ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	163/992	423/7206	1.12195624919e-39
ko04724	Glutamatergic synapse	77/992	152/7206	4.77866217125e-28
ko05033	Nicotine addiction	43/992	56/7206	1.30582663602e-26
ko05032	Morphine addiction	57/992	110/7206	1.21432215411e-21
ko04727	GABAergic synapse	55/992	110/7206	5.71781789865e-20
ko04713	Circadian entrainment	61/992	136/7206	5.47411996674e-19
ko04728	Dopaminergic synapse	72/992	185/7206	5.79777514994e-18
ko04725	Cholinergic synapse	64/992	160/7206	8.75194183615e-17
ko04723	Retrograde endocannabinoid signaling	66/992	175/7206	9.5289454534e-16
ko04721	Synaptic vesicle cycle	41/992	80/7206	1.11003137347e-15
ko04742	Taste transduction	34/992	61/7206	1.18516175688e-14
ko04726	Serotonergic synapse	53/992	137/7206	2.1182124675e-13
ko04911	Insulin secretion	47/992	117/7206	9.98893191197e-13
ko04024	cAMP signaling pathway	82/992	279/7206	4.15969876186e-12
ko04020	Calcium signaling pathway	72/992	265/7206	5.02862366958e-09
ko04261	Adrenergic signaling in cardiomyocytes	60/992	205/7206	5.97302631001e-09
ko03040	Spliceosome	1/992	145/7206	1.44491984847e-08
ko04744	Phototransduction	19/992	36/7206	3.11006773141e-08
ko05031	Amphetamine addiction	33/992	91/7206	5.0261799957e-08
ko04360	Axon guidance	63/992	233/7206	5.73916491598e-08
ko04921	Oxytocin signaling pathway	58/992	209/7206	6.41197674988e-08
ko05203	Viral carcinogenesis	12/992	277/7206	2.66162198928e-07
ko05030	Cocaine addiction	27/992	73/7206	5.24320119945e-07
ko04514	Cell adhesion molecules (CAMs)	39/992	130/7206	1.09887727971e-06
ko04740	Olfactory transduction	28/992	80/7206	1.19378498385e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/992	74/7206	2.63577500591e-06
ko03013	RNA transport	5/992	166/7206	3.55906286685e-06
ko04720	Long-term potentiation	31/992	99/7206	5.27097680617e-06
ko05322	Systemic lupus erythematosus	4/992	151/7206	6.19939396725e-06
ko04010	MAPK signaling pathway	73/992	321/7206	9.16239212356e-06
ko05164	Influenza A	6/992	167/7206	1.87271035123e-05
ko04970	Salivary secretion	29/992	95/7206	2.85107520071e-05
ko04621	NOD-like receptor signaling pathway	6/992	157/7206	5.27805377359e-05
ko04060	Cytokine-cytokine receptor interaction	9/992	191/7206	6.59368944385e-05
ko04972	Pancreatic secretion	31/992	111/7206	7.23619969232e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/992	79/7206	0.000104937466488
ko04141	Protein processing in endoplasmic reticulum	9/992	184/7206	0.000124455280363
ko04120	Ubiquitin mediated proteolysis	5/992	138/7206	0.000138952877296
ko04971	Gastric acid secretion	28/992	98/7206	0.000151888234373
ko04925	Aldosterone synthesis and secretion	29/992	105/7206	0.000154855259647
ko05168	Herpes simplex infection	9/992	182/7206	0.000175347559469
ko03008	Ribosome biogenesis in eukaryotes	1/992	79/7206	0.000203760497798
ko04022	cGMP-PKG signaling pathway	49/992	216/7206	0.000279057998881
ko04260	Cardiac muscle contraction	27/992	98/7206	0.00029224248076
ko04730	Long-term depression	23/992	78/7206	0.000344068479314
ko05205	Proteoglycans in cancer	19/992	271/7206	0.000586130696593
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/992	182/7206	0.00142178655842
ko04610	Complement and coagulation cascades	2/992	79/7206	0.00145192798991
ko04072	Phospholipase D signaling pathway	43/992	197/7206	0.00157748447879
ko04217	Necroptosis	11/992	178/7206	0.00186969959504
