ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	156/883	423/7206	8.59199110816e-42
ko05033	Nicotine addiction	47/883	56/7206	1.19457772726e-34
ko04724	Glutamatergic synapse	78/883	152/7206	1.86888928329e-32
ko04727	GABAergic synapse	60/883	110/7206	4.92345108144e-27
ko05032	Morphine addiction	60/883	110/7206	4.92345108144e-27
ko04728	Dopaminergic synapse	74/883	185/7206	2.61709850383e-22
ko04723	Retrograde endocannabinoid signaling	69/883	175/7206	1.91472292516e-20
ko04713	Circadian entrainment	58/883	136/7206	2.69562723584e-19
ko04024	cAMP signaling pathway	85/883	279/7206	1.91851254743e-16
ko04725	Cholinergic synapse	59/883	160/7206	5.03936447315e-16
ko04744	Phototransduction	25/883	36/7206	1.86959990538e-15
ko04721	Synaptic vesicle cycle	38/883	80/7206	6.40842039185e-15
ko04742	Taste transduction	31/883	61/7206	2.03054172122e-13
ko04020	Calcium signaling pathway	73/883	265/7206	5.82875461026e-12
ko04726	Serotonergic synapse	47/883	137/7206	1.06227953873e-11
ko04921	Oxytocin signaling pathway	61/883	209/7206	2.50802414205e-11
ko04911	Insulin secretion	42/883	117/7206	2.57141503904e-11
ko05031	Amphetamine addiction	35/883	91/7206	1.32286136444e-10
ko04261	Adrenergic signaling in cardiomyocytes	57/883	205/7206	9.24688292395e-10
ko05030	Cocaine addiction	29/883	73/7206	2.12856979667e-09
ko05203	Viral carcinogenesis	7/883	277/7206	6.01409156286e-09
ko04720	Long-term potentiation	34/883	99/7206	7.75026261605e-09
ko04970	Salivary secretion	31/883	95/7206	1.36103597837e-07
ko03040	Spliceosome	1/883	145/7206	2.32840636214e-07
ko04060	Cytokine-cytokine receptor interaction	4/883	191/7206	4.87794904146e-07
ko05164	Influenza A	3/883	167/7206	1.05372590814e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	24/883	74/7206	3.99240832982e-06
ko04010	MAPK signaling pathway	67/883	321/7206	7.33499149564e-06
ko05168	Herpes simplex infection	6/883	182/7206	2.95883420784e-05
ko04260	Cardiac muscle contraction	27/883	98/7206	3.28237799451e-05
ko05169	Epstein-Barr virus infection	8/883	206/7206	5.18431227807e-05
ko04925	Aldosterone synthesis and secretion	28/883	105/7206	5.7248230566e-05
ko04110	Cell cycle	4/883	145/7206	9.13347778383e-05
ko05205	Proteoglycans in cancer	14/883	271/7206	9.48368455398e-05
ko04514	Cell adhesion molecules (CAMs)	32/883	130/7206	0.000110694345374
ko04971	Gastric acid secretion	26/883	98/7206	0.000122283158798
ko04072	Phospholipase D signaling pathway	43/883	197/7206	0.000145676452912
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	22/883	79/7206	0.000167460044651
ko04972	Pancreatic secretion	28/883	111/7206	0.000182625924349
ko05162	Measles	3/883	120/7206	0.000213089278609
ko05322	Systemic lupus erythematosus	5/883	151/7206	0.000217017147071
ko04022	cGMP-PKG signaling pathway	45/883	216/7206	0.000293725058036
ko04730	Long-term depression	21/883	78/7206	0.00035682431301
ko04621	NOD-like receptor signaling pathway	6/883	157/7206	0.000470863507503
ko04120	Ubiquitin mediated proteolysis	5/883	138/7206	0.000590566666567
ko04966	Collecting duct acid secretion	10/883	26/7206	0.000606501629758
ko03013	RNA transport	7/883	166/7206	0.00067944934525
ko05166	HTLV-I infection	18/883	292/7206	0.000690760487353
ko05161	Hepatitis B	8/883	173/7206	0.000909314354733
ko05414	Dilated cardiomyopathy	26/883	112/7206	0.00114053909897
ko04070	Phosphatidylinositol signaling system	26/883	112/7206	0.00114053909897
ko04915	Estrogen signaling pathway	29/883	131/7206	0.00115833162415
ko04350	TGF-beta signaling pathway	3/883	103/7206	0.00131790103442
ko04740	Olfactory transduction	20/883	80/7206	0.00156306802006
