ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1178	423/7206	1.57930765305e-51
ko04724	Glutamatergic synapse	91/1178	152/7206	1.11298123238e-34
ko05033	Nicotine addiction	50/1178	56/7206	2.30361644835e-33
ko05032	Morphine addiction	70/1178	110/7206	3.1450046628e-29
ko04713	Circadian entrainment	78/1178	136/7206	4.56037601399e-28
ko04727	GABAergic synapse	65/1178	110/7206	1.45085520434e-24
ko04728	Dopaminergic synapse	84/1178	185/7206	4.78146264272e-21
ko04024	cAMP signaling pathway	107/1178	279/7206	1.4751339296e-19
ko04723	Retrograde endocannabinoid signaling	78/1178	175/7206	5.13293473476e-19
ko04725	Cholinergic synapse	73/1178	160/7206	1.43001062085e-18
ko04020	Calcium signaling pathway	98/1178	265/7206	1.27016081668e-16
ko04721	Synaptic vesicle cycle	45/1178	80/7206	3.16310949843e-16
ko04726	Serotonergic synapse	60/1178	137/7206	1.82716247241e-14
ko04911	Insulin secretion	54/1178	117/7206	2.62728649019e-14
ko04921	Oxytocin signaling pathway	78/1178	209/7206	1.20373123117e-13
ko05031	Amphetamine addiction	44/1178	91/7206	8.98252243757e-13
ko04744	Phototransduction	25/1178	36/7206	1.66444391887e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1178	205/7206	9.11572076339e-12
ko04742	Taste transduction	33/1178	61/7206	1.30656941285e-11
ko04720	Long-term potentiation	44/1178	99/7206	3.28300632604e-11
ko03040	Spliceosome	1/1178	145/7206	1.94449142043e-10
ko03010	Ribosome	1/1178	129/7206	4.13689881497e-09
ko04022	cGMP-PKG signaling pathway	69/1178	216/7206	1.00636483377e-08
ko04360	Axon guidance	72/1178	233/7206	2.16753621032e-08
ko04925	Aldosterone synthesis and secretion	41/1178	105/7206	2.29017441844e-08
ko05030	Cocaine addiction	32/1178	73/7206	2.44765819662e-08
ko04970	Salivary secretion	38/1178	95/7206	2.58625148004e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1178	74/7206	1.44152790001e-07
ko05322	Systemic lupus erythematosus	5/1178	151/7206	5.80682454002e-07
ko05203	Viral carcinogenesis	18/1178	277/7206	8.05299877417e-07
ko04070	Phosphatidylinositol signaling system	39/1178	112/7206	1.71189797184e-06
ko03013	RNA transport	7/1178	166/7206	1.91381761581e-06
ko04010	MAPK signaling pathway	85/1178	321/7206	2.91700958476e-06
ko04740	Olfactory transduction	30/1178	80/7206	4.31951027023e-06
ko04072	Phospholipase D signaling pathway	57/1178	197/7206	8.18351089108e-06
ko05168	Herpes simplex infection	10/1178	182/7206	1.0117054701e-05
ko04060	Cytokine-cytokine receptor interaction	11/1178	191/7206	1.05269941876e-05
ko04971	Gastric acid secretion	34/1178	98/7206	1.11061665354e-05
ko04730	Long-term depression	27/1178	78/7206	7.33795698638e-05
ko05164	Influenza A	10/1178	167/7206	7.42160287548e-05
ko04514	Cell adhesion molecules (CAMs)	39/1178	130/7206	9.7680161954e-05
ko04014	Ras signaling pathway	70/1178	279/7206	0.000133051598484
ko04745	Phototransduction - fly	16/1178	38/7206	0.000144229107204
ko04972	Pancreatic secretion	34/1178	111/7206	0.000144619764088
ko03008	Ribosome biogenesis in eukaryotes	2/1178	79/7206	0.000171733224882
ko04141	Protein processing in endoplasmic reticulum	13/1178	184/7206	0.000244565078148
ko05162	Measles	6/1178	120/7206	0.000246925253168
ko04621	NOD-like receptor signaling pathway	10/1178	157/7206	0.000270684008636
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1178	79/7206	0.000304262357342
ko04110	Cell cycle	9/1178	145/7206	0.000374663436235
ko04915	Estrogen signaling pathway	37/1178	131/7206	0.000488548679386
ko04924	Renin secretion	27/1178	86/7206	0.000565746159226
ko05169	Epstein-Barr virus infection	17/1178	206/7206	0.000777684031877
ko04626	Plant-pathogen interaction	9/1178	18/7206	0.000962923703072
ko04923	Regulation of lipolysis in adipocytes	24/1178	77/7206	0.00101253948197
ko04610	Complement and coagulation cascades	3/1178	79/7206	0.00105748893386
ko04064	NF-kappa B signaling pathway	5/1178	96/7206	0.00128374000009
ko04540	Gap junction	35/1178	128/7206	0.00152757707782
ko04612	Antigen processing and presentation	3/1178	77/7206	0.00157292370871
ko04371	Apelin signaling pathway	45/1178	177/7206	0.00186440444843
ko00590	Arachidonic acid metabolism	1/1178	52/7206	0.00200039042546
