ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 46/459 134/7206 1.25208220277e-22 ko04621 NOD-like receptor signaling pathway 42/459 157/7206 3.15803569572e-16 ko04668 TNF signaling pathway 35/459 120/7206 5.89371508867e-15 ko04060 Cytokine-cytokine receptor interaction 44/459 191/7206 2.32344342033e-14 ko04064 NF-kappa B signaling pathway 29/459 96/7206 5.01111566145e-13 ko04630 Jak-STAT signaling pathway 33/459 132/7206 4.29980298974e-12 ko05168 Herpes simplex infection 37/459 182/7206 1.51593032357e-10 ko04659 Th17 cell differentiation 27/459 106/7206 2.56836636058e-10 ko05140 Leishmaniasis 22/459 75/7206 6.53745586338e-10 ko05164 Influenza A 34/459 167/7206 8.35323526895e-10 ko04620 Toll-like receptor signaling pathway 25/459 100/7206 1.83825275607e-09 ko04658 Th1 and Th2 cell differentiation 24/459 96/7206 3.9063896133e-09 ko05321 Inflammatory bowel disease (IBD) 18/459 56/7206 4.74794280006e-09 ko05162 Measles 27/459 120/7206 5.0057763131e-09 ko05161 Hepatitis B 33/459 173/7206 8.45580682011e-09 ko04217 Necroptosis 32/459 178/7206 6.2760790772e-08 ko04657 IL-17 signaling pathway 21/459 87/7206 7.23291513676e-08 ko04662 B cell receptor signaling pathway 21/459 88/7206 8.94794613682e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 33/459 191/7206 1.04533576219e-07 ko04660 T cell receptor signaling pathway 25/459 124/7206 1.86956738748e-07 ko05145 Toxoplasmosis 25/459 126/7206 2.58591085022e-07 ko04210 Apoptosis 31/459 180/7206 2.77385706319e-07 ko04622 RIG-I-like receptor signaling pathway 16/459 62/7206 1.01041876414e-06 ko00120 Primary bile acid biosynthesis 9/459 20/7206 1.42619685107e-06 ko04623 Cytosolic DNA-sensing pathway 12/459 41/7206 5.58311234754e-06 ko05142 Chagas disease (American trypanosomiasis) 23/459 130/7206 6.17654360899e-06 ko04610 Complement and coagulation cascades 17/459 79/7206 6.98703096351e-06 ko04650 Natural killer cell mediated cytotoxicity 19/459 97/7206 8.76543626635e-06 ko05340 Primary immunodeficiency 10/459 30/7206 9.4096495465e-06 ko05152 Tuberculosis 29/459 187/7206 9.90312875898e-06 ko05160 Hepatitis C 25/459 153/7206 1.0596010712e-05 ko04933 AGE-RAGE signaling pathway in diabetic complications 23/459 135/7206 1.18342782286e-05 ko05133 Pertussis 17/459 87/7206 2.68922295179e-05 ko05323 Rheumatoid arthritis 17/459 89/7206 3.65905411452e-05 ko05166 HTLV-I infection 37/459 292/7206 4.3781330018e-05 ko05150 Staphylococcus aureus infection 10/459 36/7206 5.62719375409e-05 ko04611 Platelet activation 23/459 163/7206 0.000261885266566 ko04672 Intestinal immune network for IgA production 9/459 37/7206 0.00039872099913 ko05144 Malaria 10/459 45/7206 0.000420586796745 ko04920 Adipocytokine signaling pathway 15/459 89/7206 0.000440997488237 ko05134 Legionellosis 13/459 74/7206 0.000698462517261 ko00643 Styrene degradation 3/459 4/7206 0.000978647773535 ko05034 Alcoholism 4/459 238/7206 0.00101183449763 ko04724 Glutamatergic synapse 1/459 152/7206 0.00106576463395 ko04062 Chemokine signaling pathway 25/459 201/7206 0.00109200001681 ko04723 