ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 53/463 191/7206 7.15260128888e-21 ko04380 Osteoclast differentiation 43/463 134/7206 9.19724667263e-20 ko04621 NOD-like receptor signaling pathway 38/463 157/7206 3.7711554982e-13 ko04064 NF-kappa B signaling pathway 29/463 96/7206 6.25239453364e-13 ko05140 Leishmaniasis 25/463 75/7206 2.16835025053e-12 ko05340 Primary immunodeficiency 16/463 30/7206 4.12900829739e-12 ko05321 Inflammatory bowel disease (IBD) 21/463 56/7206 9.72409975395e-12 ko04659 Th17 cell differentiation 28/463 106/7206 5.70628572883e-11 ko05164 Influenza A 36/463 167/7206 6.01207554291e-11 ko05145 Toxoplasmosis 30/463 126/7206 1.92736255217e-10 ko04630 Jak-STAT signaling pathway 30/463 132/7206 6.51842636357e-10 ko04650 Natural killer cell mediated cytotoxicity 25/463 97/7206 1.10236903318e-09 ko05162 Measles 27/463 120/7206 6.04263467135e-09 ko05168 Herpes simplex infection 34/463 182/7206 1.0865889573e-08 ko04620 Toll-like receptor signaling pathway 24/463 100/7206 1.114082363e-08 ko05150 Staphylococcus aureus infection 14/463 36/7206 1.72367712707e-08 ko04217 Necroptosis 33/463 178/7206 2.19107965204e-08 ko05152 Tuberculosis 34/463 187/7206 2.21677246477e-08 ko04658 Th1 and Th2 cell differentiation 23/463 96/7206 2.34573640772e-08 ko04672 Intestinal immune network for IgA production 14/463 37/7206 2.61190232712e-08 ko04660 T cell receptor signaling pathway 26/463 124/7206 5.4580606756e-08 ko05330 Allograft rejection 11/463 24/7206 7.96425379001e-08 ko05133 Pertussis 21/463 87/7206 8.39726481622e-08 ko04640 Hematopoietic cell lineage 17/463 64/7206 3.33262096053e-07 ko05144 Malaria 14/463 45/7206 4.42503505954e-07 ko05161 Hepatitis B 30/463 173/7206 4.486001631e-07 ko05320 Autoimmune thyroid disease 11/463 29/7206 8.21818126032e-07 ko04612 Antigen processing and presentation 18/463 77/7206 1.18484648561e-06 ko00120 Primary bile acid biosynthesis 9/463 20/7206 1.53417412219e-06 ko04668 TNF signaling pathway 23/463 120/7206 1.72233362506e-06 ko04610 Complement and coagulation cascades 18/463 79/7206 1.76870847402e-06 ko04662 B cell receptor signaling pathway 19/463 88/7206 2.178228044e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 30/463 191/7206 3.83329144472e-06 ko05310 Asthma 8/463 17/7206 3.96936560777e-06 ko04622 RIG-I-like receptor signaling pathway 15/463 62/7206 5.88204522659e-06 ko05142 Chagas disease (American trypanosomiasis) 22/463 130/7206 2.33784824769e-05 ko04062 Chemokine signaling pathway 29/463 201/7206 3.09402878641e-05 ko05323 Rheumatoid arthritis 17/463 89/7206 4.08651582437e-05 ko05332 Graft-versus-host disease 7/463 18/7206 7.38273344532e-05 ko04623 Cytosolic DNA-sensing pathway 10/463 41/7206 0.000199778406112 ko04723 Retrograde endocannabinoid signaling 1/463 175/7206 0.000226501360895 ko04210 Apoptosis 25/463 180/7206 0.000269717470738 ko04611 Platelet activation 23/463 163/7206 0.000292724809622 ko04728 Dopaminergic synapse 2/463 185/7206 0.000685809562565 ko04724 Glutamatergic synapse 1/463 152/7206 0.000689747590488 ko05134 Legionellosis 13/463 74/7206 0.000757827481372 ko05034 Alcoholism 4/463 238/7206 0.00103990157779 ko05160 Hepatitis C 21/463 153/7206 0.00113573592931 ko04657 IL-17 signaling pathway 14/463 87/7206 0.00118535368669 ko04145 Phagosome 21/463 162/7206 0.0017686548033 ko04713 Circadian entrainment 1/463 136/7206 0.00219115994678 ko04664 Fc epsilon RI signaling pathway 12/463 77/7206 0.00343477445097 ko04940 Type I diabetes mellitus 7/463 32/7206 0.00356034446203 ko04310 Wnt signaling pathway 3/463 181/7206 0.0049808728937 ko05132 Salmonella infection 14/463 98/7206 0.00516775415993 ko00590 Arachidonic acid metabolism 9/463 52/7206 0.00533164724945 ko05131 Shigellosis 12/463 82/7206 0.00579036009437 ko00592 alpha-Linolenic acid metabolism 5/463 19/7206 0.00586763018609 ko05224 Breast cancer 3/463 174/7206 0.00691641960716 ko04916 Melanogenesis 2/463 142/7206 0.00852452049841 ko04012 ErbB signaling pathway 1/463 109/7206 0.00978505145469 ko04390 Hippo signaling pathway 4/463 188/7206 0.00987541192059 ko04080 Neuroactive ligand-receptor interaction 15/463 423/7206 0.0103546274551 ko04726 Serotonergic synapse 2/463 137/7206 0.012272066042 ko04360 Axon guidance 6/463 233/7206 0.0134704669949 ko00140 Steroid hormone biosynthesis 7/463 41/7206 0.0144463833521 ko05143 African trypanosomiasis 6/463 32/7206 0.0147682432702 ko04540 Gap junction 2/463 128/7206 0.0169740895174 ko05418 Fluid shear stress and atherosclerosis 19/463 173/7206 0.0182930324171 ko04933 AGE-RAGE signaling pathway in diabetic complications 16/463 135/7206 0.0189052540248 ko04020 Calcium signaling pathway 8/463 265/7206 0.0205470563397 ko00643 Styrene degradation 2/463 4/7206 0.0226611976431 ko00511 Other glycan degradation 5/463 26/7206 0.0229210435867 ko04912 GnRH signaling pathway 2/463 122/7206 0.023985973977 ko04110 Cell cycle 3/463 145/7206 0.025184980975 ko04142 Lysosome 17/463 151/7206 0.0268139844946 ko04514 Cell adhesion molecules (CAMs) 15/463 130/7206 0.0275505621513 ko05169 Epstein-Barr virus infection 21/463 206/7206 0.0304203296288 ko04911 Insulin secretion 2/463 117/7206 0.0340736033367 ko05146 Amoebiasis 12/463 99/7206 0.0347205733345 ko04114 Oocyte meiosis 3/463 139/7206 0.03474323422 ko04550 Signaling pathways regulating pluripotency of stem cells 4/463 165/7206 0.0347650569695 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/463 5/7206 0.0361750980507 ko04666 Fc gamma R-mediated phagocytosis 14/463 122/7206 0.0370067020202 ko05166 HTLV-I infection 28/463 292/7206 0.03702726557 ko01230 Biosynthesis of amino acids 1/463 85/7206 0.0431135557215 ko00051 Fructose and mannose metabolism 6/463 42/7206 0.0499863169516