ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	154/923	423/7206	6.2821572602e-38
ko04724	Glutamatergic synapse	76/923	152/7206	2.48605675885e-29
ko05033	Nicotine addiction	41/923	56/7206	2.76890278293e-25
ko04721	Synaptic vesicle cycle	47/923	80/7206	1.87398774855e-22
ko05032	Morphine addiction	55/923	110/7206	1.75106214213e-21
ko04728	Dopaminergic synapse	73/923	185/7206	1.92028943546e-20
ko04713	Circadian entrainment	60/923	136/7206	7.652930836e-20
ko04727	GABAergic synapse	52/923	110/7206	5.56227563557e-19
ko04723	Retrograde endocannabinoid signaling	67/923	175/7206	5.07266479131e-18
ko04725	Cholinergic synapse	61/923	160/7206	2.11756197133e-16
ko04911	Insulin secretion	50/923	117/7206	5.00568438697e-16
ko04921	Oxytocin signaling pathway	69/923	209/7206	1.19459620779e-14
ko04024	cAMP signaling pathway	82/923	279/7206	6.91266750115e-14
ko04726	Serotonergic synapse	49/923	137/7206	3.43194573253e-12
ko04742	Taste transduction	30/923	61/7206	4.83500751542e-12
ko05031	Amphetamine addiction	37/923	91/7206	2.08994587494e-11
ko04020	Calcium signaling pathway	73/923	265/7206	5.74536088546e-11
ko04720	Long-term potentiation	37/923	99/7206	3.79011135755e-10
ko04261	Adrenergic signaling in cardiomyocytes	59/923	205/7206	7.91564600362e-10
ko04966	Collecting duct acid secretion	15/923	26/7206	7.18955468567e-08
ko03040	Spliceosome	1/923	145/7206	9.38866922214e-08
ko04514	Cell adhesion molecules (CAMs)	39/923	130/7206	1.67916823077e-07
ko05203	Viral carcinogenesis	10/923	277/7206	1.77900478538e-07
ko05164	Influenza A	3/923	167/7206	4.56171507938e-07
ko04744	Phototransduction	17/923	36/7206	4.60641295302e-07
ko05030	Cocaine addiction	26/923	73/7206	4.80463538777e-07
ko04971	Gastric acid secretion	31/923	98/7206	8.0666097519e-07
ko04970	Salivary secretion	30/923	95/7206	1.26249836282e-06
ko04925	Aldosterone synthesis and secretion	32/923	105/7206	1.85877175515e-06
ko05162	Measles	1/923	120/7206	2.55990593283e-06
ko04060	Cytokine-cytokine receptor interaction	6/923	191/7206	4.80570429291e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	24/923	74/7206	8.68930423379e-06
ko04260	Cardiac muscle contraction	29/923	98/7206	9.39706250936e-06
ko05168	Herpes simplex infection	6/923	182/7206	1.41425021894e-05
ko04120	Ubiquitin mediated proteolysis	3/923	138/7206	1.47414931012e-05
ko05322	Systemic lupus erythematosus	4/923	151/7206	1.98164975746e-05
ko04745	Phototransduction - fly	15/923	38/7206	3.21387693105e-05
ko04010	MAPK signaling pathway	67/923	321/7206	3.53248634527e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/923	79/7206	4.84640295248e-05
ko04621	NOD-like receptor signaling pathway	5/923	157/7206	5.02701793934e-05
ko05110	Vibrio cholerae infection	20/923	63/7206	6.81913931994e-05
ko03013	RNA transport	6/923	166/7206	8.17536037987e-05
ko05161	Hepatitis B	7/923	173/7206	0.000122460797832
ko05166	HTLV-I infection	18/923	292/7206	0.000226811782001
ko04972	Pancreatic secretion	28/923	111/7206	0.000291819772324
ko05215	Prostate cancer	3/923	111/7206	0.000452629345472
ko04612	Antigen processing and presentation	1/923	77/7206	0.000480011058476
ko04976	Bile secretion	22/923	80/7206	0.000526840573864
ko04964	Proximal tubule bicarbonate reclamation	11/923	29/7206	0.000550985320102
ko05205	Proteoglycans in cancer	17/923	271/7206	0.000557357138985
ko04630	Jak-STAT signaling pathway	5/923	132/7206	0.00057117619502
ko04110	Cell cycle	6/923	145/7206	0.00061126599012
ko05169	Epstein-Barr virus infection	11/923	206/7206	0.000626299126356
ko04730	Long-term depression	21/923	78/7206	0.000858268627004
ko04070	Phosphatidylinositol signaling system	27/923	112/7206	0.000887503652004
ko05414	Dilated cardiomyopathy	27/923	112/7206	0.000887503652004
ko04626	Plant-pathogen interaction	8/923	18/7206	0.000939160672315
ko04740	Olfactory transduction	21/923	80/7206	0.00105513696399
ko04214	Apoptosis - fly	1/923	72/7206	0.00108381505
ko04141	Protein processing in endoplasmic reticulum	10/923	184/7206	0.00157576103102