Retrograde endocannabinoid signaling 2/459 175/7206 0.00143336088625 ko04666 Fc gamma R-mediated phagocytosis 17/459 122/7206 0.00206527365088 ko05212 Pancreatic cancer 13/459 83/7206 0.00209095433168 ko04114 Oocyte meiosis 1/459 139/7206 0.00225697381546 ko05016 Huntington's disease 4/459 215/7206 0.00270755119562 ko04917 Prolactin signaling pathway 13/459 87/7206 0.00320706027223 ko04624 Toll and Imd signaling pathway 9/459 49/7206 0.00333225271307 ko00360 Phenylalanine metabolism 5/459 17/7206 0.00334516691279 ko04728 Dopaminergic synapse 3/459 185/7206 0.00343894862368 ko05169 Epstein-Barr virus infection 24/459 206/7206 0.00347910729945 ko00350 Tyrosine metabolism 7/459 33/7206 0.0040735501823 ko05132 Salmonella infection 14/459 98/7206 0.00497202466383 ko00040 Pentose and glucuronate interconversions 6/459 26/7206 0.00498207499606 ko05131 Shigellosis 12/459 82/7206 0.00540732460827 ko04640 Hematopoietic cell lineage 10/459 64/7206 0.00674802770551 ko04932 Non-alcoholic fatty liver disease (NAFLD) 21/459 182/7206 0.00797168699733 ko04916 Melanogenesis 2/459 142/7206 0.00847184882233 ko04612 Antigen processing and presentation 11/459 77/7206 0.00908364129261 ko04727 GABAergic synapse 1/459 110/7206 0.00980152456005 ko05418 Fluid shear stress and atherosclerosis 20/459 173/7206 0.0103720663291 ko04218 Cellular senescence 20/459 177/7206 0.0115826658986 ko04713 Circadian entrainment 2/459 136/7206 0.0120413353388 ko04726 Serotonergic synapse 2/459 137/7206 0.0121290407241 ko05222 Small cell lung cancer 12/459 89/7206 0.0131176587157 ko04360 Axon guidance 6/459 233/7206 0.0132330399759 ko05143 African trypanosomiasis 6/459 32/7206 0.0141933529071 ko05120 Epithelial cell signaling in Helicobacter pylori infection 12/459 92/7206 0.0155952009605 ko04072 Phospholipase D signaling pathway 21/459 197/7206 0.0174241854702 ko05012 Parkinson's disease 3/459 155/7206 0.0184622007881 ko04137 Mitophagy - animal 11/459 82/7206 0.0187100937579 ko04931 Insulin resistance 16/459 137/7206 0.0193509342386 ko04720 Long-term potentiation 1/459 99/7206 0.0207585016981 ko00920 Sulfur metabolism 3/459 10/7206 0.0220029404126 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/459 4/7206 0.0222880417598 ko04068 FoxO signaling pathway 18/459 167/7206 0.0242295673474 ko05332 Graft-versus-host disease 4/459 18/7206 0.0243318992537 ko04115 p53 signaling pathway 10/459 74/7206 0.0256616004388 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/459 11/7206 0.0288510249365 ko05146 Amoebiasis 12/459 99/7206 0.0338620232459 ko04010 MAPK signaling pathway 30/459 321/7206 0.0342626853256 ko00281 Geraniol degradation 2/459 5/7206 0.0355928517607 ko01523 Antifolate resistance 5/459 30/7206 0.0390139326014 ko04144 Endocytosis 31/459 342/7206 0.0410195939359 ko00140 Steroid hormone biosynthesis 6/459 41/7206 0.0436092419405 ko05200 Pathways in cancer 42/459 492/7206 0.0446790277294 ko00590 Arachidonic acid metabolism 7/459 52/7206 0.0453016628876 ko04940 Type I diabetes mellitus 5/459 32/7206 0.0497290674188