ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 59/533 191/7206 1.28179928794e-22 ko04380 Osteoclast differentiation 40/533 134/7206 4.56704690655e-15 ko04621 NOD-like receptor signaling pathway 42/533 157/7206 6.41133564296e-14 ko04064 NF-kappa B signaling pathway 29/533 96/7206 2.13248781715e-11 ko05340 Primary immunodeficiency 16/533 30/7206 3.5478612762e-11 ko05164 Influenza A 39/533 167/7206 5.14226270133e-11 ko05321 Inflammatory bowel disease (IBD) 21/533 56/7206 1.40633458138e-10 ko04659 Th17 cell differentiation 29/533 106/7206 3.05984251872e-10 ko04650 Natural killer cell mediated cytotoxicity 27/533 97/7206 8.31738194418e-10 ko05140 Leishmaniasis 23/533 75/7206 1.89798269461e-09 ko04672 Intestinal immune network for IgA production 16/533 37/7206 1.92572667867e-09 ko04217 Necroptosis 37/533 178/7206 5.28186905527e-09 ko05145 Toxoplasmosis 30/533 126/7206 5.70093918357e-09 ko05162 Measles 29/533 120/7206 7.14615671376e-09 ko05168 Herpes simplex infection 37/533 182/7206 9.97566001344e-09 ko04640 Hematopoietic cell lineage 20/533 64/7206 1.52791691804e-08 ko04658 Th1 and Th2 cell differentiation 25/533 96/7206 1.5803315806e-08 ko05330 Allograft rejection 12/533 24/7206 2.82028430127e-08 ko04620 Toll-like receptor signaling pathway 25/533 100/7206 3.84643072439e-08 ko05152 Tuberculosis 36/533 187/7206 6.98746255982e-08 ko04612 Antigen processing and presentation 21/533 77/7206 9.5349933774e-08 ko05150 Staphylococcus aureus infection 14/533 36/7206 1.02765506681e-07 ko05332 Graft-versus-host disease 10/533 18/7206 1.14849712048e-07 ko05320 Autoimmune thyroid disease 12/533 29/7206 3.83583152408e-07 ko04660 T cell receptor signaling pathway 25/533 124/7206 3.04592695578e-06 ko00120 Primary bile acid biosynthesis 9/533 20/7206 4.97086115722e-06 ko05323 Rheumatoid arthritis 20/533 89/7206 5.34916782997e-06 ko04622 RIG-I-like receptor signaling pathway 16/533 62/7206 7.15844586035e-06 ko05161 Hepatitis B 30/533 173/7206 9.7304550163e-06 ko04630 Jak-STAT signaling pathway 25/533 132/7206 9.80267330201e-06 ko04940 Type I diabetes mellitus 11/533 32/7206 1.00743554273e-05 ko05310 Asthma 8/533 17/7206 1.13670602643e-05 ko04610 Complement and coagulation cascades 18/533 79/7206 1.28656306146e-05 ko05144 Malaria 13/533 45/7206 1.38038766834e-05 ko04723 Retrograde endocannabinoid signaling 1/533 175/7206 2.91983327597e-05 ko05133 Pertussis 18/533 87/7206 5.14843865691e-05 ko04668 TNF signaling pathway 22/533 120/7206 5.61055105158e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 30/533 191/7206 6.51546081137e-05 ko05142 Chagas disease (American trypanosomiasis) 23/533 130/7206 0.000109920208546 ko04062 Chemokine signaling pathway 30/533 201/7206 0.000178027519313 ko04611 Platelet activation 26/533 163/7206 0.000186527998249 ko04662 B cell receptor signaling pathway 17/533 88/7206 0.000201301639037 ko03040 Spliceosome 1/533 145/7206 0.000307022258094 ko00590 Arachidonic acid metabolism 12/533 52/7206 0.000315879546644 ko04210 Apoptosis 27/533 180/7206 0.000402257347496 