ko04022	cGMP-PKG signaling pathway	44/923	216/7206	0.00176277430327
ko04064	NF-kappa B signaling pathway	3/923	96/7206	0.00183397605338
ko04540	Gap junction	29/923	128/7206	0.00187233981322
ko05410	Hypertrophic cardiomyopathy (HCM)	24/923	100/7206	0.00214246312484
ko04137	Mitophagy - animal	2/923	82/7206	0.00225895867845
ko04140	Autophagy - animal	9/923	164/7206	0.00289510178243
ko04924	Renin secretion	21/923	86/7206	0.00293924486467
ko03008	Ribosome biogenesis in eukaryotes	2/923	79/7206	0.00330672936394
ko04330	Notch signaling pathway	1/923	62/7206	0.0035348332309
ko05222	Small cell lung cancer	3/923	89/7206	0.00373211160702
ko04750	Inflammatory mediator regulation of TRP channels	27/923	122/7206	0.00373828039229
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/923	92/7206	0.00399884106439
ko05140	Leishmaniasis	2/923	75/7206	0.00468122377654
ko01524	Platinum drug resistance	2/923	76/7206	0.0048329967063
ko04550	Signaling pathways regulating pluripotency of stem cells	10/923	165/7206	0.00641225371951
ko04360	Axon guidance	44/923	233/7206	0.00692663123316
ko04922	Glucagon signaling pathway	27/923	128/7206	0.00729799085989
ko05010	Alzheimer's disease	39/923	202/7206	0.00736546685838
ko00520	Amino sugar and nucleotide sugar metabolism	1/923	55/7206	0.00773871755212
ko05220	Chronic myeloid leukemia	3/923	85/7206	0.00789609933659
ko04668	TNF signaling pathway	6/923	120/7206	0.00813297227793
ko04072	Phospholipase D signaling pathway	38/923	197/7206	0.00905170131462
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/923	59/7206	0.00908493579806
ko04210	Apoptosis	12/923	180/7206	0.00930044675372
ko04915	Estrogen signaling pathway	27/923	131/7206	0.0114377098947
ko00590	Arachidonic acid metabolism	1/923	52/7206	0.0114552346791
ko05200	Pathways in cancer	45/923	492/7206	0.0116811179123
ko04218	Cellular senescence	12/923	177/7206	0.0120426673242
ko04640	Hematopoietic cell lineage	2/923	64/7206	0.01384431209
ko00190	Oxidative phosphorylation	26/923	127/7206	0.0149380494235
ko04611	Platelet activation	11/923	163/7206	0.0172212939689
ko04510	Focal adhesion	19/923	240/7206	0.018320110126
ko00310	Lysine degradation	3/923	73/7206	0.0211087228621
ko04371	Apelin signaling pathway	33/923	177/7206	0.0225881348302
ko04217	Necroptosis	13/923	178/7206	0.0229889121421
ko05323	Rheumatoid arthritis	19/923	89/7206	0.0238003237307
ko00562	Inositol phosphate metabolism	19/923	89/7206	0.0238003237307
ko05144	Malaria	1/923	45/7206	0.0249484558256
ko00071	Fatty acid degradation	1/923	45/7206	0.0249484558256
ko03420	Nucleotide excision repair	1/923	46/7206	0.0250297344689
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/923	14/7206	0.0252548394937
ko05219	Bladder cancer	1/923	48/7206	0.0265849819138
ko01521	EGFR tyrosine kinase inhibitor resistance	6/923	106/7206	0.0267384474257
ko04912	GnRH signaling pathway	24/923	122/7206	0.0281567347762
ko04014	Ras signaling pathway	48/923	279/7206	0.0282816507724
ko05212	Pancreatic cancer	4/923	83/7206	0.0298204453077
ko05145	Toxoplasmosis	8/923	126/7206	0.0301866401837
ko04145	Phagosome	30/923	162/7206	0.0322236275536
ko00680	Methane metabolism	9/923	34/7206	0.0332441395214
ko00010	Glycolysis / Gluconeogenesis	16/923	74/7206	0.0336080277208
ko04350	TGF-beta signaling pathway	6/923	103/7206	0.0359367629505
ko00565	Ether lipid metabolism	1/923	42/7206	0.0366632583516
ko04146	Peroxisome	5/923	89/7206	0.0377838513807
ko03022	Basal transcription factors	1/923	44/7206	0.0378473671353
ko04664	Fc epsilon RI signaling pathway	4/923	77/7206	0.039923088604
ko04114	Oocyte meiosis	26/923	139/7206	0.0402981867956
ko00280	Valine, leucine and isoleucine degradation	2/923	54/7206	0.0404914132922
ko00480	Glutathione metabolism	2/923	55/7206	0.0407639254022
ko05321	Inflammatory bowel disease (IBD)	2/923	56/7206	0.0415758698933
ko05217	Basal cell carcinoma	3/923	68/7206	0.0421965424195
ko04620	Toll-like receptor signaling pathway	6/923	100/7206	0.0480987166975