ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	149/916	423/7206	3.94336535803e-35
ko05033	Nicotine addiction	47/916	56/7206	6.69912100798e-34
ko04724	Glutamatergic synapse	80/916	152/7206	3.9069315759e-33
ko04727	GABAergic synapse	60/916	110/7206	3.71084304338e-26
ko05032	Morphine addiction	60/916	110/7206	3.71084304338e-26
ko04723	Retrograde endocannabinoid signaling	71/916	175/7206	6.37727102003e-21
ko04713	Circadian entrainment	60/916	136/7206	5.18738059782e-20
ko04728	Dopaminergic synapse	71/916	185/7206	2.69277954198e-19
ko04744	Phototransduction	27/916	36/7206	1.39126357604e-17
ko04725	Cholinergic synapse	62/916	160/7206	3.19539968009e-17
ko04721	Synaptic vesicle cycle	41/916	80/7206	6.24453795974e-17
ko04742	Taste transduction	34/916	61/7206	1.03180289935e-15
ko04024	cAMP signaling pathway	82/916	279/7206	5.21129052526e-14
ko04726	Serotonergic synapse	50/916	137/7206	6.27005630978e-13
ko04911	Insulin secretion	45/916	117/7206	1.0840486889e-12
ko04921	Oxytocin signaling pathway	60/916	209/7206	4.9320856203e-10
ko04740	Olfactory transduction	32/916	80/7206	6.52977879778e-10
ko04020	Calcium signaling pathway	70/916	265/7206	7.59988385664e-10
ko05031	Amphetamine addiction	34/916	91/7206	1.62363436748e-09
ko04261	Adrenergic signaling in cardiomyocytes	57/916	205/7206	3.814881642e-09
ko05030	Cocaine addiction	28/916	73/7206	2.3163499854e-08
ko04720	Long-term potentiation	33/916	99/7206	7.34844676414e-08
ko03040	Spliceosome	1/916	145/7206	9.08209717189e-08
ko05203	Viral carcinogenesis	11/916	277/7206	7.60672893432e-07
ko04970	Salivary secretion	30/916	95/7206	1.07263677356e-06
ko04120	Ubiquitin mediated proteolysis	2/916	138/7206	2.04817221271e-06
ko04010	MAPK signaling pathway	70/916	321/7206	3.04732538179e-06
ko05164	Influenza A	4/916	167/7206	3.0643532293e-06
ko04514	Cell adhesion molecules (CAMs)	35/916	130/7206	1.22005680323e-05
ko05168	Herpes simplex infection	6/916	182/7206	1.40916926542e-05
ko05322	Systemic lupus erythematosus	4/916	151/7206	1.97614349397e-05
ko05162	Measles	2/916	120/7206	2.19559374582e-05
ko04260	Cardiac muscle contraction	28/916	98/7206	2.20900510548e-05
ko04060	Cytokine-cytokine receptor interaction	7/916	191/7206	2.26381869102e-05
ko05205	Proteoglycans in cancer	14/916	271/7206	3.73598096076e-05
ko04925	Aldosterone synthesis and secretion	29/916	105/7206	3.91484012406e-05
ko04621	NOD-like receptor signaling pathway	5/916	157/7206	4.98640039698e-05
ko03013	RNA transport	6/916	166/7206	8.08174487635e-05
ko04971	Gastric acid secretion	27/916	98/7206	8.13270543737e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/916	79/7206	0.000101096346732
ko04964	Proximal tubule bicarbonate reclamation	12/916	29/7206	0.000108004276941
ko05014	Amyotrophic lateral sclerosis (ALS)	22/916	74/7206	0.000121732994787
ko04972	Pancreatic secretion	29/916	111/7206	0.00012766327711
ko04610	Complement and coagulation cascades	1/916	79/7206	0.000491302105718
ko04745	Phototransduction - fly	13/916	38/7206	0.00052606003058
ko04110	Cell cycle	6/916	145/7206	0.000615373368673
ko04966	Collecting duct acid secretion	10/916	26/7206	0.000814651180619
ko04072	Phospholipase D signaling pathway	41/916	197/7206	0.00107708388114
ko04022	cGMP-PKG signaling pathway	44/916	216/7206	0.00121321128058
ko04140	Autophagy - animal	8/916	164/7206	0.0012173068179
