ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1277	423/7206	8.19562222871e-52
ko04724	Glutamatergic synapse	88/1277	152/7206	2.99111163304e-29
ko05033	Nicotine addiction	48/1277	56/7206	1.31826526766e-28
ko05032	Morphine addiction	68/1277	110/7206	3.69363224261e-25
ko04713	Circadian entrainment	76/1277	136/7206	4.82436739363e-24
ko04727	GABAergic synapse	64/1277	110/7206	1.05152079564e-21
ko04728	Dopaminergic synapse	86/1277	185/7206	5.81562093067e-20
ko04725	Cholinergic synapse	78/1277	160/7206	9.27234173473e-20
ko04721	Synaptic vesicle cycle	49/1277	80/7206	3.29074365805e-18
ko04020	Calcium signaling pathway	105/1277	265/7206	1.57422616728e-17
ko04723	Retrograde endocannabinoid signaling	79/1277	175/7206	1.74915716536e-17
ko04911	Insulin secretion	59/1277	117/7206	4.25173316686e-16
ko04024	cAMP signaling pathway	104/1277	279/7206	2.47003508821e-15
ko04726	Serotonergic synapse	63/1277	137/7206	1.198633857e-14
ko04921	Oxytocin signaling pathway	82/1277	209/7206	9.84637846991e-14
ko04742	Taste transduction	36/1277	61/7206	5.13405309603e-13
ko05031	Amphetamine addiction	44/1277	91/7206	1.56653523553e-11
ko04720	Long-term potentiation	45/1277	99/7206	1.27512120659e-10
ko03010	Ribosome	1/1277	129/7206	5.77371585527e-10
ko03040	Spliceosome	3/1277	145/7206	3.79685250754e-09
ko04970	Salivary secretion	41/1277	95/7206	5.72877047847e-09
ko04925	Aldosterone synthesis and secretion	44/1277	105/7206	5.91105322355e-09
ko04744	Phototransduction	21/1277	36/7206	5.23124234318e-08
ko04971	Gastric acid secretion	40/1277	98/7206	6.27935168515e-08
ko05322	Systemic lupus erythematosus	5/1277	151/7206	6.80753687828e-08
ko04261	Adrenergic signaling in cardiomyocytes	68/1277	205/7206	6.99695779776e-08
ko05168	Herpes simplex infection	9/1277	182/7206	3.36764917156e-07
ko05030	Cocaine addiction	31/1277	73/7206	6.41862935621e-07
ko04022	cGMP-PKG signaling pathway	68/1277	216/7206	7.03574243186e-07
ko04740	Olfactory transduction	33/1277	80/7206	7.82338389e-07
ko03013	RNA transport	8/1277	166/7206	8.77250855354e-07
ko04730	Long-term depression	32/1277	78/7206	1.3021501515e-06
ko04966	Collecting duct acid secretion	15/1277	26/7206	5.37541114382e-06
ko04360	Axon guidance	69/1277	233/7206	6.82096166121e-06
ko04010	MAPK signaling pathway	88/1277	321/7206	1.23906734418e-05
ko04110	Cell cycle	8/1277	145/7206	2.21917302201e-05
ko04976	Bile secretion	30/1277	80/7206	2.25605550033e-05
ko04745	Phototransduction - fly	18/1277	38/7206	2.44337731232e-05
ko04972	Pancreatic secretion	38/1277	111/7206	2.46290352693e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1277	74/7206	3.91665028075e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1277	79/7206	4.53334739197e-05
ko04060	Cytokine-cytokine receptor interaction	14/1277	191/7206	4.57101611909e-05
ko04621	NOD-like receptor signaling pathway	10/1277	157/7206	4.75025648215e-05
ko04120	Ubiquitin mediated proteolysis	8/1277	138/7206	6.32775384455e-05
ko04540	Gap junction	41/1277	128/7206	8.88503295498e-05
ko05203	Viral carcinogenesis	26/1277	277/7206	0.000105761516452
ko04514	Cell adhesion molecules (CAMs)	41/1277	130/7206	0.000106345337087
ko04750	Inflammatory mediator regulation of TRP channels	39/1277	122/7206	0.000107339920294
ko05164	Influenza A	12/1277	167/7206	0.000124689552087
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1277	79/7206	0.000148964737713
ko04710	Circadian rhythm	18/1277	43/7206	0.000180846575712
ko04014	Ras signaling pathway	74/1277	279/7206	0.000213712777936
ko04070	Phosphatidylinositol signaling system	36/1277	112/7206	0.000234219606772
ko04141	Protein processing in endoplasmic reticulum	15/1277	184/7206	0.000265835599379
ko04072	Phospholipase D signaling pathway	55/1277	197/7206	0.000301895995393
ko04612	Antigen processing and presentation	3/1277	77/7206	0.000442605819664
ko05162	Measles	8/1277	120/7206	0.000646629117893
ko04964	Proximal tubule bicarbonate reclamation	13/1277	29/7206	0.000649212511742
ko04260	Cardiac muscle contraction	31/1277	98/7206	0.000734035058709