ko04140	Autophagy - animal	8/883	164/7206	0.00233380507027
ko04510	Focal adhesion	15/883	240/7206	0.00254739948297
ko04064	NF-kappa B signaling pathway	3/883	96/7206	0.00269302426738
ko04141	Protein processing in endoplasmic reticulum	10/883	184/7206	0.00283258152146
ko05215	Prostate cancer	4/883	111/7206	0.00305938161205
ko04540	Gap junction	27/883	128/7206	0.00395580708436
ko04924	Renin secretion	20/883	86/7206	0.00417149491209
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/883	14/7206	0.00417815020293
ko04745	Phototransduction - fly	11/883	38/7206	0.00460678494015
ko04612	Antigen processing and presentation	2/883	77/7206	0.00472563129601
ko03008	Ribosome biogenesis in eukaryotes	2/883	79/7206	0.00488489652136
ko04964	Proximal tubule bicarbonate reclamation	9/883	29/7206	0.00612257632555
ko00290	Valine, leucine and isoleucine biosynthesis	3/883	4/7206	0.00666540813016
ko05140	Leishmaniasis	2/883	75/7206	0.00693335461156
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/883	182/7206	0.00801601735933
ko05110	Vibrio cholerae infection	15/883	63/7206	0.0103401658473
ko04218	Cellular senescence	11/883	177/7206	0.0103718466905
ko04630	Jak-STAT signaling pathway	7/883	132/7206	0.0105194725877
ko03018	RNA degradation	3/883	84/7206	0.0109950603868
ko04550	Signaling pathways regulating pluripotency of stem cells	10/883	165/7206	0.0113081935178
ko00480	Glutathione metabolism	1/883	55/7206	0.0117817494969
ko05200	Pathways in cancer	43/883	492/7206	0.0125672292103
ko05410	Hypertrophic cardiomyopathy (HCM)	21/883	100/7206	0.0128234561999
ko05217	Basal cell carcinoma	2/883	68/7206	0.0142790049724
ko04014	Ras signaling pathway	48/883	279/7206	0.0150234969197
ko00590	Arachidonic acid metabolism	1/883	52/7206	0.0174800938079
ko05145	Toxoplasmosis	7/883	126/7206	0.0189183725747
ko04640	Hematopoietic cell lineage	2/883	64/7206	0.0202898139227
ko04210	Apoptosis	12/883	180/7206	0.0205680222719
ko05034	Alcoholism	41/883	238/7206	0.020670198445
ko04146	Peroxisome	4/883	89/7206	0.0216564248565
ko05222	Small cell lung cancer	4/883	89/7206	0.0216564248565
ko04976	Bile secretion	17/883	80/7206	0.02366630608
ko05219	Bladder cancer	1/883	48/7206	0.0254439227642
ko05224	Breast cancer	12/883	174/7206	0.0260332585219
ko05016	Huntington's disease	16/883	215/7206	0.0264440902497
ko00240	Pyrimidine metabolism	6/883	110/7206	0.0269251909547
ko04810	Regulation of actin cytoskeleton	21/883	264/7206	0.0277679307034
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/883	15/7206	0.0286120419902
ko04214	Apoptosis - fly	3/883	72/7206	0.0299600271246
ko00310	Lysine degradation	3/883	73/7206	0.0300474370398
ko04115	p53 signaling pathway	3/883	74/7206	0.0304512244187
ko00513	Various types of N-glycan biosynthesis	10/883	42/7206	0.0313930650152
ko04670	Leukocyte transendothelial migration	10/883	151/7206	0.0322881676493
ko03022	Basal transcription factors	1/883	44/7206	0.0372260608042
ko05144	Malaria	1/883	45/7206	0.0375373308465
ko00071	Fatty acid degradation	1/883	45/7206	0.0375373308465
ko03420	Nucleotide excision repair	1/883	46/7206	0.0384407736675
ko05131	Shigellosis	4/883	82/7206	0.0406606035274
ko04137	Mitophagy - animal	4/883	82/7206	0.0406606035274
ko05321	Inflammatory bowel disease (IBD)	2/883	56/7206	0.0411353911565
ko04360	Axon guidance	39/883	233/7206	0.0415381551606
ko03320	PPAR signaling pathway	3/883	69/7206	0.0416775376614
ko04068	FoxO signaling pathway	12/883	167/7206	0.0421245863998
ko00230	Purine metabolism	33/883	194/7206	0.0455070373477
ko04217	Necroptosis	13/883	178/7206	0.0479650830016