ko05169	Epstein-Barr virus infection	12/916	206/7206	0.00138296350322
ko05166	HTLV-I infection	20/916	292/7206	0.00158550246048
ko05161	Hepatitis B	9/916	173/7206	0.00162744527647
ko04730	Long-term depression	20/916	78/7206	0.00167936855332
ko04064	NF-kappa B signaling pathway	3/916	96/7206	0.0018406589441
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/916	182/7206	0.00212037148905
ko05215	Prostate cancer	4/916	111/7206	0.00217219515598
ko05414	Dilated cardiomyopathy	26/916	112/7206	0.00226759617053
ko04070	Phosphatidylinositol signaling system	26/916	112/7206	0.00226759617053
ko04612	Antigen processing and presentation	2/916	77/7206	0.00319917589375
ko03008	Ribosome biogenesis in eukaryotes	2/916	79/7206	0.00325945341656
ko04141	Protein processing in endoplasmic reticulum	11/916	184/7206	0.00343059675796
ko05140	Leishmaniasis	2/916	75/7206	0.00465319658787
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/916	14/7206	0.00503378679155
ko04976	Bile secretion	19/916	80/7206	0.00603817256633
ko03018	RNA degradation	3/916	84/7206	0.00761023675735
ko04630	Jak-STAT signaling pathway	7/916	132/7206	0.00777490144378
ko00480	Glutathione metabolism	1/916	55/7206	0.00778189186833
ko04150	mTOR signaling pathway	12/916	184/7206	0.0094377570333
ko05217	Basal cell carcinoma	2/916	68/7206	0.00966489374133
ko00590	Arachidonic acid metabolism	1/916	52/7206	0.0114943690309
ko04217	Necroptosis	12/916	178/7206	0.0120896927519
ko04510	Focal adhesion	18/916	240/7206	0.0132927055306
ko04924	Renin secretion	19/916	86/7206	0.0136255545933
ko04640	Hematopoietic cell lineage	2/916	64/7206	0.0139052055261
ko05145	Toxoplasmosis	7/916	126/7206	0.0142087136694
ko04146	Peroxisome	4/916	89/7206	0.0154374964626
ko04218	Cellular senescence	12/916	177/7206	0.0157805177683
ko05016	Huntington's disease	16/916	215/7206	0.0165068318864
ko04915	Estrogen signaling pathway	26/916	131/7206	0.0170892947405
ko05224	Breast cancer	12/916	174/7206	0.0204160789644
ko00310	Lysine degradation	3/916	73/7206	0.021134722957
ko04657	IL-17 signaling pathway	4/916	87/7206	0.0217638780032
ko05410	Hypertrophic cardiomyopathy (HCM)	21/916	100/7206	0.0217768627438
ko04210	Apoptosis	13/916	180/7206	0.0230599922147
ko00562	Inositol phosphate metabolism	19/916	89/7206	0.023181392394
ko03420	Nucleotide excision repair	1/916	46/7206	0.0250249983432
ko05219	Bladder cancer	1/916	48/7206	0.0262429526536
ko04014	Ras signaling pathway	48/916	279/7206	0.0273274283146
ko05034	Alcoholism	42/916	238/7206	0.0287944204825
ko04137	Mitophagy - animal	4/916	82/7206	0.029255243244
ko05200	Pathways in cancer	47/916	492/7206	0.0295490101418
ko04214	Apoptosis - fly	3/916	72/7206	0.0305084834454
ko04540	Gap junction	25/916	128/7206	0.0307994955281
ko05110	Vibrio cholerae infection	14/916	63/7206	0.0340227317435
ko05418	Fluid shear stress and atherosclerosis	13/916	173/7206	0.0371320754569
ko03022	Basal transcription factors	1/916	44/7206	0.0375722992404
ko05144	Malaria	1/916	45/7206	0.0389059876023
ko00071	Fatty acid degradation	1/916	45/7206	0.0389059876023
ko00280	Valine, leucine and isoleucine degradation	2/916	54/7206	0.0406403407305
ko05416	Viral myocarditis	2/916	55/7206	0.0406900009989
ko05321	Inflammatory bowel disease (IBD)	2/916	56/7206	0.0412720535234
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/916	59/7206	0.0462018519025
ko04142	Lysosome	11/916	151/7206	0.0471298193993