ko05169	Epstein-Barr virus infection	19/1277	206/7206	0.000790289221908
ko04371	Apelin signaling pathway	49/1277	177/7206	0.000918187177348
ko04922	Glucagon signaling pathway	38/1277	128/7206	0.000933994657277
ko04630	Jak-STAT signaling pathway	10/1277	132/7206	0.00115931729812
ko05110	Vibrio cholerae infection	22/1277	63/7206	0.00124658903572
ko04915	Estrogen signaling pathway	38/1277	131/7206	0.00162760854443
ko04924	Renin secretion	27/1277	86/7206	0.00165588663139
ko04916	Melanogenesis	40/1277	142/7206	0.001768260322
ko04930	Type II diabetes mellitus	19/1277	54/7206	0.00190261634147
ko05414	Dilated cardiomyopathy	33/1277	112/7206	0.00245785315547
ko05144	Malaria	1/1277	45/7206	0.00272740032841
ko03420	Nucleotide excision repair	1/1277	46/7206	0.00283408051476
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1277	59/7206	0.00291998451128
ko05131	Shigellosis	5/1277	82/7206	0.00331556339675
ko05140	Leishmaniasis	4/1277	75/7206	0.0033217986301
ko04960	Aldosterone-regulated sodium reabsorption	15/1277	41/7206	0.00343642338264
ko00520	Amino sugar and nucleotide sugar metabolism	2/1277	55/7206	0.00375822730717
ko04622	RIG-I-like receptor signaling pathway	3/1277	62/7206	0.00419568086936
ko03022	Basal transcription factors	1/1277	44/7206	0.00438029489662
ko04064	NF-kappa B signaling pathway	7/1277	96/7206	0.0045231681514
ko05161	Hepatitis B	17/1277	173/7206	0.00459424065087
ko04217	Necroptosis	18/1277	178/7206	0.00530260458452
ko04270	Vascular smooth muscle contraction	41/1277	154/7206	0.00530325835878
ko04912	GnRH signaling pathway	34/1277	122/7206	0.00553041484901
ko05145	Toxoplasmosis	11/1277	126/7206	0.00639357461118
ko04657	IL-17 signaling pathway	6/1277	87/7206	0.00660287378399
ko05133	Pertussis	6/1277	87/7206	0.00660287378399
ko04626	Plant-pathogen interaction	8/1277	18/7206	0.00775576707566
ko05205	Proteoglycans in cancer	32/1277	271/7206	0.00922833394641
ko03410	Base excision repair	1/1277	38/7206	0.00938937145822
ko04015	Rap1 signaling pathway	66/1277	278/7206	0.010135833343
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1277	100/7206	0.0114378823882
ko04146	Peroxisome	7/1277	89/7206	0.0114847109455
ko05321	Inflammatory bowel disease (IBD)	3/1277	56/7206	0.0126405869097
ko04658	Th1 and Th2 cell differentiation	8/1277	96/7206	0.0146091725545
ko04672	Intestinal immune network for IgA production	1/1277	37/7206	0.0149680458014
ko00240	Pyrimidine metabolism	10/1277	110/7206	0.0161287118741
ko04610	Complement and coagulation cascades	6/1277	79/7206	0.016758940595
ko04711	Circadian rhythm - fly	6/1277	13/7206	0.0169321274254
ko00071	Fatty acid degradation	2/1277	45/7206	0.0169768250788
ko04620	Toll-like receptor signaling pathway	9/1277	100/7206	0.0176439337306
ko04142	Lysosome	16/1277	151/7206	0.0177751897199
ko00590	Arachidonic acid metabolism	3/1277	52/7206	0.0178278382079
ko00280	Valine, leucine and isoleucine degradation	3/1277	54/7206	0.0182865765175
ko03018	RNA degradation	7/1277	84/7206	0.0209473175489
ko00860	Porphyrin and chlorophyll metabolism	1/1277	34/7206	0.0216579923268
ko04918	Thyroid hormone synthesis	24/1277	86/7206	0.021759633243
ko05231	Choline metabolism in cancer	34/1277	134/7206	0.0224126984315
ko05166	HTLV-I infection	37/1277	292/7206	0.0229353698723
ko05132	Salmonella infection	9/1277	98/7206	0.0232686469214
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1277	14/7206	0.0252724578107
ko04210	Apoptosis	21/1277	180/7206	0.0295897625301
ko00310	Lysine degradation	6/1277	73/7206	0.0305358258541
ko04115	p53 signaling pathway	6/1277	74/7206	0.0308434407012
ko05340	Primary immunodeficiency	1/1277	30/7206	0.0318431587134
ko04640	Hematopoietic cell lineage	5/1277	64/7206	0.0328882263584
ko05222	Small cell lung cancer	8/1277	89/7206	0.0347457378649
ko05219	Bladder cancer	3/1277	48/7206	0.0358042037667
ko04973	Carbohydrate digestion and absorption	13/1277	42/7206	0.0393580869317
ko04113	Meiosis - yeast	6/1277	70/7206	0.0411837056676
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1277	182/7206	0.0486182883252