ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 56/541 191/7206 5.62728846404e-20 ko04380 Osteoclast differentiation 42/541 134/7206 2.20363116074e-16 ko04621 NOD-like receptor signaling pathway 41/541 157/7206 5.139768521e-13 ko04064 NF-kappa B signaling pathway 30/541 96/7206 5.27777080766e-12 ko05164 Influenza A 39/541 167/7206 8.08894558506e-11 ko05140 Leishmaniasis 24/541 75/7206 4.25564490244e-10 ko05321 Inflammatory bowel disease (IBD) 20/541 56/7206 1.39543497646e-09 ko05145 Toxoplasmosis 31/541 126/7206 1.92047548723e-09 ko04672 Intestinal immune network for IgA production 16/541 37/7206 2.3954440358e-09 ko04650 Natural killer cell mediated cytotoxicity 25/541 97/7206 2.67482990978e-08 ko04217 Necroptosis 36/541 178/7206 2.70703187855e-08 ko04668 TNF signaling pathway 28/541 120/7206 4.10946561489e-08 ko04659 Th17 cell differentiation 26/541 106/7206 4.24931015111e-08 ko05340 Primary immunodeficiency 13/541 30/7206 7.60993611398e-08 ko04630 Jak-STAT signaling pathway 29/541 132/7206 9.68656038074e-08 ko05162 Measles 27/541 120/7206 1.60704412928e-07 ko04660 T cell receptor signaling pathway 27/541 124/7206 3.26744917204e-07 ko00120 Primary bile acid biosynthesis 10/541 20/7206 4.86546205628e-07 ko04620 Toll-like receptor signaling pathway 23/541 100/7206 8.87938241033e-07 ko05150 Staphylococcus aureus infection 13/541 36/7206 9.6363918704e-07 ko05152 Tuberculosis 34/541 187/7206 1.3218976306e-06 ko05161 Hepatitis B 32/541 173/7206 1.34338197924e-06 ko04658 Th1 and Th2 cell differentiation 22/541 96/7206 1.63923472767e-06 ko05144 Malaria 14/541 45/7206 2.88978624461e-06 ko05330 Allograft rejection 10/541 24/7206 3.91887539168e-06 ko04610 Complement and coagulation cascades 19/541 79/7206 3.92704163386e-06 ko05133 Pertussis 20/541 87/7206 4.62979194453e-06 ko05168 Herpes simplex infection 32/541 182/7206 4.75780874015e-06 ko05310 Asthma 8/541 17/7206 1.26954406282e-05 ko04640 Hematopoietic cell lineage 16/541 64/7206 1.34429474955e-05 ko04662 B cell receptor signaling pathway 19/541 88/7206 2.08964184052e-05 ko05160 Hepatitis C 27/541 153/7206 2.78634598738e-05 ko05320 Autoimmune thyroid disease 10/541 29/7206 2.83681726323e-05 ko04611 Platelet activation 28/541 163/7206 2.87634903945e-05 ko04666 Fc gamma R-mediated phagocytosis 23/541 122/7206 3.04118112219e-05 ko04622 RIG-I-like receptor signaling pathway 15/541 62/7206 3.79634623931e-05 ko05034 Alcoholism 4/541 238/7206 8.46797041733e-05 ko00350 Tyrosine metabolism 10/541 33/7206 9.96166745584e-05 ko04062 Chemokine signaling pathway 31/541 201/7206 0.000104065394094 ko04670 Leukocyte transendothelial migration 25/541 151/7206 0.000137252325742 ko04657 IL-17 signaling pathway 17/541 87/7206 0.000208305775154 ko05167 Kaposi's sarcoma-associated herpesvirus infection 29/541 191/7206 0.000227997460837 ko04210 Apoptosis 28/541 180/7206 0.000244032599131 ko05142 Chagas disease (American trypanosomiasis) 22/541 130/7206 0.000272814942172 ko05323 Rheumatoid arthritis 17/541 89/7206 0.000277217236029 ko05132 Salmonella infection 18/541 98/7206 0.000307814440567 ko03040 Spliceosome 1/541 145/7206 0.000318797770541 ko00590 Arachidonic acid metabolism 12/541 52/7206 0.00036241907761 ko04612 Antigen processing and presentation 15/541 77/7206 0.000502890089795 ko04623 Cytosolic DNA-sensing pathway 10/541 41/7206 0.000698260300946 ko05012 Parkinson's disease 2/541 155/7206 0.000964506572149 ko05131 Shigellosis 15/541 82/7206 0.00100197620168 ko04723 Retrograde endocannabinoid signaling 3/541 175/7206 0.00118160674947 ko04933 AGE-RAGE signaling pathway in diabetic complications 21/541 135/7206 0.00132402171094 ko05332 Graft-versus-host disease 6/541 18/7206 0.00147977654459 ko04664 Fc epsilon RI signaling pathway 14/541 77/7206 0.00155396201743 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/541 4/7206 0.00158964957291 ko00643 Styrene degradation 3/541 4/7206 0.00158964957291 ko04390 Hippo signaling pathway 4/541 188/7206 0.00187231817965 ko00140 Steroid hormone biosynthesis 9/541 41/7206 0.0028239518112 ko05146 Amoebiasis 16/541 99/7206 0.00308383239147 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/541 5/7206 0.00375235666178 ko00950 Isoquinoline alkaloid biosynthesis 4/541 10/7206 0.00457686428411 ko00190 Oxidative phosphorylation 2/541 127/7206 0.00578433964664 ko00360 Phenylalanine metabolism 5/541 17/7206 0.00678293819978 ko05143 African trypanosomiasis 7/541 32/7206 0.00834102545038 ko05010 Alzheimer's disease 6/541 202/7206 0.00952294322351 ko04260 Cardiac muscle contraction 1/541 98/7206 0.0101358182302 ko00592 alpha-Linolenic acid metabolism 5/541 19/7206 0.0112495061351 ko05016 Huntington's disease 7/541 215/7206 0.0121687419207 ko05418 Fluid shear stress and atherosclerosis 22/541 173/7206 0.0126205534586 ko05224 Breast cancer 5/541 174/7206 0.0131317617715 ko04145 Phagosome 21/541 162/7206 0.014459355884 ko04512 ECM-receptor interaction 12/541 79/7206 0.0161414479728 ko05134 Legionellosis 11/541 74/7206 0.0243218374092 ko04940 Type I diabetes mellitus 6/541 32/7206 0.0295071676911 ko00051 Fructose and mannose metabolism 7/541 42/7206 0.0350235090693 ko00565 Ether lipid metabolism 7/541 42/7206 0.0350235090693 ko04068 FoxO signaling pathway 20/541 167/7206 0.0359395335657 ko04910 Insulin signaling pathway 6/541 172/7206 0.0398673041479 ko04713 Circadian entrainment 4/541 136/7206 0.046203585536 ko04728 Dopaminergic synapse 7/541 185/7206 0.048002947889