellular senescence	19/1158	177/7206	0.049153249987