ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1153	423/7206	4.28154922142e-46
ko04724	Glutamatergic synapse	90/1153	152/7206	1.55643159998e-34
ko05033	Nicotine addiction	48/1153	56/7206	1.04336990227e-30
ko05032	Morphine addiction	68/1153	110/7206	6.85174725872e-28
ko04713	Circadian entrainment	75/1153	136/7206	3.78530917889e-26
ko04727	GABAergic synapse	66/1153	110/7206	5.09986361821e-26
ko04728	Dopaminergic synapse	85/1153	185/7206	2.36657951814e-22
ko04725	Cholinergic synapse	77/1153	160/7206	6.92372451803e-22
ko04723	Retrograde endocannabinoid signaling	81/1153	175/7206	1.34243064318e-21
ko04721	Synaptic vesicle cycle	45/1153	80/7206	1.36142859026e-16
ko04020	Calcium signaling pathway	95/1153	265/7206	8.04495909599e-16
ko04911	Insulin secretion	55/1153	117/7206	2.1577355632e-15
ko04742	Taste transduction	37/1153	61/7206	2.51422339337e-15
ko04744	Phototransduction	27/1153	36/7206	5.40386393167e-15
ko04921	Oxytocin signaling pathway	78/1153	209/7206	3.02376942357e-14
ko04024	cAMP signaling pathway	95/1153	279/7206	4.11340690358e-14
ko04726	Serotonergic synapse	58/1153	137/7206	1.16323142407e-13
ko05031	Amphetamine addiction	41/1153	91/7206	4.57837197022e-11
ko04720	Long-term potentiation	43/1153	99/7206	6.72662392424e-11
ko04740	Olfactory transduction	37/1153	80/7206	1.60458717425e-10
ko04970	Salivary secretion	40/1153	95/7206	9.7262396798e-10
ko04261	Adrenergic signaling in cardiomyocytes	65/1153	205/7206	1.72621827181e-08
ko04925	Aldosterone synthesis and secretion	40/1153	105/7206	4.00012738339e-08
ko03040	Spliceosome	3/1153	145/7206	6.0403845634e-08
ko04971	Gastric acid secretion	37/1153	98/7206	1.64502548136e-07
ko03013	RNA transport	6/1153	166/7206	5.32633502477e-07
ko05322	Systemic lupus erythematosus	5/1153	151/7206	8.89767781237e-07
ko04745	Phototransduction - fly	19/1153	38/7206	1.08907290386e-06
ko05168	Herpes simplex infection	8/1153	182/7206	1.61135606229e-06
ko04621	NOD-like receptor signaling pathway	6/1153	157/7206	2.40769418999e-06
ko05030	Cocaine addiction	28/1153	73/7206	3.06264232113e-06
ko05203	Viral carcinogenesis	19/1153	277/7206	5.21018330375e-06
ko04972	Pancreatic secretion	37/1153	111/7206	5.31018786413e-06
ko04120	Ubiquitin mediated proteolysis	5/1153	138/7206	5.87201034905e-06
ko04730	Long-term depression	28/1153	78/7206	1.46662659425e-05
ko04010	MAPK signaling pathway	81/1153	321/7206	1.56656430804e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1153	74/7206	1.59429584246e-05
ko04022	cGMP-PKG signaling pathway	59/1153	216/7206	1.79484580935e-05
ko04514	Cell adhesion molecules (CAMs)	40/1153	130/7206	2.79165318272e-05
ko04072	Phospholipase D signaling pathway	54/1153	197/7206	4.29836418643e-05
ko04966	Collecting duct acid secretion	13/1153	26/7206	5.65063120269e-05
ko04540	Gap junction	38/1153	128/7206	7.95874635972e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1153	122/7206	8.26589485734e-05
ko05164	Influenza A	10/1153	167/7206	0.000105367697411
ko04110	Cell cycle	8/1153	145/7206	0.000204077323149
ko03008	Ribosome biogenesis in eukaryotes	2/1153	79/7206	0.000272051192545
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1153	79/7206	0.000512796192524
ko04064	NF-kappa B signaling pathway	4/1153	96/7206	0.000612555264554
ko04070	Phosphatidylinositol signaling system	32/1153	112/7206	0.000642312131913
ko04360	Axon guidance	57/1153	233/7206	0.000715650256192
ko04014	Ras signaling pathway	66/1153	279/7206	0.000804685677421
ko04924	Renin secretion	26/1153	86/7206	0.000905572387644
ko04141	Protein processing in endoplasmic reticulum	14/1153	184/7206	0.00101823099203
ko04060	Cytokine-cytokine receptor interaction	15/1153	191/7206	0.00125479431395
ko00520	Amino sugar and nucleotide sugar metabolism	1/1153	55/7206	0.00132694827756
ko04612	Antigen processing and presentation	3/1153	77/7206	0.0015292916518
ko04915	Estrogen signaling pathway	35/1153	131/7206	0.00158360803954
ko05110	Vibrio cholerae infection	20/1153	63/7206	0.00159017101427
ko04976	Bile secretion	24/1153	80/7206	0.00175995676615