ko05034 Alcoholism 5/533 238/7206 0.000558052771766 ko04623 Cytosolic DNA-sensing pathway 10/533 41/7206 0.000620940669205 ko04713 Circadian entrainment 1/533 136/7206 0.000686744656915 ko03010 Ribosome 1/533 129/7206 0.000979178778855 ko04145 Phagosome 24/533 162/7206 0.00111375133155 ko04724 Glutamatergic synapse 2/533 152/7206 0.00139931446291 ko00592 alpha-Linolenic acid metabolism 6/533 19/7206 0.00187738770774 ko00350 Tyrosine metabolism 8/533 33/7206 0.00225543014197 ko05160 Hepatitis C 22/533 153/7206 0.00249361198656 ko04137 Mitophagy - animal 14/533 82/7206 0.00250642609553 ko00140 Steroid hormone biosynthesis 9/533 41/7206 0.00255086944883 ko04728 Dopaminergic synapse 4/533 185/7206 0.00262165784591 ko05134 Legionellosis 13/533 74/7206 0.00272307109874 ko04916 Melanogenesis 2/533 142/7206 0.0029379626489 ko04972 Pancreatic secretion 1/533 111/7206 0.00305074850869 ko04310 Wnt signaling pathway 4/533 181/7206 0.00365393142554 ko05166 HTLV-I infection 35/533 292/7206 0.00405282850892 ko00950 Isoquinoline alkaloid biosynthesis 4/533 10/7206 0.00433552847035 ko05032 Morphine addiction 1/533 110/7206 0.00475152468371 ko00982 Drug metabolism - cytochrome P450 8/533 37/7206 0.00482798448598 ko00254 Aflatoxin biosynthesis 2/533 2/7206 0.00546148315381 ko05204 Chemical carcinogenesis 9/533 48/7206 0.00769487476042 ko00980 Metabolism of xenobiotics by cytochrome P450 8/533 40/7206 0.00790975043506 ko04550 Signaling pathways regulating pluripotency of stem cells 4/533 165/7206 0.00970955781727 ko04390 Hippo signaling pathway 5/533 188/7206 0.01007289832 ko04114 Oocyte meiosis 3/533 139/7206 0.0129400994059 ko03320 PPAR signaling pathway 11/533 69/7206 0.0165883281581 ko05132 Salmonella infection 14/533 98/7206 0.0170908880835 ko04514 Cell adhesion molecules (CAMs) 17/533 130/7206 0.017639391002 ko05224 Breast cancer 5/533 174/7206 0.017931248553 ko05416 Viral myocarditis 9/533 55/7206 0.0184440902585 ko04530 Tight junction 8/533 228/7206 0.0199279432491 ko04666 Fc gamma R-mediated phagocytosis 16/533 122/7206 0.0219895699279 ko04110 Cell cycle 4/533 145/7206 0.0246603350336 ko05418 Fluid shear stress and atherosclerosis 21/533 173/7206 0.0257055789702 ko04664 Fc epsilon RI signaling pathway 11/533 77/7206 0.027892281376 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/533 4/7206 0.0296372748244 ko00643 Styrene degradation 2/533 4/7206 0.0296372748244 ko00360 Phenylalanine metabolism 4/533 17/7206 0.0324940481466 ko00051 Fructose and mannose metabolism 7/533 42/7206 0.032649657269 ko04720 Long-term potentiation 2/533 99/7206 0.0328649954309 ko05016 Huntington's disease 8/533 215/7206 0.0337736429251 ko04657 IL-17 signaling pathway 12/533 87/7206 0.035307470535 ko04142 Lysosome 18/533 151/7206 0.0398566875241 ko04360 Axon guidance 9/533 233/7206 0.0403332496959 ko00010 Glycolysis / Gluconeogenesis 1/533 74/7206 0.0422505793737 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/533 5/7206 0.0469992230541 ko04911 Insulin secretion 3/533 117/7206 0.047459818132