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/992	59/7206	0.00203773239963
ko05140	Leishmaniasis	2/992	75/7206	0.00208081928296
ko04612	Antigen processing and presentation	2/992	77/7206	0.00220752210883
ko00330	Arginine and proline metabolism	1/992	61/7206	0.00227318781339
ko04976	Bile secretion	21/992	80/7206	0.00278087034038
ko05162	Measles	6/992	120/7206	0.00297847832109
ko00240	Pyrimidine metabolism	5/992	110/7206	0.00298846357033
ko04745	Phototransduction - fly	12/992	38/7206	0.00374593533834
ko04964	Proximal tubule bicarbonate reclamation	10/992	29/7206	0.0039124902104
ko04064	NF-kappa B signaling pathway	4/992	96/7206	0.00401872887296
ko04110	Cell cycle	9/992	145/7206	0.00495041644063
ko00280	Valine, leucine and isoleucine degradation	1/992	54/7206	0.00500045986719
ko05169	Epstein-Barr virus infection	15/992	206/7206	0.00529610282861
ko04070	Phosphatidylinositol signaling system	26/992	112/7206	0.00553240075012
ko04924	Renin secretion	21/992	86/7206	0.00688477094363
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/992	14/7206	0.0075072672569
ko04014	Ras signaling pathway	54/992	279/7206	0.00770014981314
ko04146	Peroxisome	4/992	89/7206	0.00773200567989
ko01200	Carbon metabolism	8/992	128/7206	0.00938611162565
ko04640	Hematopoietic cell lineage	2/992	64/7206	0.00945096215613
ko05133	Pertussis	4/992	87/7206	0.0110837212619
ko05414	Dilated cardiomyopathy	25/992	112/7206	0.0122223078807
ko05161	Hepatitis B	13/992	173/7206	0.0136286761171
ko04214	Apoptosis - fly	3/992	72/7206	0.0147344291993
ko04137	Mitophagy - animal	4/992	82/7206	0.0148503111323
ko04630	Jak-STAT signaling pathway	9/992	132/7206	0.0153442879564
ko04140	Autophagy - animal	12/992	164/7206	0.0153707436832
ko03018	RNA degradation	4/992	84/7206	0.0154392385019
ko04930	Type II diabetes mellitus	14/992	54/7206	0.0156321192645
ko00071	Fatty acid degradation	1/992	45/7206	0.0163572829935
ko00620	Pyruvate metabolism	1/992	46/7206	0.0164638580747
ko03420	Nucleotide excision repair	1/992	46/7206	0.0164638580747
ko00270	Cysteine and methionine metabolism	1/992	47/7206	0.0169467781299
ko04540	Gap junction	27/992	128/7206	0.0194990059017
ko04071	Sphingolipid signaling pathway	33/992	162/7206	0.0202722726037
ko04750	Inflammatory mediator regulation of TRP channels	26/992	122/7206	0.0230883894312
ko00983	Drug metabolism - other enzymes	1/992	42/7206	0.0241909274956
ko04711	Circadian rhythm - fly	5/992	13/7206	0.0242314389147
ko03022	Basal transcription factors	1/992	44/7206	0.0250360347227
ko04371	Apelin signaling pathway	35/992	177/7206	0.0263610554204
ko05410	Hypertrophic cardiomyopathy (HCM)	22/992	100/7206	0.0267918021834
ko04657	IL-17 signaling pathway	5/992	87/7206	0.0273087732516
ko00480	Glutathione metabolism	2/992	55/7206	0.0282313356154
ko01524	Platinum drug resistance	4/992	76/7206	0.0284175296211
ko05016	Huntington's disease	19/992	215/7206	0.0342864215975
ko00980	Metabolism of xenobiotics by cytochrome P450	1/992	40/7206	0.0359366523523
ko04210	Apoptosis	15/992	180/7206	0.036474137871
ko05166	HTLV-I infection	28/992	292/7206	0.0369513381568
ko00380	Tryptophan metabolism	2/992	50/7206	0.0394782827272
ko04622	RIG-I-like receptor signaling pathway	3/992	62/7206	0.0401954257127
ko00561	Glycerolipid metabolism	3/992	63/7206	0.0408665617651
ko04710	Circadian rhythm	11/992	43/7206	0.0411020657931