ko05140	Leishmaniasis	3/1153	75/7206	0.00223208423039
ko05205	Proteoglycans in cancer	26/1153	271/7206	0.00231820243226
ko05016	Huntington's disease	19/1153	215/7206	0.00243403795256
ko05169	Epstein-Barr virus infection	18/1153	206/7206	0.00269775852226
ko05161	Hepatitis B	14/1153	173/7206	0.00307949065073
ko04260	Cardiac muscle contraction	27/1153	98/7206	0.00325250968051
ko04371	Apelin signaling pathway	43/1153	177/7206	0.00353842028782
ko04964	Proximal tubule bicarbonate reclamation	11/1153	29/7206	0.00356239040835
ko05414	Dilated cardiomyopathy	30/1153	112/7206	0.00382752425412
ko04626	Plant-pathogen interaction	8/1153	18/7206	0.00407276389622
ko04930	Type II diabetes mellitus	17/1153	54/7206	0.00428841548663
ko05219	Bladder cancer	1/1153	48/7206	0.0046126971846
ko04146	Peroxisome	5/1153	89/7206	0.00513710637103
ko05166	HTLV-I infection	30/1153	292/7206	0.00545871873927
ko04630	Jak-STAT signaling pathway	10/1153	132/7206	0.0055930572794
ko04710	Circadian rhythm	14/1153	43/7206	0.0059524318242
ko03022	Basal transcription factors	1/1153	44/7206	0.00673564256666
ko05144	Malaria	1/1153	45/7206	0.00681022405729
ko00071	Fatty acid degradation	1/1153	45/7206	0.00681022405729
ko03420	Nucleotide excision repair	1/1153	46/7206	0.0071248919791
ko04916	Melanogenesis	35/1153	142/7206	0.00740332432274
ko05162	Measles	9/1153	120/7206	0.00802063142807
ko00280	Valine, leucine and isoleucine degradation	2/1153	54/7206	0.00842798587727
ko00240	Pyrimidine metabolism	8/1153	110/7206	0.00858565316901
ko04217	Necroptosis	16/1153	178/7206	0.00924132551352
ko00310	Lysine degradation	4/1153	73/7206	0.00974933526445
ko05131	Shigellosis	5/1153	82/7206	0.00976196184998
ko04960	Aldosterone-regulated sodium reabsorption	13/1153	41/7206	0.0100112321107
ko04270	Vascular smooth muscle contraction	37/1153	154/7206	0.0100801579295
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1153	59/7206	0.0115679535801
ko00590	Arachidonic acid metabolism	2/1153	52/7206	0.0123473956364
ko04330	Notch signaling pathway	3/1153	62/7206	0.0135468044583
ko04622	RIG-I-like receptor signaling pathway	3/1153	62/7206	0.0135468044583
ko04214	Apoptosis - fly	4/1153	72/7206	0.0140583324913
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1153	14/7206	0.0156313178721
ko04658	Th1 and Th2 cell differentiation	7/1153	96/7206	0.0165832939861
ko04973	Carbohydrate digestion and absorption	13/1153	42/7206	0.0173161703945
ko04657	IL-17 signaling pathway	6/1153	87/7206	0.0177243832648
ko05133	Pertussis	6/1153	87/7206	0.0177243832648
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1153	100/7206	0.0187863381578
ko04610	Complement and coagulation cascades	5/1153	79/7206	0.0191926200165
ko03320	PPAR signaling pathway	4/1153	69/7206	0.0194104778129
ko04672	Intestinal immune network for IgA production	1/1153	37/7206	0.0225916852831
ko00630	Glyoxylate and dicarboxylate metabolism	1/1153	38/7206	0.023377060372
ko03410	Base excision repair	1/1153	38/7206	0.023377060372
ko04210	Apoptosis	18/1153	180/7206	0.0235035721047
ko03018	RNA degradation	6/1153	84/7206	0.0239338595194
ko04062	Chemokine signaling pathway	44/1153	201/7206	0.0246248740613
ko04115	p53 signaling pathway	5/1153	74/7206	0.0253631562436
ko05321	Inflammatory bowel disease (IBD)	3/1153	56/7206	0.0268198486437
ko04923	Regulation of lipolysis in adipocytes	20/1153	77/7206	0.0269310736757
ko04922	Glucagon signaling pathway	30/1153	128/7206	0.0276930883101
ko05214	Glioma	20/1153	79/7206	0.0299011934059
ko05231	Choline metabolism in cancer	31/1153	134/7206	0.0313314647678
ko04918	Thyroid hormone synthesis	21/1153	86/7206	0.0380140239622
ko04668	TNF signaling pathway	11/1153	120/7206	0.043483617772
ko04711	Circadian rhythm - fly	5/1153	13/7206	0.0436774954117
ko04912	GnRH signaling pathway	28/1153	122/7206	0.0451320811832
ko04666	Fc gamma R-mediated phagocytosis	28/1153	122/7206	0.0451320811832
ko04114	Oocyte meiosis	31/1153	139/7206	0.0466510811246
ko04962	Vasopressin-regulated water reabsorption	15/1153	58/7206	0.0473136513088
ko05145	Toxoplasmosis	12/1153	126/7206	0.0489896351049