ko04260	Cardiac muscle contraction	28/1178	98/7206	0.00217841403996
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1178	59/7206	0.00225288844988
ko04930	Type II diabetes mellitus	18/1178	54/7206	0.00235514091815
ko05414	Dilated cardiomyopathy	31/1178	112/7206	0.00270863280518
ko05205	Proteoglycans in cancer	27/1178	271/7206	0.00324138616976
ko04146	Peroxisome	5/1178	89/7206	0.00356901974189
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1178	14/7206	0.00363457363372
ko03420	Nucleotide excision repair	1/1178	46/7206	0.0044159938286
ko05110	Vibrio cholerae infection	19/1178	63/7206	0.00553439247102
ko04966	Collecting duct acid secretion	10/1178	26/7206	0.00562275123647
ko05321	Inflammatory bowel disease (IBD)	2/1178	56/7206	0.00571641539716
ko04750	Inflammatory mediator regulation of TRP channels	32/1178	122/7206	0.00609658438454
ko03022	Basal transcription factors	1/1178	44/7206	0.00669107570794
ko04115	p53 signaling pathway	4/1178	74/7206	0.00683054023122
ko05144	Malaria	1/1178	45/7206	0.00699631770677
ko00071	Fatty acid degradation	1/1178	45/7206	0.00699631770677
ko04270	Vascular smooth muscle contraction	38/1178	154/7206	0.00777567911715
ko00240	Pyrimidine metabolism	8/1178	110/7206	0.00869431071224
ko04622	RIG-I-like receptor signaling pathway	3/1178	62/7206	0.00922737237583
ko00562	Inositol phosphate metabolism	24/1178	89/7206	0.00924124045794
ko04976	Bile secretion	22/1178	80/7206	0.00962103463365
ko04710	Circadian rhythm	14/1178	43/7206	0.0108601993443
ko04922	Glucagon signaling pathway	32/1178	128/7206	0.0109000429823
ko04711	Circadian rhythm - fly	6/1178	13/7206	0.0114506069348
ko05231	Choline metabolism in cancer	33/1178	134/7206	0.012774356087
ko03320	PPAR signaling pathway	4/1178	69/7206	0.0134748861882
ko00330	Arginine and proline metabolism	3/1178	61/7206	0.013488824107
ko04120	Ubiquitin mediated proteolysis	12/1178	138/7206	0.01400686169
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1178	182/7206	0.0147006523071
ko03410	Base excision repair	1/1178	38/7206	0.0148682234414
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1178	40/7206	0.0157125320755
ko05161	Hepatitis B	17/1178	173/7206	0.0165446816647
ko03018	RNA degradation	6/1178	84/7206	0.0174429864697
ko04912	GnRH signaling pathway	30/1178	122/7206	0.0182818944354
ko05140	Leishmaniasis	5/1178	75/7206	0.0183036599668
ko04964	Proximal tubule bicarbonate reclamation	10/1178	29/7206	0.0189107664181
ko04722	Neurotrophin signaling pathway	37/1178	160/7206	0.022967965805
ko04217	Necroptosis	18/1178	178/7206	0.0233948682714
ko05131	Shigellosis	6/1178	82/7206	0.0236300491021
ko05016	Huntington's disease	23/1178	215/7206	0.0241425898806
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1178	15/7206	0.0249453637263
ko00310	Lysine degradation	5/1178	73/7206	0.0251150527153
ko00280	Valine, leucine and isoleucine degradation	3/1178	54/7206	0.0264440638994
ko00480	Glutathione metabolism	3/1178	55/7206	0.026587275815
ko05222	Small cell lung cancer	7/1178	89/7206	0.0294853230543
ko04015	Rap1 signaling pathway	59/1178	278/7206	0.0310992105363
ko04210	Apoptosis	19/1178	180/7206	0.0319383347392
ko04510	Focal adhesion	27/1178	240/7206	0.0326135947739
ko04113	Meiosis - yeast	5/1178	70/7206	0.034217256031
ko04658	Th1 and Th2 cell differentiation	8/1178	96/7206	0.0358401798804
ko04114	Oocyte meiosis	32/1178	139/7206	0.0368023117676
ko05145	Toxoplasmosis	12/1178	126/7206	0.0380918744328
ko04657	IL-17 signaling pathway	7/1178	87/7206	0.0396232259411
ko05133	Pertussis	7/1178	87/7206	0.0396232259411
ko05034	Alcoholism	51/1178	238/7206	0.0397785569589
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1178	100/7206	0.0413675390574
ko04630	Jak-STAT signaling pathway	13/1178	132/7206	0.0428771752686
ko05130	Pathogenic Escherichia coli infection	6/1178	77/7206	0.0428986531096
ko05166	HTLV-I infection	35/1178	292/7206	0.0430113490984
ko00230	Purine metabolism	42/1178	194/7206	0.04868196683
ko05230	Central carbon metabolism in cancer	20/1178	81/7206	0.0487634389117
ko05340	Primary immunodeficiency	1/1178	30/7206	0.0493069898668